KEGG_COLORECTAL_CANCER | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | RHOA | Transforming protein RhoA | [1] | -1.56[2] | -1.69[3] | -1.58[4] | -1.48[5] | -1.18[6] | -1.42[7] |
2 | RAC1 | Ras-related C3 botulinum toxin substrate 1 | [8] | -1.01[9] | -0.98[10] | -0.38[11] | -0.24[12] | -0.41[13] | -1.06[14] |
3 | JUN | Transcription factor AP-1 | [15] | -1.11[16] | -2.29[17] | -2.13[18] | -1.96[19] | -1.54[20] | -1.91[21] |
4 | FOS | Proto-oncogene c-Fos | [22] | -6.63[23] | -5.00[24] | -5.78[25] | -6.42[26] | -5.51[27] | -1.40[28] |
5 | AKT1 | RAC-alpha serine/threonine-protein kinase | [29] | -0.54[30] | -0.41[31] | -1.60[32] | -0.31[33] | -0.44[34] | -0.34[35] |
6 | CTNNB1 | Catenin beta-1 | [36] | 1.00[37] | 0.86[38] | 1.64[39] | 0.50[40] | 0.57[41] | 1.01[42] |
7 | MYC | Myc proto-oncogene protein | [43] | -0.19[44] | -0.16[45] | -2.30[46] | -3.05[47] | -0.83[48] | -2.09[49] |
8 | MAP2K1 | Dual specificity mitogen-activated protein kinase kinase 1 | [50] | -1.54[51] | -1.51[52] | -1.04[53] | -0.80[54] | -0.44[55] | -1.29[56] |
9 | BAX | Apoptosis regulator BAX | [57] | -0.29[58] | -0.72[59] | -1.29[60] | -1.86[61] | -1.63[62] | -4.05[63] |
10 | CCND1 | G1/S-specific cyclin-D1 | [64] | 2.44[65] | 0.29[66] | 1.01[67] | 1.62[68] | -0.01[69] | 0.96[70] |
11 | BAD | Bcl2-associated agonist of cell death | [71] | -2.29[72] | -1.79[73] | -2.86[74] | -1.32[75] | -1.07[76] | -1.52[77] |
12 | RAF1 | RAF proto-oncogene serine/threonine-protein kinase | [78] | -0.68[79] | 0.09[80] | 1.24[81] | -0.44[82] | 0.27[83] | 1.00[84] |
13 | CYCS | Cytochrome c | [85] | 0.72[86] | 1.27[87] | 1.24[88] | 1.08[89] | 1.33[90] | 1.22[91] |
14 | CASP3 | Caspase-3 | [92] | -0.48[93] | 0.56[94] | -2.10[95] | -1.15[96] | -0.31[97] | -0.90[98] |
15 | ARAF | Serine/threonine-protein kinase A-Raf | [99] | -1.07[100] | -1.02[101] | -0.86[102] | -0.35[103] | -0.47[104] | 0.78[105] |
16 | TGFBR2 | TGF-beta receptor type-2 | [106] | 2.20[107] | 2.03[108] | 1.57[109] | 0.81[110] | 2.37[111] | 1.41[112] |
17 | MSH6 | DNA mismatch repair protein Msh6 | [113] | -0.30[114] | 0.55[115] | 0.64[116] | 0.64[117] | 0.91[118] | 0.19[119] |
18 | MAPK1 | Mitogen-activated protein kinase 1 | [120] | 1.09[121] | 1.59[122] | 1.31[123] | 1.59[124] | 1.09[125] | 1.68[126] |
19 | AKT2 | RAC-beta serine/threonine-protein kinase | [127] | 0.34[128] | 0.98[129] | 1.00[130] | 0.60[131] | 0.24[132] | 1.03[133] |
20 | KRAS | GTPase KRas | [134] | -1.13[135] | -0.79[136] | 0.70[137] | 0.54[138] | 0.05[139] | 0.58[140] |
21 | PIK3R1 | Phosphatidylinositol 3-kinase regulatory subunit alpha | [141] | -1.09[142] | -0.61[143] | 0.37[144] | 1.81[145] | 1.16[146] | 2.90[147] |
