KEGG_ASCORBATE_AND_ALDARATE_METABOLISM Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 ALDH2 Aldehyde dehydrogenase, mitochondrial [1] -0.38[2] -1.53[3] -0.19[4] -1.15[5] -0.20[6] -0.10[7]
2 UGT1A6 UDP-glucuronosyltransferase 1-6 [8] -6.31[9] -14.32[10] -7.43[11] -4.57[12] -9.48[13] -3.54[14]
3 UGT2B4 UDP-glucuronosyltransferase 2B4 [15] -6.93[16] -7.36[17] -1.12[18] -7.81[19] -10.37[20] 1.12[21]
4 UGDH UDP-glucose 6-dehydrogenase [22] 1.49[23] 1.14[24] 1.07[25] 1.89[26] -0.33[27] -0.23[28]
5 UGT2B7 UDP-glucuronosyltransferase 2B7 [29] -0.82[30] -0.94[31] -5.40[32] -9.03[33] -9.66[34] -0.17[35]
6 UGT2B10 UDP-glucuronosyltransferase 2B10 [36] -1.25[37] 1.12[38] -5.53[39] -9.15[40] -11.70[41] -1.26[42]
7 UGT2B15 UDP-glucuronosyltransferase 2B15 [43] -9.16[44] -7.87[45] -6.15[46] -8.89[47] -8.51[48] -0.63[49]
8 UGT1A1 UDP-glucuronosyltransferase 1-1 [50] -3.84[51] -10.36[52] -4.20[53] 0.95[54] -8.12[55] 0.30[56]
9 UGT1A4 UDP-glucuronosyltransferase 1-4 [57] -11.22[58] [59] -10.10[60] -8.33[61] [62] 0.49[63]
10 ALDH1B1 Aldehyde dehydrogenase X, mitochondrial [64] 1.87[65] 1.56[66] 0.68[67] 1.16[68] 1.57[69] 0.11[70]
11 ALDH9A1 4-trimethylaminobutyraldehyde dehydrogenase [71] -0.35[72] 0.17[73] 2.41[74] 1.74[75] 2.83[76] 0.39[77]
12 ALDH3A2 Fatty aldehyde dehydrogenase [78] 2.51[79] 2.16[80] 2.62[81] 2.58[82] 2.66[83] 0.76[84]
13 ALDH7A1 Alpha-aminoadipic semialdehyde dehydrogenase [85] 3.17[86] 2.85[87] 3.65[88] 3.23[89] 4.52[90] 0.63[91]
14 UGT1A9 UDP-glucuronosyltransferase 1-9 [92] -5.19[93] -10.32[94] -5.51[95] -3.38[96] -7.71[97] -0.29[98]
15 UGT2B17 UDP-glucuronosyltransferase 2B17 [99] -8.51[100] -8.15[101] -9.96[102] [103] [104] -1.01[105]
16 UGT2A3 UDP-glucuronosyltransferase 2A3 [106] 3.80[107] 5.40[108] -1.00[109] -3.75[110] -5.67[111] 1.85[112]
17 UGT1A3 UDP-glucuronosyltransferase 1-3 [113] -0.44[114] [115] -6.36[116] -3.12[117] -7.30[118] 1.59[119]
18 UGT1A5 UDP-glucuronosyltransferase 1-5 [120] -3.73[121] [122] -4.18[123] 0.02[124] [125] 1.66[126]
19 UGT2B11 UDP-glucuronosyltransferase 2B11 [127] 2.73[128] 1.12[129] 3.37[130] -2.98[131] [132] 1.17[133]
20 UGT2B28 UDP-glucuronosyltransferase 2B28 [134] 2.50[135] 2.76[136] -0.49[137] -3.57[138] [139] 1.12[140]
21 UGT1A7 UDP-glucuronosyltransferase 1-7 [141] 1.69[142] [143] 1.71[144] 7.99[145] 3.55[146] 3.60[147]
22 UGT1A8 UDP-glucuronosyltransferase 1-8 [148] [149] [150] [151] [152] [153] [154]
23 MIOX Inositol oxygenase [155] [156] [157] [158] [159] [160] [161]
24 UGT1A10 UDP-glucuronosyltransferase 1-10 [162] [163] [164] [165] [166] [167] [168]
