KEGG_DRUG_METABOLISM_CYTOCHROME_P450 Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 CYP2E1 Cytochrome P450 2E1 [1] -9.86[2] -10.60[3] -7.55[4] -12.67[5] -10.57[6] -0.22[7]
2 MGST1 Microsomal glutathione S-transferase 1 [8] 0.38[9] -0.56[10] 0.14[11] -0.47[12] 0.77[13] -0.69[14]
3 ADH1B Alcohol dehydrogenase 1B [15] -9.04[16] [17] -6.09[18] [19] [20] 0.24[21]
4 GSTA1 Glutathione S-transferase A1 [22] -1.00[23] -5.38[24] 0.64[25] -4.26[26] -8.54[27] -3.43[28]
5 ADH4 Alcohol dehydrogenase 4 [29] -1.83[30] -2.94[31] -7.32[32] -11.15[33] -8.65[34] -2.28[35]
6 ADH1A Alcohol dehydrogenase 1A [36] -10.46[37] [38] -6.68[39] -14.23[40] [41] -1.74[42]
7 CYP2C8 Cytochrome P450 2C8 [43] -11.86[44] -7.72[45] -5.72[46] -9.75[47] [48] 0.71[49]
8 CYP2C9 Cytochrome P450 2C9 [50] [51] -12.64[52] -5.93[53] -12.44[54] -11.10[55] 1.21[56]
9 CYP3A4 Cytochrome P450 3A4 [57] -7.11[58] -7.83[59] -9.74[60] -12.75[61] -10.67[62] 0.92[63]
10 UGT1A6 UDP-glucuronosyltransferase 1-6 [64] -4.20[65] -12.54[66] -6.85[67] -4.10[68] -9.40[69] -3.70[70]
11 CYP2A6 Cytochrome P450 2A6 [71] -13.23[72] [73] -6.17[74] -9.51[75] -11.41[76] -1.43[77]
12 UGT2B4 UDP-glucuronosyltransferase 2B4 [78] -4.82[79] -5.59[80] -0.54[81] -7.34[82] -10.30[83] 0.96[84]
13 GSTA2 Glutathione S-transferase A2 [85] -2.11[86] -5.21[87] -1.00[88] -5.68[89] -8.69[90] -3.24[91]
14 AOX1 Aldehyde oxidase [92] 0.96[93] 0.19[94] -6.40[95] -1.55[96] 0.63[97] 2.44[98]
15 GSTO1 Glutathione S-transferase omega-1 [99] 2.69[100] 2.81[101] 2.09[102] -0.41[103] 2.31[104] -1.02[105]
16 CYP3A5 Cytochrome P450 3A5 [106] -2.18[107] -0.55[108] -3.49[109] -5.32[110] -7.01[111] 1.29[112]
17 ADH1C Alcohol dehydrogenase 1C [113] -10.84[114] -9.26[115] -8.07[116] -8.05[117] -9.86[118] -0.93[119]
18 FMO3 Dimethylaniline monooxygenase [N-oxide-forming] 3 [120] [121] -11.49[122] -4.84[123] -5.01[124] -11.31[125] -0.92[126]
19 UGT2B7 UDP-glucuronosyltransferase 2B7 [127] 1.29[128] 0.84[129] -4.82[130] -8.55[131] -9.59[132] -0.33[133]
20 GSTK1 Glutathione S-transferase kappa 1 [134] 1.60[135] 1.59[136] 1.63[137] 0.64[138] 0.60[139] -0.84[140]
21 UGT2B10 UDP-glucuronosyltransferase 2B10 [141] 0.86[142] 2.89[143] -4.95[144] -8.68[145] -11.62[146] -1.42[147]
22 CYP1A2 Cytochrome P450 1A2 [148] -6.29[149] -5.59[150] -6.44[151] -6.32[152] -6.20[153] -1.46[154]
23 MGST2 Microsomal glutathione S-transferase 2 [155] 2.56[156] 3.35[157] 1.46[158] -0.21[159] 0.31[160] -1.74[161]
24 ADH6 Alcohol dehydrogenase 6 [162] 1.08[163] 1.25[164] 1.14[165] -7.05[166] -6.69[167] -0.51[168]
25 UGT2B15 UDP-glucuronosyltransferase 2B15 [169] -7.05[170] -6.09[171] -5.57[172] -8.42[173] -8.43[174] -0.79[175]
26 UGT1A1 UDP-glucuronosyltransferase 1-1 [176] -1.73[177] -8.59[178] -3.62[179] 1.42[180] -8.04[181] 0.14[182]
27 ADH5 Alcohol dehydrogenase class-3 [183] 4.34[184] 3.73[185] 4.05[186] 2.68[187] 3.49[188] -0.17[189]
28 UGT1A4 UDP-glucuronosyltransferase 1-4 [190] -9.11[191] [192] -9.52[193] -7.86[194] [195] 0.33[196]
29 GSTT1 Glutathione S-transferase theta-1 [197] 2.59[198] 2.19[199] -8.29[200] -9.24[201] -0.31[202] -0.81[203]
30 CYP2B6 Cytochrome P450 2B6 [204] -5.01[205] -2.17[206] -1.00[207] -7.30[208] -7.77[209] 2.59[210]
31 MAOB Amine oxidase [flavin-containing] B [211] 2.26[212] 1.26[213] 1.73[214] 1.55[215] -5.63[216] 0.19[217]
32 GSTZ1 Maleylacetoacetate isomerase [218] 0.67[219] 0.85[220] 0.27[221] -0.60[222] -0.02[223] -1.62[224]
33 CYP2C18 Cytochrome P450 2C18 [225] -6.83[226] -8.91[227] -3.26[228] -9.58[229] -7.11[230] -0.27[231]
34 CYP2D6 Cytochrome P450 2D6 [232] -3.27[233] -1.39[234] -4.11[235] -5.81[236] -5.80[237] 1.41[238]
35 MGST3 Microsomal glutathione S-transferase 3 [239] 2.44[240] 1.88[241] 2.42[242] 2.92[243] 3.42[244] -0.02[245]
36 CYP3A7 Cytochrome P450 3A7 [246] -2.29[247] -0.62[248] -5.54[249] [250] -8.47[251] -1.48[252]
37 FMO5 Dimethylaniline monooxygenase [N-oxide-forming] 5 [253] 1.21[254] 4.01[255] 1.76[256] -0.47[257] -4.16[258] 0.99[259]
38 MAOA Amine oxidase [flavin-containing] A [260] 1.43[261] 1.62[262] 3.69[263] -0.88[264] 4.84[265] 1.69[266]
39 CYP2C19 Cytochrome P450 2C19 [267] [268] [269] -3.08[270] -10.13[271] -9.40[272] 1.77[273]
40 UGT1A9 UDP-glucuronosyltransferase 1-9 [274] -3.08[275] -8.55[276] -4.93[277] -2.91[278] -7.63[279] -0.45[280]
41 CYP2A7 Cytochrome P450 2A7 [281] [282] [283] -1.58[284] -8.11[285] [286] -1.58[287]
42 GSTA4 Glutathione S-transferase A4 [288] 3.45[289] 3.13[290] 4.12[291] 3.84[292] 2.52[293] -1.29[294]
43 UGT2B17 UDP-glucuronosyltransferase 2B17 [295] -6.40[296] -6.38[297] -9.38[298] [299] [300] -1.17[301]
44 GSTM4 Glutathione S-transferase Mu 4 [302] 3.82[303] 2.68[304] 2.67[305] 3.53[306] 0.89[307] -0.06[308]
45 UGT2A3 UDP-glucuronosyltransferase 2A3 [309] 5.91[310] 7.17[311] -0.43[312] -3.28[313] -5.59[314] 1.69[315]
46 GSTP1 Glutathione S-transferase P [316] 0.67[317] 0.95[318] 8.45[319] 9.47[320] 7.77[321] 0.13[322]
47 FMO4 Dimethylaniline monooxygenase [N-oxide-forming] 4 [323] -0.17[324] -4.08[325] 1.93[326] 0.33[327] 1.21[328] 0.30[329]
48 UGT1A3 UDP-glucuronosyltransferase 1-3 [330] 1.67[331] [332] -5.78[333] -2.65[334] -7.22[335] 1.43[336]
49 GSTT2 Glutathione S-transferase theta-2 [337] -2.70[338] -5.24[339] -6.28[340] -1.20[341] 1.00[342] -3.39[343]
50 GSTM3 Glutathione S-transferase Mu 3 [344] 7.00[345] 5.75[346] 3.23[347] 6.63[348] 7.00[349] 1.71[350]
51 ALDH3A1 Aldehyde dehydrogenase, dimeric NADP-preferring [351] 2.13[352] -2.59[353] -0.21[354] 2.00[355] -0.52[356] -2.39[357]
52 CYP3A43 Cytochrome P450 3A43 [358] -0.22[359] 2.07[360] 1.69[361] [362] -5.84[363] 1.57[364]
