KEGG_DRUG_METABOLISM_OTHER_ENZYMES Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 CES1 Liver carboxylesterase 1 [1] -0.56[2] -7.48[3] -8.20[4] -0.36[5] -7.74[6] -1.22[7]
2 CYP3A4 Cytochrome P450 3A4 [8] -8.75[9] -9.07[10] -10.61[11] -13.11[12] -11.09[13] 1.01[14]
3 UGT1A6 UDP-glucuronosyltransferase 1-6 [15] -5.84[16] -13.78[17] -7.72[18] -4.46[19] -9.82[20] -3.61[21]
4 CYP2A6 Cytochrome P450 2A6 [22] -14.86[23] [24] -7.04[25] -9.87[26] -11.83[27] -1.33[28]
5 UGT2B4 UDP-glucuronosyltransferase 2B4 [29] -6.45[30] -6.83[31] -1.41[32] -7.70[33] -10.72[34] 1.05[35]
6 CYP3A5 Cytochrome P450 3A5 [36] -3.81[37] -1.79[38] -4.36[39] -5.68[40] -7.43[41] 1.38[42]
7 UGT2B7 UDP-glucuronosyltransferase 2B7 [43] -0.35[44] -0.40[45] -5.69[46] -8.91[47] -10.01[48] -0.24[49]
8 UGT2B10 UDP-glucuronosyltransferase 2B10 [50] -0.77[51] 1.65[52] -5.82[53] -9.04[54] -12.04[55] -1.32[56]
9 UGT2B15 UDP-glucuronosyltransferase 2B15 [57] -8.68[58] -7.33[59] -6.44[60] -8.78[61] -8.85[62] -0.70[63]
10 DPYS Dihydropyrimidinase [64] [65] [66] -12.90[67] -9.60[68] [69] 1.02[70]
11 UGT1A1 UDP-glucuronosyltransferase 1-1 [71] -3.37[72] -9.83[73] -4.49[74] 1.07[75] -8.46[76] 0.23[77]
12 TYMP Thymidine phosphorylase [78] -1.61[79] -1.20[80] -3.99[81] -5.54[82] -2.57[83] -1.90[84]
13 UGT1A4 UDP-glucuronosyltransferase 1-4 [85] -10.75[86] [87] -10.39[88] -8.21[89] [90] 0.42[91]
14 CES2 Cocaine esterase [92] 1.99[93] 2.36[94] 0.33[95] 1.00[96] 1.10[97] 1.57[98]
15 IMPDH2 Inosine-5'-monophosphate dehydrogenase 2 [99] 3.19[100] 3.43[101] 5.07[102] 2.24[103] 3.14[104] -1.98[105]
16 UPB1 Beta-ureidopropionase [106] -5.45[107] -3.27[108] -1.42[109] -5.03[110] -9.73[111] 0.31[112]
17 CYP3A7 Cytochrome P450 3A7 [113] -3.93[114] -1.86[115] -6.41[116] [117] -8.89[118] -1.39[119]
18 CDA Cytidine deaminase [120] 0.87[121] -0.96[122] -3.62[123] -1.55[124] -2.45[125] -1.95[126]
19 GUSB Beta-glucuronidase [127] 1.38[128] 1.49[129] 2.17[130] 2.53[131] 2.50[132] 0.51[133]
20 TPMT Thiopurine S-methyltransferase [134] 1.37[135] 1.95[136] 0.65[137] 2.01[138] 2.08[139] 0.14[140]
21 ITPA Inosine triphosphate pyrophosphatase [141] 2.92[142] 2.82[143] 1.29[144] 2.49[145] 2.09[146] -1.45[147]
22 UGT1A9 UDP-glucuronosyltransferase 1-9 [148] -4.71[149] -9.79[150] -5.80[151] -3.27[152] -8.05[153] -0.35[154]
23 CYP2A7 Cytochrome P450 2A7 [155] [156] [157] -2.45[158] -8.47[159] [160] -1.49[161]
24 NAT2 Arylamine N-acetyltransferase 2 [162] -4.96[163] -4.71[164] -2.97[165] -6.20[166] -5.79[167] 0.42[168]
25 HPRT1 Hypoxanthine-guanine phosphoribosyltransferase [169] 2.16[170] 2.16[171] 3.32[172] 3.40[173] 3.85[174] -1.55[175]
26 UPP1 Uridine phosphorylase 1 [176] 0.49[177] 0.24[178] 0.70[179] 1.64[180] 3.00[181] -1.91[182]
27 GMPS GMP synthase [glutamine-hydrolyzing] [183] 3.24[184] 3.20[185] 3.59[186] 4.28[187] 4.90[188] -0.36[189]
28 UGT2B17 UDP-glucuronosyltransferase 2B17 [190] -8.03[191] -7.62[192] -10.25[193] [194] [195] -1.08[196]
29 UCK1 Uridine-cytidine kinase 1 [197] 2.20[198] 2.83[199] 2.42[200] 2.68[201] 3.88[202] 0.47[203]
30 UCKL1 Uridine-cytidine kinase-like 1 [204] 3.95[205] 4.01[206] 2.08[207] 3.04[208] 2.79[209] -0.08[210]
31 UGT2A3 UDP-glucuronosyltransferase 2A3 [211] 4.27[212] 5.93[213] -1.30[214] -3.64[215] -6.01[216] 1.78[217]
32 TK1 Thymidine kinase, cytosolic [218] 4.90[219] 3.98[220] 3.75[221] 4.66[222] 5.29[223] -1.27[224]
33 DPYD Dihydropyrimidine dehydrogenase [NADP(+)] [225] -1.98[226] -1.21[227] 4.61[228] 4.15[229] 3.94[230] 3.66[231]
34 XDH Xanthine dehydrogenase/oxidase [232] -7.08[233] -6.12[234] -0.45[235] -3.99[236] -1.49[237] 3.06[238]
35 UMPS Uridine 5'-monophosphate synthase [239] 4.53[240] 4.59[241] 4.25[242] 3.94[243] 5.03[244] 1.91[245]
36 UCK2 Uridine-cytidine kinase 2 [246] 4.44[247] 4.12[248] 4.34[249] 5.26[250] 5.69[251] 0.49[252]
37 IMPDH1 Inosine-5'-monophosphate dehydrogenase 1 [253] 4.90[254] 4.00[255] 3.92[256] 5.46[257] 5.40[258] -0.96[259]
