KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY |
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Order |
Gene |
Description |
ref_hepatocyte |
HepG2 |
HepG2.C3A |
HuH.7 |
SNU475 |
THLE |
liver |
1 |
CD81 |
CD81 antigen |
[1] |
-9.85[2] |
-11.10[3] |
-2.90[4] |
-1.76[5] |
-2.30[6] |
-2.02[7] |
2 |
NFKBIA |
NF-kappa-B inhibitor alpha |
[8] |
-0.68[9] |
-2.56[10] |
-3.08[11] |
-3.16[12] |
-1.30[13] |
-1.23[14] |
3 |
RAC1 |
Ras-related C3 botulinum toxin substrate 1 |
[15] |
-0.02[16] |
-0.44[17] |
0.13[18] |
0.37[19] |
0.34[20] |
-1.05[21] |
4 |
JUN |
Transcription factor AP-1 |
[22] |
-0.12[23] |
-1.75[24] |
-1.62[25] |
-1.34[26] |
-0.79[27] |
-1.90[28] |
5 |
FOS |
Proto-oncogene c-Fos |
[29] |
-5.64[30] |
-4.46[31] |
-5.27[32] |
-5.81[33] |
-4.76[34] |
-1.39[35] |
6 |
AKT1 |
RAC-alpha serine/threonine-protein kinase |
[36] |
0.45[37] |
0.13[38] |
-1.09[39] |
0.31[40] |
0.31[41] |
-0.33[42] |
7 |
IFITM1 |
Interferon-induced transmembrane protein 1 |
[43] |
-5.21[44] |
-3.09[45] |
-8.12[46] |
-5.02[47] |
-3.88[48] |
-1.16[49] |
8 |
MAP2K1 |
Dual specificity mitogen-activated protein kinase kinase 1 |
[50] |
-0.56[51] |
-0.97[52] |
-0.54[53] |
-0.18[54] |
0.31[55] |
-1.28[56] |
9 |
MAP2K2 |
Dual specificity mitogen-activated protein kinase kinase 2 |
[57] |
0.43[58] |
0.02[59] |
0.74[60] |
-0.48[61] |
-0.02[62] |
-1.79[63] |
10 |
IKBKG |
NF-kappa-B essential modulator |
[64] |
-0.52[65] |
-0.46[66] |
-2.85[67] |
-0.49[68] |
-1.72[69] |
-0.69[70] |
11 |
GRB2 |
Growth factor receptor-bound protein 2 |
[71] |
1.57[72] |
1.32[73] |
1.30[74] |
0.91[75] |
0.81[76] |
0.21[77] |
12 |
RELA |
Transcription factor p65 |
[78] |
0.50[79] |
-0.08[80] |
-0.09[81] |
0.30[82] |
0.19[83] |
-0.97[84] |
13 |
RAF1 |
RAF proto-oncogene serine/threonine-protein kinase |
[85] |
0.31[86] |
0.63[87] |
1.75[88] |
0.17[89] |
1.02[90] |
1.01[91] |
14 |
NRAS |
GTPase NRas |
[92] |
1.00[93] |
1.35[94] |
1.61[95] |
1.36[96] |
0.91[97] |
-0.34[98] |
15 |
PIK3AP1 |
Phosphoinositide 3-kinase adapter protein 1 |
[99] |
-2.42[100] |
-0.13[101] |
0.34[102] |
-2.57[103] |
-7.43[104] |
2.41[105] |
16 |
NFKBIB |
NF-kappa-B inhibitor beta |
[106] |
-0.79[107] |
-1.05[108] |
-0.87[109] |
-1.46[110] |
-1.13[111] |
-1.82[112] |
17 |
PPP3R1 |
Calcineurin subunit B type 1 |
[113] |
0.56[114] |
0.66[115] |
0.42[116] |
1.06[117] |
0.81[118] |
-1.24[119] |
18 |
HRAS |
GTPase HRas |
[120] |
-0.64[121] |
-1.43[122] |
-2.36[123] |
-0.59[124] |
-0.82[125] |
-2.75[126] |
19 |
MAPK1 |
Mitogen-activated protein kinase 1 |
[127] |
2.08[128] |
2.13[129] |
1.82[130] |
2.21[131] |
1.84[132] |
1.69[133] |
20 |
AKT2 |