53 GSTO2 Glutathione S-transferase omega-2 [365] 3.39[366] 5.47[367] 2.84[368] -1.07[369] 1.64[370] -1.05[371]
54 ALDH3B1 Aldehyde dehydrogenase family 3 member B1 [372] 6.50[373] 5.99[374] 5.35[375] 8.52[376] 7.17[377] 0.11[378]
55 GSTM2 Glutathione S-transferase Mu 2 [379] 5.02[380] 3.18[381] 4.77[382] 5.24[383] 5.13[384] 0.20[385]
56 GSTM1 Glutathione S-transferase Mu 1 [386] 2.32[387] 0.44[388] 6.40[389] 7.85[390] -0.02[391] 6.74[392]
57 UGT1A5 UDP-glucuronosyltransferase 1-5 [393] -1.62[394] [395] -3.60[396] 0.49[397] [398] 1.50[399]
58 UGT2B11 UDP-glucuronosyltransferase 2B11 [400] 4.84[401] 2.89[402] 3.95[403] -2.51[404] [405] 1.01[406]
59 UGT2B28 UDP-glucuronosyltransferase 2B28 [407] 4.61[408] 4.53[409] 0.09[410] -3.10[411] [412] 0.96[413]
60 GSTA5 Glutathione S-transferase A5 [414] -2.44[415] [416] -2.65[417] [418] [419] [420]
61 ALDH1A3 Aldehyde dehydrogenase family 1 member A3 [421] 4.78[422] 0.17[423] 2.57[424] 7.81[425] 13.47[426] 3.89[427]
62 GSTA3 Glutathione S-transferase A3 [428] -1.70[429] [430] 0.24[431] 1.77[432] [433] [434]
63 FMO1 Dimethylaniline monooxygenase [N-oxide-forming] 1 [435] -0.52[436] 0.38[437] 6.97[438] -0.33[439] [440] 1.60[441]
64 CYP2A13 Cytochrome P450 2A13 [442] [443] [444] [445] [446] [447] -0.33[448]
65 UGT1A7 UDP-glucuronosyltransferase 1-7 [449] 3.80[450] [451] 2.29[452] 8.46[453] 3.63[454] 3.44[455]
66 ADH7 Alcohol dehydrogenase class 4 mu/sigma chain [456] [457] [458] [459] [460] [461] -2.82[462]
67 UGT1A10 UDP-glucuronosyltransferase 1-10 [463] [464] [465] [466] [467] [468] [469]
68 FMO2 Dimethylaniline monooxygenase [N-oxide-forming] 2 [470] [471] [472] [473] [474] [475] [476]
69 UGT1A8 UDP-glucuronosyltransferase 1-8 [477] [478] [479] [480] [481] [482] [483]
70 GSTM5 Glutathione S-transferase Mu 5 [484] [485] [486] [487] [488] [489] [490]
71 UGT2A1 UDP-glucuronosyltransferase 2A1 [491] [492] [493] [494] [495] [496] [497]
72 ALDH3B2 Aldehyde dehydrogenase family 3 member B2 [498] [499] [500] [501] [502] [503] [504]
[1]
ref_hepatocyte CYP2E1
Mean 1.39e+03
Standard deviation 1.9e+03
Values 0 4.6 2.7e+03 90 4.1e+03
[2]
HepG2 CYP2E1
Mean 0.133
Standard deviation 0.1
Values 0.21 0.06
[3]
HepG2.C3A CYP2E1
Mean 0.107
Standard deviation 0.15
Values 0.21 0
[4]
HuH.7 CYP2E1
Mean 0.975
Standard deviation 0.29
Values 0.67 1.3 0.99
[5]
SNU475 CYP2E1
Mean 0.0289
Standard deviation 0.005
Values 0.032 0.025
[6]
THLE CYP2E1
Mean 0.0955
Standard deviation 0.082
Values 0.15 0.037
[7]
liver CYP2E1
Mean 1.49e+03
Standard deviation 8.2e+02
Values 1e+03 2.6e+03 1.7e+03 6.9e+02
[8]
ref_hepatocyte MGST1
Mean 720
Standard deviation 4.5e+02
Values 2.4e+02 7.2e+02 7.8e+02 4.4e+02 1.4e+03
[9]
HepG2 MGST1
Mean 83.4
Standard deviation 3.7
Values 86 81
[10]
HepG2.C3A MGST1
Mean 58.5
Standard deviation 26
Values 40 77
[11]
HuH.7 MGST1
Mean 105
Standard deviation 17
Values 97 93 1.2e+02
[12]
SNU475 MGST1
Mean 70.5
Standard deviation 6
Values 66 75
[13]
THLE MGST1
Mean 128
Standard deviation 3.8
Values 1.3e+02 1.3e+02
[14]
liver MGST1
Mean 558
Standard deviation 6e+02
Values 62 9.8e+02 1.2e+03 31
[15]
ref_hepatocyte ADH1B
Mean 512
Standard deviation 8.3e+02
Values 0.096 0.69 6.3e+02 6.9 1.9e+03
[16]
HepG2 ADH1B
Mean 0.0866
Standard deviation 0.017
Values 0.074 0.099
[17]
HepG2.C3A ADH1B
Mean 0
Standard deviation 0
Values 0 0
[18]
HuH.7 ADH1B
Mean 0.991
Standard deviation 1.6
Values 0.049 2.9 0.028
[19]
SNU475 ADH1B
Mean 0
Standard deviation 0
Values 0 0
[20]
THLE ADH1B
Mean 0
Standard deviation 0
Values 0 0
[21]
liver ADH1B
Mean 756
Standard deviation 3.8e+02
Values 5.3e+02 1.3e+03 5.5e+02 6.2e+02
[22]
ref_hepatocyte GSTA1
Mean 456
Standard deviation 5.8e+02
Values 1.3e+02 2.2e+02 4.8e+02 8.4 1.4e+03
[23]
HepG2 GSTA1
Mean 20.3
Standard deviation 5.9
Values 16 24
[24]
HepG2.C3A GSTA1
Mean 1.31
Standard deviation 0.69
Values 0.83 1.8
[25]
HuH.7 GSTA1
Mean 93.3
Standard deviation 39
Values 95 53 1.3e+02
[26]
SNU475 GSTA1
Mean 3.21
Standard deviation 3.3
Values 5.5 0.88
[27]
THLE GSTA1
Mean 0.127
Standard deviation 0.11
Values 0.21 0.048
[28]
liver GSTA1
Mean 52.8
Standard deviation 52
Values 29 48 1.3e+02 6.8
[29]
ref_hepatocyte ADH4
Mean 397
Standard deviation 7e+02
Values 29 4.9 3.3e+02 1.5 1.6e+03
[30]
HepG2 ADH4
Mean 9.95
Standard deviation 0.32
Values 9.7 10
[31]
HepG2.C3A ADH4
Mean 6.21
Standard deviation 2.8
Values 4.3 8.2
[32]
HuH.7 ADH4
Mean 0.326
Standard deviation 0.33
Values 0.2 0.71 0.075
[33]
SNU475 ADH4
Mean 0.0236
Standard deviation 0.019
Values 0.037 0.01
[34]
THLE ADH4
Mean 0.103
Standard deviation 0.02
Values 0.089 0.12
[35]
liver ADH4
Mean 102
Standard deviation 66
Values 40 1.9e+02 58 1.2e+02
[36]
ref_hepatocyte ADH1A
Mean 362
Standard deviation 6e+02
Values 0 0.45 4.1e+02 9.8 1.4e+03
[37]
HepG2 ADH1A
Mean 0.0229
Standard deviation 0.016
Values 0.011 0.034
[38]
HepG2.C3A ADH1A
Mean 0
Standard deviation 0
Values 0 0
[39]
HuH.7 ADH1A
Mean 0.465
Standard deviation 0.75
Values 0.057 1.3 0.0094
[40]
SNU475 ADH1A
Mean 0.00253
Standard deviation 0.0036
Values 0 0.0051
[41]
THLE ADH1A
Mean 0
Standard deviation 0
Values 0 0
[42]
liver ADH1A
Mean 135
Standard deviation 1.5e+02
Values 47 3.6e+02 93 38
[43]
ref_hepatocyte CYP2C8
Mean 328
Standard deviation 4.4e+02
Values 0 1.2 7.1e+02 19 9.1e+02
[44]
HepG2 CYP2C8
Mean 0.00788
Standard deviation 0.0051
Values 0.011 0.0043
[45]
HepG2.C3A CYP2C8
Mean 0.186
Standard deviation 0.071
Values 0.14 0.24
[46]
HuH.7 CYP2C8
Mean 0.822
Standard deviation 1
Values 0.16 2 0.3
[47]
SNU475 CYP2C8
Mean 0.0515
Standard deviation 0.02
Values 0.037 0.066
[48]
THLE CYP2C8
Mean 0
Standard deviation 0
Values 0 0
