KEGG_CHRONIC_MYELOID_LEUKEMIA | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | NFKBIA | NF-kappa-B inhibitor alpha | [1] | -1.94[2] | -3.54[3] | -3.98[4] | -4.09[5] | -2.36[6] | -1.43[7] |
2 | CDKN1A | Cyclin-dependent kinase inhibitor 1 | [8] | -0.05[9] | -1.24[10] | -4.00[11] | -2.56[12] | -0.16[13] | -2.12[14] |
3 | AKT1 | RAC-alpha serine/threonine-protein kinase | [15] | -0.80[16] | -0.85[17] | -1.99[18] | -0.62[19] | -0.75[20] | -0.53[21] |
4 | MYC | Myc proto-oncogene protein | [22] | -0.46[23] | -0.60[24] | -2.69[25] | -3.36[26] | -1.14[27] | -2.29[28] |
5 | MAP2K1 | Dual specificity mitogen-activated protein kinase kinase 1 | [29] | -1.81[30] | -1.95[31] | -1.43[32] | -1.11[33] | -0.76[34] | -1.48[35] |
6 | MAP2K2 | Dual specificity mitogen-activated protein kinase kinase 2 | [36] | -0.83[37] | -0.96[38] | -0.16[39] | -1.41[40] | -1.08[41] | -1.99[42] |
7 | BCL2L1 | Bcl-2-like protein 1 | [43] | 1.25[44] | 0.83[45] | 1.73[46] | -1.18[47] | -0.95[48] | -1.11[49] |
8 | CCND1 | G1/S-specific cyclin-D1 | [50] | 2.17[51] | -0.15[52] | 0.62[53] | 1.31[54] | -0.32[55] | 0.76[56] |
9 | IKBKG | NF-kappa-B essential modulator | [57] | -1.77[58] | -1.44[59] | -3.75[60] | -1.42[61] | -2.79[62] | -0.89[63] |
10 | PTPN11 | Tyrosine-protein phosphatase non-receptor type 11 | [64] | -0.44[65] | 0.18[66] | 0.07[67] | 0.32[68] | 0.80[69] | 0.97[70] |
11 | HDAC1 | Histone deacetylase 1 | [71] | -0.38[72] | -0.17[73] | 0.45[74] | 0.08[75] | -0.30[76] | -0.75[77] |
12 | CTBP1 | C-terminal-binding protein 1 | [78] | -0.83[79] | -0.53[80] | -0.31[81] | -0.16[82] | -1.27[83] | -0.56[84] |
13 | GRB2 | Growth factor receptor-bound protein 2 | [85] | 0.31[86] | 0.34[87] | 0.40[88] | -0.02[89] | -0.26[90] | 0.01[91] |
14 | CDK4 | Cyclin-dependent kinase 4 | [92] | 0.45[93] | 1.22[94] | 0.79[95] | -0.39[96] | 0.11[97] | -1.12[98] |
15 | CRK | Adapter molecule crk | [99] | -1.09[100] | -0.96[101] | -0.96[102] | -0.81[103] | -0.57[104] | 0.55[105] |
16 | BAD | Bcl2-associated agonist of cell death | [106] | -2.55[107] | -2.23[108] | -3.25[109] | -1.63[110] | -1.39[111] | -1.71[112] |
17 | SHC1 | SHC-transforming protein 1 | [113] | 0.28[114] | 0.69[115] | 0.70[116] | 2.08[117] | 1.41[118] | 0.49[119] |
18 | RELA | Transcription factor p65 | [120] | -0.75[121] | -1.07[122] | -0.99[123] | -0.62[124] | -0.87[125] | -1.17[126] |
19 | RAF1 | RAF proto-oncogene serine/threonine-protein kinase | [127] | -0.95[128] | -0.35[129] | 0.85[130] | -0.75[131] | -0.05[132] | 0.81[133] |
20 | NRAS | GTPase NRas | [134] | -0.26[135] | 0.37[136] | 0.72[137] | 0.43[138] | -0.16[139] | -0.54[140] |
21 | CDKN1B | Cyclin-dependent kinase inhibitor 1B | [141] | -0.97[142] | -0.34[143] | -0.20[144] | -1.68[145] | -1.37[146] | -1.20[147] |
22 | ARAF | Serine/threonine-protein kinase A-Raf | [148] | -1.34[149] | -1.46[150] | -1.25[151] | -0.66[152] | -0.79[153] | 0.59[154] |
23 | HRAS | GTPase HRas | [155] | -1.89[156] | -2.41[157] | -3.26[158] | -1.52[159] | -1.89[160] | -2.95[161] |
24 | TGFBR2 | TGF-beta receptor type-2 | [162] | 1.93[163] | 1.59[164] | 1.18[165] | 0.49[166] | 2.06[167] | 1.22[168] |
25 | MAPK1 | Mitogen-activated protein kinase 1 | [169] | 0.82[170] | 1.15[171] | 0.92[172] | 1.28[173] | 0.77[174] | 1.49[175] |