RAC-beta serine/threonine-protein kinase |
[134] |
1.33[135] |
1.52[136] |
1.50[137] |
1.22[138] |
0.99[139] |
1.04[140] |
21 |
KRAS |
GTPase KRas |
[141] |
-0.14[142] |
-0.25[143] |
1.21[144] |
1.16[145] |
0.80[146] |
0.59[147] |
22 |
VAV2 |
Guanine nucleotide exchange factor VAV2 |
[148] |
1.67[149] |
1.84[150] |
1.18[151] |
-0.17[152] |
0.23[153] |
0.42[154] |
23 |
PIK3R1 |
Phosphatidylinositol 3-kinase regulatory subunit alpha |
[155] |
-0.10[156] |
-0.07[157] |
0.88[158] |
2.43[159] |
1.91[160] |
2.91[161] |
24 |
SOS1 |
Son of sevenless homolog 1 |
[162] |
0.27[163] |
1.72[164] |
1.08[165] |
1.20[166] |
0.42[167] |
0.45[168] |
25 |
BLNK |
B-cell linker protein |
[169] |
-9.23[170] |
-9.45[171] |
-7.26[172] |
-9.93[173] |
-8.51[174] |
-0.17[175] |
26 |
NFKB1 |
Nuclear factor NF-kappa-B p105 subunit |
[176] |
1.04[177] |
0.63[178] |
0.28[179] |
0.11[180] |
1.00[181] |
0.36[182] |
27 |
LYN |
Tyrosine-protein kinase Lyn |
[183] |
-0.49[184] |
-0.75[185] |
-0.37[186] |
1.41[187] |
0.15[188] |
-0.07[189] |
28 |
PTPN6 |
Tyrosine-protein phosphatase non-receptor type 6 |
[190] |
-0.09[191] |
0.02[192] |
0.45[193] |
-6.78[194] |
-1.78[195] |
-0.27[196] |
29 |
PIK3R2 |
Phosphatidylinositol 3-kinase regulatory subunit beta |
[197] |
2.24[198] |
2.38[199] |
2.85[200] |
1.07[201] |
1.61[202] |
-0.38[203] |
30 |
PPP3CB |
Serine/threonine-protein phosphatase
2B catalytic subunit beta isoform |
0.86[204] |
1.56[205] |
0.93[206] |
1.11[207] |
0.84[208] |
-0.24[209] |
31 |
NFATC3 |
Nuclear factor of activated T-cells, cytoplasmic 3 |
[210] |
1.84[211] |
2.53[212] |
2.28[213] |
1.22[214] |
1.58[215] |
2.31[216] |
32 |
MAPK3 |
Mitogen-activated protein kinase 3 |
[217] |
2.22[218] |
2.18[219] |
2.08[220] |
0.78[221] |
0.78[222] |
-1.13[223] |
33 |
GSK3B |
Glycogen synthase kinase-3 beta |
[224] |
1.64[225] |
1.19[226] |
1.62[227] |
2.17[228] |
1.98[229] |
1.07[230] |
34 |
NFKBIE |
NF-kappa-B inhibitor epsilon |
[231] |
0.41[232] |
1.25[233] |
-0.76[234] |
-0.42[235] |
0.02[236] |
-1.36[237] |
35 |
CHUK |
Inhibitor of nuclear factor kappa-B kinase subunit alpha |
[238] |
1.27[239] |
2.41[240] |
2.23[241] |
1.01[242] |
1.80[243] |
1.43[244] |
36 |
PPP3CC |
Serine/threonine-protein phosphatase
2B catalytic subunit gamma isoform |
-0.33[245] |
-0.28[246] |
-0.82[247] |
-0.73[248] |
0.17[249] |
-0.03[250] |
37 |
RAC2 |
Ras-related C3 botulinum toxin substrate 2 |
[251] |
-1.34[252] |
-7.42[253] |
-8.17[254] |
-1.03[255] |
2.76[256] |
-1.32[257] |
38 |
IKBKB |
Inhibitor of nuclear factor kappa-B kinase subunit beta |
[258] |
0.89[259] |
0.87[260] |
0.83[261] |
0.62[262] |
0.69[263] |
1.09[264] |
39 |