38 UGT1A3 UDP-glucuronosyltransferase 1-3 [260] 0.03[261] [262] -6.65[263] -3.01[264] -7.64[265] 1.52[266]
39 TK2 Thymidine kinase 2, mitochondrial [267] 3.06[268] 3.29[269] 2.27[270] 3.72[271] 5.08[272] 2.39[273]
40 NAT1 Arylamine N-acetyltransferase 1 [274] 1.68[275] 2.09[276] 3.52[277] 2.00[278] 3.08[279] 1.05[280]
41 CYP3A43 Cytochrome P450 3A43 [281] -1.86[282] 0.83[283] 0.82[284] [285] -6.26[286] 1.66[287]
42 CES5A Carboxylesterase 5A [288] -4.19[289] [290] [291] -3.20[292] -5.63[293] -0.53[294]
43 UPP2 Uridine phosphorylase 2 [295] -4.48[296] [297] -2.06[298] [299] -4.59[300] 1.66[301]
44 UGT1A5 UDP-glucuronosyltransferase 1-5 [302] -3.25[303] [304] -4.47[305] 0.13[306] [307] 1.59[308]
45 UGT2B11 UDP-glucuronosyltransferase 2B11 [309] 3.21[310] 1.65[311] 3.08[312] -2.87[313] [314] 1.10[315]
46 UGT2B28 UDP-glucuronosyltransferase 2B28 [316] 2.98[317] 3.29[318] -0.78[319] -3.46[320] [321] 1.05[322]
47 CYP2A13 Cytochrome P450 2A13 [323] [324] [325] [326] [327] [328] -0.24[329]
48 UGT1A7 UDP-glucuronosyltransferase 1-7 [330] 2.17[331] [332] 1.42[333] 8.11[334] 3.21[335] 3.53[336]
49 UGT2A1 UDP-glucuronosyltransferase 2A1 [337] [338] [339] [340] [341] [342] [343]
50 UGT1A10 UDP-glucuronosyltransferase 1-10 [344] [345] [346] [347] [348] [349] [350]
51 UGT1A8 UDP-glucuronosyltransferase 1-8 [351] [352] [353] [354] [355] [356] [357]
[1]
ref_hepatocyte CES1
Mean 819
Standard deviation 9e+02
Values 1.5e+02 1.8e+02 1.9e+03 1.5e+02 1.7e+03
[2]
HepG2 CES1
Mean 154
Standard deviation 89
Values 2.2e+02 91
[3]
HepG2.C3A CES1
Mean 1.3
Standard deviation 0.53
Values 1.7 0.92
[4]
HuH.7 CES1
Mean 0.67
Standard deviation 0.32
Values 0.52 1 0.46
[5]
SNU475 CES1
Mean 111
Standard deviation 23
Values 1.3e+02 94
[6]
THLE CES1
Mean 0.535
Standard deviation 0.14
Values 0.63 0.44
[7]
liver CES1
Mean 411
Standard deviation 2.6e+02
Values 3.2e+02 4.6e+02 7.4e+02 1.3e+02
[8]
ref_hepatocyte CYP3A4
Mean 259
Standard deviation 4.1e+02
Values 0.24 11 3.2e+02 11 9.6e+02
[9]
HepG2 CYP3A4
Mean 0.167
Standard deviation 0.098
Values 0.097 0.24
[10]
HepG2.C3A CYP3A4
Mean 0.136
Standard deviation 0.096
Values 0.068 0.2
[11]
HuH.7 CYP3A4
Mean 0.0397
Standard deviation 0.029
Values 0.0082 0.064 0.047
[12]
SNU475 CYP3A4
Mean 0.00507
Standard deviation 0.0072
Values 0 0.01
[13]
THLE CYP3A4
Mean 0.0166
Standard deviation 0.0067
Values 0.012 0.021
[14]
liver CYP3A4
Mean 610
Standard deviation 5.3e+02
Values 6.4e+02 4.3e+02 1.3e+03 49
[15]
ref_hepatocyte UGT1A6
Mean 242
Standard deviation 2.6e+02
Values 0.45 1.7e+02 4.3e+02 11 5.9e+02
[16]
HepG2 UGT1A6
Mean 1.17
Standard deviation 0.86
Values 1.8 0.56
[17]
HepG2.C3A UGT1A6
Mean 0.00486
Standard deviation 0.0069
Values 0.0097 0
[18]
HuH.7 UGT1A6
Mean 0.277
Standard deviation 0.33
Values 0.041 0.65 0.14
[19]
SNU475 UGT1A6
Mean 1.9
Standard deviation 0.11
Values 2 1.8
[20]
THLE UGT1A6
Mean 0.0372
Standard deviation 0.053
Values 0 0.074
[21]
liver UGT1A6
Mean 23.2
Standard deviation 17
Values 34 9 42 8.2
[22]
ref_hepatocyte CYP2A6
Mean 231
Standard deviation 3e+02
Values 0 4.6 5.6e+02 38 5.5e+02
[23]
HepG2 CYP2A6
Mean 0.00214
Standard deviation 0.003
Values 0 0.0043
[24]
HepG2.C3A CYP2A6
Mean 0
Standard deviation 0
Values 0 0
[25]
HuH.7 CYP2A6
Mean 0.421
Standard deviation 0.53
Values 0.11 1 0.12
[26]
SNU475 CYP2A6
Mean 0.0428
Standard deviation 0.025
Values 0.06 0.025
[27]
THLE CYP2A6
Mean 0.00887
Standard deviation 0.013
Values 0.018 0
[28]
liver CYP2A6
Mean 107
Standard deviation 1e+02
Values 1.8e+02 29 2.1e+02 13
[29]
ref_hepatocyte UGT2B4
Mean 210
Standard deviation 2.5e+02
Values 0.056 68 4.6e+02 15 5e+02
[30]
HepG2 UGT2B4
Mean 0.666
Standard deviation 0.42
Values 0.96 0.37
[31]
HepG2.C3A UGT2B4
Mean 0.523
Standard deviation 0.23
Values 0.36 0.69
[32]
HuH.7 UGT2B4
Mean 19.1
Standard deviation 13
Values 11 34 12
[33]
SNU475 UGT2B4
Mean 0.176
