KEGG_ARGININE_AND_PROLINE_METABOLISM Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 ALDH2 Aldehyde dehydrogenase, mitochondrial [1] -1.46[2] -2.90[3] -2.15[4] -1.88[5] -2.03[6] -0.74[7]
2 ASS1 Argininosuccinate synthase [8] -1.79[9] -2.03[10] -1.32[11] -2.34[12] -2.35[13] -1.31[14]
3 SAT1 Diamine acetyltransferase 1 [15] -0.63[16] -1.23[17] -0.93[18] -1.51[19] -0.06[20] -1.80[21]
4 GATM Glycine amidinotransferase, mitochondrial [22] -8.48[23] -3.97[24] -4.01[25] -9.70[26] -10.51[27] 0.02[28]
5 ARG1 Arginase-1 [29] -8.38[30] -9.03[31] -2.24[32] -9.90[33] -10.61[34] 0.77[35]
6 GLUD1 Glutamate dehydrogenase 1, mitochondrial [36] 0.60[37] 1.46[38] 0.64[39] -0.85[40] -0.15[41] 0.76[42]
7 CPS1 Carbamoyl-phosphate synthase [ammonia], mitochondrial [43] -2.50[44] -2.92[45] -2.73[46] -9.22[47] -2.71[48] 2.26[49]
8 GAMT Guanidinoacetate N-methyltransferase [50] -0.88[51] -0.80[52] -0.20[53] -1.73[54] -1.86[55] -0.59[56]
9 SAT2 Diamine acetyltransferase 2 [57] -1.49[58] -1.66[59] -0.88[60] -1.27[61] -1.38[62] -2.30[63]
10 ODC1 Ornithine decarboxylase [64] 1.23[65] 1.31[66] 0.54[67] 0.49[68] 1.23[69] -2.23[70]
11 ALDH4A1 Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial [71] 0.46[72] 1.62[73] -2.27[74] -1.34[75] -2.49[76] 0.66[77]
12 ASL Argininosuccinate lyase [78] -0.73[79] -1.22[80] 0.03[81] -0.36[82] -1.97[83] -0.15[84]
13 GOT1 Aspartate aminotransferase, cytoplasmic [85] 0.15[86] 1.23[87] 0.11[88] -1.28[89] -0.51[90] 0.11[91]
14 GLUL Glutamine synthetase [92] 0.50[93] 1.16[94] 1.88[95] -0.32[96] 0.74[97] 1.24[98]
15 ACY1 Aminoacylase-1 [99] -4.59[100] -4.46[101] -3.45[102] -6.07[103] -5.76[104] -5.51[105]
16 GOT2 Aspartate aminotransferase, mitochondrial [106] 1.04[107] 0.03[108] 0.64[109] 0.82[110] 1.71[111] 0.44[112]
17 SMS Spermine synthase [113] 0.61[114] -0.18[115] 0.55[116] 1.82[117] 1.67[118] -2.89[119]
18 ALDH1B1 Aldehyde dehydrogenase X, mitochondrial [120] 0.80[121] 0.18[122] -1.27[123] 0.43[124] -0.26[125] -0.52[126]
19 MAOB Amine oxidase [flavin-containing] B [127] -0.92[128] -1.89[129] -0.80[130] 0.34[131] -7.54[132] -0.28[133]
20 ALDH9A1 4-trimethylaminobutyraldehyde dehydrogenase [134] -1.42[135] -1.21[136] 0.46[137] 1.00[138] 1.00[139] -0.25[140]
21 ALDH3A2 Fatty aldehyde dehydrogenase [141] 1.44[142] 0.78[143] 0.67[144] 1.84[145] 0.83[146] 0.13[147]
22 LAP3 Cytosol aminopeptidase [148] 0.66[149] 0.42[150] 0.83[151] 1.21[152] 0.74[153] 0.36[154]
23 OTC Ornithine carbamoyltransferase, mitochondrial [155] -8.72[156] -8.37[157] -2.68[158] -10.37[159] -9.25[160] -0.98[161]
24 PRODH2 Hydroxyproline dehydrogenase [162] -2.31[163] -0.10[164] -3.04[165] -10.99[166] -9.73[167] -0.14[168]
25 SRM Spermidine synthase [169] 0.91[170] 1.02[171] -0.01[172] 1.54[173] 1.69[174] -2.56[175]
26 AMD1 S-adenosylmethionine decarboxylase proenzyme [176] 1.69[177] 1.65[178] 1.55[179] 2.12[180] 2.77[181] -0.70[182]
27 MAOA Amine oxidase [flavin-containing] A [183] -1.75[184] -1.53[185] 1.16[186] -2.09[187] 2.94[188] 1.22[189]
28 OAT Ornithine aminotransferase, mitochondrial [190] 1.19[191] 1.72[192] 0.55[193] 1.60[194] 2.50[195] -0.10[196]
29 AGMAT Agmatinase, mitochondrial [197] 2.76[198] 3.19[199] 0.60[200] -1.73[201] -2.59[202] 0.37[203]
30 ALDH7A1 Alpha-aminoadipic semialdehyde dehydrogenase [204] 2.10[205] 1.47[206] 1.69[207] 2.49[208] 2.70[209] 0.00[210]
31 GLS2 Glutaminase liver isoform, mitochondrial [211] -1.04[212] -1.02[213] -4.93[214] -4.53[215] -4.18[216] 0.19[217]
32 ALDH18A1 Delta-1-pyrroline-5-carboxylate synthase [218] 2.90[219] 3.47[220] 4.18[221] 2.24[222] 2.22[223] -0.32[224]
33 PYCR2 Pyrroline-5-carboxylate reductase 2 [225] 1.70[226] 1.14[227] 2.10[228] 3.21[229] 2.18[230] -1.14[231]
34 P4HA1 Prolyl 4-hydroxylase subunit alpha-1 [232] 3.40[233] 3.39[234] 3.02[235] 4.28[236] 3.73[237] 0.56[238]
35 NAGS N-acetylglutamate synthase, mitochondrial [239] -1.36[240] -0.52[241] -0.05[242] -4.04[243] -2.61[244] -0.05[245]
36 GLS Glutaminase kidney isoform, mitochondrial [246] 2.73[247] 3.00[248] 2.35[249] 5.53[250] 3.76[251] -0.84[252]