25 UGT2A1 UDP-glucuronosyltransferase 2A1 [169] [170] [171] [172] [173] [174] [175]
[1]
ref_hepatocyte ALDH2
Mean 413
Standard deviation 5.9e+02
Values 20 27 6.4e+02 22 1.4e+03
[2]
HepG2 ALDH2
Mean 122
Standard deviation 2.9
Values 1.2e+02 1.2e+02
[3]
HepG2.C3A ALDH2
Mean 58.8
Standard deviation 8.6
Values 65 53
[4]
HuH.7 ALDH2
Mean 71
Standard deviation 19
Values 81 49 83
[5]
SNU475 ALDH2
Mean 34.9
Standard deviation 8.2
Values 41 29
[6]
THLE ALDH2
Mean 39.5
Standard deviation 1.8
Values 38 41
[7]
liver ALDH2
Mean 429
Standard deviation 2.9e+02
Values 1.8e+02 7.1e+02 6.5e+02 1.8e+02
[8]
ref_hepatocyte UGT1A6
Mean 242
Standard deviation 2.6e+02
Values 0.45 1.7e+02 4.3e+02 11 5.9e+02
[9]
HepG2 UGT1A6
Mean 1.17
Standard deviation 0.86
Values 1.8 0.56
[10]
HepG2.C3A UGT1A6
Mean 0.00486
Standard deviation 0.0069
Values 0.0097 0
[11]
HuH.7 UGT1A6
Mean 0.277
Standard deviation 0.33
Values 0.041 0.65 0.14
[12]
SNU475 UGT1A6
Mean 1.9
Standard deviation 0.11
Values 2 1.8
[13]
THLE UGT1A6
Mean 0.0372
Standard deviation 0.053
Values 0 0.074
[14]
liver UGT1A6
Mean 23.2
Standard deviation 17
Values 34 9 42 8.2
[15]
ref_hepatocyte UGT2B4
Mean 210
Standard deviation 2.5e+02
Values 0.056 68 4.6e+02 15 5e+02
[16]
HepG2 UGT2B4
Mean 0.666
Standard deviation 0.42
Values 0.96 0.37
[17]
HepG2.C3A UGT2B4
Mean 0.523
Standard deviation 0.23
Values 0.36 0.69
[18]
HuH.7 UGT2B4
Mean 19.1
Standard deviation 13
Values 11 34 12
[19]
SNU475 UGT2B4
Mean 0.176
Standard deviation 0.04
Values 0.2 0.15
[20]
THLE UGT2B4
Mean 0.0175
Standard deviation 0.017
Values 0.03 0.0053
[21]
liver UGT2B4
Mean 509
Standard deviation 93
Values 5.3e+02 4.5e+02 6.3e+02 4.3e+02
[22]
ref_hepatocyte UGDH
Mean 162
Standard deviation 1.3e+02
Values 3.1e+02 3.1e+02 49 88 58
[23]
HepG2 UGDH
Mean 175
Standard deviation 29
Values 2e+02 1.5e+02
[24]
HepG2.C3A UGDH
Mean 146
Standard deviation 14
Values 1.4e+02 1.6e+02
[25]
HuH.7 UGDH
Mean 67
Standard deviation 29
Values 53 1e+02 48
[26]
SNU475 UGDH
Mean 113
Standard deviation 49
Values 1.5e+02 78
[27]
THLE UGDH
Mean 14.2
Standard deviation 2.7
Values 12 16
[28]
liver UGDH
Mean 155
Standard deviation 1.2e+02
Values 1.9e+02 56 3.2e+02 61
[29]
ref_hepatocyte UGT2B7
Mean 122
Standard deviation 1.9e+02
Values 3.3 8.1 1.6e+02 5.3 4.3e+02
[30]
HepG2 UGT2B7
Mean 26.6
Standard deviation 9
Values 33 20
[31]
HepG2.C3A UGT2B7
Mean 26.2
Standard deviation 13
Values 17 35
[32]
HuH.7 UGT2B7
Mean 0.568
Standard deviation 0.44
Values 0.3 1.1 0.34
[33]
SNU475 UGT2B7
Mean 0.0439
Standard deviation 0.0096
Values 0.037 0.051
[34]
THLE UGT2B7
Mean 0.0166
Standard deviation 0.0067
