KEGG_ERBB_SIGNALING_PATHWAY |
Return to index |
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Order |
Gene |
Description |
ref_hepatocyte |
HepG2 |
HepG2.C3A |
HuH.7 |
SNU475 |
THLE |
liver |
1 |
EIF4EBP1 |
Eukaryotic translation initiation factor 4E-binding protein 1 |
[1] |
-1.52[2] |
-1.87[3] |
-1.33[4] |
-3.71[5] |
-2.22[6] |
-1.92[7] |
2 |
JUN |
Transcription factor AP-1 |
[8] |
-1.02[9] |
-2.59[10] |
-2.39[11] |
-2.11[12] |
-1.61[13] |
-2.13[14] |
3 |
CDKN1A |
Cyclin-dependent kinase inhibitor 1 |
[15] |
0.31[16] |
-1.11[17] |
-3.87[18] |
-2.40[19] |
0.10[20] |
-2.16[21] |
4 |
AKT1 |
RAC-alpha serine/threonine-protein kinase |
[22] |
-0.45[23] |
-0.71[24] |
-1.86[25] |
-0.46[26] |
-0.50[27] |
-0.57[28] |
5 |
MYC |
Myc proto-oncogene protein |
[29] |
-0.10[30] |
-0.47[31] |
-2.56[32] |
-3.20[33] |
-0.89[34] |
-2.32[35] |
6 |
MAP2K1 |
Dual specificity mitogen-activated protein kinase kinase 1 |
[36] |
-1.46[37] |
-1.82[38] |
-1.30[39] |
-0.95[40] |
-0.51[41] |
-1.52[42] |
7 |
MAP2K2 |
Dual specificity mitogen-activated protein kinase kinase 2 |
[43] |
-0.48[44] |
-0.83[45] |
-0.02[46] |
-1.25[47] |
-0.83[48] |
-2.03[49] |
8 |
GRB2 |
Growth factor receptor-bound protein 2 |
[50] |
0.66[51] |
0.47[52] |
0.53[53] |
0.15[54] |
0.00[55] |
-0.03[56] |
9 |
CRK |
Adapter molecule crk |
[57] |
-0.73[58] |
-0.83[59] |
-0.83[60] |
-0.65[61] |
-0.31[62] |
0.52[63] |
10 |
RPS6KB2 |
Ribosomal protein S6 kinase beta-2 |
[64] |
[65] |
[66] |
[67] |
[68] |
[69] |
[70] |
11 |
BAD |
Bcl2-associated agonist of cell death |
[71] |
-2.20[72] |
-2.10[73] |
-3.11[74] |
-1.47[75] |
-1.14[76] |
-1.74[77] |
12 |
SHC1 |
SHC-transforming protein 1 |
[78] |
0.63[79] |
0.82[80] |
0.83[81] |
2.24[82] |
1.67[83] |
0.45[84] |
13 |
RAF1 |
RAF proto-oncogene serine/threonine-protein kinase |
[85] |
-0.59[86] |
-0.22[87] |
0.98[88] |
-0.59[89] |
0.21[90] |
0.77[91] |
14 |
NRAS |
GTPase NRas |
[92] |
0.10[93] |
0.50[94] |
0.85[95] |
0.59[96] |
0.10[97] |
-0.58[98] |
15 |
CDKN1B |
Cyclin-dependent kinase inhibitor 1B |
[99] |
-0.62[100] |
-0.20[101] |
-0.07[102] |
-1.52[103] |
-1.12[104] |
-1.23[105] |
16 |
ARAF |
Serine/threonine-protein kinase A-Raf |
[106] |
-0.99[107] |
-1.32[108] |
-1.12[109] |
-0.50[110] |
-0.53[111] |
0.55[112] |
17 |
HRAS |
GTPase HRas |
[113] |
-1.54[114] |
-2.27[115] |
-3.13[116] |
-1.36[117] |
-1.63[118] |
-2.99[119] |
18 |
NCK1 |
Cytoplasmic protein NCK1 |
[120] |
-2.13[121] |
-2.05[122] |
-2.01[123] |
-0.97[124] |
-0.92[125] |
-0.79[126] |
19 |
PAK2 |
Serine/threonine-protein kinase PAK 2 |
[127] |
0.92[128] |
0.63[129] |
0.86[130] |
0.35[131] |
0.83[132] |
1.04[133] |
20 |
MAPK1 |
Mitogen-activated protein kinase 1 |
[134] |
1.18[135] |
1.29[136] |
1.05[137] |
1.44[138] |
1.03[139] |
1.45[140] |
21 |
AKT2 |
RAC-beta serine/threonine-protein kinase |
[141] |
0.43[142] |
0.67[143] |
0.74[144] |
0.45[145] |
0.18[146] |
0.81[147] |
22 |
SHC2 |
SHC-transforming protein 2 |
[148] |
-1.91[149] |