37 DAO D-amino-acid oxidase [253] -2.72[254] -3.19[255] -3.70[256] -10.36[257] [258] -0.27[259]
38 P4HA2 Prolyl 4-hydroxylase subunit alpha-2 [260] 2.88[261] 1.30[262] 1.05[263] 3.95[264] 4.26[265] -1.80[266]
39 PYCR1 Pyrroline-5-carboxylate reductase 1, mitochondrial [267] 4.94[268] 4.42[269] 4.08[270] 3.24[271] 1.81[272] -2.18[273]
40 CKB Creatine kinase B-type [274] 4.81[275] 3.25[276] 6.05[277] 4.21[278] 2.98[279] -0.57[280]
41 ARG2 Arginase-2, mitochondrial [281] 2.66[282] 2.46[283] 1.52[284] 1.35[285] 1.60[286] -1.49[287]
42 GLUD2 Glutamate dehydrogenase 2, mitochondrial [288] -6.58[289] -5.54[290] 1.72[291] -5.25[292] -2.95[293] -0.18[294]
43 PRODH Proline dehydrogenase 1, mitochondrial [295] -0.18[296] -2.93[297] 1.49[298] -0.68[299] -0.89[300] 1.26[301]
44 NOS2 Nitric oxide synthase, inducible [302] 1.47[303] [304] -4.91[305] -2.30[306] -3.35[307] -7.60[308]
45 NOS3 Nitric oxide synthase, endothelial [309] 6.22[310] 2.76[311] 2.65[312] 2.62[313] 3.79[314] 2.49[315]
46 CKMT2 Creatine kinase S-type, mitochondrial [316] 2.40[317] 3.18[318] -0.92[319] 0.16[320] 0.10[321] 1.75[322]
47 P4HA3 Prolyl 4-hydroxylase subunit alpha-3 [323] -1.78[324] -4.88[325] -2.05[326] 4.05[327] 5.02[328] -0.16[329]
48 NOS1 Nitric oxide synthase, brain [330] -0.11[331] 1.30[332] 0.15[333] 1.89[334] 1.62[335] 0.40[336]
49 CKMT1B [337] 1.27[338] 0.03[339] [340] 0.85[341] -0.70[342] [343]
50 CKMT1A Creatine kinase U-type, mitochondrial [344] -0.67[345] -2.40[346] 1.89[347] -0.62[348] 0.55[349] [350]
51 CKM Creatine kinase M-type [351] 6.05[352] 4.58[353] 0.34[354] 0.08[355] -1.00[356] -1.42[357]
52 AZIN2 Antizyme inhibitor 2 [358] [359] [360] [361] [362] [363] [364]
53 PYCR3 Pyrroline-5-carboxylate reductase 3 [365] [366] [367] [368] [369] [370] [371]
54 AOC1 Amiloride-sensitive amine oxidase [copper-containing] [372] [373] [374] [375] [376] [377] [378]
[1]
ref_hepatocyte ALDH2
Mean 413
Standard deviation 5.9e+02
Values 20 27 6.4e+02 22 1.4e+03
[2]
HepG2 ALDH2
Mean 122
Standard deviation 2.9
Values 1.2e+02 1.2e+02
[3]
HepG2.C3A ALDH2
Mean 58.8
Standard deviation 8.6
Values 65 53
[4]
HuH.7 ALDH2
Mean 71
Standard deviation 19
Values 81 49 83
[5]
SNU475 ALDH2
Mean 34.9
Standard deviation 8.2
Values 41 29
[6]
THLE ALDH2
Mean 39.5
Standard deviation 1.8
Values 38 41
[7]
liver ALDH2
Mean 429
Standard deviation 2.9e+02
Values 1.8e+02 7.1e+02 6.5e+02 1.8e+02
[8]
ref_hepatocyte ASS1
Mean 312
Standard deviation 3.6e+02
Values 57 90 5.1e+02 56 8.5e+02
[9]
HepG2 ASS1
Mean 73
Standard deviation 14
Values 83 63
[10]
HepG2.C3A ASS1
Mean 81.4
Standard deviation 45
Values 1.1e+02 50
[11]
HuH.7 ASS1
Mean 94.9
Standard deviation 22
Values 79 1.2e+02 86
[12]
SNU475 ASS1
Mean 19.2
Standard deviation 7
Values 24 14
[13]
THLE ASS1
Mean 23.8
Standard deviation 0.31
Values 24 24
[14]
liver ASS1
Mean 218
Standard deviation 27
Values 2.5e+02 2.3e+02 2e+02 1.9e+02
[15]
ref_hepatocyte SAT1
Mean 281
Standard deviation 1.6e+02
Values 89 3.7e+02 1.9e+02 5.1e+02 2.5e+02
[16]
HepG2 SAT1
Mean 147
Standard deviation 54
Values 1.9e+02 1.1e+02
[17]
HepG2.C3A SAT1
Mean 128
Standard deviation 33
Values 1.5e+02 1e+02
[18]
HuH.7 SAT1
Mean 112
Standard deviation 22
Values 86 1.2e+02 1.3e+02
[19]
SNU475 SAT1
Mean 30.8
Standard deviation 7.6
Values 25 36
[20]
THLE SAT1
Mean 105
Standard deviation 31
Values 1.3e+02 84
[21]
liver SAT1
Mean 139
Standard deviation 1.2e+02
Values 48 2.9e+02 1.8e+02 42
[22]
ref_hepatocyte GATM
Mean 270
Standard deviation 4.7e+02
Values 0.68 50 1.9e+02 12 1.1e+03
[23]
HepG2 GATM
Mean 0.609
Standard deviation 0.19
Values 0.48 0.74
[24]
HepG2.C3A GATM
Mean 18.3
Standard deviation 1.2
Values 17 19
[25]
HuH.7 GATM
Mean 12.8
Standard deviation 4.6
Values 14 7.8 17
[26]
SNU475 GATM
Mean 0.101
Standard deviation 0.065
Values 0.056 0.15
[27]
THLE GATM
Mean 0.0721
Standard deviation 0.018
Values 0.059 0.085
[28]
liver GATM
Mean 474
Standard deviation 2.1e+02
Values 3.2e+02 7.7e+02 4.5e+02 3.5e+02
[29]
ref_hepatocyte ARG1
Mean 190
Standard deviation 2.6e+02