22 | BIRC5 | Baculoviral IAP repeat-containing protein 5 | [148] | 0.96[149] | 1.77[150] | 1.62[151] | 0.42[152] | 1.10[153] | -2.41[154] |
23 | MAPK8 | Mitogen-activated protein kinase 8 | [155] | -2.06[156] | -0.29[157] | -1.53[158] | -1.16[159] | -1.45[160] | -0.61[161] |
24 | MLH1 | DNA mismatch repair protein Mlh1 | [162] | 0.23[163] | 0.72[164] | 1.35[165] | -0.12[166] | 0.39[167] | 0.33[168] |
25 | SMAD3 | Mothers against decapentaplegic homolog 3 | [169] | 1.31[170] | 1.07[171] | 1.19[172] | 1.54[173] | 2.27[174] | 0.12[175] |
26 | TP53 | Cellular tumor antigen p53 | [176] | 1.02[177] | 0.95[178] | 1.59[179] | 1.04[180] | 0.55[181] | -0.14[182] |
27 | PIK3R2 | Phosphatidylinositol 3-kinase regulatory subunit beta | [183] | 1.26[184] | 1.84[185] | 2.34[186] | 0.45[187] | 0.86[188] | -0.39[189] |
28 | AXIN1 | Axin-1 | [190] | 0.73[191] | 1.41[192] | -0.26[193] | -8.95[194] | -0.25[195] | -0.75[196] |
29 | TGFBR1 | TGF-beta receptor type-1 | [197] | -0.29[198] | 0.30[199] | -0.31[200] | 0.09[201] | 1.04[202] | 1.24[203] |
30 | APPL1 | DCC-interacting protein 13-alpha | [204] | -0.57[205] | 0.98[206] | 0.10[207] | 0.51[208] | 0.86[209] | 1.70[210] |
31 | MAPK9 | Mitogen-activated protein kinase 9 | [211] | 0.61[212] | 1.20[213] | 1.15[214] | 1.46[215] | 0.76[216] | 0.41[217] |
32 | MAPK3 | Mitogen-activated protein kinase 3 | [218] | 1.23[219] | 1.64[220] | 1.57[221] | 0.17[222] | 0.04[223] | -1.14[224] |
33 | GSK3B | Glycogen synthase kinase-3 beta | [225] | 0.65[226] | 0.65[227] | 1.11[228] | 1.56[229] | 1.24[230] | 1.07[231] |
34 | MSH2 | DNA mismatch repair protein Msh2 | [232] | 0.21[233] | 1.86[234] | 1.19[235] | 1.88[236] | 1.09[237] | -0.79[238] |
35 | AXIN2 | Axin-2 | [239] | 2.85[240] | 0.82[241] | -3.34[242] | -1.35[243] | -1.87[244] | -2.44[245] |
36 | RAC2 | Ras-related C3 botulinum toxin substrate 2 | [246] | -2.33[247] | -7.96[248] | -8.68[249] | -1.65[250] | 2.01[251] | -1.33[252] |
37 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | 0.59[253] | 1.46[254] | 1.51[255] | 0.79[256] | 0.80[257] | 1.06[258] | |
38 | SMAD4 | Mothers against decapentaplegic homolog 4 | [259] | 0.78[260] | 1.77[261] | 1.62[262] | 1.65[263] | 1.87[264] | 2.69[265] |
39 | TGFB2 | Transforming growth factor beta-2 | [266] | -4.91[267] | -7.07[268] | -1.39[269] | 3.20[270] | 1.65[271] | -2.87[272] |
40 | RAC3 | Ras-related C3 botulinum toxin substrate 3 | [273] | -0.98[274] | 2.44[275] | 1.16[276] | -0.15[277] | -1.78[278] | -3.57[279] |
41 | CASP9 | Caspase-9 | [280] | -0.46[281] | 0.86[282] | -0.13[283] | -0.01[284] | -0.85[285] | -0.63[286] |
42 | SMAD2 | Mothers against decapentaplegic homolog 2 | [287] | 1.40[288] | 2.03[289] | 1.41[290] | 2.13[291] | 2.17[292] | 2.47[293] |