Standard deviation 0.04
Values 0.2 0.15
[34]
THLE UGT2B4
Mean 0.0175
Standard deviation 0.017
Values 0.03 0.0053
[35]
liver UGT2B4
Mean 509
Standard deviation 93
Values 5.3e+02 4.5e+02 6.3e+02 4.3e+02
[36]
ref_hepatocyte CYP3A5
Mean 139
Standard deviation 1.6e+02
Values 22 55 2e+02 35 3.9e+02
[37]
HepG2 CYP3A5
Mean 2.75
Standard deviation 2.1
Values 1.3 4.2
[38]
HepG2.C3A CYP3A5
Mean 11.4
Standard deviation 3.8
Values 14 8.7
[39]
HuH.7 CYP3A5
Mean 1.63
Standard deviation 1.6
Values 0.58 3.5 0.83
[40]
SNU475 CYP3A5
Mean 0.471
Standard deviation 0.12
Values 0.56 0.39
[41]
THLE CYP3A5
Mean 0.113
Standard deviation 0.032
Values 0.14 0.09
[42]
liver CYP3A5
Mean 424
Standard deviation 3.2e+02
Values 2.7e+02 9e+02 2.5e+02 2.8e+02
[43]
ref_hepatocyte UGT2B7
Mean 122
Standard deviation 1.9e+02
Values 3.3 8.1 1.6e+02 5.3 4.3e+02
[44]
HepG2 UGT2B7
Mean 26.6
Standard deviation 9
Values 33 20
[45]
HepG2.C3A UGT2B7
Mean 26.2
Standard deviation 13
Values 17 35
[46]
HuH.7 UGT2B7
Mean 0.568
Standard deviation 0.44
Values 0.3 1.1 0.34
[47]
SNU475 UGT2B7
Mean 0.0439
Standard deviation 0.0096
Values 0.037 0.051
[48]
THLE UGT2B7
Mean 0.0166
Standard deviation 0.0067
Values 0.012 0.021
[49]
liver UGT2B7
Mean 121
Standard deviation 61
Values 77 1.7e+02 1.7e+02 61
[50]
ref_hepatocyte UGT2B10
Mean 89.2
Standard deviation 1.3e+02
Values 13 1.3 1.2e+02 2.6 3.1e+02
[51]
HepG2 UGT2B10
Mean 14.5
Standard deviation 5.1
Values 11 18
[52]
HepG2.C3A UGT2B10
Mean 79.3
Standard deviation 33
Values 56 1e+02
[53]
HuH.7 UGT2B10
Mean 0.379
Standard deviation 0.38
Values 0.098 0.82 0.22
[54]
SNU475 UGT2B10
Mean 0.0293
Standard deviation 0.0087
Values 0.023 0.035
[55]
THLE UGT2B10
Mean 0.00296
Standard deviation 0.0042
Values 0.0059 0
[56]
liver UGT2B10
Mean 41.7
Standard deviation 22
Values 68 16 33 50
[57]
ref_hepatocyte UGT2B15
Mean 72.3
Standard deviation 99
Values 0.2 13 1.2e+02 3.3 2.3e+02
[58]
HepG2 UGT2B15
Mean 0.0487
Standard deviation 0.004
Values 0.046 0.051
[59]
HepG2.C3A UGT2B15
Mean 0.127
Standard deviation 0.013
Values 0.14 0.12
[60]
HuH.7 UGT2B15
Mean 0.2
Standard deviation 0.22
Values 0.066 0.45 0.084
[61]
SNU475 UGT2B15
Mean 0.0285
Standard deviation 0.019
Values 0.042 0.015
[62]
THLE UGT2B15
Mean 0.0219
Standard deviation 0.014
Values 0.012 0.032
[63]
liver UGT2B15
Mean 52
Standard deviation 21
Values 56 66 64 21
[64]
ref_hepatocyte DPYS
Mean 68
Standard deviation 1e+02
Values 0 3.8 96 1.4 2.4e+02
[65]
HepG2 DPYS
Mean 0
Standard deviation 0
Values 0 0
[66]
HepG2.C3A DPYS
Mean 0
Standard deviation 0
Values 0 0
[67]
HuH.7 DPYS
Mean 0.00214
Standard deviation 0.0037
Values 0 0.0064 0
[68]
SNU475 DPYS
Mean 0.0152
Standard deviation 0.022
Values 0 0.03
[69]
THLE DPYS
Mean 0
Standard deviation 0
Values 0 0
[70]
liver DPYS
Mean 161
Standard deviation 36
Values 2.1e+02 1.6e+02 1.2e+02 1.6e+02
[71]
ref_hepatocyte UGT1A1
Mean 67.2
Standard deviation 89
Values 0.52 12 2.1e+02 15 96
[72]
HepG2 UGT1A1
Mean 1.8
Standard deviation 0.2
Values 1.9 1.7
[73]
HepG2.C3A UGT1A1
Mean 0.0209
Standard deviation 0.016
Values 0.0097 0.032
[74]
HuH.7 UGT1A1
Mean 0.72
Standard deviation 0.5
Values 0.57 1.3 0.31
[75]
SNU475 UGT1A1
Mean 24.4
Standard deviation 21
Values 39 9.8
[76]
THLE UGT1A1
Mean 0.0266
Standard deviation 0.038
Values 0 0.053
[77]
liver UGT1A1
Mean 92.4
Standard deviation 46
Values 83 1.1e+02 1.4e+02 34
[78]
ref_hepatocyte TYMP
Mean 63.3
Standard deviation 55
Values 1.8 1.5e+02 56 70 38
[79]
HepG2 TYMP
Mean 5.73
Standard deviation 3.7
Values 8.4 3.1
[80]
HepG2.C3A TYMP
Mean 7.77
Standard deviation 1.5
Values 8.9 6.7
[81]
HuH.7 TYMP
Mean 0.958
Standard deviation 0.51
Values 0.41 1.4 1
[82]
SNU475 TYMP
Mean 0.235
Standard deviation 0.14
Values 0.33 0.14
[83]
THLE TYMP
Mean 1.49
Standard deviation 0.28
Values 1.3 1.7
[84]
liver TYMP
Mean 19.9
Standard deviation 5.7
Values 19 17 15 28
[85]
ref_hepatocyte UGT1A4
Mean 53.1