Values 0.48 1.9 3.9e+02 15 5.4e+02
[30]
HepG2 ARG1
Mean 0.462
Standard deviation 0.059
Values 0.5 0.42
[31]
HepG2.C3A ARG1
Mean 0.387
Standard deviation 0.27
Values 0.19 0.58
[32]
HuH.7 ARG1
Mean 30.5
Standard deviation 25
Values 14 60 18
[33]
SNU475 ARG1
Mean 0.062
Standard deviation 0.03
Values 0.083 0.041
[34]
THLE ARG1
Mean 0.0476
Standard deviation 0.00039
Values 0.047 0.048
[35]
liver ARG1
Mean 562
Standard deviation 3.3e+02
Values 4.1e+02 7.7e+02 8.9e+02 1.8e+02
[36]
ref_hepatocyte GLUD1
Mean 132
Standard deviation 1.1e+02
Values 2.2e+02 24 1.4e+02 15 2.7e+02
[37]
HepG2 GLUD1
Mean 161
Standard deviation 65
Values 1.2e+02 2.1e+02
[38]
HepG2.C3A GLUD1
Mean 386
Standard deviation 27
Values 4.1e+02 3.7e+02
[39]
HuH.7 GLUD1
Mean 157
Standard deviation 18
Values 1.5e+02 1.8e+02 1.5e+02
[40]
SNU475 GLUD1
Mean 22.7
Standard deviation 0.64
Values 23 22
[41]
THLE GLUD1
Mean 46.4
Standard deviation 7.4
Values 41 52
[42]
liver GLUD1
Mean 386
Standard deviation 1.2e+02
Values 4.1e+02 5.5e+02 2.7e+02 3.1e+02
[43]
ref_hepatocyte CPS1
Mean 128
Standard deviation 1.9e+02
Values 7.7 8.2 2e+02 1.6 4.2e+02
[44]
HepG2 CPS1
Mean 18.3
Standard deviation 4.2
Values 15 21
[45]
HepG2.C3A CPS1
Mean 18
Standard deviation 4.7
Values 15 21
[46]
HuH.7 CPS1
Mean 14.7
Standard deviation 2.6
Values 15 17 12
[47]
SNU475 CPS1
Mean 0.0667
Standard deviation 0.042
Values 0.037 0.096
[48]
THLE CPS1
Mean 7.64
Standard deviation 0.35
Values 7.4 7.9
[49]
liver CPS1
Mean 1.06e+03
Standard deviation 4.4e+02
Values 1.7e+03 7.5e+02 7.9e+02 1e+03
[50]
ref_hepatocyte GAMT
Mean 94.4
Standard deviation 1.2e+02
Values 15 6 1.8e+02 11 2.6e+02
[51]
HepG2 GAMT
Mean 41.4
Standard deviation 4.1
Values 44 38
[52]
HepG2.C3A GAMT
Mean 57.7
Standard deviation 8.1
Values 63 52
[53]
HuH.7 GAMT
Mean 62.6
Standard deviation 22
Values 72 38 78
[54]
SNU475 GAMT
Mean 8.87
Standard deviation 1.8
Values 10 7.6
[55]
THLE GAMT
Mean 10.1
Standard deviation 0.71
Values 11 9.6
[56]
liver GAMT
Mean 108
Standard deviation 90
Values 31 2e+02 1.7e+02 32
[57]
ref_hepatocyte SAT2
Mean 81.3
Standard deviation 52
Values 64 31 1.3e+02 39 1.4e+02
[58]
HepG2 SAT2
Mean 23.3
Standard deviation 0.68
Values 24 23
[59]
HepG2.C3A SAT2
Mean 27.4
Standard deviation 5.7
Values 31 23
[60]
HuH.7 SAT2
Mean 33.7
Standard deviation 22
Values 18 58 25
[61]
SNU475 SAT2
Mean 10.6
Standard deviation 1.3
Values 11 9.6
[62]
THLE SAT2
Mean 12.2
Standard deviation 2.1
Values 11 14
[63]
liver SAT2
Mean 28.5
Standard deviation 28
Values 6 62 40 5.9
[64]
ref_hepatocyte ODC1
Mean 80.4
Standard deviation 64
Values 34 1.7e+02 54 1.3e+02 20
[65]
HepG2 ODC1
Mean 152
Standard deviation 16
Values 1.4e+02 1.6e+02
[66]
HepG2.C3A ODC1
Mean 213
Standard deviation 1.3e+02
Values 1.2e+02 3e+02
[67]
HuH.7 ODC1
Mean 89.1
Standard deviation 41
Values 1e+02 42 1.2e+02
[68]
SNU475 ODC1
Mean 35.1
Standard deviation 2.2
Values 37 34
[69]
THLE ODC1
Mean 73.4
Standard deviation 18
Values 60 87
[70]
liver ODC1
Mean 29.6
Standard deviation 18
Values 50 10 39 20
[71]
ref_hepatocyte ALDH4A1
Mean 76.6
Standard deviation 93
Values 7.7 17 1.4e+02 7.4 2.1e+02
[72]
HepG2 ALDH4A1
Mean 85.5
Standard deviation 16
Values 74 96
[73]
HepG2.C3A ALDH4A1
Mean 251
Standard deviation 61
Values 2.9e+02 2.1e+02
[74]
HuH.7 ALDH4A1
Mean 12.1
Standard deviation 3.6
Values 14 8 14
[75]
SNU475 ALDH4A1
Mean 9.43
Standard deviation 4.6
Values 13 6.2
[76]
THLE ALDH4A1
Mean 5.31
Standard deviation 0.91
Values 4.7 6
[77]
liver ALDH4A1
Mean 209
Standard deviation 57
Values 1.5e+02 2.6e+02 2.5e+02 1.7e+02
[78]
ref_hepatocyte ASL
Mean 75.2
Standard deviation 60
Values 8.2 57 1.3e+02 35 1.4e+02
[79]
HepG2 ASL
Mean 36.6
Standard deviation 1.9
Values 35 38
[80]
HepG2.C3A ASL
Mean 34.4
Standard deviation 3
Values 37 32
[81]
HuH.7 ASL
Mean 58.5
Standard deviation 21
Values 63 36 77
[82]
SNU475 ASL
Mean 18.3
Standard deviation 1.6
Values 19 17
[83]
THLE ASL
Mean 7.49
Standard deviation 0.63
Values 7 7.9
[84]
liver ASL
Mean 118
Standard deviation 52
Values 67 1.7e+02 1.5e+02 81
[85]
