KEGG_CELL_CYCLE | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | YWHAE | 14-3-3 protein epsilon | [1] | -1.55[2] | -1.54[3] | -1.25[4] | -1.35[5] | -1.38[6] | -1.05[7] |
2 | YWHAZ | 14-3-3 protein zeta/delta | [8] | -0.89[9] | -1.13[10] | -0.88[11] | 0.41[12] | -1.07[13] | -1.14[14] |
3 | SKP1 | S-phase kinase-associated protein 1 | [15] | -1.29[16] | -1.00[17] | -1.93[18] | -0.99[19] | -0.84[20] | -0.19[21] |
4 | GADD45B | Growth arrest and DNA damage-inducible protein GADD45 beta | [22] | -4.49[23] | -5.34[24] | -4.19[25] | -4.51[26] | -3.59[27] | -1.67[28] |
5 | GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha | [29] | -2.78[30] | -3.96[31] | -3.83[32] | -4.47[33] | -2.81[34] | -2.51[35] |
6 | YWHAH | 14-3-3 protein eta | [36] | -1.68[37] | -2.19[38] | -2.28[39] | -1.68[40] | -2.15[41] | -1.46[42] |
7 | YWHAQ | 14-3-3 protein theta | [43] | -0.05[44] | -0.33[45] | -0.69[46] | 0.87[47] | 0.13[48] | -0.10[49] |
8 | SFN | 14-3-3 protein sigma | [50] | -2.67[51] | -3.13[52] | -2.80[53] | -8.32[54] | -9.31[55] | -9.59[56] |
9 | ANAPC11 | Anaphase-promoting complex subunit 11 | [57] | -2.15[58] | -1.80[59] | -2.29[60] | -2.81[61] | -2.49[62] | -0.89[63] |
10 | RBX1 | E3 ubiquitin-protein ligase RBX1 | [64] | -2.37[65] | -2.04[66] | -2.22[67] | -3.19[68] | -2.83[69] | -1.60[70] |
11 | YWHAG | 14-3-3 protein gamma | [71] | -0.11[72] | -0.74[73] | -0.75[74] | 0.23[75] | -0.53[76] | -0.84[77] |
12 | YWHAB | 14-3-3 protein beta/alpha | [78] | 0.73[79] | 0.34[80] | -0.44[81] | 0.81[82] | 0.18[83] | 0.41[84] |
13 | GADD45G | Growth arrest and DNA damage-inducible protein GADD45 gamma | [85] | -10.23[86] | [87] | -8.87[88] | -8.32[89] | -8.32[90] | -1.22[91] |
14 | CDKN1A | Cyclin-dependent kinase inhibitor 1 | [92] | 0.53[93] | -0.96[94] | -3.72[95] | -2.48[96] | 0.01[97] | -1.33[98] |
15 | PCNA | Proliferating cell nuclear antigen | [99] | 0.58[100] | 0.46[101] | -1.01[102] | -0.71[103] | -0.49[104] | -2.57[105] |
16 | CDC26 | Anaphase-promoting complex subunit CDC26 | [106] | -3.09[107] | -2.71[108] | -2.81[109] | -3.52[110] | -2.69[111] | -1.70[112] |
17 | MYC | Myc proto-oncogene protein | [113] | 0.12[114] | -0.32[115] | -2.41[116] | -3.28[117] | -0.97[118] | -1.50[119] |
18 | MAD2L2 | Mitotic spindle assembly checkpoint protein MAD2B | [120] | -1.85[121] | -0.53[122] | -1.87[123] | -2.16[124] | -2.01[125] | -0.92[126] |
19 | CCND1 | G1/S-specific cyclin-D1 | [127] | 2.74[128] | 0.14[129] | 0.90[130] | 1.39[131] | -0.15[132] | 1.56[133] |
20 | BUB3 | Mitotic checkpoint protein BUB3 | [134] | 0.00[135] | 0.78[136] | 0.10[137] | -0.79[138] | 0.59[139] | -0.09[140] |