Standard deviation 73
Values 0 4.2 99 2.5 1.6e+02
[86]
HepG2 UGT1A4
Mean 0.00858
Standard deviation 0.012
Values 0 0.017
[87]
HepG2.C3A UGT1A4
Mean 0
Standard deviation 0
Values 0 0
[88]
HuH.7 UGT1A4
Mean 0.00954
Standard deviation 0.0096
Values 0 0.019 0.0094
[89]
SNU475 UGT1A4
Mean 0.031
Standard deviation 0.015
Values 0.042 0.02
[90]
THLE UGT1A4
Mean 0
Standard deviation 0
Values 0 0
[91]
liver UGT1A4
Mean 83.1
Standard deviation 65
Values 95 36 1.7e+02 32
[92]
ref_hepatocyte CES2
Mean 49.3
Standard deviation 49
Values 14 17 94 11 1.1e+02
[93]
HepG2 CES2
Mean 54.1
Standard deviation 2.1
Values 53 56
[94]
HepG2.C3A CES2
Mean 71.8
Standard deviation 6.4
Values 76 67
[95]
HuH.7 CES2
Mean 14.9
Standard deviation 3.2
Values 17 11 16
[96]
SNU475 CES2
Mean 17.1
Standard deviation 1.6
Values 18 16
[97]
THLE CES2
Mean 14.8
Standard deviation 0.53
Values 14 15
[98]
liver CES2
Mean 171
Standard deviation 92
Values 89 2.4e+02 2.6e+02 95
[99]
ref_hepatocyte IMPDH2
Mean 45.4
Standard deviation 20
Values 52 62 38 61 15
[100]
HepG2 IMPDH2
Mean 115
Standard deviation 9.1
Values 1.2e+02 1.1e+02
[101]
HepG2.C3A IMPDH2
Mean 139
Standard deviation 31
Values 1.6e+02 1.2e+02
[102]
HuH.7 IMPDH2
Mean 368
Standard deviation 41
Values 3.5e+02 3.4e+02 4.2e+02
[103]
SNU475 IMPDH2
Mean 37.3
Standard deviation 14
Values 28 47
[104]
THLE IMPDH2
Mean 56.1
Standard deviation 6.5
Values 51 61
[105]
liver IMPDH2
Mean 13.5
Standard deviation 5.2
Values 13 13 20 7.8
[106]
ref_hepatocyte UPB1
Mean 34.1
Standard deviation 46
Values 0.23 4 52 8 1.1e+02
[107]
HepG2 UPB1
Mean 0.216
Standard deviation 0.0023
Values 0.22 0.21
[108]
HepG2.C3A UPB1
Mean 1
Standard deviation 0.041
Values 0.97 1
[109]
HuH.7 UPB1
Mean 3.08
Standard deviation 0.98
Values 3.2 2 4
[110]
SNU475 UPB1
Mean 0.181
Standard deviation 0.11
Values 0.26 0.1
[111]
THLE UPB1
Mean 0.00562
Standard deviation 0.00042
Values 0.0059 0.0053
[112]
liver UPB1
Mean 49.6
Standard deviation 25
Values 30 75 67 26
[113]
ref_hepatocyte CYP3A7
Mean 29.1
Standard deviation 41
Values 8.7 0.12 1e+02 5 32
[114]
HepG2 CYP3A7
Mean 0.531
Standard deviation 0.38
Values 0.26 0.8
[115]
HepG2.C3A CYP3A7
Mean 2.26
Standard deviation 0.013
Values 2.3 2.3
[116]
HuH.7 CYP3A7
Mean 0.0822
Standard deviation 0.074
Values 0.033 0.17 0.047
[117]
SNU475 CYP3A7
Mean 0
Standard deviation 0
Values 0 0
[118]
THLE CYP3A7
Mean 0.00858
Standard deviation 0.0046
Values 0.012 0.0053
[119]
liver CYP3A7
Mean 13
Standard deviation 12
Values 5.2 30 11 5.1
[120]
ref_hepatocyte CDA
Mean 27.6
Standard deviation 20
Values 1.1 26 30 58 23
[121]
HepG2 CDA
Mean 14
Standard deviation 5.9
Values 18 9.9
[122]
HepG2.C3A CDA
Mean 4.04
Standard deviation 1.4
Values 5 3
[123]
HuH.7 CDA
Mean 0.54
Standard deviation 0.2
Values 0.49 0.76 0.37
[124]
SNU475 CDA
Mean 1.64
Standard deviation 0.19
Values 1.5 1.8
[125]
THLE CDA
Mean 0.708
Standard deviation 0.2
Values 0.85 0.57
[126]
liver CDA
Mean 8.36
Standard deviation 8.4
Values 1.1 16 15 1.2
[127]
ref_hepatocyte GUSB
Mean 25.3
Standard deviation 23
Values 7 7.5 52 11 49
[128]
HepG2 GUSB
Mean 18.3
Standard deviation 3.5
Values 21 16
[129]
HepG2.C3A GUSB
Mean 20.1
Standard deviation 2
Values 22 19
[130]
HuH.7 GUSB
Mean 27.5
Standard deviation 3.9
Values 26 25 32
[131]
SNU475 GUSB
Mean 25.3
Standard deviation 2.9
Values 23 27
[132]
THLE GUSB
Mean 20
Standard deviation 0.097
Values 20 20
[133]
liver GUSB
Mean 42.1
Standard deviation 30
Values 22 54 79 14
[134]
ref_hepatocyte TPMT
Mean 23.4
Standard deviation 7.6
Values 18 24 14 32 29
[135]
HepG2 TPMT
Mean 16.8
Standard deviation 5.6
Values 13 21
[136]
HepG2.C3A TPMT
Mean 25.6
Standard deviation 12
Values 17 34
[137]
HuH.7 TPMT
Mean 8.85
Standard deviation 2.1
Values 9.3 6.6 11
[138]
SNU475 TPMT
Mean 16.4
Standard deviation 0.91
Values 17 16
[139]
THLE TPMT
Mean 13.9
Standard deviation 0.98
Values 13 15
[140]
liver TPMT
Mean 30.1