ref_hepatocyte GOT1
Mean 75.1
Standard deviation 57
Values 6.4 44 1.5e+02 62 1.1e+02
[86]
HepG2 GOT1
Mean 67.6
Standard deviation 26
Values 86 49
[87]
HepG2.C3A GOT1
Mean 188
Standard deviation 68
Values 2.4e+02 1.4e+02
[88]
HuH.7 GOT1
Mean 61.7
Standard deviation 15
Values 65 45 75
[89]
SNU475 GOT1
Mean 9.68
Standard deviation 0.11
Values 9.6 9.8
[90]
THLE GOT1
Mean 20.6
Standard deviation 1.6
Values 20 22
[91]
liver GOT1
Mean 140
Standard deviation 1e+02
Values 1.1e+02 1.1e+02 2.8e+02 51
[92]
ref_hepatocyte GLUL
Mean 74.1
Standard deviation 65
Values 1.8e+02 19 41 43 83
[93]
HepG2 GLUL
Mean 84.8
Standard deviation 1.4
Values 84 86
[94]
HepG2.C3A GLUL
Mean 177
Standard deviation 69
Values 2.3e+02 1.3e+02
[95]
HuH.7 GLUL
Mean 208
Standard deviation 35
Values 1.9e+02 2.5e+02 1.8e+02
[96]
SNU475 GLUL
Mean 18.5
Standard deviation 6.7
Values 23 14
[97]
THLE GLUL
Mean 48.5
Standard deviation 7.4
Values 43 54
[98]
liver GLUL
Mean 304
Standard deviation 1.6e+02
Values 1.3e+02 5.2e+02 2.6e+02 3.1e+02
[99]
ref_hepatocyte ACY1
Mean 72.1
Standard deviation 60
Values 21 45 1.2e+02 22 1.5e+02
[100]
HepG2 ACY1
Mean 2.42
Standard deviation 0.67
Values 2.9 2
[101]
HepG2.C3A ACY1
Mean 3.49
Standard deviation 0.8
Values 2.9 4.1
[102]
HuH.7 ACY1
Mean 5.02
Standard deviation 1.4
Values 6.3 3.5 5.3
[103]
SNU475 ACY1
Mean 0.334
Standard deviation 0.16
Values 0.45 0.22
[104]
THLE ACY1
Mean 0.518
Standard deviation 0.013
Values 0.51 0.53
[105]
liver ACY1
Mean 2.74
Standard deviation 2.8
Values 0.36 5.1 5.2 0.26
[106]
ref_hepatocyte GOT2
Mean 58.1
Standard deviation 35
Values 32 39 86 29 1e+02
[107]
HepG2 GOT2
Mean 96.4
Standard deviation 0.81
Values 96 97
[108]
HepG2.C3A GOT2
Mean 63.2
Standard deviation 7.6
Values 58 69
[109]
HuH.7 GOT2
Mean 69
Standard deviation 13
Values 80 55 72
[110]
SNU475 GOT2
Mean 31.9
Standard deviation 2.4
Values 34 30
[111]
THLE GOT2
Mean 74.4
Standard deviation 6.4
Values 70 79
[112]
liver GOT2
Mean 136
Standard deviation 87
Values 77 1.8e+02 2.4e+02 50
[113]
ref_hepatocyte SMS
Mean 48.6
Standard deviation 41
Values 35 1.1e+02 12 65 18
[114]
HepG2 SMS
Mean 60
Standard deviation 5.2
Values 64 56
[115]
HepG2.C3A SMS
Mean 45.7
Standard deviation 8.7
Values 40 52
[116]
HuH.7 SMS
Mean 54.1
Standard deviation 17
Values 59 35 69
[117]
SNU475 SMS
Mean 53.5
Standard deviation 0.37
Values 53 54
[118]
THLE SMS
Mean 60.3
Standard deviation 9.2
Values 54 67
[119]
liver SMS
Mean 11.4
Standard deviation 7.2
Values 6 16 19 4.4
[120]
ref_hepatocyte ALDH1B1
Mean 46.8
Standard deviation 30
Values 84 73 22 19 36
[121]
HepG2 ALDH1B1
Mean 65.8
Standard deviation 15
Values 56 76
[122]
HepG2.C3A ALDH1B1
Mean 56.7
Standard deviation 1.3
Values 56 58
[123]
HuH.7 ALDH1B1
Mean 14.8
Standard deviation 4.6
Values 18 9.5 17
[124]
SNU475 ALDH1B1
Mean 19.6
Standard deviation 10
Values 27 12
[125]
THLE ALDH1B1
Mean 15.3
Standard deviation 3.4
Values 13 18
[126]
liver ALDH1B1
Mean 56.5
Standard deviation 35
Values 31 1.1e+02 57 32
[127]
ref_hepatocyte MAOB
Mean 46.4
Standard deviation 48
Values 20 15 70 6.9 1.2e+02
[128]
HepG2 MAOB
Mean 19.9
Standard deviation 8.1
Values 14 26
[129]
HepG2.C3A MAOB
Mean 13.4
Standard deviation 5.7
Values 9.3 17
[130]
HuH.7 MAOB
Mean 20.3
Standard deviation 0.76
Values 21 21 19
[131]
SNU475 MAOB
Mean 18.4
Standard deviation 15
Values 29 7.7
[132]
THLE MAOB
Mean 0.0976
Standard deviation 0.012
Values 0.089 0.11
[133]
liver MAOB
Mean 66.2
Standard deviation 42
Values 35 1.1e+02 92 26
[134]
ref_hepatocyte ALDH9A1
Mean 45
Standard deviation 33
Values 14 49 53 14 94
[135]
HepG2 ALDH9A1
Mean 13.7
Standard deviation 4.1
Values 11 17
[136]
HepG2.C3A ALDH9A1
Mean 20.8
Standard deviation 1.7
Values 20 22
[137]
HuH.7 ALDH9A1
Mean 47.2
Standard deviation 5.8
Values 43 54 45
[138]
SNU475 ALDH9A1
Mean 28.2
Standard deviation 2.2
Values 30 27
[139]
THLE ALDH9A1
Mean 35.2
Standard deviation 4.8
Values 32 39
[140]
liver ALDH9A1
Mean 65.7
Standard deviation 27
Values 50 78 97 38
[141]
ref_hepatocyte ALDH3A2
Mean 44.1
Standard deviation 25