[49]
liver CYP2C8
Mean 666
Standard deviation 3.9e+02
Values 6.2e+02 6.8e+02 1.2e+03 2e+02
[50]
ref_hepatocyte CYP2C9
Mean 285
Standard deviation 4.1e+02
Values 0.064 20 4.7e+02 21 9.2e+02
[51]
HepG2 CYP2C9
Mean 0
Standard deviation 0
Values 0 0
[52]
HepG2.C3A CYP2C9
Mean 0.00536
Standard deviation 0.0076
Values 0 0.011
[53]
HuH.7 CYP2C9
Mean 0.616
Standard deviation 0.63
Values 0.25 1.3 0.25
[54]
SNU475 CYP2C9
Mean 0.00696
Standard deviation 0.0098
Values 0.014 0
[55]
THLE CYP2C9
Mean 0.0136
Standard deviation 0.011
Values 0.0059 0.021
[56]
liver CYP2C9
Mean 822
Standard deviation 5.3e+02
Values 6.1e+02 8.6e+02 1.5e+03 2.9e+02
[57]
ref_hepatocyte CYP3A4
Mean 259
Standard deviation 4.1e+02
Values 0.24 11 3.2e+02 11 9.6e+02
[58]
HepG2 CYP3A4
Mean 0.167
Standard deviation 0.098
Values 0.097 0.24
[59]
HepG2.C3A CYP3A4
Mean 0.136
Standard deviation 0.096
Values 0.068 0.2
[60]
HuH.7 CYP3A4
Mean 0.0397
Standard deviation 0.029
Values 0.0082 0.064 0.047
[61]
SNU475 CYP3A4
Mean 0.00507
Standard deviation 0.0072
Values 0 0.01
[62]
THLE CYP3A4
Mean 0.0166
Standard deviation 0.0067
Values 0.012 0.021
[63]
liver CYP3A4
Mean 610
Standard deviation 5.3e+02
Values 6.4e+02 4.3e+02 1.3e+03 49
[64]
ref_hepatocyte UGT1A6
Mean 242
Standard deviation 2.6e+02
Values 0.45 1.7e+02 4.3e+02 11 5.9e+02
[65]
HepG2 UGT1A6
Mean 1.17
Standard deviation 0.86
Values 1.8 0.56
[66]
HepG2.C3A UGT1A6
Mean 0.00486
Standard deviation 0.0069
Values 0.0097 0
[67]
HuH.7 UGT1A6
Mean 0.277
Standard deviation 0.33
Values 0.041 0.65 0.14
[68]
SNU475 UGT1A6
Mean 1.9
Standard deviation 0.11
Values 2 1.8
[69]
THLE UGT1A6
Mean 0.0372
Standard deviation 0.053
Values 0 0.074
[70]
liver UGT1A6
Mean 23.2
Standard deviation 17
Values 34 9 42 8.2
[71]
ref_hepatocyte CYP2A6
Mean 231
Standard deviation 3e+02
Values 0 4.6 5.6e+02 38 5.5e+02
[72]
HepG2 CYP2A6
Mean 0.00214
Standard deviation 0.003
Values 0 0.0043
[73]
HepG2.C3A CYP2A6
Mean 0
Standard deviation 0
Values 0 0
[74]
HuH.7 CYP2A6
Mean 0.421
Standard deviation 0.53
Values 0.11 1 0.12
[75]
SNU475 CYP2A6
Mean 0.0428
Standard deviation 0.025
Values 0.06 0.025
[76]
THLE CYP2A6
Mean 0.00887
Standard deviation 0.013
Values 0.018 0
[77]
liver CYP2A6
Mean 107
Standard deviation 1e+02
Values 1.8e+02 29 2.1e+02 13
[78]
ref_hepatocyte UGT2B4
Mean 210
Standard deviation 2.5e+02
Values 0.056 68 4.6e+02 15 5e+02
[79]
HepG2 UGT2B4
Mean 0.666
Standard deviation 0.42
Values 0.96 0.37
[80]
HepG2.C3A UGT2B4
Mean 0.523
Standard deviation 0.23
Values 0.36 0.69
[81]
HuH.7 UGT2B4
Mean 19.1
Standard deviation 13
Values 11 34 12
[82]
SNU475 UGT2B4
Mean 0.176
Standard deviation 0.04
Values 0.2 0.15
[83]
THLE UGT2B4
Mean 0.0175
Standard deviation 0.017
Values 0.03 0.0053
[84]
liver UGT2B4
Mean 509
Standard deviation 93
Values 5.3e+02 4.5e+02 6.3e+02 4.3e+02
[85]
ref_hepatocyte GSTA2
Mean 199
Standard deviation 3.4e+02
Values 27 48 1.2e+02 1.1 8e+02
[86]
HepG2 GSTA2
Mean 4.11
Standard deviation 1.5
Values 3.1 5.2
[87]
HepG2.C3A GSTA2
Mean 0.647
Standard deviation 0.13
Values 0.55 0.74
[88]
HuH.7 GSTA2
Mean 13.1
Standard deviation 7.6
Values 7.6 22 10
[89]
SNU475 GSTA2
Mean 0.525
Standard deviation 0.65
Values 0.98 0.066
[90]
THLE GSTA2
Mean 0.0506
Standard deviation 0.0038
Values 0.053 0.048
[91]
liver GSTA2
Mean 26.3
Standard deviation 39
Values 20 0.73 84 0.29
[92]
ref_hepatocyte AOX1
Mean 166
Standard deviation 2e+02
Values 12 68 2.5e+02 25 4.8e+02
[93]
HepG2 AOX1
Mean 28.7
Standard deviation 3.3
Values 26 31
[94]
HepG2.C3A AOX1
Mean 22.6
Standard deviation 2.4
Values 21 24
[95]
HuH.7 AOX1
Mean 0.258
Standard deviation 0.25
Values 0.16 0.55 0.066
[96]
SNU475 AOX1
Mean 7.67
Standard deviation 6.2
Values 3.3 12
[97]
THLE AOX1
Mean 26.7
Standard deviation 2.8
Values 29 25
[98]
liver AOX1
Mean 1.12e+03
Standard deviation 5.3e+02
Values 1.8e+03 5.6e+02 9.6e+02 1.1e+03
[99]
ref_hepatocyte GSTO1
Mean 150
Standard deviation 1e+02
Values 51 1.2e+02 2.1e+02 79 3e+02
[100]
HepG2 GSTO1
Mean 86.3
Standard deviation 4.3
Values 83 89
[101]
HepG2.C3A GSTO1
Mean 126
Standard deviation 39
Values 98 1.5e+02
[102]
HuH.7 GSTO1
Mean 84.1
Standard deviation 20
Values 84 65 1e+02
[103]
SNU475 GSTO1
Mean 15.2
Standard deviation 0.17
Values 15 15
[104]
THLE GSTO1
Mean 77.6
Standard deviation 17
Values 66 90
[105]
liver GSTO1
Mean 92.1
Standard deviation 75
Values 39 1.4e+02 1.7e+02 19
[106]
ref_hepatocyte CYP3A5
Mean 139
Standard deviation 1.6e+02
Values 22 55 2e+02 35 3.9e+02
[107]
HepG2 CYP3A5
Mean 2.75
Standard deviation 2.1
Values 1.3 4.2
[108]
HepG2.C3A CYP3A5
Mean 11.4
Standard deviation 3.8
Values 14 8.7
[109]
HuH.7 CYP3A5
Mean 1.63
Standard deviation 1.6
Values 0.58 3.5 0.83
[110]
SNU475 CYP3A5
Mean 0.471
Standard deviation 0.12
Values 0.56 0.39
[111]
THLE CYP3A5
Mean 0.113
Standard deviation 0.032
Values 0.14 0.09
[112]
liver CYP3A5
Mean 424
Standard deviation 3.2e+02
Values 2.7e+02 9e+02 2.5e+02 2.8e+02
[113]
ref_hepatocyte ADH1C
Mean 132
Standard deviation 2e+02
Values 0.14 2.1 2e+02 4 4.5e+02
[114]
HepG2 ADH1C
Mean 0.00643
Standard deviation 0.0091
Values 0 0.013
[115]
HepG2.C3A ADH1C
Mean 0.0258
Standard deviation 0.009
Values 0.019 0.032
[116]
HuH.7 ADH1C
Mean 0.0645
Standard deviation 0.029
Values 0.041 0.096 0.056
[117]
SNU475 ADH1C
Mean 0.0673
Standard deviation 0.062
Values 0.023 0.11
[118]
THLE ADH1C
Mean 0.0148
Standard deviation 0.021
Values 0.03 0
[119]
liver ADH1C
Mean 86.2
Standard deviation 1.1e+02
Values 32 2.6e+02 44 13
[120]
ref_hepatocyte FMO3
Mean 129
Standard deviation 2.2e+02
Values 0 3.5 1.2e+02 4.9 5.1e+02
[121]
HepG2 FMO3
Mean 0
Standard deviation 0
Values 0 0
[122]