21 | ANAPC13 | Anaphase-promoting complex subunit 13 | [141] | -1.14[142] | -0.79[143] | -0.87[144] | -1.36[145] | -1.39[146] | 0.33[147] |
22 | HDAC1 | Histone deacetylase 1 | [148] | 0.19[149] | 0.11[150] | 0.73[151] | 0.16[152] | -0.13[153] | 0.04[154] |
23 | CDK4 | Cyclin-dependent kinase 4 | [155] | 1.02[156] | 1.50[157] | 1.07[158] | -0.31[159] | 0.28[160] | -0.33[161] |
24 | RAD21 | Double-strand-break repair protein rad21 homolog | [162] | 0.13[163] | 1.42[164] | 1.45[165] | 1.57[166] | 1.13[167] | 0.88[168] |
25 | ANAPC5 | Anaphase-promoting complex subunit 5 | [169] | 0.56[170] | 1.13[171] | 1.23[172] | -0.15[173] | 0.24[174] | 1.21[175] |
26 | CCNH | Cyclin-H | [176] | -1.98[177] | -1.22[178] | -1.90[179] | -2.27[180] | -0.94[181] | -0.42[182] |
27 | TFDP1 | Transcription factor Dp-1 | [183] | 0.35[184] | -0.41[185] | -0.41[186] | 0.12[187] | 0.63[188] | -0.64[189] |
28 | CUL1 | Cullin-1 | [190] | -0.70[191] | -0.11[192] | -0.63[193] | 0.09[194] | -0.32[195] | 1.25[196] |
29 | CDKN1B | Cyclin-dependent kinase inhibitor 1B | [197] | -0.40[198] | -0.05[199] | 0.08[200] | -1.60[201] | -1.20[202] | -0.40[203] |
30 | CDC27 | Cell division cycle protein 27 homolog | [204] | -0.10[205] | 0.64[206] | -0.07[207] | 0.69[208] | 0.17[209] | 0.65[210] |
31 | MCM7 | DNA replication licensing factor MCM7 | [211] | 1.60[212] | 1.30[213] | 2.46[214] | 0.80[215] | 1.29[216] | -0.30[217] |
32 | MCM3 | DNA replication licensing factor MCM3 | [218] | 1.99[219] | 1.74[220] | 1.79[221] | 0.49[222] | 1.52[223] | -0.18[224] |
33 | CDC16 | Cell division cycle protein 16 homolog | [225] | -0.81[226] | -0.68[227] | -1.39[228] | -0.91[229] | -0.53[230] | 0.37[231] |
34 | CDK2 | Cyclin-dependent kinase 2 | [232] | -0.73[233] | -0.66[234] | -0.35[235] | -0.51[236] | 0.02[237] | -1.68[238] |
35 | CDK7 | Cyclin-dependent kinase 7 | [239] | -0.96[240] | -0.04[241] | -0.39[242] | -1.06[243] | -1.44[244] | -1.85[245] |
36 | SMC3 | Structural maintenance of chromosomes protein 3 | [246] | -1.48[247] | 1.07[248] | 1.47[249] | -0.08[250] | 0.29[251] | 0.56[252] |
37 | E2F4 | Transcription factor E2F4 | [253] | 0.82[254] | 0.83[255] | -0.20[256] | -0.07[257] | -0.14[258] | 0.26[259] |
38 | MCM4 | DNA replication licensing factor MCM4 | [260] | 1.75[261] | 1.54[262] | 2.19[263] | 1.51[264] | 2.09[265] | -0.48[266] |
39 | MCM5 | DNA replication licensing factor MCM5 | [267] | 0.90[268] | 0.67[269] | 1.24[270] | 0.03[271] | 0.89[272] | -0.42[273] |
40 | MAD2L1 | Mitotic spindle assembly checkpoint protein MAD2A | [274] | 0.28[275] | 1.31[276] | 0.57[277] | -0.44[278] | 0.61[279] | -2.37[280] |
41 | CCNB1 | G2/mitotic-specific cyclin-B1 | [281] | 1.53[282] | 1.67[283] | 1.79[284] | 1.12[285] | 2.03[286] | -1.84[287] |