Values 0.012 0.021
[35]
liver UGT2B7
Mean 121
Standard deviation 61
Values 77 1.7e+02 1.7e+02 61
[36]
ref_hepatocyte UGT2B10
Mean 89.2
Standard deviation 1.3e+02
Values 13 1.3 1.2e+02 2.6 3.1e+02
[37]
HepG2 UGT2B10
Mean 14.5
Standard deviation 5.1
Values 11 18
[38]
HepG2.C3A UGT2B10
Mean 79.3
Standard deviation 33
Values 56 1e+02
[39]
HuH.7 UGT2B10
Mean 0.379
Standard deviation 0.38
Values 0.098 0.82 0.22
[40]
SNU475 UGT2B10
Mean 0.0293
Standard deviation 0.0087
Values 0.023 0.035
[41]
THLE UGT2B10
Mean 0.00296
Standard deviation 0.0042
Values 0.0059 0
[42]
liver UGT2B10
Mean 41.7
Standard deviation 22
Values 68 16 33 50
[43]
ref_hepatocyte UGT2B15
Mean 72.3
Standard deviation 99
Values 0.2 13 1.2e+02 3.3 2.3e+02
[44]
HepG2 UGT2B15
Mean 0.0487
Standard deviation 0.004
Values 0.046 0.051
[45]
HepG2.C3A UGT2B15
Mean 0.127
Standard deviation 0.013
Values 0.14 0.12
[46]
HuH.7 UGT2B15
Mean 0.2
Standard deviation 0.22
Values 0.066 0.45 0.084
[47]
SNU475 UGT2B15
Mean 0.0285
Standard deviation 0.019
Values 0.042 0.015
[48]
THLE UGT2B15
Mean 0.0219
Standard deviation 0.014
Values 0.012 0.032
[49]
liver UGT2B15
Mean 52
Standard deviation 21
Values 56 66 64 21
[50]
ref_hepatocyte UGT1A1
Mean 67.2
Standard deviation 89
Values 0.52 12 2.1e+02 15 96
[51]
HepG2 UGT1A1
Mean 1.8
Standard deviation 0.2
Values 1.9 1.7
[52]
HepG2.C3A UGT1A1
Mean 0.0209
Standard deviation 0.016
Values 0.0097 0.032
[53]
HuH.7 UGT1A1
Mean 0.72
Standard deviation 0.5
Values 0.57 1.3 0.31
[54]
SNU475 UGT1A1
Mean 24.4
Standard deviation 21
Values 39 9.8
[55]
THLE UGT1A1
Mean 0.0266
Standard deviation 0.038
Values 0 0.053
[56]
liver UGT1A1
Mean 92.4
Standard deviation 46
Values 83 1.1e+02 1.4e+02 34
[57]
ref_hepatocyte UGT1A4
Mean 53.1
Standard deviation 73
Values 0 4.2 99 2.5 1.6e+02
[58]
HepG2 UGT1A4
Mean 0.00858
Standard deviation 0.012
Values 0 0.017
[59]
HepG2.C3A UGT1A4
Mean 0
Standard deviation 0
Values 0 0
[60]
HuH.7 UGT1A4
Mean 0.00954
Standard deviation 0.0096
Values 0 0.019 0.0094
[61]
SNU475 UGT1A4
Mean 0.031
Standard deviation 0.015
Values 0.042 0.02
[62]
THLE UGT1A4
Mean 0
Standard deviation 0
Values 0 0
[63]
liver UGT1A4
Mean 83.1
Standard deviation 65
Values 95 36 1.7e+02 32
[64]
ref_hepatocyte ALDH1B1
Mean 46.8
Standard deviation 30
Values 84 73 22 19 36
[65]
HepG2 ALDH1B1
Mean 65.8
Standard deviation 15
Values 56 76
[66]
HepG2.C3A ALDH1B1
Mean 56.7
Standard deviation 1.3
Values 56 58
[67]
HuH.7 ALDH1B1
Mean 14.8
Standard deviation 4.6
Values 18 9.5 17
[68]
SNU475 ALDH1B1
Mean 19.6
Standard deviation 10
Values 27 12
[69]
THLE ALDH1B1
Mean 15.3