HepG2.C3A FMO3
Mean 0.00536
Standard deviation 0.0076
Values 0 0.011
[123]
HuH.7 FMO3
Mean 0.593
Standard deviation 0.31
Values 0.36 0.95 0.47
[124]
SNU475 FMO3
Mean 0.542
Standard deviation 0.086
Values 0.6 0.48
[125]
THLE FMO3
Mean 0.00532
Standard deviation 0.0075
Values 0 0.011
[126]
liver FMO3
Mean 85.3
Standard deviation 26
Values 64 1.2e+02 75 80
[127]
ref_hepatocyte UGT2B7
Mean 122
Standard deviation 1.9e+02
Values 3.3 8.1 1.6e+02 5.3 4.3e+02
[128]
HepG2 UGT2B7
Mean 26.6
Standard deviation 9
Values 33 20
[129]
HepG2.C3A UGT2B7
Mean 26.2
Standard deviation 13
Values 17 35
[130]
HuH.7 UGT2B7
Mean 0.568
Standard deviation 0.44
Values 0.3 1.1 0.34
[131]
SNU475 UGT2B7
Mean 0.0439
Standard deviation 0.0096
Values 0.037 0.051
[132]
THLE UGT2B7
Mean 0.0166
Standard deviation 0.0067
Values 0.012 0.021
[133]
liver UGT2B7
Mean 121
Standard deviation 61
Values 77 1.7e+02 1.7e+02 61
[134]
ref_hepatocyte GSTK1
Mean 94
Standard deviation 81
Values 43 51 1.6e+02 16 2e+02
[135]
HepG2 GSTK1
Mean 25.5
Standard deviation 6
Values 21 30
[136]
HepG2.C3A GSTK1
Mean 33.8
Standard deviation 0.97
Values 34 33
[137]
HuH.7 GSTK1
Mean 38.4
Standard deviation 8.4
Values 40 30 46
[138]
SNU475 GSTK1
Mean 19.8
Standard deviation 7.5
Values 25 14
[139]
THLE GSTK1
Mean 14.9
Standard deviation 0.92
Values 16 14
[140]
liver GSTK1
Mean 65.4
Standard deviation 45
Values 28 1.1e+02 95 26
[141]
ref_hepatocyte UGT2B10
Mean 89.2
Standard deviation 1.3e+02
Values 13 1.3 1.2e+02 2.6 3.1e+02
[142]
HepG2 UGT2B10
Mean 14.5
Standard deviation 5.1
Values 11 18
[143]
HepG2.C3A UGT2B10
Mean 79.3
Standard deviation 33
Values 56 1e+02
[144]
HuH.7 UGT2B10
Mean 0.379
Standard deviation 0.38
Values 0.098 0.82 0.22
[145]
SNU475 UGT2B10
Mean 0.0293
Standard deviation 0.0087
Values 0.023 0.035
[146]
THLE UGT2B10
Mean 0.00296
Standard deviation 0.0042
Values 0.0059 0
[147]
liver UGT2B10
Mean 41.7
Standard deviation 22
Values 68 16 33 50
[148]
ref_hepatocyte CYP1A2
Mean 78.9
Standard deviation 1.3e+02
Values 0.4 18 71 0.97 3e+02
[149]
HepG2 CYP1A2
Mean 0.0901
Standard deviation 0.055
Values 0.052 0.13
[150]
HepG2.C3A CYP1A2
Mean 0.197
Standard deviation 0.066
Values 0.24 0.15
[151]
HuH.7 CYP1A2
Mean 0.12
Standard deviation 0.026
Values 0.11 0.1 0.15
[152]
SNU475 CYP1A2
Mean 0.134
Standard deviation 0.091
Values 0.07 0.2
[153]
THLE CYP1A2
Mean 0.112
Standard deviation 0.068
Values 0.16 0.064
[154]
liver CYP1A2
Mean 35.7
Standard deviation 24
Values 12 55 58 19
[155]
ref_hepatocyte MGST2
Mean 73.6
Standard deviation 69
Values 20 29 1.2e+02 25 1.7e+02
[156]
HepG2 MGST2
Mean 38.6
Standard deviation 7.7
Values 33 44
[157]
HepG2.C3A MGST2
Mean 89.8
Standard deviation 3.2
Values 88 92
[158]
HuH.7 MGST2
Mean 26.6
Standard deviation 6.5
Values 24 22 34
[159]
SNU475 MGST2
Mean 8.62
Standard deviation 2.3
Values 10 7
[160]
THLE MGST2
Mean 9.5
Standard deviation 0.2
Values 9.4 9.6
[161]
liver MGST2
Mean 27.6
Standard deviation 24
Values 7.8 59 35 8.6
[162]
ref_hepatocyte ADH6
Mean 72.8
Standard deviation 92
Values 50 11 72 1.2 2.3e+02
[163]
HepG2 ADH6
Mean 13.8
Standard deviation 5.3
Values 10 17
[164]
HepG2.C3A ADH6
Mean 20.8
Standard deviation 0.45
Values 21 20
[165]
HuH.7 ADH6
Mean 21.2
Standard deviation 7
Values 19 29 15
[166]
SNU475 ADH6
Mean 0.0743
Standard deviation 0.053
Values 0.037 0.11
[167]
THLE ADH6
Mean 0.0733
Standard deviation 0.013
Values 0.083 0.064
[168]
liver ADH6
Mean 63.7
Standard deviation 33
Values 30 1.1e+02 46 74
[169]
ref_hepatocyte UGT2B15
Mean 72.3
Standard deviation 99
Values 0.2 13 1.2e+02 3.3 2.3e+02
[170]
HepG2 UGT2B15
Mean 0.0487
Standard deviation 0.004
Values 0.046 0.051
[171]
HepG2.C3A UGT2B15
Mean 0.127
Standard deviation 0.013
Values 0.14 0.12
[172]
HuH.7 UGT2B15
Mean 0.2
Standard deviation 0.22
Values 0.066 0.45 0.084
[173]
SNU475 UGT2B15
Mean 0.0285
Standard deviation 0.019
Values 0.042 0.015
[174]
THLE UGT2B15
Mean 0.0219
Standard deviation 0.014
Values 0.012 0.032
[175]
liver UGT2B15
Mean 52
Standard deviation 21
Values 56 66 64 21
[176]
ref_hepatocyte UGT1A1
Mean 67.2
Standard deviation 89
Values 0.52 12 2.1e+02 15 96
[177]
HepG2 UGT1A1
Mean 1.8
Standard deviation 0.2
Values 1.9 1.7
[178]
HepG2.C3A UGT1A1
Mean 0.0209
Standard deviation 0.016
Values 0.0097 0.032
[179]
HuH.7 UGT1A1
Mean 0.72
Standard deviation 0.5
Values 0.57 1.3 0.31
[180]
SNU475 UGT1A1
Mean 24.4
Standard deviation 21
Values 39 9.8
[181]
THLE UGT1A1
Mean 0.0266
Standard deviation 0.038
Values 0 0.053
[182]
liver UGT1A1
Mean 92.4
Standard deviation 46
Values 83 1.1e+02 1.4e+02 34
[183]
ref_hepatocyte ADH5
Mean 65.9
Standard deviation 32
Values 84 59 61 19 1.1e+02
[184]
HepG2 ADH5
Mean 119
Standard deviation 17
Values 1.1e+02 1.3e+02
[185]
HepG2.C3A ADH5
Mean 104
Standard deviation 26
Values 86 1.2e+02
[186]
HuH.7 ADH5
Mean 144
Standard deviation 17
Values 1.3e+02 1.4e+02 1.6e+02
[187]
SNU475 ADH5
Mean 57.2
Standard deviation 13
Values 66 48
[188]
THLE ADH5
Mean 77.4
Standard deviation 11
Values 69 85
[189]
liver ADH5
Mean 73.2
Standard deviation 37
Values 49 1.2e+02 76 43
[190]
ref_hepatocyte UGT1A4
Mean 53.1
Standard deviation 73
Values 0 4.2 99 2.5 1.6e+02
[191]
HepG2 UGT1A4
Mean 0.00858
Standard deviation 0.012
Values 0 0.017
[192]
HepG2.C3A UGT1A4
Mean 0
Standard deviation 0
Values 0 0
[193]
HuH.7 UGT1A4
Mean 0.00954
Standard deviation 0.0096
Values 0 0.019 0.0094
[194]
SNU475 UGT1A4
Mean 0.031
Standard deviation 0.015
Values 0.042 0.02
[195]
THLE UGT1A4
Mean 0
Standard deviation 0
Values 0 0
[196]
liver UGT1A4
Mean 83.1
Standard deviation 65
Values 95 36 1.7e+02 32
[197]
ref_hepatocyte GSTT1
Mean 52