42 | ORC4 | Origin recognition complex subunit 4 | [288] | -0.26[289] | 0.83[290] | 0.49[291] | 0.88[292] | 0.07[293] | 3.47[294] |
43 | CDC23 | Cell division cycle protein 23 homolog | [295] | 0.06[296] | 0.17[297] | 0.36[298] | 0.54[299] | 0.19[300] | 0.70[301] |
44 | HDAC2 | Histone deacetylase 2 | [302] | 1.41[303] | 2.64[304] | 1.95[305] | 1.67[306] | 1.75[307] | 0.70[308] |
45 | ORC5 | Origin recognition complex subunit 5 | [309] | -1.29[310] | -1.05[311] | -0.53[312] | -0.63[313] | -0.94[314] | 0.32[315] |
46 | MDM2 | E3 ubiquitin-protein ligase Mdm2 | [316] | 1.80[317] | 3.12[318] | 0.29[319] | 0.02[320] | 0.83[321] | 2.67[322] |
47 | RBL2 | Retinoblastoma-like protein 2 | [323] | 0.52[324] | 1.27[325] | 1.26[326] | 0.74[327] | 0.39[328] | 2.64[329] |
48 | SMAD3 | Mothers against decapentaplegic homolog 3 | [330] | 1.62[331] | 0.92[332] | 1.08[333] | 1.31[334] | 2.12[335] | 0.71[336] |
49 | FZR1 | Fizzy-related protein homolog | [337] | 0.44[338] | -0.02[339] | 0.00[340] | -0.45[341] | 0.07[342] | 1.13[343] |
50 | CDK1 | Cyclin-dependent kinase 1 | [344] | 0.94[345] | 2.90[346] | 1.57[347] | 1.78[348] | 2.53[349] | -1.97[350] |
51 | ANAPC7 | Anaphase-promoting complex subunit 7 | [351] | 0.69[352] | 0.99[353] | 0.40[354] | 0.41[355] | 0.60[356] | 0.69[357] |
52 | CHEK2 | Serine/threonine-protein kinase Chk2 | [358] | -0.21[359] | 0.13[360] | 0.47[361] | -0.74[362] | -1.18[363] | -2.78[364] |
53 | ANAPC2 | Anaphase-promoting complex subunit 2 | [365] | 0.29[366] | -0.36[367] | 0.18[368] | -0.45[369] | -0.55[370] | 0.55[371] |
54 | TP53 | Cellular tumor antigen p53 | [372] | 1.32[373] | 0.79[374] | 1.48[375] | 0.80[376] | 0.40[377] | 0.46[378] |
55 | STAG2 | Cohesin subunit SA-2 | [379] | -0.03[380] | 1.88[381] | 2.84[382] | 2.05[383] | 1.46[384] | 2.45[385] |
56 | ORC2 | Origin recognition complex subunit 2 | [386] | 0.15[387] | 1.01[388] | 0.68[389] | -0.18[390] | 0.04[391] | 0.07[392] |
57 | MAD1L1 | Mitotic spindle assembly checkpoint protein MAD1 | [393] | 0.33[394] | -0.28[395] | -0.25[396] | -1.14[397] | -0.66[398] | 0.22[399] |
58 | PLK1 | Serine/threonine-protein kinase PLK1 | [400] | 2.18[401] | 1.82[402] | 1.62[403] | 0.76[404] | 1.73[405] | -2.13[406] |
59 | WEE1 | Wee1-like protein kinase | [407] | -0.01[408] | 0.31[409] | 0.98[410] | 0.24[411] | -0.31[412] | -0.04[413] |
60 | CDC14B | Dual specificity protein phosphatase CDC14B | [414] | 0.50[415] | 0.53[416] | 0.46[417] | -0.31[418] | 0.29[419] | 1.91[420] |
61 | CDC6 | Cell division control protein 6 homolog | [421] | 1.55[422] | 1.02[423] | 1.56[424] | 1.08[425] | 1.28[426] | -1.56[427] |
62 | SMC1A | Structural maintenance of chromosomes protein 1A | [428] | 1.79[429] | 1.56[430] | 2.50[431] | 2.53[432] | 3.30[433] | 2.95[434] |