26 | AKT2 | RAC-beta serine/threonine-protein kinase | [176] | 0.07[177] | 0.54[178] | 0.61[179] | 0.29[180] | -0.08[181] | 0.84[182] |
27 | SHC2 | SHC-transforming protein 2 | [183] | -2.27[184] | -1.72[185] | -2.63[186] | -5.24[187] | -5.02[188] | -0.66[189] |
28 | KRAS | GTPase KRas | [190] | -1.40[191] | -1.23[192] | 0.31[193] | 0.23[194] | -0.26[195] | 0.39[196] |
29 | CRKL | Crk-like protein | [197] | 0.82[198] | 1.11[199] | 1.65[200] | 0.56[201] | 0.60[202] | 1.16[203] |
30 | PIK3R1 | Phosphatidylinositol 3-kinase regulatory subunit alpha | [204] | -1.36[205] | -1.05[206] | -0.02[207] | 1.50[208] | 0.84[209] | 2.71[210] |
31 | CBLC | E3 ubiquitin-protein ligase CBL-C | [211] | -2.91[212] | -1.60[213] | -10.00[214] | -12.09[215] | -10.74[216] | -1.38[217] |
32 | SOS1 | Son of sevenless homolog 1 | [218] | -0.98[219] | 0.74[220] | 0.18[221] | 0.28[222] | -0.65[223] | 0.25[224] |
33 | HDAC2 | Histone deacetylase 2 | [225] | 0.84[226] | 2.35[227] | 1.67[228] | 1.59[229] | 1.58[230] | -0.09[231] |
34 | MDM2 | E3 ubiquitin-protein ligase Mdm2 | [232] | 1.22[233] | 2.84[234] | 0.01[235] | -0.06[236] | 0.66[237] | 1.88[238] |
35 | NFKB1 | Nuclear factor NF-kappa-B p105 subunit | [239] | -0.22[240] | -0.35[241] | -0.62[242] | -0.82[243] | -0.06[244] | 0.16[245] |
36 | SMAD3 | Mothers against decapentaplegic homolog 3 | [246] | 1.05[247] | 0.63[248] | 0.80[249] | 1.23[250] | 1.95[251] | -0.08[252] |
37 | TP53 | Cellular tumor antigen p53 | [253] | 0.75[254] | 0.51[255] | 1.20[256] | 0.72[257] | 0.23[258] | -0.33[259] |
38 | PIK3R2 | Phosphatidylinositol 3-kinase regulatory subunit beta | [260] | 0.99[261] | 1.40[262] | 1.95[263] | 0.14[264] | 0.54[265] | -0.58[266] |
39 | TGFBR1 | TGF-beta receptor type-1 | [267] | -0.56[268] | -0.14[269] | -0.70[270] | -0.23[271] | 0.73[272] | 1.04[273] |
40 | MAPK3 | Mitogen-activated protein kinase 3 | [274] | 0.97[275] | 1.20[276] | 1.18[277] | -0.15[278] | -0.28[279] | -1.33[280] |
41 | CDK6 | Cyclin-dependent kinase 6 | [281] | 1.16[282] | 2.05[283] | 0.39[284] | 0.35[285] | 0.99[286] | 1.78[287] |
42 | ABL1 | Tyrosine-protein kinase ABL1 | [288] | 1.34[289] | 0.93[290] | 1.66[291] | 1.50[292] | 2.03[293] | 0.65[294] |
43 | STAT5B | Signal transducer and activator of transcription 5B | [295] | 0.47[296] | 0.29[297] | 0.93[298] | 0.98[299] | -0.03[300] | 1.33[301] |
44 | CHUK | Inhibitor of nuclear factor kappa-B kinase subunit alpha | [302] | 0.02[303] | 1.43[304] | 1.33[305] | 0.08[306] | 0.74[307] | 1.23[308] |
45 | BCR | Breakpoint cluster region protein | [309] | 1.34[310] | 0.78[311] | 0.97[312] | 0.45[313] | 0.67[314] | 1.41[315] |
46 | IKBKB | Inhibitor of nuclear factor kappa-B kinase subunit beta | [316] | -0.36[317] | -0.11[318] | -0.07[319] | -0.31[320] | -0.37[321] | 0.89[322] |
47 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | 0.33[323] | 1.02[324] | 1.12[325] | 0.48[326] | 0.48[327] | 0.87[328] | |
48 | SMAD4 | Mothers against decapentaplegic homolog 4 | [329] | 0.51[330] | 1.33[331] | 1.23[332] | 1.34[333] | 1.55[334] | 2.50[335] |
49 | TGFB2 | Transforming growth factor beta-2 | [336] | -5.17[337] | -7.51[338] | -1.78[339] | 2.89[340] | 1.33[341] | -3.06[342] |