Values 41 52 44 7.1 76
[142]
HepG2 ALDH3A2
Mean 97
Standard deviation 12
Values 89 1.1e+02
[143]
HepG2.C3A ALDH3A2
Mean 80.8
Standard deviation 15
Values 70 91
[144]
HuH.7 ALDH3A2
Mean 53.4
Standard deviation 2.9
Values 55 55 50
[145]
SNU475 ALDH3A2
Mean 49.4
Standard deviation 7.9
Values 55 44
[146]
THLE ALDH3A2
Mean 30.6
Standard deviation 2.4
Values 29 32
[147]
liver ALDH3A2
Mean 83.6
Standard deviation 21
Values 88 85 1.1e+02 55
[148]
ref_hepatocyte LAP3
Mean 37.6
Standard deviation 20
Values 26 26 46 20 70
[149]
HepG2 LAP3
Mean 48
Standard deviation 2.9
Values 46 50
[150]
HepG2.C3A LAP3
Mean 53.6
Standard deviation 1.3
Values 53 55
[151]
HuH.7 LAP3
Mean 51.1
Standard deviation 16
Values 58 33 62
[152]
SNU475 LAP3
Mean 27.2
Standard deviation 2.7
Values 29 25
[153]
THLE LAP3
Mean 24.5
Standard deviation 6.8
Values 20 29
[154]
liver LAP3
Mean 83.6
Standard deviation 24
Values 73 99 1.1e+02 55
[155]
ref_hepatocyte OTC
Mean 32.4
Standard deviation 50
Values 1.7 0.78 41 2.1 1.2e+02
[156]
HepG2 OTC
Mean 0.0623
Standard deviation 0.015
Values 0.052 0.073
[157]
HepG2.C3A OTC
Mean 0.104
Standard deviation 0.065
Values 0.058 0.15
[158]
HuH.7 OTC
Mean 3.85
Standard deviation 0.39
Values 4.3 3.6 3.7
[159]
SNU475 OTC
Mean 0.0076
Standard deviation 0.011
Values 0 0.015
[160]
THLE OTC
Mean 0.0207
Standard deviation 0.029
Values 0.041 0
[161]
liver OTC
Mean 28.5
Standard deviation 16
Values 19 52 24 19
[162]
ref_hepatocyte PRODH2
Mean 31.6
Standard deviation 34
Values 14 5.4 65 2.2 71
[163]
HepG2 PRODH2
Mean 5.15
Standard deviation 0.96
Values 4.5 5.8
[164]
HepG2.C3A PRODH2
Mean 31.3
Standard deviation 11
Values 39 24
[165]
HuH.7 PRODH2
Mean 2.92
Standard deviation 1.6
Values 2.8 1.4 4.6
[166]
SNU475 PRODH2
Mean 0.00485
Standard deviation 0.0003
Values 0.0046 0.0051
[167]
THLE PRODH2
Mean 0.0145
Standard deviation 0.013
Values 0.024 0.0053
[168]
liver PRODH2
Mean 49.5
Standard deviation 29
Values 26 85 61 26
[169]
ref_hepatocyte SRM
Mean 28.1
Standard deviation 25
Values 6.5 15 33 70 16
[170]
HepG2 SRM
Mean 42.7
Standard deviation 0.29
Values 43 43
[171]
HepG2.C3A SRM
Mean 60.7
Standard deviation 5.5
Values 57 65
[172]
HuH.7 SRM
Mean 21.2
Standard deviation 10
Values 27 9.7 27
[173]
SNU475 SRM
Mean 25.5
Standard deviation 6.7
Values 21 30
[174]
THLE SRM
Mean 35.3
Standard deviation 5.7
Values 31 39
[175]
liver SRM
Mean 8.26
Standard deviation 6.7
Values 2.4 14 14 2.5
[176]
ref_hepatocyte AMD1
Mean 24.4
Standard deviation 20
Values 42 51 8.6 14 6.2
[177]
HepG2 AMD1
Mean 63.6
Standard deviation 14
Values 53 74
[178]
HepG2.C3A AMD1
Mean 81.5
Standard deviation 16
Values 70 93
[179]
HuH.7 AMD1
Mean 54.3
Standard deviation 9.8
Values 61 43 58
[180]
SNU475 AMD1
Mean 33.1
Standard deviation 11
Values 25 41
[181]
THLE AMD1
Mean 65.1
Standard deviation 0.15
Values 65 65
[182]
liver AMD1
Mean 26.1
Standard deviation 4.4
Values 29 20 29 27
[183]
ref_hepatocyte MAOA
Mean 22.1
Standard deviation 16
Values 3.4 23 34 8.6 41
[184]
HepG2 MAOA
Mean 5.32
Standard deviation 0.22
Values 5.5 5.2
[185]
HepG2.C3A MAOA
Mean 8.16
Standard deviation 2.3
Values 9.8 6.5
[186]
HuH.7 MAOA
Mean 37.5
Standard deviation 10
Values 36 49 28
[187]
SNU475 MAOA
Mean 1.62
Standard deviation 0.75
Values 1.1 2.1
[188]
THLE MAOA
Mean 66.1
Standard deviation 1.4
Values 67 65
[189]
liver MAOA
Mean 88.9
Standard deviation 19
Values 90 1.1e+02 88 65
[190]
ref_hepatocyte OAT
Mean 20.8
Standard deviation 20
Values 31 5.3 17 1.5 49
[191]
HepG2 OAT
Mean 38.4
Standard deviation 12
Values 30 47
[192]
HepG2.C3A OAT
Mean 72.9
Standard deviation 11
Values 65 81
[193]
HuH.7 OAT
Mean 23.1
Standard deviation 2.5
Values 21 26 23
[194]
SNU475 OAT
Mean 19.6
Standard deviation 6.9
Values 25 15
[195]
THLE OAT
Mean 45.9
Standard deviation 12
Values 37 54
[196]
liver OAT
Mean 33.7
Standard deviation 22
Values 14 65 32 24
[197]
ref_hepatocyte AGMAT
Mean 17.9
Standard deviation 11
Values 27 10 20 3.4 28
[198]
HepG2 AGMAT
Mean 98
Standard deviation 26
Values 80 1.2e+02
[199]
HepG2.C3A AGMAT
Mean 175