Standard deviation 58
Values 17 5 86 14 1.4e+02
[198]
HepG2 GSTT1
Mean 28
Standard deviation 9.8
Values 21 35
[199]
HepG2.C3A GSTT1
Mean 28.3
Standard deviation 1.1
Values 28 29
[200]
HuH.7 GSTT1
Mean 0.0218
Standard deviation 0.015
Values 0.0082 0.039 0.019
[201]
SNU475 GSTT1
Mean 0.0116
Standard deviation 0.016
Values 0.023 0
[202]
THLE GSTT1
Mean 4.36
Standard deviation 0.38
Values 4.6 4.1
[203]
liver GSTT1
Mean 36.9
Standard deviation 41
Values 8.6 50 89 0
[204]
ref_hepatocyte CYP2B6
Mean 49.6
Standard deviation 62
Values 0 4.1 1.3e+02 12 1e+02
[205]
HepG2 CYP2B6
Mean 0.138
Standard deviation 0.15
Values 0.24 0.034
[206]
HepG2.C3A CYP2B6
Mean 1.32
Standard deviation 0.56
Values 1.7 0.92
[207]
HuH.7 CYP2B6
Mean 3.27
Standard deviation 2.3
Values 2.1 5.9 1.9
[208]
SNU475 CYP2B6
Mean 0.0424
Standard deviation 0.04
Values 0.014 0.071
[209]
THLE CYP2B6
Mean 0.0237
Standard deviation 0.033
Values 0.047 0
[210]
liver CYP2B6
Mean 372
Standard deviation 5.3e+02
Values 3.2e+02 23 1.1e+03 7.4
[211]
ref_hepatocyte MAOB
Mean 46.4
Standard deviation 48
Values 20 15 70 6.9 1.2e+02
[212]
HepG2 MAOB
Mean 19.9
Standard deviation 8.1
Values 14 26
[213]
HepG2.C3A MAOB
Mean 13.4
Standard deviation 5.7
Values 9.3 17
[214]
HuH.7 MAOB
Mean 20.3
Standard deviation 0.76
Values 21 21 19
[215]
SNU475 MAOB
Mean 18.4
Standard deviation 15
Values 29 7.7
[216]
THLE MAOB
Mean 0.0976
Standard deviation 0.012
Values 0.089 0.11
[217]
liver MAOB
Mean 66.2
Standard deviation 42
Values 35 1.1e+02 92 26
[218]
ref_hepatocyte GSTZ1
Mean 46.1
Standard deviation 60
Values 4.8 6.8 66 9 1.4e+02
[219]
HepG2 GSTZ1
Mean 6.52
Standard deviation 0.28
Values 6.7 6.3
[220]
HepG2.C3A GSTZ1
Mean 9.98
Standard deviation 2.1
Values 11 8.5
[221]
HuH.7 GSTZ1
Mean 7.32
Standard deviation 1
Values 6.6 6.9 8.5
[222]
SNU475 GSTZ1
Mean 4.11
Standard deviation 1.9
Values 5.4 2.8
[223]
THLE GSTZ1
Mean 4.72
Standard deviation 0.55
Values 4.3 5.1
[224]
liver GSTZ1
Mean 18.6
Standard deviation 9.1
Values 7.5 28 16 23
[225]
ref_hepatocyte CYP2C18
Mean 43
Standard deviation 35
Values 0 90 51 18 56
[226]
HepG2 CYP2C18
Mean 0.0336
Standard deviation 0.017
Values 0.046 0.021
[227]
HepG2.C3A CYP2C18
Mean 0.0107
Standard deviation 0.015
Values 0 0.021
[228]
HuH.7 CYP2C18
Mean 0.593
Standard deviation 0.1
Values 0.53 0.71 0.53
[229]
SNU475 CYP2C18
Mean 0.0076
Standard deviation 0.011
Values 0 0.015
[230]
THLE CYP2C18
Mean 0.0325
Standard deviation 0.029
Values 0.012 0.053
[231]
liver CYP2C18
Mean 44.5
Standard deviation 13
Values 57 36 54 31
[232]
ref_hepatocyte CYP2D6
Mean 41.3
Standard deviation 55
Values 0.24 0.47 1.1e+02 3.7 87
[233]
HepG2 CYP2D6
Mean 0.382
Standard deviation 0.03
Values 0.36 0.4
[234]
HepG2.C3A CYP2D6
Mean 1.89
Standard deviation 1
Values 2.6 1.2
[235]
HuH.7 CYP2D6
Mean 0.314
Standard deviation 0.087
Values 0.23 0.4 0.31
[236]
SNU475 CYP2D6
Mean 0.0992
Standard deviation 0.004
Values 0.1 0.096
[237]
THLE CYP2D6
Mean 0.0775
Standard deviation 0.049
Values 0.11 0.043
[238]
liver CYP2D6
Mean 137
Standard deviation 1.2e+02
Values 53 3.1e+02 1.3e+02 57
[239]
ref_hepatocyte MGST3
Mean 29.9
Standard deviation 13
Values 15 35 48 20 33
[240]
HepG2 MGST3
Mean 14.5
Standard deviation 2.5
Values 13 16
[241]
HepG2.C3A MGST3
Mean 13.2
Standard deviation 1.3
Values 12 14
[242]
HuH.7 MGST3
Mean 21
Standard deviation 3.7
Values 19 19 25
[243]
SNU475 MGST3
Mean 30.6
Standard deviation 11
Values 38 23
[244]
THLE MGST3
Mean 33.4
Standard deviation 7.3
Values 28 39
[245]
liver MGST3
Mean 36.8
Standard deviation 33
Values 10 56 73 7.7
[246]
ref_hepatocyte CYP3A7
Mean 29.1
Standard deviation 41
Values 8.7 0.12 1e+02 5 32
[247]
HepG2 CYP3A7
Mean 0.531
Standard deviation 0.38
Values 0.26 0.8
[248]
HepG2.C3A CYP3A7
Mean 2.26
Standard deviation 0.013
Values 2.3 2.3
[249]
HuH.7 CYP3A7
Mean 0.0822
Standard deviation 0.074
Values 0.033 0.17 0.047
[250]
SNU475 CYP3A7
Mean 0
Standard deviation 0
Values 0 0
[251]
THLE CYP3A7
Mean 0.00858
Standard deviation 0.0046
Values 0.012 0.0053
[252]
liver CYP3A7
Mean 13
Standard deviation 12
Values 5.2 30 11 5.1
[253]
ref_hepatocyte FMO5
Mean 27.7
Standard deviation 35
Values 14 3.7 31 2.2 87
[254]
HepG2 FMO5
Mean 5.7
Standard deviation 2.6
Values 3.9 7.5
[255]
HepG2.C3A FMO5
Mean 53.5
Standard deviation 4.2
Values 56 51
[256]
HuH.7 FMO5
Mean 12.3
Standard deviation 5.7
Values 10 19 8.2
[257]
SNU475 FMO5
Mean 2.69
Standard deviation 2.5
Values 4.5 0.93
[258]
THLE FMO5
Mean 0.161
Standard deviation 0.048
Values 0.2 0.13
[259]
liver FMO5
Mean 68.6
Standard deviation 29
Values 48 1.1e+02 47 71
[260]
ref_hepatocyte MAOA
Mean 22.1
Standard deviation 16
Values 3.4 23 34 8.6 41
[261]
HepG2 MAOA
Mean 5.32
Standard deviation 0.22
Values 5.5 5.2
[262]
HepG2.C3A MAOA
Mean 8.16
Standard deviation 2.3
Values 9.8 6.5
[263]
HuH.7 MAOA
Mean 37.5
Standard deviation 10
Values 36 49 28
[264]
SNU475 MAOA
Mean 1.62
Standard deviation 0.75
Values 1.1 2.1
[265]
THLE MAOA
Mean 66.1
Standard deviation 1.4
Values 67 65
[266]
liver MAOA
Mean 88.9
Standard deviation 19
Values 90 1.1e+02 88 65
[267]
ref_hepatocyte CYP2C19
Mean 19.2
Standard deviation 30
Values 0 5.9 18 0 72
[268]
HepG2 CYP2C19
Mean 0
Standard deviation 0
Values 0 0
[269]
HepG2.C3A CYP2C19
Mean 0
Standard deviation 0
Values 0 0
[270]
HuH.7 CYP2C19
Mean 0.3
Standard deviation 0.27
Values 0.098 0.6 0.2
[271]
SNU475 CYP2C19
Mean 0.00232
Standard deviation 0.0033
Values 0.0046 0
[272]
THLE CYP2C19
Mean 0.00296
Standard deviation 0.0042
Values 0.0059 0
[273]
liver CYP2C19
Mean 81.4
Standard deviation 39
Values 92 65 1.3e+02 38
[274]
ref_hepatocyte UGT1A9
Mean 15.2