Standard deviation 12
Values 22 40 42 18
[141]
ref_hepatocyte ITPA
Mean 21
Standard deviation 5.1
Values 17 22 22 28 15
[142]
HepG2 ITPA
Mean 44
Standard deviation 4.2
Values 47 41
[143]
HepG2.C3A ITPA
Mean 42.1
Standard deviation 1.5
Values 43 41
[144]
HuH.7 ITPA
Mean 12.3
Standard deviation 5.6
Values 14 6 17
[145]
SNU475 ITPA
Mean 20.4
Standard deviation 4.7
Values 24 17
[146]
THLE ITPA
Mean 12.5
Standard deviation 2.1
Values 11 14
[147]
liver ITPA
Mean 8.99
Standard deviation 7.5
Values 2.6 16 15 2.4
[148]
ref_hepatocyte UGT1A9
Mean 15.2
Standard deviation 13
Values 0 21 26 2.6 27
[149]
HepG2 UGT1A9
Mean 0.16
Standard deviation 0.057
Values 0.2 0.12
[150]
HepG2.C3A UGT1A9
Mean 0.00486
Standard deviation 0.0069
Values 0.0097 0
[151]
HuH.7 UGT1A9
Mean 0.0656
Standard deviation 0.056
Values 0.066 0.12 0.0094
[152]
SNU475 UGT1A9
Mean 0.273
Standard deviation 0.34
Values 0.51 0.03
[153]
THLE UGT1A9
Mean 0.00798
Standard deviation 0.011
Values 0 0.016
[154]
liver UGT1A9
Mean 13.9
Standard deviation 9.6
Values 22 8.7 22 3
[155]
ref_hepatocyte CYP2A7
Mean 15.1
Standard deviation 22
Values 0 0.06 52 11 12
[156]
HepG2 CYP2A7
Mean 0
Standard deviation 0
Values 0 0
[157]
HepG2.C3A CYP2A7
Mean 0
Standard deviation 0
Values 0 0
[158]
HuH.7 CYP2A7
Mean 0.663
Standard deviation 0.76
Values 0.16 1.5 0.3
[159]
SNU475 CYP2A7
Mean 0.00739
Standard deviation 0.0039
Values 0.0046 0.01
[160]
THLE CYP2A7
Mean 0
Standard deviation 0
Values 0 0
[161]
liver CYP2A7
Mean 6.31
Standard deviation 5.5
Values 13 2 9 1.4
[162]
ref_hepatocyte NAT2
Mean 14.9
Standard deviation 17
Values 0.36 3.4 24 5.7 41
[163]
HepG2 NAT2
Mean 0.132
Standard deviation 0.00084
Values 0.13 0.13
[164]
HepG2.C3A NAT2
Mean 0.161
Standard deviation 0.091
Values 0.097 0.23
[165]
HuH.7 NAT2
Mean 0.456
Standard deviation 0.17
Values 0.3 0.64 0.43
[166]
SNU475 NAT2
Mean 0.035
Standard deviation 0.036
Values 0.0093 0.061
[167]
THLE NAT2
Mean 0.0376
Standard deviation 0.031
Values 0.059 0.016
[168]
liver NAT2
Mean 23.3
Standard deviation 17
Values 9.5 42 32 9.2
[169]
ref_hepatocyte HPRT1
Mean 13.6
Standard deviation 5.4
Values 17 20 7.3 8.9 15
[170]
HepG2 HPRT1
Mean 16.9
Standard deviation 0.27
Values 17 17
[171]
HepG2.C3A HPRT1
Mean 17.3
Standard deviation 2.3
Values 16 19
[172]
HuH.7 HPRT1
Mean 32.8
Standard deviation 5.1
Values 32 28 38
[173]
SNU475 HPRT1
Mean 24.8
Standard deviation 3.3
Values 27 22
[174]
THLE HPRT1
Mean 27.5
Standard deviation 1.6
Values 26 29
[175]
liver HPRT1
Mean 5.44
Standard deviation 5.1
Values 1.6 7.1 12 1.1
[176]
ref_hepatocyte UPP1
Mean 12.8
Standard deviation 18
Values 0.33 9.2 7 44 3.2
[177]
HepG2 UPP1
Mean 4.99
Standard deviation 3.1
Values 7.2 2.8
[178]
HepG2.C3A UPP1
Mean 4.26
Standard deviation 0.42
Values 4 4.6
[179]
HuH.7 UPP1
Mean 4.99
Standard deviation 0.45
Values 4.9 4.6 5.5
[180]
SNU475 UPP1
Mean 6.88
Standard deviation 4.7
Values 3.6 10
[181]
THLE UPP1
Mean 14.3
Standard deviation 0.9
Values 14 15
[182]
liver UPP1
Mean 3.98
Standard deviation 3
Values 2.2 4.1 8.1 1.5
[183]
ref_hepatocyte GMPS
Mean 11.5
Standard deviation 5.8
Values 14 21 8.4 7.9 6.5
[184]
HepG2 GMPS
Mean 30
Standard deviation 2.7
Values 28 32
[185]
HepG2.C3A GMPS
Mean 29.9
Standard deviation 0.16
Values 30 30
[186]
HuH.7 GMPS
Mean 33.2
Standard deviation 3.7
Values 37 31 32
[187]
SNU475 GMPS
Mean 38.6
Standard deviation 7.3
Values 33 44
[188]
THLE GMPS
Mean 47.7
Standard deviation 4.7
Values 44 51
[189]
liver GMPS
Mean 10.5
Standard deviation 1.7
Values 10 11 12 8.1
[190]
ref_hepatocyte UGT2B17
Mean 10.8
Standard deviation 16
Values 0 1.3 15 1.3 37
[191]
HepG2 UGT2B17
Mean 0.0114
Standard deviation 0.0081
Values 0.0057 0.017
[192]
HepG2.C3A UGT2B17
Mean 0.0156
Standard deviation 0.0083
Values 0.0097 0.021
[193]
HuH.7 UGT2B17
Mean 0.00214
Standard deviation 0.0037
Values 0 0.0064 0
[194]
SNU475 UGT2B17
Mean 0
Standard deviation 0
Values 0 0