Standard deviation 47
Values 1.4e+02 2.1e+02
[200]
HuH.7 AGMAT
Mean 20.6
Standard deviation 10
Values 26 8.9 27
[201]
SNU475 AGMAT
Mean 1.68
Standard deviation 0.032
Values 1.7 1.7
[202]
THLE AGMAT
Mean 1.16
Standard deviation 0.1
Values 1.2 1.1
[203]
liver AGMAT
Mean 40
Standard deviation 7.3
Values 35 49 33 43
[204]
ref_hepatocyte ALDH7A1
Mean 17.3
Standard deviation 15
Values 24 6.2 16 1 39
[205]
HepG2 ALDH7A1
Mean 60.1
Standard deviation 16
Values 49 72
[206]
HepG2.C3A ALDH7A1
Mean 51.1
Standard deviation 14
Values 41 61
[207]
HuH.7 ALDH7A1
Mean 42.6
Standard deviation 10
Values 48 31 49
[208]
SNU475 ALDH7A1
Mean 30.3
Standard deviation 10
Values 38 23
[209]
THLE ALDH7A1
Mean 43.7
Standard deviation 3.2
Values 41 46
[210]
liver ALDH7A1
Mean 30
Standard deviation 18
Values 17 50 40 14
[211]
ref_hepatocyte GLS2
Mean 17.1
Standard deviation 20
Values 1.3 3.2 36 2.5 43
[212]
HepG2 GLS2
Mean 6.74
Standard deviation 0.93
Values 6.1 7.4
[213]
HepG2.C3A GLS2
Mean 9.03
Standard deviation 1.6
Values 7.9 10
[214]
HuH.7 GLS2
Mean 0.429
Standard deviation 0.081
Values 0.4 0.52 0.37
[215]
SNU475 GLS2
Mean 0.231
Standard deviation 0.061
Values 0.27 0.19
[216]
THLE GLS2
Mean 0.37
Standard deviation 0.071
Values 0.42 0.32
[217]
liver GLS2
Mean 33.9
Standard deviation 12
Values 35 31 50 20
[218]
ref_hepatocyte ALDH18A1
Mean 15.8
Standard deviation 13
Values 40 9 11 9.2 11
[219]
HepG2 ALDH18A1
Mean 95.7
Standard deviation 18
Values 83 1.1e+02
[220]
HepG2.C3A ALDH18A1
Mean 187
Standard deviation 39
Values 2.1e+02 1.6e+02
[221]
HuH.7 ALDH18A1
Mean 218
Standard deviation 2
Values 2.2e+02 2.2e+02 2.2e+02
[222]
SNU475 ALDH18A1
Mean 23.3
Standard deviation 5.2
Values 27 20
[223]
THLE ALDH18A1
Mean 28.8
Standard deviation 5.2
Values 25 33
[224]
liver ALDH18A1
Mean 21.9
Standard deviation 5.3
Values 25 15 27 20
[225]
ref_hepatocyte PYCR2
Mean 12.7
Standard deviation 8.3
Values 3.6 5.2 20 22 13
[226]
HepG2 PYCR2
Mean 33.5
Standard deviation 0.26
Values 34 33
[227]
HepG2.C3A PYCR2
Mean 30
Standard deviation 1.9
Values 29 31
[228]
HuH.7 PYCR2
Mean 41.6
Standard deviation 19
Values 45 21 59
[229]
SNU475 PYCR2
Mean 36.8
Standard deviation 3
Values 39 35
[230]
THLE PYCR2
Mean 22.6
Standard deviation 1.3
Values 24 22
[231]
liver PYCR2
Mean 10
Standard deviation 5
Values 6.2 11 17 6.2
[232]
ref_hepatocyte P4HA1
Mean 12.2
Standard deviation 9.8
Values 18 8.2 6 2.3 26
[233]
HepG2 P4HA1
Mean 104
Standard deviation 3.8
Values 1.1e+02 1e+02
[234]
HepG2.C3A P4HA1
Mean 137
Standard deviation 3.5
Values 1.3e+02 1.4e+02
[235]
HuH.7 P4HA1
Mean 75.5
Standard deviation 40
Values 52 1.2e+02 53
[236]
SNU475 P4HA1
Mean 74.1
Standard deviation 5.4
Values 78 70
[237]
THLE P4HA1
Mean 63.2
Standard deviation 5.6
Values 67 59
[238]
liver P4HA1
Mean 31.1
Standard deviation 16
Values 46 7.8 39 32
[239]
ref_hepatocyte NAGS
Mean 11.3
Standard deviation 9.6
Values 0.8 2.6 17 13 23
[240]
HepG2 NAGS
Mean 3.57
Standard deviation 2.1
Values 5 2.1
[241]
HepG2.C3A NAGS
Mean 8.44
Standard deviation 4.2
Values 11 5.5
[242]
HuH.7 NAGS
Mean 8.34
Standard deviation 1.5
Values 6.8 9.8 8.5
[243]
SNU475 NAGS
Mean 0.215
Standard deviation 0.075
Values 0.16 0.27
[244]
THLE NAGS
Mean 0.725
Standard deviation 0.054
Values 0.76 0.69
[245]
liver NAGS
Mean 19
Standard deviation 5.9
Values 15 26 21 13
[246]
ref_hepatocyte GLS
Mean 9.86
Standard deviation 9.8
Values 16 23 1 6.9 1.5
[247]
HepG2 GLS
Mean 53
Standard deviation 14
Values 43 63
[248]
HepG2.C3A GLS
Mean 84.4
Standard deviation 0.68
Values 85 84
[249]
HuH.7 GLS
Mean 38.2
Standard deviation 5.2
Values 42 32 40
[250]
SNU475 GLS
Mean 142
Standard deviation 34
Values 1.7e+02 1.2e+02
[251]
THLE GLS
Mean 52.3
Standard deviation 7.1
Values 47 57
[252]
liver GLS
Mean 9.55
Standard deviation 3
Values 12 8.7 5.7 11
[253]
ref_hepatocyte DAO
Mean 9.8
Standard deviation 13
Values 0.74 0.44 25 0.56 23
[254]
HepG2 DAO
Mean 1.2
Standard deviation 0.36
Values 1.5 0.95
[255]
HepG2.C3A DAO
Mean 1.15
Standard deviation 0.41
Values 0.86 1.4
[256]
HuH.7 DAO
Mean 0.574