-1.59[150] |
-2.50[151] |
-5.07[152] |
-4.77[153] |
-0.70[154] |
23 |
KRAS |
GTPase KRas |
[155] |
-1.05[156] |
-1.10[157] |
0.44[158] |
0.39[159] |
-0.01[160] |
0.35[161] |
24 |
PTK2 |
Focal adhesion kinase 1 |
[162] |
0.20[163] |
0.66[164] |
0.98[165] |
1.54[166] |
0.68[167] |
0.44[168] |
25 |
ERBB3 |
Receptor tyrosine-protein kinase erbB-3 |
[169] |
1.47[170] |
2.82[171] |
1.80[172] |
-6.28[173] |
-6.09[174] |
1.98[175] |
26 |
CRKL |
Crk-like protein |
[176] |
1.17[177] |
1.24[178] |
1.78[179] |
0.72[180] |
0.86[181] |
1.13[182] |
27 |
PIK3R1 |
Phosphatidylinositol 3-kinase regulatory subunit alpha |
[183] |
-1.00[184] |
-0.91[185] |
0.11[186] |
1.66[187] |
1.10[188] |
2.68[189] |
28 |
CBLC |
E3 ubiquitin-protein ligase CBL-C |
[190] |
-2.55[191] |
-1.46[192] |
-9.87[193] |
-11.93[194] |
-10.49[195] |
-1.41[196] |
29 |
MAPK8 |
Mitogen-activated protein kinase 8 |
[197] |
-1.98[198] |
-0.59[199] |
-1.79[200] |
-1.31[201] |
-1.52[202] |
-0.84[203] |
30 |
SOS1 |
Son of sevenless homolog 1 |
[204] |
-0.63[205] |
0.87[206] |
0.31[207] |
0.44[208] |
-0.39[209] |
0.21[210] |
31 |
ELK1 |
ETS domain-containing protein Elk-1 |
[211] |
-0.85[212] |
-3.01[213] |
-0.66[214] |
-0.13[215] |
0.39[216] |
-0.49[217] |
32 |
ERBB2 |
Receptor tyrosine-protein kinase erbB-2 |
[218] |
1.84[219] |
0.63[220] |
1.74[221] |
0.85[222] |
0.39[223] |
-0.17[224] |
33 |
CAMK2D |
Calcium/calmodulin-dependent protein kinase type II subunit delta |
[225] |
-0.40[226] |
-0.12[227] |
1.34[228] |
0.27[229] |
-0.60[230] |
1.09[231] |
34 |
EGFR |
Epidermal growth factor receptor |
[232] |
-1.23[233] |
-1.63[234] |
1.19[235] |
0.03[236] |
0.58[237] |
2.33[238] |
35 |
PIK3R2 |
Phosphatidylinositol 3-kinase regulatory subunit beta |
[239] |
1.34[240] |
1.54[241] |
2.08[242] |
0.30[243] |
0.80[244] |
-0.62[245] |
36 |
AREG |
Amphiregulin |
[246] |
-3.39[247] |
-6.66[248] |
-8.49[249] |
-10.11[250] |
0.13[251] |
-10.63[252] |
37 |
MAP2K4 |
Dual specificity mitogen-activated protein kinase kinase 4 |
[253] |
0.17[254] |
0.78[255] |
-0.09[256] |
0.80[257] |
0.13[258] |
0.74[259] |
38 |
NCK2 |
Cytoplasmic protein NCK2 |
[260] |
0.27[261] |
-0.18[262] |
-1.83[263] |
-0.74[264] |
-0.06[265] |
-1.15[266] |
39 |
PAK4 |
Serine/threonine-protein kinase PAK 4 |
[267] |
0.36[268] |
0.37[269] |
1.00[270] |
0.61[271] |
0.27[272] |
-0.65[273] |
40 |
MAPK9 |
Mitogen-activated protein kinase 9 |
[274] |
0.70[275] |
0.89[276] |
0.89[277] |
1.31[278] |
0.70[279] |
0.19[280] |
41 |
MAPK3 |
Mitogen-activated protein kinase 3 |
[281] |
1.32[282] |
1.34[283] |
1.31[284] |
0.02[285] |
-0.03[286] |
-1.36[287] |
42 |
GSK3B |
Glycogen synthase kinase-3 beta |
[288] |
0.74[289] |
0.34[290] |
0.85[291] |
1.41[292] |
1.17[293] |
0.84[294] |
43 |
ABL1 |
Tyrosine-protein kinase ABL1 |
[295] |
1.70[296] |
1.06[297] |
1.79[298] |
1.66[299] |
2.28[300] |
0.62[301] |
44 |
STAT5B |
Signal transducer and activator of transcription 5B |
[302] |
0.83[303] |
0.42[304] |