[195]
THLE UGT2B17
Mean 0
Standard deviation 0
Values 0 0
[196]
liver UGT2B17
Mean 6
Standard deviation 4.8
Values 8.6 3.7 11 0.5
[197]
ref_hepatocyte UCK1
Mean 9.05
Standard deviation 4.7
Values 4.2 5.1 15 8.2 13
[198]
HepG2 UCK1
Mean 11.5
Standard deviation 1.6
Values 10 13
[199]
HepG2.C3A UCK1
Mean 18.3
Standard deviation 0.63
Values 18 19
[200]
HuH.7 UCK1
Mean 11.7
Standard deviation 1.2
Values 11 13 11
[201]
SNU475 UCK1
Mean 10
Standard deviation 0.3
Values 10 9.8
[202]
THLE UCK1
Mean 18.6
Standard deviation 4
Values 16 21
[203]
liver UCK1
Mean 14.7
Standard deviation 3.9
Values 12 19 17 11
[204]
ref_hepatocyte UCKL1
Mean 8.33
Standard deviation 4.8
Values 16 6 9.1 3.5 7
[205]
HepG2 UCKL1
Mean 35.7
Standard deviation 6
Values 40 32
[206]
HepG2.C3A UCKL1
Mean 38.1
Standard deviation 10
Values 45 31
[207]
HuH.7 UCKL1
Mean 8.47
Standard deviation 2
Values 7.2 7.4 11
[208]
SNU475 UCKL1
Mean 11.9
Standard deviation 4.2
Values 15 8.9
[209]
THLE UCKL1
Mean 8.02
Standard deviation 0.23
Values 8.2 7.9
[210]
liver UCKL1
Mean 9.25
Standard deviation 3.9
Values 5.6 14 10 6.9
[211]
ref_hepatocyte UGT2A3
Mean 7.91
Standard deviation 6.4
Values 18 5.7 9.3 0.33 6.3
[212]
HepG2 UGT2A3
Mean 42.4
Standard deviation 14
Values 33 52
[213]
HepG2.C3A UGT2A3
Mean 137
Standard deviation 28
Values 1.2e+02 1.6e+02
[214]
HuH.7 UGT2A3
Mean 0.775
Standard deviation 0.72
Values 0.33 1.6 0.39
[215]
SNU475 UGT2A3
Mean 0.11
Standard deviation 0.13
Values 0.2 0.02
[216]
THLE UGT2A3
Mean 0.0172
Standard deviation 0.0092
Values 0.024 0.011
[217]
liver UGT2A3
Mean 31.9
Standard deviation 15
Values 24 55 25 24
[218]
ref_hepatocyte TK1
Mean 7.77
Standard deviation 6.2
Values 15 14 5.1 1 3.9
[219]
HepG2 TK1
Mean 64.4
Standard deviation 11
Values 57 72
[220]
HepG2.C3A TK1
Mean 34.6
Standard deviation 19
Values 21 48
[221]
HuH.7 TK1
Mean 25.2
Standard deviation 17
Values 32 5.8 38
[222]
SNU475 TK1
Mean 33.9
Standard deviation 0.54
Values 34 34
[223]
THLE TK1
Mean 42.5
Standard deviation 7.2
Values 37 48
[224]
liver TK1
Mean 3.78
Standard deviation 3.4
Values 1.8 4.3 8.3 0.65
[225]
ref_hepatocyte DPYD
Mean 5.41
Standard deviation 7.8
Values 0.66 1.2 5.5 0.79 19
[226]
HepG2 DPYD
Mean 0.381
Standard deviation 0.23
Values 0.22 0.54
[227]
HepG2.C3A DPYD
Mean 0.663
Standard deviation 0.13
Values 0.76 0.57
[228]
HuH.7 DPYD
Mean 31.7
Standard deviation 5.8
Values 29 38 28
[229]
SNU475 DPYD
Mean 16.6
Standard deviation 0.43
Values 17 16
[230]
THLE DPYD
Mean 11.6
Standard deviation 1
Values 11 12
[231]
liver DPYD
Mean 80.3
Standard deviation 30
Values 93 69 45 1.1e+02
[232]
ref_hepatocyte XDH
Mean 5.26
Standard deviation 5.8
Values 0 0.81 9.2 2.8 13
[233]
HepG2 XDH
Mean 0.0107
Standard deviation 0.0091
Values 0.017 0.0043
[234]
HepG2.C3A XDH
Mean 0.0215
Standard deviation 0.03
Values 0 0.043
[235]
HuH.7 XDH
Mean 0.929
Standard deviation 0.041
Values 0.9 0.98 0.91
[236]
SNU475 XDH
Mean 0.0574
Standard deviation 0.055
Values 0.019 0.096
[237]
THLE XDH
Mean 0.262
Standard deviation 0.11
Values 0.18 0.34
[238]
liver XDH
Mean 51.2
Standard deviation 29
Values 61 19 38 87
[239]
ref_hepatocyte UMPS
Mean 5.13
Standard deviation 2
Values 7.5 7.1 3.6 4.2 3.3
[240]
HepG2 UMPS
Mean 32.8
Standard deviation 4.8
Values 29 36
[241]
HepG2.C3A UMPS
Mean 35
Standard deviation 4.5
Values 32 38
[242]
HuH.7 UMPS
Mean 23.6
Standard deviation 3.4
Values 26 20 25
[243]
SNU475 UMPS
Mean 13.6
Standard deviation 0.94
Values 13 14
[244]
THLE UMPS
Mean 23.4
Standard deviation 4.7
Values 20 27
[245]
liver UMPS
Mean 22.6
Standard deviation 3.3
Values 22 20 27 20
[246]
ref_hepatocyte UCK2
Mean 5.1
Standard deviation 3.9
Values 3.5 9.5 2.1 9.2 1.2
[247]
HepG2 UCK2
Mean 30.7
Standard deviation 7.2
Values 36 26
[248]
HepG2.C3A UCK2
Mean 25.1
Standard deviation 0.56
Values 25 25
[249]
HuH.7 UCK2
Mean 24.8
Standard deviation 7.6
Values 29 16 30
[250]
SNU475 UCK2
Mean 33.8