Standard deviation 0.33
Values 0.43 0.95 0.34
[257]
SNU475 DAO
Mean 0.00232
Standard deviation 0.0033
Values 0.0046 0
[258]
THLE DAO
Mean 0
Standard deviation 0
Values 0 0
[259]
liver DAO
Mean 14.1
Standard deviation 12
Values 5.7 31 9.8 9.5
[260]
ref_hepatocyte P4HA2
Mean 9.33
Standard deviation 4.5
Values 12 14 6.8 10 3.1
[261]
HepG2 P4HA2
Mean 55.7
Standard deviation 14
Values 65 46
[262]
HepG2.C3A P4HA2
Mean 24.4
Standard deviation 3.6
Values 27 22
[263]
HuH.7 P4HA2
Mean 14.7
Standard deviation 3.1
Values 13 18 13
[264]
SNU475 P4HA2
Mean 45.1
Standard deviation 5
Values 42 49
[265]
THLE P4HA2
Mean 69.8
Standard deviation 6.3
Values 65 74
[266]
liver P4HA2
Mean 4.65
Standard deviation 1.2
Values 4.4 4.4 6.4 3.4
[267]
ref_hepatocyte PYCR1
Mean 8.14
Standard deviation 7
Values 18 1.6 6.7 12 2
[268]
HepG2 PYCR1
Mean 202
Standard deviation 52
Values 2.4e+02 1.7e+02
[269]
HepG2.C3A PYCR1
Mean 185
Standard deviation 66
Values 2.3e+02 1.4e+02
[270]
HuH.7 PYCR1
Mean 105
Standard deviation 35
Values 1.1e+02 68 1.4e+02
[271]
SNU475 PYCR1
Mean 24
Standard deviation 8.4
Values 30 18
[272]
THLE PYCR1
Mean 11.2
Standard deviation 2.1
Values 13 9.7
[273]
liver PYCR1
Mean 3.12
Standard deviation 1.6
Values 1 4.7 4 2.7
[274]
ref_hepatocyte CKB
Mean 4.4
Standard deviation 5.3
Values 13 1 1.8 4.9 0.89
[275]
HepG2 CKB
Mean 99.7
Standard deviation 12
Values 1.1e+02 91
[276]
HepG2.C3A CKB
Mean 44.6
Standard deviation 6.7
Values 40 49
[277]
HuH.7 CKB
Mean 222
Standard deviation 17
Values 2.1e+02 2.1e+02 2.4e+02
[278]
SNU475 CKB
Mean 25.4
Standard deviation 1.2
Values 26 25
[279]
THLE CKB
Mean 13.5
Standard deviation 1.3
Values 14 13
[280]
liver CKB
Mean 5.14
Standard deviation 6.3
Values 0.56 14 4.3 1.5
[281]
ref_hepatocyte ARG2
Mean 3.18
Standard deviation 1.9
Values 3.3 1.7 2 6.5 2.5
[282]
HepG2 ARG2
Mean 16.3
Standard deviation 5.8
Values 20 12
[283]
HepG2.C3A ARG2
Mean 18.6
Standard deviation 2.3
Values 20 17
[284]
HuH.7 ARG2
Mean 6.92
Standard deviation 0.27
Values 7.1 7 6.6
[285]
SNU475 ARG2
Mean 2.53
Standard deviation 0.049
Values 2.5 2.6
[286]
THLE ARG2
Mean 3.75
Standard deviation 0.28
Values 4 3.6
[287]
liver ARG2
Mean 1.96
Standard deviation 0.4
Values 2.5 1.8 1.6 1.9
[288]
ref_hepatocyte GLUD2
Mean 1.78
Standard deviation 0.84
Values 0.68 1.7 1.4 2.9 2.2
[289]
HepG2 GLUD2
Mean 0.015
Standard deviation 0.021
Values 0 0.03
[290]
HepG2.C3A GLUD2
Mean 0.0409
Standard deviation 0.0028
Values 0.039 0.043
[291]
HuH.7 GLUD2
Mean 4.46
Standard deviation 1.7
Values 3.2 6.4 3.7
[292]
SNU475 GLUD2
Mean 0.0146
Standard deviation 0.00091
Values 0.014 0.015
[293]
THLE GLUD2
Mean 0.0896
Standard deviation 0.0012
Values 0.089 0.09
[294]
liver GLUD2
Mean 2.71
Standard deviation 0.95
Values 3.6 2.3 1.6 3.4
[295]
ref_hepatocyte PRODH
Mean 0.812
Standard deviation 1.2
Values 0.83 0 2.9 0.13 0.2
[296]
HepG2 PRODH
Mean 0.579
Standard deviation 0.66
Values 1 0.12
[297]
HepG2.C3A PRODH
Mean 0.113
Standard deviation 0.037
Values 0.087 0.14
[298]
HuH.7 PRODH
Mean 1.74
Standard deviation 0.13
Values 1.6 1.8 1.8
[299]
SNU475 PRODH
Mean 0.158
Standard deviation 0.059
Values 0.2 0.12
[300]
THLE PRODH
Mean 0.171
Standard deviation 0.017
Values 0.18 0.16
[301]
liver PRODH
Mean 3.35
Standard deviation 1.3
Values 3.6 4.7 3.5 1.6
[302]
ref_hepatocyte NOS2
Mean 0.74
Standard deviation 1.6
Values 0 0 0 3.7 0.024
[303]
HepG2 NOS2
Mean 1.66
Standard deviation 0.53
Values 1.3 2
[304]
HepG2.C3A NOS2
Mean 0
Standard deviation 0
Values 0 0
[305]
HuH.7 NOS2
Mean 0.0187
Standard deviation 0.017
Values 0.0082 0.039 0.0094
[306]
SNU475 NOS2
Mean 0.0469
Standard deviation 0.027
Values 0.028 0.066
[307]
THLE NOS2
Mean 0.0284
Standard deviation 0.01
Values 0.035 0.021
[308]
liver NOS2
Mean 0.00662
Standard deviation 0.013
Values 0 0 0 0.026
[309]
ref_hepatocyte NOS3
Mean 0.251
Standard deviation 0.22
Values 0.58 0.37 0.12 0.014 0.18
[310]
HepG2 NOS3
Mean 15.1
Standard deviation 1.3
Values 14 16
[311]
HepG2.C3A NOS3
Mean 1.81
Standard deviation 0.061
Values 1.8 1.9
[312]
HuH.7 NOS3
Mean 1.2