63 | ORC6 | Origin recognition complex subunit 6 | [435] | 0.44[436] | 0.91[437] | 0.07[438] | 0.30[439] | 0.48[440] | -3.20[441] |
64 | MCM6 | DNA replication licensing factor MCM6 | [442] | 0.89[443] | 0.50[444] | 2.46[445] | 1.93[446] | 2.66[447] | -0.79[448] |
65 | MCM2 | DNA replication licensing factor MCM2 | [449] | 2.61[450] | 1.96[451] | 3.19[452] | 1.64[453] | 2.58[454] | -1.12[455] |
66 | GSK3B | Glycogen synthase kinase-3 beta | [456] | 0.95[457] | 0.49[458] | 1.00[459] | 1.33[460] | 1.09[461] | 1.66[462] |
67 | CDK6 | Cyclin-dependent kinase 6 | [463] | 1.73[464] | 2.34[465] | 0.67[466] | 0.43[467] | 1.16[468] | 2.57[469] |
68 | ABL1 | Tyrosine-protein kinase ABL1 | [470] | 1.92[471] | 1.21[472] | 1.94[473] | 1.58[474] | 2.20[475] | 1.44[476] |
69 | ORC3 | Origin recognition complex subunit 3 | [477] | -0.23[478] | 0.88[479] | 0.95[480] | 0.05[481] | 0.96[482] | 0.76[483] |
70 | CDC20 | Cell division cycle protein 20 homolog | [484] | 2.04[485] | 1.97[486] | 2.27[487] | 2.02[488] | 2.60[489] | -1.80[490] |
71 | CDC25B | M-phase inducer phosphatase 2 | [491] | 1.55[492] | 1.64[493] | 0.95[494] | 2.23[495] | 2.33[496] | 0.84[497] |
72 | PTTG1 | Securin | [498] | 1.18[499] | 1.75[500] | 2.29[501] | 0.93[502] | 2.16[503] | -1.57[504] |
73 | ANAPC1 | Anaphase-promoting complex subunit 1 | [505] | 2.10[506] | 2.18[507] | 2.00[508] | 1.43[509] | 1.39[510] | 1.96[511] |
74 | CCND3 | G1/S-specific cyclin-D3 | [512] | 0.64[513] | -0.52[514] | -2.21[515] | 3.18[516] | 2.28[517] | 1.16[518] |
75 | SKP2 | S-phase kinase-associated protein 2 | [519] | 1.00[520] | 1.36[521] | 2.43[522] | 0.77[523] | 0.79[524] | 1.58[525] |
76 | CCNE1 | G1/S-specific cyclin-E1 | [526] | 0.92[527] | 0.94[528] | -0.94[529] | -0.89[530] | -0.36[531] | -4.13[532] |
77 | PRKDC | DNA-dependent protein kinase catalytic subunit | [533] | 3.90[534] | 3.27[535] | 5.09[536] | 4.40[537] | 4.42[538] | 4.74[539] |
78 | ZBTB17 | Zinc finger and BTB domain-containing protein 17 | [540] | 0.34[541] | 0.87[542] | 0.02[543] | 0.19[544] | -0.06[545] | 0.64[546] |
79 | CCNA2 | Cyclin-A2 | [547] | 1.89[548] | 2.81[549] | 2.08[550] | 1.51[551] | 2.84[552] | -0.73[553] |
80 | SMAD4 | Mothers against decapentaplegic homolog 4 | [554] | 1.08[555] | 1.61[556] | 1.51[557] | 1.42[558] | 1.72[559] | 3.29[560] |
81 | TGFB2 | Transforming growth factor beta-2 | [561] | -4.60[562] | -7.23[563] | -1.49[564] | 2.97[565] | 1.50[566] | -2.27[567] |
82 | RB1 | Retinoblastoma-associated protein | [568] | 0.91[569] | 1.31[570] | 1.81[571] | 1.79[572] | 2.05[573] | 1.98[574] |
83 | STAG1 | Cohesin subunit SA-1 | [575] | 0.14[576] | 1.33[577] | 0.45[578] | 1.09[579] | 1.12[580] | 2.68[581] |