1.06[305] |
1.14[306] |
0.22[307] |
1.30[308] |
45 |
MAP2K7 |
Dual specificity mitogen-activated protein kinase kinase 7 |
[309] |
0.43[310] |
0.55[311] |
1.06[312] |
-0.13[313] |
0.37[314] |
-1.08[315] |
46 |
SRC |
Proto-oncogene tyrosine-protein kinase Src |
[316] |
2.49[317] |
2.45[318] |
1.38[319] |
1.99[320] |
1.10[321] |
-1.17[322] |
47 |
PLCG1 |
1-phosphatidylinositol
4,5-bisphosphate phosphodiesterase gamma-1 |
2.96[323] |
2.55[324] |
1.81[325] |
2.41[326] |
1.84[327] |
0.02[328] |
48 |
MTOR |
Serine/threonine-protein kinase mTOR |
[329] |
2.00[330] |
2.99[331] |
2.49[332] |
2.28[333] |
2.29[334] |
3.13[335] |
49 |
RPS6KB1 |
Ribosomal protein S6 kinase beta-1 |
[336] |
[337] |
[338] |
[339] |
[340] |
[341] |
[342] |
50 |
PIK3CB |
Phosphatidylinositol
4,5-bisphosphate 3-kinase catalytic subunit beta isoform |
0.68[343] |
1.16[344] |
1.25[345] |
0.64[346] |
0.74[347] |
0.83[348] |
51 |
CAMK2G |
Calcium/calmodulin-dependent protein
kinase type II subunit gamma |
0.24[349] |
1.43[350] |
0.97[351] |
1.28[352] |
0.78[353] |
0.63[354] |
52 |
SOS2 |
Son of sevenless homolog 2 |
[355] |
-0.56[356] |
0.54[357] |
-0.30[358] |
1.28[359] |
1.08[360] |
1.52[361] |
53 |
PRKCA |
Protein kinase C alpha type |
[362] |
2.31[363] |
2.32[364] |
2.61[365] |
1.74[366] |
2.04[367] |
1.59[368] |
54 |
STAT5A |
Signal transducer and activator of transcription 5A |
[369] |
-2.48[370] |
-1.33[371] |
-2.33[372] |
-1.25[373] |
-0.56[374] |
-0.09[375] |
55 |
PAK1 |
Serine/threonine-protein kinase PAK 1 |
[376] |
-0.54[377] |
-1.33[378] |
1.01[379] |
-2.26[380] |
1.45[381] |
-0.06[382] |
56 |
CBLB |
E3 ubiquitin-protein ligase CBL-B |
[383] |
-1.18[384] |
0.04[385] |
0.40[386] |
0.37[387] |
1.17[388] |
1.05[389] |
57 |
TGFA |
Protransforming growth factor alpha |
[390] |
1.26[391] |
2.30[392] |
-8.82[393] |
-1.37[394] |
-2.66[395] |
-0.72[396] |
58 |
PIK3CA |
Phosphatidylinositol
4,5-bisphosphate 3-kinase catalytic subunit alpha isoform |
-0.91[397] |
0.70[398] |
0.82[399] |
0.72[400] |
0.86[401] |
1.59[402] |
59 |
PIK3CD |
Phosphatidylinositol
4,5-bisphosphate 3-kinase catalytic subunit delta isoform |
1.36[403] |
2.41[404] |
-1.46[405] |
-0.13[406] |
0.57[407] |
-0.03[408] |
60 |
HBEGF |
Proheparin-binding EGF-like growth factor |
[409] |
-1.52[410] |
-2.36[411] |
-3.49[412] |
-0.10[413] |
-0.48[414] |
-2.75[415] |
61 |
NRG1 |
Pro-neuregulin-1, membrane-bound isoform |
[416] |
-0.20[417] |
-6.36[418] |
-3.54[419] |
1.64[420] |
-5.90[421] |
0.45[422] |
62 |
ABL2 |
Abelson tyrosine-protein kinase 2 |
[423] |
1.54[424] |
1.54[425] |
2.41[426] |
3.48[427] |
3.61[428] |
2.60[429] |
63 |
BRAF |
Serine/threonine-protein kinase B-raf |
[430] |
-0.28[431] |
-0.58[432] |
1.38[433] |
0.33[434] |
-0.04[435] |
1.53[436] |
64 |
PLCG2 |
1-phosphatidylinositol
4,5-bisphosphate phosphodiesterase gamma-2 |
-1.81[437] |
-7.59[438] |
-0.21[439] |
-3.14[440] |
-2.05[441] |
2.39[442] |
65 |
BTC |
Probetacellulin |
[443] |
-8.67[444] |