Standard deviation 3.4
Values 13 18
[70]
liver ALDH1B1
Mean 56.5
Standard deviation 35
Values 31 1.1e+02 57 32
[71]
ref_hepatocyte ALDH9A1
Mean 45
Standard deviation 33
Values 14 49 53 14 94
[72]
HepG2 ALDH9A1
Mean 13.7
Standard deviation 4.1
Values 11 17
[73]
HepG2.C3A ALDH9A1
Mean 20.8
Standard deviation 1.7
Values 20 22
[74]
HuH.7 ALDH9A1
Mean 47.2
Standard deviation 5.8
Values 43 54 45
[75]
SNU475 ALDH9A1
Mean 28.2
Standard deviation 2.2
Values 30 27
[76]
THLE ALDH9A1
Mean 35.2
Standard deviation 4.8
Values 32 39
[77]
liver ALDH9A1
Mean 65.7
Standard deviation 27
Values 50 78 97 38
[78]
ref_hepatocyte ALDH3A2
Mean 44.1
Standard deviation 25
Values 41 52 44 7.1 76
[79]
HepG2 ALDH3A2
Mean 97
Standard deviation 12
Values 89 1.1e+02
[80]
HepG2.C3A ALDH3A2
Mean 80.8
Standard deviation 15
Values 70 91
[81]
HuH.7 ALDH3A2
Mean 53.4
Standard deviation 2.9
Values 55 55 50
[82]
SNU475 ALDH3A2
Mean 49.4
Standard deviation 7.9
Values 55 44
[83]
THLE ALDH3A2
Mean 30.6
Standard deviation 2.4
Values 29 32
[84]
liver ALDH3A2
Mean 83.6
Standard deviation 21
Values 88 85 1.1e+02 55
[85]
ref_hepatocyte ALDH7A1
Mean 17.3
Standard deviation 15
Values 24 6.2 16 1 39
[86]
HepG2 ALDH7A1
Mean 60.1
Standard deviation 16
Values 49 72
[87]
HepG2.C3A ALDH7A1
Mean 51.1
Standard deviation 14
Values 41 61
[88]
HuH.7 ALDH7A1
Mean 42.6
Standard deviation 10
Values 48 31 49
[89]
SNU475 ALDH7A1
Mean 30.3
Standard deviation 10
Values 38 23
[90]
THLE ALDH7A1
Mean 43.7
Standard deviation 3.2
Values 41 46
[91]
liver ALDH7A1
Mean 30
Standard deviation 18
Values 17 50 40 14
[92]
ref_hepatocyte UGT1A9
Mean 15.2
Standard deviation 13
Values 0 21 26 2.6 27
[93]
HepG2 UGT1A9
Mean 0.16
Standard deviation 0.057
Values 0.2 0.12
[94]
HepG2.C3A UGT1A9
Mean 0.00486
Standard deviation 0.0069
Values 0.0097 0
[95]
HuH.7 UGT1A9
Mean 0.0656
Standard deviation 0.056
Values 0.066 0.12 0.0094
[96]
SNU475 UGT1A9
Mean 0.273
Standard deviation 0.34
Values 0.51 0.03
[97]
THLE UGT1A9
Mean 0.00798
Standard deviation 0.011
Values 0 0.016
[98]
liver UGT1A9
Mean 13.9
Standard deviation 9.6
Values 22 8.7 22 3
[99]
ref_hepatocyte UGT2B17
Mean 10.8
Standard deviation 16
Values 0 1.3 15 1.3 37
[100]
HepG2 UGT2B17
Mean 0.0114
Standard deviation 0.0081
Values 0.0057 0.017
[101]
HepG2.C3A UGT2B17
Mean 0.0156
Standard deviation 0.0083
Values 0.0097 0.021
[102]
HuH.7 UGT2B17
Mean 0.00214
Standard deviation 0.0037
Values 0 0.0064 0
[103]
SNU475 UGT2B17
Mean 0
Standard deviation 0
Values 0 0
[104]
THLE UGT2B17
Mean 0
Standard deviation 0
Values 0 0
[105]
liver UGT2B17
Mean 6
Standard deviation 4.8
Values 8.6 3.7 11 0.5