Standard deviation 3
Values 32 36
[251]
THLE UCK2
Mean 36.6
Standard deviation 7.6
Values 31 42
[252]
liver UCK2
Mean 8.38
Standard deviation 1.3
Values 7.5 8.1 7.6 10
[253]
ref_hepatocyte IMPDH1
Mean 4.53
Standard deviation 3.3
Values 8.6 6.6 1.2 5.1 1.2
[254]
HepG2 IMPDH1
Mean 37.5
Standard deviation 10
Values 45 30
[255]
HepG2.C3A IMPDH1
Mean 20.5
Standard deviation 4.3
Values 24 17
[256]
HuH.7 IMPDH1
Mean 16.5
Standard deviation 2.6
Values 19 14 17
[257]
SNU475 IMPDH1
Mean 34.6
Standard deviation 1.1
Values 34 35
[258]
THLE IMPDH1
Mean 26.8
Standard deviation 3.7
Values 24 29
[259]
liver IMPDH1
Mean 2.72
Standard deviation 0.62
Values 2.2 2.2 3.1 3.4
[260]
ref_hepatocyte UGT1A3
Mean 4.24
Standard deviation 4.8
Values 0 2.3 7.9 0.37 11
[261]
HepG2 UGT1A3
Mean 1.2
Standard deviation 0.2
Values 1.3 1.1
[262]
HepG2.C3A UGT1A3
Mean 0
Standard deviation 0
Values 0 0
[263]
HuH.7 UGT1A3
Mean 0.0101
Standard deviation 0.0024
Values 0.0082 0.013 0.0094
[264]
SNU475 UGT1A3
Mean 0.0911
Standard deviation 0.029
Values 0.11 0.071
[265]
THLE UGT1A3
Mean 0.00296
Standard deviation 0.0042
Values 0.0059 0
[266]
liver UGT1A3
Mean 14.2
Standard deviation 12
Values 21 2.5 28 5.8
[267]
ref_hepatocyte TK2
Mean 4.07
Standard deviation 2.8
Values 1.9 2.1 6.5 2.1 7.7
[268]
HepG2 TK2
Mean 9.37
Standard deviation 2.7
Values 7.4 11
[269]
HepG2.C3A TK2
Mean 11.3
Standard deviation 0.3
Values 11 11
[270]
HuH.7 TK2
Mean 4.72
Standard deviation 0.87
Values 3.7 5.2 5.2
[271]
SNU475 TK2
Mean 9.29
Standard deviation 3.2
Values 12 7
[272]
THLE TK2
Mean 19.2
Standard deviation 0.11
Values 19 19
[273]
liver TK2
Mean 25
Standard deviation 6.3
Values 22 32 28 18
[274]
ref_hepatocyte NAT1
Mean 1.91
Standard deviation 1.7
Values 2.8 0.7 1.6 0 4.4
[275]
HepG2 NAT1
Mean 1.7
Standard deviation 0.45
Values 1.4 2
[276]
HepG2.C3A NAT1
Mean 2.3
Standard deviation 1.3
Values 1.4 3.2
[277]
HuH.7 NAT1
Mean 5.27
Standard deviation 1.3
Values 4.1 6.7 5.1
[278]
SNU475 NAT1
Mean 1.32
Standard deviation 0.014
Values 1.3 1.3
[279]
THLE NAT1
Mean 2.25
Standard deviation 0.027
Values 2.3 2.2
[280]
liver NAT1
Mean 4.62
Standard deviation 1.7
Values 3.8 7.1 4 3.6
[281]
ref_hepatocyte CYP3A43
Mean 1.46
Standard deviation 2.7
Values 0.059 0 1.1 0 6.1
[282]
HepG2 CYP3A43
Mean 0.112
Standard deviation 0.061
Values 0.069 0.15
[283]
HepG2.C3A CYP3A43
Mean 0.735
Standard deviation 0.42
Values 1 0.44
[284]
HuH.7 CYP3A43
Mean 0.622
Standard deviation 0.91
Values 0.057 1.7 0.14
[285]
SNU475 CYP3A43
Mean 0
Standard deviation 0
Values 0 0
[286]
THLE CYP3A43
Mean 0.00266
Standard deviation 0.0038
Values 0 0.0053
[287]
liver CYP3A43
Mean 5.41
Standard deviation 4.2
Values 2.9 12 3.4 3.6
[288]
ref_hepatocyte CES5A
Mean 0.943
Standard deviation 1.1
Values 0 0 1.8 0.49 2.4
[289]
HepG2 CES5A
Mean 0.0143
Standard deviation 0.02
Values 0.029 0
[290]
HepG2.C3A CES5A
Mean 0
Standard deviation 0
Values 0 0
[291]
HuH.7 CES5A
Mean 0
Standard deviation 0
Values 0 0 0
[292]
SNU475 CES5A
Mean 0.0177
Standard deviation 0.025
Values 0 0.035
[293]
THLE CES5A
Mean 0.00266
Standard deviation 0.0038
Values 0 0.0053
[294]
liver CES5A
Mean 0.763
Standard deviation 0.35
Values 0.54 0.92 1.2 0.41
[295]
ref_hepatocyte UPP2
Mean 0.919
Standard deviation 1.8
Values 0 0 4.1 0.2 0.33
[296]
HepG2 UPP2
Mean 0.0114
Standard deviation 0.0081
Values 0.0057 0.017
[297]
HepG2.C3A UPP2
Mean 0
Standard deviation 0
Values 0 0
[298]
HuH.7 UPP2
Mean 0.053
Standard deviation 0.014
Values 0.057 0.064 0.037
[299]
SNU475 UPP2
Mean 0
Standard deviation 0
Values 0 0
[300]
THLE UPP2
Mean 0.00532
Standard deviation 0.0075
Values 0 0.011
[301]
liver UPP2
Mean 3.41
Standard deviation 4.2
Values 1.8 9.7 1.5 0.62
[302]
ref_hepatocyte UGT1A5
Mean 0.393
Standard deviation 0.32
Values 0 0.38 0.82 0.19 0.58
[303]
HepG2 UGT1A5
Mean 0.0114
Standard deviation 0.0081
Values 0.0057 0.017
[304]
HepG2.C3A UGT1A5
Mean 0