Standard deviation 13
Values 0 21 26 2.6 27
[275]
HepG2 UGT1A9
Mean 0.16
Standard deviation 0.057
Values 0.2 0.12
[276]
HepG2.C3A UGT1A9
Mean 0.00486
Standard deviation 0.0069
Values 0.0097 0
[277]
HuH.7 UGT1A9
Mean 0.0656
Standard deviation 0.056
Values 0.066 0.12 0.0094
[278]
SNU475 UGT1A9
Mean 0.273
Standard deviation 0.34
Values 0.51 0.03
[279]
THLE UGT1A9
Mean 0.00798
Standard deviation 0.011
Values 0 0.016
[280]
liver UGT1A9
Mean 13.9
Standard deviation 9.6
Values 22 8.7 22 3
[281]
ref_hepatocyte CYP2A7
Mean 15.1
Standard deviation 22
Values 0 0.06 52 11 12
[282]
HepG2 CYP2A7
Mean 0
Standard deviation 0
Values 0 0
[283]
HepG2.C3A CYP2A7
Mean 0
Standard deviation 0
Values 0 0
[284]
HuH.7 CYP2A7
Mean 0.663
Standard deviation 0.76
Values 0.16 1.5 0.3
[285]
SNU475 CYP2A7
Mean 0.00739
Standard deviation 0.0039
Values 0.0046 0.01
[286]
THLE CYP2A7
Mean 0
Standard deviation 0
Values 0 0
[287]
liver CYP2A7
Mean 6.31
Standard deviation 5.5
Values 13 2 9 1.4
[288]
ref_hepatocyte GSTA4
Mean 11.5
Standard deviation 10
Values 29 9.2 8 0.55 11
[289]
HepG2 GSTA4
Mean 11.2
Standard deviation 1.3
Values 10 12
[290]
HepG2.C3A GSTA4
Mean 12.1
Standard deviation 1.1
Values 11 13
[291]
HuH.7 GSTA4
Mean 26.2
Standard deviation 3.6
Values 25 24 30
[292]
SNU475 GSTA4
Mean 22.2
Standard deviation 8.7
Values 28 16
[293]
THLE GSTA4
Mean 6.87
Standard deviation 0.55
Values 6.5 7.3
[294]
liver GSTA4
Mean 5.88
Standard deviation 4
Values 2.3 11 7.6 2.9
[295]
ref_hepatocyte UGT2B17
Mean 10.8
Standard deviation 16
Values 0 1.3 15 1.3 37
[296]
HepG2 UGT2B17
Mean 0.0114
Standard deviation 0.0081
Values 0.0057 0.017
[297]
HepG2.C3A UGT2B17
Mean 0.0156
Standard deviation 0.0083
Values 0.0097 0.021
[298]
HuH.7 UGT2B17
Mean 0.00214
Standard deviation 0.0037
Values 0 0.0064 0
[299]
SNU475 UGT2B17
Mean 0
Standard deviation 0
Values 0 0
[300]
THLE UGT2B17
Mean 0
Standard deviation 0
Values 0 0
[301]
liver UGT2B17
Mean 6
Standard deviation 4.8
Values 8.6 3.7 11 0.5
[302]
ref_hepatocyte GSTM4
Mean 9.44
Standard deviation 5.5
Values 11 5.2 14 2.4 15
[303]
HepG2 GSTM4
Mean 11.9
Standard deviation 5
Values 8.4 15
[304]
HepG2.C3A GSTM4
Mean 7.23
Standard deviation 1
Values 8 6.5
[305]
HuH.7 GSTM4
Mean 7.9
Standard deviation 0.7
Values 8.4 7.1 8.2
[306]
SNU475 GSTM4
Mean 14.8
Standard deviation 7.9
Values 20 9.2
[307]
THLE GSTM4
Mean 1.82
Standard deviation 0.44
Values 2.1 1.5
[308]
liver GSTM4
Mean 11.3
Standard deviation 5.6
Values 5.7 18 14 7.7
[309]
ref_hepatocyte UGT2A3
Mean 7.91
Standard deviation 6.4
Values 18 5.7 9.3 0.33 6.3
[310]
HepG2 UGT2A3
Mean 42.4
Standard deviation 14
Values 33 52
[311]
HepG2.C3A UGT2A3
Mean 137
Standard deviation 28
Values 1.2e+02 1.6e+02
[312]
HuH.7 UGT2A3
Mean 0.775
Standard deviation 0.72
Values 0.33 1.6 0.39
[313]
SNU475 UGT2A3
Mean 0.11
Standard deviation 0.13
Values 0.2 0.02
[314]
THLE UGT2A3
Mean 0.0172
Standard deviation 0.0092
Values 0.024 0.011
[315]
liver UGT2A3
Mean 31.9
Standard deviation 15
Values 24 55 25 24
[316]
ref_hepatocyte GSTP1
Mean 6.16
Standard deviation 5.2
Values 0 2.2 6 13 9.9
[317]
HepG2 GSTP1
Mean 0.872
Standard deviation 0.24
Values 0.7 1
[318]
HepG2.C3A GSTP1
Mean 1.43
Standard deviation 0.0018
Values 1.4 1.4
[319]
HuH.7 GSTP1
Mean 283
Standard deviation 1e+02
Values 2.9e+02 1.8e+02 3.8e+02
[320]
SNU475 GSTP1
Mean 592
Standard deviation 1.2e+02
Values 6.7e+02 5.1e+02
[321]
THLE GSTP1
Mean 140
Standard deviation 16
Values 1.3e+02 1.5e+02
[322]
liver GSTP1
Mean 8.38
Standard deviation 7.4
Values 2 17 12 2.6
[323]
ref_hepatocyte FMO4
Mean 4.55
Standard deviation 5.9
Values 0.16 0.88 8.6 0.098 13
[324]
HepG2 FMO4
Mean 0.36
Standard deviation 0.16
Values 0.48 0.24
[325]
HepG2.C3A FMO4
Mean 0.0322
Standard deviation 0.046
Values 0 0.064
[326]
HuH.7 FMO4
Mean 2.28
Standard deviation 1.1
Values 1.5 3.5 1.9
[327]
SNU475 FMO4
Mean 0.771
Standard deviation 0.35
Values 1 0.53
[328]
THLE FMO4
Mean 1.09
Standard deviation 0.0089
Values 1.1 1.1
[329]
liver FMO4
Mean 6.99
Standard deviation 1.4
Values 5.2 8.5 7.1 7.2
[330]
ref_hepatocyte UGT1A3
Mean 4.24
Standard deviation 4.8
Values 0 2.3 7.9 0.37 11
[331]
HepG2 UGT1A3
Mean 1.2
Standard deviation 0.2
Values 1.3 1.1
[332]
HepG2.C3A UGT1A3
Mean 0
Standard deviation 0
Values 0 0
[333]
HuH.7 UGT1A3
Mean 0.0101
Standard deviation 0.0024
Values 0.0082 0.013 0.0094
[334]
SNU475 UGT1A3
Mean 0.0911
Standard deviation 0.029
Values 0.11 0.071
[335]
THLE UGT1A3
Mean 0.00296
Standard deviation 0.0042
Values 0.0059 0
[336]
liver UGT1A3
Mean 14.2
Standard deviation 12
Values 21 2.5 28 5.8
[337]
ref_hepatocyte GSTT2
Mean 3.22
Standard deviation 3.2
Values 0 1.1 7.8 2.2 5.1
[338]
HepG2 GSTT2
Mean 0.0444
Standard deviation 0.022
Values 0.029 0.06
[339]
HepG2.C3A GSTT2
Mean 0.0102
Standard deviation 0.00071
Values 0.0097 0.011
[340]
HuH.7 GSTT2
Mean 0.00547
Standard deviation 0.0095
Values 0.016 0 0
[341]
SNU475 GSTT2
Mean 0.19
Standard deviation 0.13
Values 0.28 0.1
[342]
THLE GSTT2
Mean 0.671
Standard deviation 0.33
Values 0.44 0.9
[343]
liver GSTT2
Mean 0.384
Standard deviation 0.24
Values 0.16 0.73 0.36 0.29
[344]
ref_hepatocyte GSTM3
Mean 2.88
Standard deviation 2.5
Values 6.2 4.8 1.6 0.21 1.6
[345]
HepG2 GSTM3
Mean 32.9
Standard deviation 4.6
Values 30 36
[346]
HepG2.C3A GSTM3
Mean 18.6
Standard deviation 2.4
Values 17 20
[347]
HuH.7 GSTM3
Mean 3.57
Standard deviation 0.4
Values 3.4 3.3 4
[348]
SNU475 GSTM3
Mean 38.7
Standard deviation 3.4
Values 41 36
[349]
THLE GSTM3
Mean 38.5
Standard deviation 4.1
Values 41 36
[350]
liver GSTM3
Mean 11.7
Standard deviation 7.4
Values 4.8 22 13 7.3
[351]
ref_hepatocyte ALDH3A1