84 | ANAPC4 | Anaphase-promoting complex subunit 4 | [582] | -0.12[583] | 0.71[584] | 0.97[585] | 0.70[586] | 0.11[587] | 1.48[588] |
85 | SMAD2 | Mothers against decapentaplegic homolog 2 | [589] | 1.71[590] | 1.87[591] | 1.30[592] | 1.89[593] | 2.02[594] | 3.07[595] |
86 | CDC45 | Cell division control protein 45 homolog | [596] | 0.89[597] | 0.74[598] | 1.34[599] | 0.77[600] | 1.04[601] | -2.41[602] |
87 | E2F1 | Transcription factor E2F1 | [603] | 1.63[604] | 1.39[605] | 1.46[606] | 1.38[607] | 1.75[608] | -3.11[609] |
88 | EP300 | Histone acetyltransferase p300 | [610] | 2.41[611] | 1.91[612] | 2.73[613] | 2.08[614] | 2.07[615] | 3.26[616] |
89 | CHEK1 | Serine/threonine-protein kinase Chk1 | [617] | 1.22[618] | 1.49[619] | 0.99[620] | 1.66[621] | 1.82[622] | -1.53[623] |
90 | CDKN2B | Cyclin-dependent kinase 4 inhibitor B | [624] | 0.05[625] | -4.51[626] | -0.73[627] | 0.67[628] | 0.91[629] | -1.58[630] |
91 | TGFB1 | Transforming growth factor beta-1 | [631] | 3.16[632] | 2.02[633] | -0.79[634] | 3.35[635] | 2.51[636] | -0.73[637] |
92 | E2F3 | Transcription factor E2F3 | [638] | 1.40[639] | 1.14[640] | 0.33[641] | 2.14[642] | 1.52[643] | 0.33[644] |
93 | ANAPC10 | Anaphase-promoting complex subunit 10 | [645] | -0.55[646] | 0.24[647] | -0.44[648] | -0.71[649] | 0.00[650] | 0.62[651] |
94 | CDC25A | M-phase inducer phosphatase 1 | [652] | 1.11[653] | 1.65[654] | 1.94[655] | -0.14[656] | 1.25[657] | -2.16[658] |
95 | CDKN2C | Cyclin-dependent kinase 4 inhibitor C | [659] | -0.09[660] | 0.42[661] | 0.51[662] | 1.69[663] | 1.75[664] | -0.31[665] |
96 | CCNB2 | G2/mitotic-specific cyclin-B2 | [666] | 1.78[667] | 2.44[668] | 2.76[669] | 2.03[670] | 2.95[671] | -1.10[672] |
97 | TFDP2 | Transcription factor Dp-2 | [673] | 1.59[674] | 2.19[675] | 2.14[676] | 1.90[677] | 2.06[678] | 2.85[679] |
98 | BUB1B | Mitotic checkpoint serine/threonine-protein kinase BUB1 beta | [680] | 1.83[681] | 2.44[682] | 2.29[683] | 2.58[684] | 2.80[685] | -1.10[686] |
99 | BUB1 | Mitotic checkpoint serine/threonine-protein kinase BUB1 | [687] | 1.87[688] | 2.93[689] | 2.49[690] | 2.60[691] | 2.89[692] | -0.81[693] |
100 | CDKN2D | Cyclin-dependent kinase 4 inhibitor D | [694] | -0.82[695] | -0.53[696] | -0.84[697] | -1.32[698] | 0.08[699] | -1.21[700] |
101 | PKMYT1 | Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase | 1.00[701] | 0.68[702] | 0.75[703] | 0.15[704] | 1.28[705] | -2.05[706] | |
102 | CREBBP | CREB-binding protein | [707] | 2.59[708] | 1.71[709] | 2.25[710] | 2.27[711] | 2.21[712] | 3.74[713] |
103 | DBF4 | Protein DBF4 homolog A | [714] | 0.18[715] | 1.72[716] | 1.39[717] | 1.09[718] | 1.29[719] | 0.04[720] |