43 | TCF7L2 | Transcription factor 7-like 2 | [294] | 0.25[295] | 1.38[296] | 1.47[297] | 0.44[298] | 0.27[299] | 1.63[300] |
44 | TGFB1 | Transforming growth factor beta-1 | [301] | 2.86[302] | 2.18[303] | -0.68[304] | 3.58[305] | 2.66[306] | -1.33[307] |
45 | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | -1.00[308] | 1.00[309] | 1.08[310] | 0.87[311] | 0.92[312] | 1.82[313] | |
46 | PIK3CD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform | 1.27[314] | 2.72[315] | -1.21[316] | 0.02[317] | 0.64[318] | 0.20[319] | |
47 | TCF7L1 | Transcription factor 7-like 1 | [320] | -3.67[321] | -1.50[322] | 0.58[323] | -2.08[324] | -2.11[325] | 0.20[326] |
48 | TCF7 | Transcription factor 7 | [327] | 1.82[328] | 0.84[329] | -0.22[330] | -0.10[331] | -0.55[332] | -0.47[333] |
49 | MSH3 | DNA mismatch repair protein Msh3 | [334] | 0.13[335] | 1.11[336] | 0.78[337] | 1.22[338] | 0.96[339] | 2.32[340] |
50 | TGFB3 | Transforming growth factor beta-3 | [341] | -2.16[342] | -2.67[343] | -3.02[344] | -0.09[345] | -1.30[346] | 0.36[347] |
51 | APC | Adenomatous polyposis coli protein | [348] | -0.04[349] | 1.99[350] | 1.71[351] | 1.97[352] | 2.45[353] | 3.64[354] |
52 | BRAF | Serine/threonine-protein kinase B-raf | [355] | -0.37[356] | -0.28[357] | 1.64[358] | 0.48[359] | 0.03[360] | 1.76[361] |
53 | RALGDS | Ral guanine nucleotide dissociation stimulator | [362] | 2.43[363] | 2.45[364] | 1.12[365] | 2.53[366] | 1.94[367] | 1.18[368] |
54 | PIK3R3 | Phosphatidylinositol 3-kinase regulatory subunit gamma | [369] | 1.11[370] | 1.48[371] | 2.21[372] | 2.91[373] | 1.78[374] | 2.58[375] |
55 | AKT3 | RAC-gamma serine/threonine-protein kinase | [376] | -2.46[377] | -4.66[378] | -4.08[379] | 5.59[380] | 4.39[381] | 3.51[382] |
56 | PIK3R5 | Phosphoinositide 3-kinase regulatory subunit 5 | [383] | -7.78[384] | [385] | -2.90[386] | -4.18[387] | -3.99[388] | 2.24[389] |
57 | BCL2 | Apoptosis regulator Bcl-2 | [390] | -3.47[391] | 2.30[392] | -5.22[393] | 1.52[394] | 1.08[395] | 3.13[396] |
58 | PIK3CG | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | [397] | [398] | [399] | 1.08[400] | -3.95[401] | 4.00[402] | |
59 | LEF1 | Lymphoid enhancer-binding factor 1 | [403] | 2.04[404] | -4.53[405] | 3.28[406] | 0.82[407] | -1.03[408] | 0.99[409] |
60 | APC2 | Adenomatous polyposis coli protein 2 | [410] | 3.00[411] | 3.38[412] | 3.27[413] | 2.61[414] | 2.49[415] | 4.32[416] |
61 | MAPK10 | Mitogen-activated protein kinase 10 | [417] | -2.10[418] | [419] | [420] | 8.65[421] | 4.24[422] | 7.15[423] |
62 | DCC | Netrin receptor DCC | [424] | [425] | [426] | [427] | [428] | [429] | [430] |