Standard deviation 0
Values 0 0
[305]
HuH.7 UGT1A5
Mean 0.00428
Standard deviation 0.0074
Values 0 0.013 0
[306]
SNU475 UGT1A5
Mean 0.0747
Standard deviation 0.012
Values 0.083 0.066
[307]
THLE UGT1A5
Mean 0
Standard deviation 0
Values 0 0
[308]
liver UGT1A5
Mean 1.38
Standard deviation 1.4
Values 3.4 0.31 0.98 0.85
[309]
ref_hepatocyte UGT2B11
Mean 0.391
Standard deviation 0.65
Values 0 0 1.5 0 0.46
[310]
HepG2 UGT2B11
Mean 1
Standard deviation 0.2
Values 0.86 1.1
[311]
HepG2.C3A UGT2B11
Mean 0.348
Standard deviation 0.19
Values 0.21 0.48
[312]
HuH.7 UGT2B11
Mean 0.795
Standard deviation 0.79
Values 0.31 1.7 0.37
[313]
SNU475 UGT2B11
Mean 0.00928
Standard deviation 0.013
Values 0.019 0
[314]
THLE UGT2B11
Mean 0
Standard deviation 0
Values 0 0
[315]
liver UGT2B11
Mean 0.98
Standard deviation 0.68
Values 0.59 2 0.49 0.87
[316]
ref_hepatocyte UGT2B28
Mean 0.294
Standard deviation 0.52
Values 0 0 0.28 0 1.2
[317]
HepG2 UGT2B28
Mean 0.642
Standard deviation 0.23
Values 0.81 0.48
[318]
HepG2.C3A UGT2B28
Mean 0.816
Standard deviation 0.45
Values 0.5 1.1
[319]
HuH.7 UGT2B28
Mean 0.0413
Standard deviation 0.043
Values 0.025 0.09 0.0094
[320]
SNU475 UGT2B28
Mean 0.00464
Standard deviation 0.0066
Values 0.0093 0
[321]
THLE UGT2B28
Mean 0
Standard deviation 0
Values 0 0
[322]
liver UGT2B28
Mean 0.714
Standard deviation 0.87
Values 1.1 0 1.8 0.013
[323]
ref_hepatocyte CYP2A13
Mean 0.0683
Standard deviation 0.12
Values 0 0 0.28 0 0.057
[324]
HepG2 CYP2A13
Mean 0
Standard deviation 0
Values 0 0
[325]
HepG2.C3A CYP2A13
Mean 0
Standard deviation 0
Values 0 0
[326]
HuH.7 CYP2A13
Mean 0
Standard deviation 0
Values 0 0 0
[327]
SNU475 CYP2A13
Mean 0
Standard deviation 0
Values 0 0
[328]
THLE CYP2A13
Mean 0
Standard deviation 0
Values 0 0
[329]
liver CYP2A13
Mean 0.0677
Standard deviation 0.059
Values 0.13 0 0.1 0.04
[330]
ref_hepatocyte UGT1A7
Mean 0.0431
Standard deviation 0.096
Values 0 0 0.22 0 0
[331]
HepG2 UGT1A7
Mean 0.0537
Standard deviation 0.021
Values 0.069 0.039
[332]
HepG2.C3A UGT1A7
Mean 0
Standard deviation 0
Values 0 0
[333]
HuH.7 UGT1A7
Mean 0.0277
Standard deviation 0.011
Values 0.016 0.039 0.028
[334]
SNU475 UGT1A7
Mean 2.06
Standard deviation 1.2
Values 1.2 2.9
[335]
THLE UGT1A7
Mean 0.0556
Standard deviation 0.012
Values 0.047 0.064
[336]
liver UGT1A7
Mean 0.582
Standard deviation 0.83
Values 1.8 0.094 0.1 0.32
[337]
ref_hepatocyte UGT2A1
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[338]
HepG2 UGT2A1
Mean 0.00214
Standard deviation 0.003
Values 0 0.0043
[339]
HepG2.C3A UGT2A1
Mean 0.00536
Standard deviation 0.0076
Values 0 0.011
[340]
HuH.7 UGT2A1
Mean 0
Standard deviation 0
Values 0 0 0
[341]
SNU475 UGT2A1
Mean 0.015
Standard deviation 0.015
Values 0.0046 0.025
[342]
THLE UGT2A1
Mean 0
Standard deviation 0
Values 0 0
[343]
liver UGT2A1
Mean 0.00999
Standard deviation 0.012
Values 0.014 0 0.026 0
[344]
ref_hepatocyte UGT1A10
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[345]
HepG2 UGT1A10
Mean 0.00788
Standard deviation 0.0051
Values 0.011 0.0043
[346]
HepG2.C3A UGT1A10
Mean 0
Standard deviation 0
Values 0 0
[347]
HuH.7 UGT1A10
Mean 0.115
Standard deviation 0.078
Values 0.066 0.21 0.075
[348]
SNU475 UGT1A10
Mean 0.012
Standard deviation 0.0027
Values 0.014 0.01
[349]
THLE UGT1A10
Mean 0
Standard deviation 0
Values 0 0
[350]
liver UGT1A10
Mean 0.0104
Standard deviation 0.014
Values 0.029 0 0 0.013
[351]
ref_hepatocyte UGT1A8
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[352]
HepG2 UGT1A8
Mean 0
Standard deviation 0
Values 0 0
[353]
HepG2.C3A UGT1A8
Mean 0
Standard deviation 0
Values 0 0
[354]
HuH.7 UGT1A8
Mean 0.0407
Standard deviation 0.027
Values 0.033 0.071 0.019
[355]
SNU475 UGT1A8
Mean 0.152
Standard deviation 0.028
Values 0.17 0.13
[356]
THLE UGT1A8
Mean 0
Standard deviation 0
Values 0 0
[357]
liver UGT1A8
Mean 0.0104
Standard deviation 0.014
Values 0.029 0 0 0.013