104 | ORC1 | Origin recognition complex subunit 1 | [721] | 1.23[722] | 1.17[723] | 2.61[724] | 0.79[725] | 1.29[726] | -1.60[727] |
105 | ATR | Serine/threonine-protein kinase ATR | [728] | 0.78[729] | 1.68[730] | 1.70[731] | 2.04[732] | 1.94[733] | 4.05[734] |
106 | TGFB3 | Transforming growth factor beta-3 | [735] | -1.85[736] | -2.83[737] | -3.13[738] | -0.32[739] | -1.45[740] | 0.95[741] |
107 | CDC7 | Cell division cycle 7-related protein kinase | [742] | 0.18[743] | 1.05[744] | 1.80[745] | 1.93[746] | 2.58[747] | -0.29[748] |
108 | E2F5 | Transcription factor E2F5 | [749] | 1.21[750] | 2.08[751] | 2.41[752] | -0.46[753] | -2.07[754] | -1.18[755] |
109 | TTK | Dual specificity protein kinase TTK | [756] | 0.54[757] | 2.94[758] | 2.88[759] | 2.48[760] | 2.96[761] | -0.62[762] |
110 | ATM | Serine-protein kinase ATM | [763] | 2.72[764] | 4.23[765] | 3.88[766] | 3.67[767] | 3.08[768] | 5.49[769] |
111 | CCNE2 | G1/S-specific cyclin-E2 | [770] | 0.11[771] | 0.41[772] | -0.12[773] | 2.55[774] | 2.39[775] | 0.15[776] |
112 | RBL1 | Retinoblastoma-like protein 1 | [777] | 1.47[778] | 2.24[779] | 0.80[780] | 2.32[781] | 2.59[782] | 1.18[783] |
113 | CDC25C | M-phase inducer phosphatase 3 | [784] | 1.62[785] | 2.68[786] | 2.64[787] | 1.44[788] | 2.22[789] | -0.91[790] |
114 | CCND2 | G1/S-specific cyclin-D2 | [791] | 2.83[792] | 1.32[793] | -4.96[794] | -4.94[795] | -2.09[796] | 2.36[797] |
115 | CDC14A | Dual specificity protein phosphatase CDC14A | [798] | 0.53[799] | 1.22[800] | 1.76[801] | 1.15[802] | 0.75[803] | 1.67[804] |
116 | ESPL1 | Separin | [805] | 3.61[806] | 3.87[807] | 3.77[808] | 4.00[809] | 3.96[810] | 2.68[811] |
117 | CDKN2A | Cyclin-dependent kinase inhibitor 2A | [812] | 3.77[813] | 1.44[814] | 4.78[815] | 4.72[816] | 6.44[817] | -1.65[818] |
118 | CDKN1C | Cyclin-dependent kinase inhibitor 1C | [819] | [820] | -5.67[821] | 0.97[822] | 0.68[823] | -0.02[824] | 1.96[825] |
119 | E2F2 | Transcription factor E2F2 | [826] | 3.93[827] | 4.73[828] | 4.18[829] | 3.56[830] | 3.83[831] | 1.92[832] |
120 | CCNB3 | G2/mitotic-specific cyclin-B3 | [833] | -1.98[834] | -2.82[835] | -3.14[836] | -2.39[837] | 0.40[838] | 2.34[839] |
121 | CCNA1 | Cyclin-A1 | [840] | [841] | -3.80[842] | [843] | -1.28[844] | 6.06[845] | [846] |
122 | WEE2 | Wee1-like protein kinase 2 | [847] | -1.63[848] | -0.96[849] | 1.28[850] | 0.54[851] | -1.35[852] | 1.73[853] |
123 | SMC1B | Structural maintenance of chromosomes protein 1B | [854] | [855] | [856] | [857] | [858] | [859] | [860] |
124 | PTTG2 | Securin-2 | [861] | [862] | [863] | [864] | [865] | [866] | [867] |
125 | SKP1P2 | [868] | [869] | [870] | [871] | [872] | [873] | [874] |