PPP3CA |
Serine/threonine-protein phosphatase
2B catalytic subunit alpha isoform |
1.10[265] |
0.77[266] |
0.43[267] |
2.30[268] |
2.03[269] |
1.72[270] |
40 |
PIK3CB |
Phosphatidylinositol
4,5-bisphosphate 3-kinase catalytic subunit beta isoform |
1.58[271] |
2.01[272] |
2.02[273] |
1.41[274] |
1.55[275] |
1.07[276] |
41 |
BCL10 |
B-cell lymphoma/leukemia 10 |
[277] |
0.46[278] |
-0.12[279] |
0.72[280] |
0.90[281] |
0.92[282] |
0.44[283] |
42 |
RAC3 |
Ras-related C3 botulinum toxin substrate 3 |
[284] |
0.00[285] |
2.98[286] |
1.67[287] |
0.47[288] |
-1.03[289] |
-3.56[290] |
43 |
SOS2 |
Son of sevenless homolog 2 |
[291] |
0.35[292] |
1.39[293] |
0.47[294] |
2.05[295] |
1.89[296] |
1.75[297] |
44 |
MALT1 |
Mucosa-associated lymphoid tissue
lymphoma translocation protein 1 |
3.23[298] |
2.99[299] |
2.26[300] |
2.40[301] |
1.66[302] |
2.17[303] |
45 |
PIK3CA |
Phosphatidylinositol
4,5-bisphosphate 3-kinase catalytic subunit alpha isoform |
-0.01[304] |
1.54[305] |
1.59[306] |
1.49[307] |
1.67[308] |
1.83[309] |
46 |
PIK3CD |
Phosphatidylinositol
4,5-bisphosphate 3-kinase catalytic subunit delta isoform |
2.26[310] |
3.26[311] |
-0.70[312] |
0.64[313] |
1.39[314] |
0.21[315] |
47 |
INPP5D |
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 |
[316] |
4.22[317] |
4.53[318] |
-5.81[319] |
-5.31[320] |
-2.37[321] |
1.19[322] |
48 |
RASGRP3 |
Ras guanyl-releasing protein 3 |
[323] |
-2.82[324] |
-6.03[325] |
2.34[326] |
1.27[327] |
-3.81[328] |
1.43[329] |
49 |
PLCG2 |
1-phosphatidylinositol
4,5-bisphosphate phosphodiesterase gamma-2 |
-0.91[330] |
-6.74[331] |
0.56[332] |
-2.38[333] |
-1.24[334] |
2.63[335] |
50 |
NFAT5 |
Nuclear factor of activated T-cells 5 |
[336] |
3.96[337] |
4.66[338] |
4.52[339] |
4.25[340] |
3.85[341] |
4.54[342] |
51 |
CD79A |
B-cell antigen receptor complex-associated protein alpha chain |
[343] |
-0.56[344] |
-2.31[345] |
-4.44[346] |
-4.16[347] |
-4.34[348] |
-0.76[349] |
52 |
FCGR2B |
Low affinity immunoglobulin gamma Fc region receptor II-b |
[350] |
-7.70[351] |
[352] |
[353] |
[354] |
-8.55[355] |
3.31[356] |
53 |
VAV3 |
Guanine nucleotide exchange factor VAV3 |
[357] |
2.18[358] |
0.38[359] |
2.41[360] |
4.04[361] |
-1.95[362] |
1.26[363] |
54 |
VAV1 |
Proto-oncogene vav |
[364] |
-8.13[365] |
-3.38[366] |
-5.24[367] |
-5.73[368] |
-7.01[369] |
1.09[370] |
55 |
LILRB3 |
Leukocyte immunoglobulin-like receptor subfamily B member 3 |
[371] |
-3.23[372] |
-2.53[373] |
-2.14[374] |
-1.99[375] |
-3.41[376] |
0.98[377] |
56 |
CD79B |
B-cell antigen receptor complex-associated protein beta chain |
[378] |
-1.14[379] |
-5.14[380] |
[381] |
-4.34[382] |