[106]
ref_hepatocyte UGT2A3
Mean 7.91
Standard deviation 6.4
Values 18 5.7 9.3 0.33 6.3
[107]
HepG2 UGT2A3
Mean 42.4
Standard deviation 14
Values 33 52
[108]
HepG2.C3A UGT2A3
Mean 137
Standard deviation 28
Values 1.2e+02 1.6e+02
[109]
HuH.7 UGT2A3
Mean 0.775
Standard deviation 0.72
Values 0.33 1.6 0.39
[110]
SNU475 UGT2A3
Mean 0.11
Standard deviation 0.13
Values 0.2 0.02
[111]
THLE UGT2A3
Mean 0.0172
Standard deviation 0.0092
Values 0.024 0.011
[112]
liver UGT2A3
Mean 31.9
Standard deviation 15
Values 24 55 25 24
[113]
ref_hepatocyte UGT1A3
Mean 4.24
Standard deviation 4.8
Values 0 2.3 7.9 0.37 11
[114]
HepG2 UGT1A3
Mean 1.2
Standard deviation 0.2
Values 1.3 1.1
[115]
HepG2.C3A UGT1A3
Mean 0
Standard deviation 0
Values 0 0
[116]
HuH.7 UGT1A3
Mean 0.0101
Standard deviation 0.0024
Values 0.0082 0.013 0.0094
[117]
SNU475 UGT1A3
Mean 0.0911
Standard deviation 0.029
Values 0.11 0.071
[118]
THLE UGT1A3
Mean 0.00296
Standard deviation 0.0042
Values 0.0059 0
[119]
liver UGT1A3
Mean 14.2
Standard deviation 12
Values 21 2.5 28 5.8
[120]
ref_hepatocyte UGT1A5
Mean 0.393
Standard deviation 0.32
Values 0 0.38 0.82 0.19 0.58
[121]
HepG2 UGT1A5
Mean 0.0114
Standard deviation 0.0081
Values 0.0057 0.017
[122]
HepG2.C3A UGT1A5
Mean 0
Standard deviation 0
Values 0 0
[123]
HuH.7 UGT1A5
Mean 0.00428
Standard deviation 0.0074
Values 0 0.013 0
[124]
SNU475 UGT1A5
Mean 0.0747
Standard deviation 0.012
Values 0.083 0.066
[125]
THLE UGT1A5
Mean 0
Standard deviation 0
Values 0 0
[126]
liver UGT1A5
Mean 1.38
Standard deviation 1.4
Values 3.4 0.31 0.98 0.85
[127]
ref_hepatocyte UGT2B11
Mean 0.391
Standard deviation 0.65
Values 0 0 1.5 0 0.46
[128]
HepG2 UGT2B11
Mean 1
Standard deviation 0.2
Values 0.86 1.1
[129]
HepG2.C3A UGT2B11
Mean 0.348
Standard deviation 0.19
Values 0.21 0.48
[130]
HuH.7 UGT2B11
Mean 0.795
Standard deviation 0.79
Values 0.31 1.7 0.37
[131]
SNU475 UGT2B11
Mean 0.00928
Standard deviation 0.013
Values 0.019 0
[132]
THLE UGT2B11
Mean 0
Standard deviation 0
Values 0 0
[133]
liver UGT2B11
Mean 0.98
Standard deviation 0.68
Values 0.59 2 0.49 0.87
[134]
ref_hepatocyte UGT2B28
Mean 0.294
Standard deviation 0.52
Values 0 0 0.28 0 1.2
[135]
HepG2 UGT2B28
Mean 0.642
Standard deviation 0.23
Values 0.81 0.48
[136]
HepG2.C3A UGT2B28
Mean 0.816
Standard deviation 0.45
Values 0.5 1.1
[137]
HuH.7 UGT2B28
Mean 0.0413
Standard deviation 0.043
Values 0.025 0.09 0.0094
[138]
SNU475 UGT2B28
Mean 0.00464
Standard deviation 0.0066
Values 0.0093 0
[139]
THLE UGT2B28
Mean 0
Standard deviation 0
Values 0 0
[140]
liver UGT2B28
Mean 0.714
Standard deviation 0.87