Mean 2.58
Standard deviation 5.2
Values 12 0.4 0.24 0 0.37
[352]
HepG2 ALDH3A1
Mean 1
Standard deviation 0.21
Values 1.2 0.85
[353]
HepG2.C3A ALDH3A1
Mean 0.0511
Standard deviation 0.0036
Values 0.049 0.054
[354]
HuH.7 ALDH3A1
Mean 0.294
Standard deviation 0.089
Values 0.36 0.19 0.33
[355]
SNU475 ALDH3A1
Mean 1.39
Standard deviation 0.1
Values 1.3 1.5
[356]
THLE ALDH3A1
Mean 0.187
Standard deviation 0.07
Values 0.24 0.14
[357]
liver ALDH3A1
Mean 0.614
Standard deviation 0.76
Values 0.59 0.071 1.7 0.11
[358]
ref_hepatocyte CYP3A43
Mean 1.46
Standard deviation 2.7
Values 0.059 0 1.1 0 6.1
[359]
HepG2 CYP3A43
Mean 0.112
Standard deviation 0.061
Values 0.069 0.15
[360]
HepG2.C3A CYP3A43
Mean 0.735
Standard deviation 0.42
Values 1 0.44
[361]
HuH.7 CYP3A43
Mean 0.622
Standard deviation 0.91
Values 0.057 1.7 0.14
[362]
SNU475 CYP3A43
Mean 0
Standard deviation 0
Values 0 0
[363]
THLE CYP3A43
Mean 0.00266
Standard deviation 0.0038
Values 0 0.0053
[364]
liver CYP3A43
Mean 5.41
Standard deviation 4.2
Values 2.9 12 3.4 3.6
[365]
ref_hepatocyte GSTO2
Mean 1.37
Standard deviation 1.2
Values 0.43 0.34 3.3 0.98 1.8
[366]
HepG2 GSTO2
Mean 1.28
Standard deviation 0.51
Values 1.6 0.92
[367]
HepG2.C3A GSTO2
Mean 7.24
Standard deviation 0.65
Values 7.7 6.8
[368]
HuH.7 GSTO2
Mean 1.29
Standard deviation 0.42
Values 1.1 0.96 1.8
[369]
SNU475 GSTO2
Mean 0.0882
Standard deviation 0.033
Values 0.065 0.11
[370]
THLE GSTO2
Mean 0.444
Standard deviation 0.026
Values 0.43 0.46
[371]
liver GSTO2
Mean 0.821
Standard deviation 0.41
Values 0.81 0.63 1.4 0.45
[372]
ref_hepatocyte ALDH3B1
Mean 1.3
Standard deviation 0.3
Values 1.8 1.2 1.1 1.2 1.2
[373]
HepG2 ALDH3B1
Mean 10.5
Standard deviation 1.5
Values 12 9.5
[374]
HepG2.C3A ALDH3B1
Mean 9.94
Standard deviation 4.7
Values 13 6.6
[375]
HuH.7 ALDH3B1
Mean 6.99
Standard deviation 0.87
Values 8 6.4 6.6
[376]
SNU475 ALDH3B1
Mean 64.9
Standard deviation 36
Values 91 39
[377]
THLE ALDH3B1
Mean 19.7
Standard deviation 1.7
Values 18 21
[378]
liver ALDH3B1
Mean 1.75
Standard deviation 0.18
Values 1.6 2 1.8 1.7
[379]
ref_hepatocyte GSTM2
Mean 0.961
Standard deviation 0.9
Values 1.9 0 1.3 0 1.7
[380]
HepG2 GSTM2
Mean 2.78
Standard deviation 0.68
Values 2.3 3.3
[381]
HepG2.C3A GSTM2
Mean 1.04
Standard deviation 0.29
Values 1.2 0.84
[382]
HuH.7 GSTM2
Mean 3.46
Standard deviation 0.18
Values 3.4 3.3 3.7
[383]
SNU475 GSTM2
Mean 4.89
Standard deviation 2.9
Values 7 2.8
[384]
THLE GSTM2
Mean 3.5
Standard deviation 0.29
Values 3.7 3.3
[385]
liver GSTM2
Mean 1.38
Standard deviation 0.62
Values 0.53 1.9 1.8 1.3
[386]
ref_hepatocyte GSTM1
Mean 0.404
Standard deviation 0.25
Values 0.52 0.62 0.52 0 0.36
[387]
HepG2 GSTM1
Mean 0.18
Standard deviation 0.14
Values 0.08 0.28
[388]
HepG2.C3A GSTM1
Mean 0.0657
Standard deviation 0.017
Values 0.078 0.054
[389]
HuH.7 GSTM1
Mean 4.5
Standard deviation 1.1
Values 5.5 3.3 4.7
[390]
SNU475 GSTM1
Mean 12.6
Standard deviation 6.3
Values 17 8.2
[391]
THLE GSTM1
Mean 0.0417
Standard deviation 0.0088
Values 0.035 0.048
[392]
liver GSTM1
Mean 54
Standard deviation 35
Values 15 93 70 38
[393]
ref_hepatocyte UGT1A5
Mean 0.393
Standard deviation 0.32
Values 0 0.38 0.82 0.19 0.58
[394]
HepG2 UGT1A5
Mean 0.0114
Standard deviation 0.0081
Values 0.0057 0.017
[395]
HepG2.C3A UGT1A5
Mean 0
Standard deviation 0
Values 0 0
[396]
HuH.7 UGT1A5
Mean 0.00428
Standard deviation 0.0074
Values 0 0.013 0
[397]
SNU475 UGT1A5
Mean 0.0747
Standard deviation 0.012
Values 0.083 0.066
[398]
THLE UGT1A5
Mean 0
Standard deviation 0
Values 0 0
[399]
liver UGT1A5
Mean 1.38
Standard deviation 1.4
Values 3.4 0.31 0.98 0.85
[400]
ref_hepatocyte UGT2B11
Mean 0.391
Standard deviation 0.65
Values 0 0 1.5 0 0.46
[401]
HepG2 UGT2B11
Mean 1
Standard deviation 0.2
Values 0.86 1.1
[402]
HepG2.C3A UGT2B11
Mean 0.348
Standard deviation 0.19
Values 0.21 0.48
[403]
HuH.7 UGT2B11
Mean 0.795
Standard deviation 0.79
Values 0.31 1.7 0.37
[404]
SNU475 UGT2B11
Mean 0.00928
Standard deviation 0.013
Values 0.019 0
[405]
THLE UGT2B11
Mean 0
Standard deviation 0
Values 0 0
[406]
liver UGT2B11
Mean 0.98
Standard deviation 0.68
Values 0.59 2 0.49 0.87
[407]
ref_hepatocyte UGT2B28
Mean 0.294
Standard deviation 0.52
Values 0 0 0.28 0 1.2
[408]
HepG2 UGT2B28
Mean 0.642
Standard deviation 0.23
Values 0.81 0.48
[409]
HepG2.C3A UGT2B28
Mean 0.816
Standard deviation 0.45
Values 0.5 1.1
[410]
HuH.7 UGT2B28
Mean 0.0413
Standard deviation 0.043
Values 0.025 0.09 0.0094
[411]
SNU475 UGT2B28
Mean 0.00464
Standard deviation 0.0066
Values 0.0093 0
[412]
THLE UGT2B28
Mean 0
Standard deviation 0
Values 0 0
[413]
liver UGT2B28
Mean 0.714
Standard deviation 0.87
Values 1.1 0 1.8 0.013
[414]
ref_hepatocyte GSTA5
Mean 0.13
Standard deviation 0.18
Values 0 0.32 0 0 0.33
[415]
HepG2 GSTA5
Mean 0.00214
Standard deviation 0.003
Values 0 0.0043
[416]
HepG2.C3A GSTA5
Mean 0
Standard deviation 0
Values 0 0
[417]
HuH.7 GSTA5
Mean 0.00273
Standard deviation 0.0047
Values 0.0082 0 0
[418]
SNU475 GSTA5
Mean 0
Standard deviation 0
Values 0 0
[419]
THLE GSTA5
Mean 0
Standard deviation 0
Values 0 0
[420]
liver GSTA5
Mean 0
Standard deviation 0
Values 0 0 0 0
[421]
ref_hepatocyte ALDH1A3
Mean 0.115
Standard deviation 0.2
Values 0 0.47 0.043 0 0.065
[422]
HepG2 ALDH1A3
Mean 0.283
Standard deviation 0.2
Values 0.42 0.14
[423]
HepG2.C3A ALDH1A3
Mean 0.0156
Standard deviation 0.0083
Values 0.0097 0.021
[424]
HuH.7 ALDH1A3
Mean 0.0903
Standard deviation 0.069
Values 0.16 0.096 0.019
[425]
SNU475 ALDH1A3
Mean 3.5
Standard deviation 1.1
Values 2.7 4.3
[426]
THLE ALDH1A3
Mean 136
Standard deviation 53
Values 99 1.7e+02