-3.42[383] |
0.60[384] |
57 |
PIK3R3 |
Phosphatidylinositol 3-kinase regulatory subunit gamma |
[385] |
2.09[386] |
2.02[387] |
2.72[388] |
3.53[389] |
2.53[390] |
2.59[391] |
58 |
NFATC1 |
Nuclear factor of activated T-cells, cytoplasmic 1 |
[392] |
-1.58[393] |
-4.18[394] |
2.28[395] |
-5.62[396] |
2.77[397] |
0.64[398] |
59 |
AKT3 |
RAC-gamma serine/threonine-protein kinase |
[399] |
-1.47[400] |
-4.12[401] |
-3.57[402] |
6.20[403] |
5.14[404] |
3.52[405] |
60 |
PIK3R5 |
Phosphoinositide 3-kinase regulatory subunit 5 |
[406] |
-6.80[407] |
[408] |
-2.39[409] |
-3.56[410] |
-3.24[411] |
2.25[412] |
61 |
CD72 |
B-cell differentiation antigen CD72 |
[413] |
-3.43[414] |
-1.06[415] |
0.20[416] |
-1.57[417] |
-2.32[418] |
0.82[419] |
62 |
NFATC2 |
Nuclear factor of activated T-cells, cytoplasmic 2 |
[420] |
2.96[421] |
4.13[422] |
3.40[423] |
0.54[424] |
1.48[425] |
3.20[426] |
63 |
CD22 |
B-cell receptor CD22 |
[427] |
3.19[428] |
1.68[429] |
-7.94[430] |
0.17[431] |
-0.58[432] |
-1.06[433] |
64 |
SYK |
Tyrosine-protein kinase SYK |
[434] |
-7.80[435] |
-2.01[436] |
-5.17[437] |
0.46[438] |
-3.07[439] |
3.27[440] |
65 |
PRKCB |
Protein kinase C beta type |
[441] |
-6.44[442] |
-5.33[443] |
[444] |
2.84[445] |
-2.48[446] |
3.45[447] |
66 |
BTK |
Tyrosine-protein kinase BTK |
[448] |
-7.01[449] |
[450] |
-0.40[451] |
-2.65[452] |
-4.89[453] |
1.74[454] |
67 |
DAPP1 |
Dual adapter for phosphotyrosine and
3-phosphotyrosine and 3-phosphoinositide |
-1.47[455] |
-0.59[456] |
-1.05[457] |
-0.94[458] |
-1.20[459] |
1.39[460] |
68 |
CHP2 |
Calcineurin B homologous protein 2 |
[461] |
-0.17[462] |
-0.70[463] |
-1.70[464] |
-1.23[465] |
-1.65[466] |
-1.98[467] |
69 |
CARD11 |
Caspase recruitment domain-containing protein 11 |
[468] |
1.50[469] |
-5.09[470] |
-6.01[471] |
1.61[472] |
6.10[473] |
2.19[474] |
70 |
PIK3CG |
Phosphatidylinositol
4,5-bisphosphate 3-kinase catalytic subunit gamma isoform |
[475] |
[476] |
[477] |
1.70[478] |
-3.20[479] |
4.01[480] |
71 |
CD19 |
B-lymphocyte antigen CD19 |
[481] |
2.48[482] |
4.09[483] |
-0.89[484] |
-1.11[485] |
[486] |
0.98[487] |
72 |
NFATC4 |
Nuclear factor of activated T-cells, cytoplasmic 4 |
[488] |
3.03[489] |
0.21[490] |
3.06[491] |
3.10[492] |
8.92[493] |
5.14[494] |
73 |
CR2 |
Complement receptor type 2 |
[495] |
-2.76[496] |
[497] |
[498] |
-1.10[499] |
-2.80[500] |
2.06[501] |
74 |
PPP3R2 |
Calcineurin subunit B type 2 |
[502] |
[503] |
[504] |
[505] |
[506] |
[507] |
[508] |
75 |
CHP1 |
Calcineurin B homologous protein 1 |
[509] |
[510] |
[511] |
[512] |
[513] |
[514] |
[515] |
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