Values 1.1 0 1.8 0.013
[141]
ref_hepatocyte UGT1A7
Mean 0.0431
Standard deviation 0.096
Values 0 0 0.22 0 0
[142]
HepG2 UGT1A7
Mean 0.0537
Standard deviation 0.021
Values 0.069 0.039
[143]
HepG2.C3A UGT1A7
Mean 0
Standard deviation 0
Values 0 0
[144]
HuH.7 UGT1A7
Mean 0.0277
Standard deviation 0.011
Values 0.016 0.039 0.028
[145]
SNU475 UGT1A7
Mean 2.06
Standard deviation 1.2
Values 1.2 2.9
[146]
THLE UGT1A7
Mean 0.0556
Standard deviation 0.012
Values 0.047 0.064
[147]
liver UGT1A7
Mean 0.582
Standard deviation 0.83
Values 1.8 0.094 0.1 0.32
[148]
ref_hepatocyte UGT1A8
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[149]
HepG2 UGT1A8
Mean 0
Standard deviation 0
Values 0 0
[150]
HepG2.C3A UGT1A8
Mean 0
Standard deviation 0
Values 0 0
[151]
HuH.7 UGT1A8
Mean 0.0407
Standard deviation 0.027
Values 0.033 0.071 0.019
[152]
SNU475 UGT1A8
Mean 0.152
Standard deviation 0.028
Values 0.17 0.13
[153]
THLE UGT1A8
Mean 0
Standard deviation 0
Values 0 0
[154]
liver UGT1A8
Mean 0.0104
Standard deviation 0.014
Values 0.029 0 0 0.013
[155]
ref_hepatocyte MIOX
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[156]
HepG2 MIOX
Mean 1.46
Standard deviation 0.12
Values 1.5 1.4
[157]
HepG2.C3A MIOX
Mean 7.26
Standard deviation 1.9
Values 8.6 5.9
[158]
HuH.7 MIOX
Mean 0.267
Standard deviation 0.11
Values 0.15 0.31 0.35
[159]
SNU475 MIOX
Mean 0.0076
Standard deviation 0.011
Values 0 0.015
[160]
THLE MIOX
Mean 0.0115
Standard deviation 0.0088
Values 0.018 0.0053
[161]
liver MIOX
Mean 0.00642
Standard deviation 0.013
Values 0 0 0.026 0
[162]
ref_hepatocyte UGT1A10
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[163]
HepG2 UGT1A10
Mean 0.00788
Standard deviation 0.0051
Values 0.011 0.0043
[164]
HepG2.C3A UGT1A10
Mean 0
Standard deviation 0
Values 0 0
[165]
HuH.7 UGT1A10
Mean 0.115
Standard deviation 0.078
Values 0.066 0.21 0.075
[166]
SNU475 UGT1A10
Mean 0.012
Standard deviation 0.0027
Values 0.014 0.01
[167]
THLE UGT1A10
Mean 0
Standard deviation 0
Values 0 0
[168]
liver UGT1A10
Mean 0.0104
Standard deviation 0.014
Values 0.029 0 0 0.013
[169]
ref_hepatocyte UGT2A1
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[170]
HepG2 UGT2A1
Mean 0.00214
Standard deviation 0.003
Values 0 0.0043
[171]
HepG2.C3A UGT2A1
Mean 0.00536
Standard deviation 0.0076
Values 0 0.011
[172]
HuH.7 UGT2A1
Mean 0
Standard deviation 0
Values 0 0 0
[173]
SNU475 UGT2A1
Mean 0.015
Standard deviation 0.015
Values 0.0046 0.025
[174]
THLE UGT2A1
Mean 0
Standard deviation 0
Values 0 0
[175]
liver UGT2A1
Mean 0.00999
Standard deviation 0.012
Values 0.014 0 0.026 0