-9.09[445] |
-4.93[446] |
-3.28[447] |
-3.38[448] |
-3.24[449] |
66 |
GAB1 |
GRB2-associated-binding protein 1 |
[450] |
0.77[451] |
1.83[452] |
1.89[453] |
1.52[454] |
1.32[455] |
2.55[456] |
67 |
CAMK2B |
Calcium/calmodulin-dependent protein kinase type II subunit beta |
[457] |
-3.07[458] |
-4.42[459] |
-7.45[460] |
-3.27[461] |
-2.70[462] |
0.82[463] |
68 |
NRG4 |
Pro-neuregulin-4, membrane-bound isoform |
[464] |
-4.62[465] |
-1.78[466] |
-1.89[467] |
-0.12[468] |
-2.38[469] |
-1.26[470] |
69 |
CBL |
E3 ubiquitin-protein ligase CBL |
[471] |
3.92[472] |
2.83[473] |
2.99[474] |
4.73[475] |
4.15[476] |
3.43[477] |
70 |
PIK3R3 |
Phosphatidylinositol 3-kinase regulatory subunit gamma |
[478] |
1.19[479] |
1.17[480] |
1.95[481] |
2.76[482] |
1.72[483] |
2.35[484] |
71 |
AKT3 |
RAC-gamma serine/threonine-protein kinase |
[485] |
-2.37[486] |
-4.96[487] |
-4.34[488] |
5.43[489] |
4.33[490] |
3.28[491] |
72 |
PIK3R5 |
Phosphoinositide 3-kinase regulatory subunit 5 |
[492] |
-7.70[493] |
[494] |
-3.16[495] |
-4.33[496] |
-4.05[497] |
2.01[498] |
73 |
PRKCB |
Protein kinase C beta type |
[499] |
-7.34[500] |
-6.18[501] |
[502] |
2.07[503] |
-3.29[504] |
3.21[505] |
74 |
EREG |
Proepiregulin |
[506] |
1.22[507] |
1.12[508] |
-3.36[509] |
-1.97[510] |
3.21[511] |
-1.80[512] |
75 |
PAK3 |
Serine/threonine-protein kinase PAK 3 |
[513] |
-6.94[514] |
[515] |
[516] |
-2.01[517] |
-0.35[518] |
0.46[519] |
76 |
PAK6 |
Serine/threonine-protein kinase PAK 6 |
[520] |
-2.21[521] |
[522] |
0.43[523] |
1.79[524] |
0.84[525] |
-1.40[526] |
77 |
PIK3CG |
Phosphatidylinositol
4,5-bisphosphate 3-kinase catalytic subunit gamma isoform |
[527] |
[528] |
[529] |
0.93[530] |
-4.02[531] |
3.77[532] |
78 |
SHC4 |
SHC-transforming protein 4 |
[533] |
-2.79[534] |
[535] |
-2.33[536] |
2.12[537] |
2.43[538] |
-1.02[539] |
79 |
SHC3 |
SHC-transforming protein 3 |
[540] |
1.58[541] |
3.93[542] |
-3.63[543] |
3.05[544] |
6.89[545] |
1.49[546] |
80 |
PRKCG |
Protein kinase C gamma type |
[547] |
-1.35[548] |
-0.71[549] |
-3.15[550] |
-1.47[551] |
-1.62[552] |
[553] |
81 |
EGF |
Pro-epidermal growth factor |
[554] |
1.44[555] |
3.20[556] |
6.74[557] |
8.62[558] |
5.97[559] |
1.25[560] |
82 |
MAPK10 |
Mitogen-activated protein kinase 10 |
[561] |
-2.02[562] |
[563] |
[564] |
8.50[565] |
4.17[566] |
6.92[567] |
83 |
PAK5 |
Serine/threonine-protein kinase PAK 5 |
[568] |
[569] |
[570] |
[571] |
[572] |
[573] |
[574] |
84 |
ERBB4 |
Receptor tyrosine-protein kinase erbB-4 |
[575] |
[576] |
[577] |
[578] |
[579] |
[580] |
[581] |
85 |
NRG3 |
Pro-neuregulin-3, membrane-bound isoform |
[582] |
[583] |
[584] |
[585] |
[586] |
[587] |
[588] |
86 |
NRG2 |
Pro-neuregulin-2, membrane-bound isoform |
[589] |
[590] |
[591] |
[592] |
[593] |
[594] |
[595] |
87 |
CAMK2A |
Calcium/calmodulin-dependent protein kinase type II subunit alpha |
[596] |
[597] |
[598] |
[599] |
[600] |
[601] |
[602] |
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