50 | RB1 | Retinoblastoma-associated protein | [343] | 0.33[344] | 1.02[345] | 1.52[346] | 1.71[347] | 1.88[348] | 1.19[349] |
51 | SOS2 | Son of sevenless homolog 2 | [350] | -0.91[351] | 0.41[352] | -0.43[353] | 1.12[354] | 0.83[355] | 1.55[356] |
52 | E2F1 | Transcription factor E2F1 | [357] | 1.06[358] | 1.11[359] | 1.17[360] | 1.30[361] | 1.58[362] | -3.90[363] |
53 | STAT5A | Signal transducer and activator of transcription 5A | [364] | -2.83[365] | -1.47[366] | -2.46[367] | -1.42[368] | -0.81[369] | -0.05[370] |
54 | RUNX1 | Runt-related transcription factor 1 | [371] | 0.32[372] | -0.70[373] | -0.66[374] | 1.61[375] | 1.16[376] | -0.93[377] |
55 | TGFB1 | Transforming growth factor beta-1 | [378] | 2.59[379] | 1.74[380] | -1.07[381] | 3.27[382] | 2.34[383] | -1.52[384] |
56 | E2F3 | Transcription factor E2F3 | [385] | 0.83[386] | 0.85[387] | 0.04[388] | 2.06[389] | 1.35[390] | -0.46[391] |
57 | CBLB | E3 ubiquitin-protein ligase CBL-B | [392] | -1.53[393] | -0.10[394] | 0.27[395] | 0.21[396] | 0.92[397] | 1.09[398] |
58 | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | -1.26[399] | 0.56[400] | 0.69[401] | 0.56[402] | 0.61[403] | 1.62[404] | |
59 | PIK3CD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform | 1.00[405] | 2.28[406] | -1.60[407] | -0.29[408] | 0.32[409] | 0.01[410] | |
60 | GAB2 | GRB2-associated-binding protein 2 | [411] | 0.68[412] | 0.66[413] | 0.84[414] | 0.35[415] | 0.28[416] | 0.25[417] |
61 | TGFB3 | Transforming growth factor beta-3 | [418] | -2.43[419] | -3.11[420] | -3.41[421] | -0.40[422] | -1.62[423] | 0.16[424] |
62 | CTBP2 | C-terminal-binding protein 2 | [425] | -2.95[426] | -2.32[427] | 1.34[428] | 2.71[429] | 2.84[430] | 1.26[431] |
63 | BRAF | Serine/threonine-protein kinase B-raf | [432] | -0.64[433] | -0.72[434] | 1.25[435] | 0.17[436] | -0.29[437] | 1.56[438] |
64 | CBL | E3 ubiquitin-protein ligase CBL | [439] | 3.56[440] | 2.70[441] | 2.86[442] | 4.57[443] | 3.89[444] | 3.47[445] |
65 | PIK3R3 | Phosphatidylinositol 3-kinase regulatory subunit gamma | [446] | 0.84[447] | 1.04[448] | 1.82[449] | 2.60[450] | 1.46[451] | 2.39[452] |
66 | AKT3 | RAC-gamma serine/threonine-protein kinase | [453] | -2.73[454] | -5.10[455] | -4.47[456] | 5.27[457] | 4.07[458] | 3.32[459] |
67 | PIK3R5 | Phosphoinositide 3-kinase regulatory subunit 5 | [460] | -8.05[461] | [462] | -3.29[463] | -4.49[464] | -4.31[465] | 2.05[466] |
68 | CDKN2A | Cyclin-dependent kinase inhibitor 2A | [467] | 3.20[468] | 1.15[469] | 4.50[470] | 4.64[471] | 6.27[472] | -2.44[473] |
69 | MECOM | MDS1 and EVI1 complex locus protein EVI1 | [474] | -2.02[475] | -3.59[476] | 5.02[477] | 1.00[478] | 3.26[479] | 2.39[480] |
70 | E2F2 | Transcription factor E2F2 | [481] | 3.36[482] | 4.45[483] | 3.89[484] | 3.48[485] | 3.65[486] | 1.13[487] |
71 | PIK3CG | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | [488] | [489] | [490] | 0.77[491] | -4.27[492] | 3.81[493] | |
72 | SHC4 | SHC-transforming protein 4 | [494] | -3.14[495] | [496] | -2.46[497] | 1.96[498] | 2.18[499] | -0.98[500] |
73 | SHC3 | SHC-transforming protein 3 | [501] | 1.22[502] | 3.79[503] | -3.76[504] | 2.89[505] | 6.64[506] | 1.53[507] |