[427]
liver ALDH1A3
Mean 2.13
Standard deviation 0.67
Values 2.4 1.3 1.9 2.9
[428]
ref_hepatocyte GSTA3
Mean 0.0781
Standard deviation 0.11
Values 0 0 0.15 0 0.24
[429]
HepG2 GSTA3
Mean 0.00214
Standard deviation 0.003
Values 0 0.0043
[430]
HepG2.C3A GSTA3
Mean 0
Standard deviation 0
Values 0 0
[431]
HuH.7 GSTA3
Mean 0.0121
Standard deviation 0.014
Values 0.0082 0 0.028
[432]
SNU475 GSTA3
Mean 0.0359
Standard deviation 0.015
Values 0.046 0.025
[433]
THLE GSTA3
Mean 0
Standard deviation 0
Values 0 0
[434]
liver GSTA3
Mean 0
Standard deviation 0
Values 0 0 0 0
[435]
ref_hepatocyte FMO1
Mean 0.0687
Standard deviation 0.12
Values 0 0.27 0.069 0 0
[436]
HepG2 FMO1
Mean 0.00429
Standard deviation 0.0061
Values 0 0.0086
[437]
HepG2.C3A FMO1
Mean 0.0107
Standard deviation 0.015
Values 0 0.021
[438]
HuH.7 FMO1
Mean 1.13
Standard deviation 1.7
Values 0.16 3.1 0.094
[439]
SNU475 FMO1
Mean 0.00739
Standard deviation 0.0039
Values 0.0046 0.01
[440]
THLE FMO1
Mean 0
Standard deviation 0
Values 0 0
[441]
liver FMO1
Mean 0.26
Standard deviation 0.27
Values 0.043 0.66 0.21 0.13
[442]
ref_hepatocyte CYP2A13
Mean 0.0683
Standard deviation 0.12
Values 0 0 0.28 0 0.057
[443]
HepG2 CYP2A13
Mean 0
Standard deviation 0
Values 0 0
[444]
HepG2.C3A CYP2A13
Mean 0
Standard deviation 0
Values 0 0
[445]
HuH.7 CYP2A13
Mean 0
Standard deviation 0
Values 0 0 0
[446]
SNU475 CYP2A13
Mean 0
Standard deviation 0
Values 0 0
[447]
THLE CYP2A13
Mean 0
Standard deviation 0
Values 0 0
[448]
liver CYP2A13
Mean 0.0677
Standard deviation 0.059
Values 0.13 0 0.1 0.04
[449]
ref_hepatocyte UGT1A7
Mean 0.0431
Standard deviation 0.096
Values 0 0 0.22 0 0
[450]
HepG2 UGT1A7
Mean 0.0537
Standard deviation 0.021
Values 0.069 0.039
[451]
HepG2.C3A UGT1A7
Mean 0
Standard deviation 0
Values 0 0
[452]
HuH.7 UGT1A7
Mean 0.0277
Standard deviation 0.011
Values 0.016 0.039 0.028
[453]
SNU475 UGT1A7
Mean 2.06
Standard deviation 1.2
Values 1.2 2.9
[454]
THLE UGT1A7
Mean 0.0556
Standard deviation 0.012
Values 0.047 0.064
[455]
liver UGT1A7
Mean 0.582
Standard deviation 0.83
Values 1.8 0.094 0.1 0.32
[456]
ref_hepatocyte ADH7
Mean 0.0374
Standard deviation 0.084
Values 0 0 0 0 0.19
[457]
HepG2 ADH7
Mean 0
Standard deviation 0
Values 0 0
[458]
HepG2.C3A ADH7
Mean 0
Standard deviation 0
Values 0 0
[459]
HuH.7 ADH7
Mean 0
Standard deviation 0
Values 0 0 0
[460]
SNU475 ADH7
Mean 0
Standard deviation 0
Values 0 0
[461]
THLE ADH7
Mean 0
Standard deviation 0
Values 0 0
[462]
liver ADH7
Mean 0.00662
Standard deviation 0.013
Values 0 0 0 0.026
[463]
ref_hepatocyte UGT1A10
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[464]
HepG2 UGT1A10
Mean 0.00788
Standard deviation 0.0051
Values 0.011 0.0043
[465]
HepG2.C3A UGT1A10
Mean 0
Standard deviation 0
Values 0 0
[466]
HuH.7 UGT1A10
Mean 0.115
Standard deviation 0.078
Values 0.066 0.21 0.075
[467]
SNU475 UGT1A10
Mean 0.012
Standard deviation 0.0027
Values 0.014 0.01
[468]
THLE UGT1A10
Mean 0
Standard deviation 0
Values 0 0
[469]
liver UGT1A10
Mean 0.0104
Standard deviation 0.014
Values 0.029 0 0 0.013
[470]
ref_hepatocyte FMO2
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[471]
HepG2 FMO2
Mean 0
Standard deviation 0
Values 0 0
[472]
HepG2.C3A FMO2
Mean 0
Standard deviation 0
Values 0 0
[473]
HuH.7 FMO2
Mean 0.141
Standard deviation 0.053
Values 0.13 0.2 0.094
[474]
SNU475 FMO2
Mean 0.0548
Standard deviation 0.027
Values 0.074 0.035
[475]
THLE FMO2
Mean 0.00798
Standard deviation 0.011
Values 0 0.016
[476]
liver FMO2
Mean 2.49
Standard deviation 1.6
Values 3.9 1.4 3.8 0.91
[477]
ref_hepatocyte UGT1A8
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[478]
HepG2 UGT1A8
Mean 0
Standard deviation 0
Values 0 0
[479]
HepG2.C3A UGT1A8
Mean 0
Standard deviation 0
Values 0 0
[480]
HuH.7 UGT1A8
Mean 0.0407
Standard deviation 0.027
Values 0.033 0.071 0.019
[481]
SNU475 UGT1A8
Mean 0.152
Standard deviation 0.028
Values 0.17 0.13
[482]
THLE UGT1A8
Mean 0
Standard deviation 0
Values 0 0
[483]
liver UGT1A8
Mean 0.0104
Standard deviation 0.014
Values 0.029 0 0 0.013
[484]
ref_hepatocyte GSTM5
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[485]
HepG2 GSTM5
Mean 0.00429
Standard deviation 0.0061
Values 0 0.0086
[486]
HepG2.C3A GSTM5
Mean 0
Standard deviation 0
Values 0 0
[487]
HuH.7 GSTM5
Mean 0.00273
Standard deviation 0.0047
Values 0.0082 0 0
[488]
SNU475 GSTM5
Mean 0.0127
Standard deviation 0.018
Values 0 0.025
[489]
THLE GSTM5
Mean 0
Standard deviation 0
Values 0 0
[490]
liver GSTM5
Mean 0.506
Standard deviation 0.46
Values 0.16 1.1 0.62 0.15
[491]
ref_hepatocyte UGT2A1
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[492]
HepG2 UGT2A1
Mean 0.00214
Standard deviation 0.003
Values 0 0.0043
[493]
HepG2.C3A UGT2A1
Mean 0.00536
Standard deviation 0.0076
Values 0 0.011
[494]
HuH.7 UGT2A1
Mean 0
Standard deviation 0
Values 0 0 0
[495]
SNU475 UGT2A1
Mean 0.015
Standard deviation 0.015
Values 0.0046 0.025
[496]
THLE UGT2A1
Mean 0
Standard deviation 0
Values 0 0
[497]
liver UGT2A1
Mean 0.00999
Standard deviation 0.012
Values 0.014 0 0.026 0
[498]
ref_hepatocyte ALDH3B2
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[499]
HepG2 ALDH3B2
Mean 0.00214
Standard deviation 0.003
Values 0 0.0043
[500]
HepG2.C3A ALDH3B2
Mean 0.00486
Standard deviation 0.0069
Values 0.0097 0
[501]
HuH.7 ALDH3B2
Mean 0.00214
Standard deviation 0.0037
Values 0 0.0064 0
[502]
SNU475 ALDH3B2
Mean 0.0312
Standard deviation 0.0083
Values 0.037 0.025
[503]
THLE ALDH3B2
Mean 0.0112
Standard deviation 0.00084
Values 0.012 0.011
[504]
liver ALDH3B2
Mean 0.00331
Standard deviation 0.0066
Values 0 0 0 0.013