Standard deviation 0.2
Values 1.4 1 1.2
[313]
SNU475 NOS3
Mean 0.48
Standard deviation 0.28
Values 0.68 0.28
[314]
THLE NOS3
Mean 1.36
Standard deviation 0.21
Values 1.5 1.2
[315]
liver NOS3
Mean 2.44
Standard deviation 1.3
Values 2.3 1.5 1.6 4.3
[316]
ref_hepatocyte CKMT2
Mean 0.174
Standard deviation 0.31
Values 0.72 0 0.095 0 0.057
[317]
HepG2 CKMT2
Mean 0.746
Standard deviation 0.05
Values 0.71 0.78
[318]
HepG2.C3A CKMT2
Mean 1.68
Standard deviation 0.29
Values 1.5 1.9
[319]
HuH.7 CKMT2
Mean 0.0703
Standard deviation 0.059
Values 0.057 0.13 0.019
[320]
SNU475 CKMT2
Mean 0.0608
Standard deviation 0.0072
Values 0.056 0.066
[321]
THLE CKMT2
Mean 0.073
Standard deviation 0.0055
Values 0.077 0.069
[322]
liver CKMT2
Mean 1.01
Standard deviation 0.86
Values 1.7 0.24 0.31 1.8
[323]
ref_hepatocyte P4HA3
Mean 0.148
Standard deviation 0.19
Values 0 0.47 0.13 0 0.15
[324]
HepG2 P4HA3
Mean 0.0351
Standard deviation 0.017
Values 0.023 0.047
[325]
HepG2.C3A P4HA3
Mean 0.00536
Standard deviation 0.0076
Values 0 0.011
[326]
HuH.7 P4HA3
Mean 0.0273
Standard deviation 0.028
Values 0 0.026 0.056
[327]
SNU475 P4HA3
Mean 0.767
Standard deviation 0.01
Values 0.77 0.76
[328]
THLE P4HA3
Mean 1.88
Standard deviation 0.77
Values 1.3 2.4
[329]
liver P4HA3
Mean 0.23
Standard deviation 0.12
Values 0.34 0.071 0.31 0.2
[330]
ref_hepatocyte NOS1
Mean 0.0628
Standard deviation 0.06
Values 0.16 0.013 0.086 0.033 0.024
[331]
HepG2 NOS1
Mean 0.0472
Standard deviation 0.042
Values 0.017 0.077
[332]
HepG2.C3A NOS1
Mean 0.165
Standard deviation 0.04
Values 0.14 0.19
[333]
HuH.7 NOS1
Mean 0.0531
Standard deviation 0.054
Values 0.0082 0.039 0.11
[334]
SNU475 NOS1
Mean 0.0724
Standard deviation 0.07
Values 0.023 0.12
[335]
THLE NOS1
Mean 0.0754
Standard deviation 0.069
Values 0.12 0.027
[336]
liver NOS1
Mean 0.144
Standard deviation 0.1
Values 0.19 0 0.23 0.16
[337]
ref_hepatocyte CKMT1B
Mean 0.048
Standard deviation 0.055
Values 0.13 0.067 0 0 0.041
[338]
HepG2 CKMT1B
Mean 0.0937
Standard deviation 0.068
Values 0.046 0.14
[339]
HepG2.C3A CKMT1B
Mean 0.0521
Standard deviation 0.032
Values 0.029 0.075
[340]
HuH.7 CKMT1B
Mean 0
Standard deviation 0
Values 0 0 0
[341]
SNU475 CKMT1B
Mean 0.027
Standard deviation 0.012
Values 0.019 0.035
[342]
THLE CKMT1B
Mean 0.0115
Standard deviation 0.0088
Values 0.018 0.0053
[343]
liver CKMT1B
Mean 0
Standard deviation 0
Values 0 0 0 0
[344]
ref_hepatocyte CKMT1A
Mean 0.048
Standard deviation 0.055
Values 0.13 0.067 0 0 0.041
[345]
HepG2 CKMT1A
Mean 0.0243
Standard deviation 0.002
Values 0.023 0.026
[346]
HepG2.C3A CKMT1A
Mean 0.00972
Standard deviation 0.014
Values 0.019 0
[347]
HuH.7 CKMT1A
Mean 0.136
Standard deviation 0.082
Values 0.16 0.045 0.21
[348]
SNU475 CKMT1A
Mean 0.00971
Standard deviation 0.00061
Values 0.0093 0.01
[349]
THLE CKMT1A
Mean 0.0275
Standard deviation 0.014
Values 0.018 0.037
[350]
liver CKMT1A
Mean 0
Standard deviation 0
Values 0 0 0 0
[351]
ref_hepatocyte CKM
Mean 0.0455
Standard deviation 0.065
Values 0.14 0 0.086 0 0
[352]
HepG2 CKM
Mean 2.45
Standard deviation 2
Values 3.9 1
[353]
HepG2.C3A CKM
Mean 1.16
Standard deviation 0.28
Values 0.96 1.4
[354]
HuH.7 CKM
Mean 0.0437
Standard deviation 0.0097
Values 0.033 0.051 0.047
[355]
SNU475 CKM
Mean 0.015
Standard deviation 0.015
Values 0.0046 0.025
[356]
THLE CKM
Mean 0.00887
Standard deviation 0.013
Values 0.018 0
[357]
liver CKM
Mean 0.0294
Standard deviation 0.034
Values 0 0 0.051 0.066
[358]
ref_hepatocyte AZIN2
Missing
[359]
HepG2 AZIN2
Missing
[360]
HepG2.C3A AZIN2
Missing
[361]
HuH.7 AZIN2
Missing
[362]
SNU475 AZIN2
Missing
[363]
THLE AZIN2
Missing
[364]
liver AZIN2
Missing
[365]
ref_hepatocyte PYCR3
Missing
[366]
HepG2 PYCR3
Missing
[367]
HepG2.C3A PYCR3
Missing
[368]
HuH.7 PYCR3
Missing
[369]
SNU475 PYCR3
Missing
[370]
THLE PYCR3
Missing
[371]
liver PYCR3
Missing
[372]
ref_hepatocyte AOC1
Missing
[373]
HepG2 AOC1
Missing
[374]
HepG2.C3A AOC1
Missing
[375]
HuH.7 AOC1
Missing
[376]
SNU475 AOC1
Missing
[377]
THLE AOC1
Missing
[378]
liver AOC1
Missing