KEGG_ARACHIDONIC_ACID_METABOLISM | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | CYP2E1 | Cytochrome P450 2E1 | [1] | -11.46[2] | -11.41[3] | -7.66[4] | -13.27[5] | -10.68[6] | -0.26[7] |
2 | PLA2G2A | Phospholipase A2, membrane associated | [8] | -1.92[9] | -5.38[10] | -12.49[11] | -12.76[12] | -11.18[13] | -1.36[14] |
3 | CYP2C8 | Cytochrome P450 2C8 | [15] | -13.46[16] | -8.53[17] | -5.82[18] | -10.35[19] | [20] | 0.66[21] |
4 | CYP2C9 | Cytochrome P450 2C9 | [22] | [23] | -13.44[24] | -6.04[25] | -13.04[26] | -11.21[27] | 1.17[28] |
5 | AKR1C3 | Aldo-keto reductase family 1 member C3 | [29] | 0.76[30] | 1.58[31] | -4.55[32] | 3.54[33] | -2.49[34] | -2.04[35] |
6 | GPX2 | Glutathione peroxidase 2 | [36] | 2.18[37] | 1.71[38] | 0.06[39] | -8.00[40] | -7.14[41] | -0.40[42] |
7 | GPX4 | Phospholipid hydroperoxide glutathione peroxidase, mitochondrial | [43] | 1.22[44] | 1.82[45] | 2.02[46] | 0.50[47] | 1.13[48] | -1.65[49] |
8 | GPX1 | Glutathione peroxidase 1 | [50] | 1.51[51] | 1.38[52] | 2.26[53] | 0.88[54] | 2.89[55] | -1.39[56] |
9 | CYP4A11 | Cytochrome P450 4A11 | [57] | -11.64[58] | -8.81[59] | -10.17[60] | -9.17[61] | -9.16[62] | 1.02[63] |
10 | CBR1 | Carbonyl reductase [NADPH] 1 | [64] | -0.81[65] | -1.01[66] | -0.21[67] | 0.66[68] | 1.30[69] | -1.33[70] |
11 | GPX3 | Glutathione peroxidase 3 | [71] | 3.34[72] | 2.12[73] | 2.58[74] | 0.13[75] | -3.52[76] | 1.23[77] |
12 | CYP2B6 | Cytochrome P450 2B6 | [78] | -6.61[79] | -2.98[80] | -1.10[81] | -7.91[82] | -7.88[83] | 2.55[84] |
13 | CYP2C18 | Cytochrome P450 2C18 | [85] | -8.43[86] | -9.71[87] | -3.36[88] | -10.18[89] | -7.22[90] | -0.31[91] |
14 | EPHX2 | Bifunctional epoxide hydrolase 2 | [92] | -0.25[93] | 1.75[94] | 3.70[95] | -2.70[96] | -1.44[97] | 1.09[98] |
15 | CYP4F2 | Phylloquinone omega-hydroxylase CYP4F2 | [99] | -3.59[100] | 0.23[101] | -10.97[102] | -10.39[103] | -7.47[104] | 0.96[105] |
16 | CYP2J2 | Cytochrome P450 2J2 | [106] | -2.37[107] | -2.17[108] | 1.45[109] | -5.02[110] | -2.52[111] | 0.42[112] |
17 | LTA4H | Leukotriene A-4 hydrolase | [113] | 3.05[114] | 3.88[115] | 4.18[116] | 2.54[117] | 4.06[118] | -1.38[119] |
18 | CYP2C19 | Cytochrome P450 2C19 | [120] | [121] | [122] | -3.18[123] | -10.73[124] | -9.51[125] | 1.72[126] |
19 | PLA2G12B | Group XIIB secretory phospholipase A2-like protein | [127] | 0.28[128] | 2.26[129] | 1.71[130] | -7.11[131] | -5.94[132] | -0.58[133] |
20 | GGT1 | Glutathione hydrolase 1 proenzyme | [134] | 2.36[135] | 2.29[136] | 2.57[137] | 0.97[138] | -2.53[139] | 0.86[140] |
21 | CYP4F3 | Docosahexaenoic acid omega-hydroxylase CYP4F3 | [141] | -0.43[142] | 0.68[143] | 2.46[144] | -1.35[145] | -6.47[146] | 2.33[147] |
22 | PTGES2 | Prostaglandin E synthase 2 | [148] | 3.48[149] | 3.79[150] | 3.55[151] | 2.68[152] | 3.57[153] | -0.37[154] |
23 | CBR3 | Carbonyl reductase [NADPH] 3 | [155] | -7.64[156] | -5.74[157] | -3.88[158] | 0.90[159] | 2.26[160] | -6.09[161] |
24 | PLA2G12A | Group XIIA secretory phospholipase A2 | [162] | 3.17[163] | 4.27[164] | 4.92[165] | 3.50[166] | 5.70[167] | 2.80[168] |
25 | CYP4A22 | Cytochrome P450 4A22 | [169] | [170] | [171] | [172] | [173] | [174] | 2.41[175] |
26 | GPX7 | Glutathione peroxidase 7 | [176] | 2.61[177] | 3.67[178] | 4.06[179] | -0.51[180] | 2.72[181] | -0.32[182] |
27 | GGT7 | Glutathione hydrolase 7 | [183] | 4.82[184] | 5.34[185] | 5.39[186] | 5.13[187] | 5.28[188] | 0.51[189] |
28 | CYP2U1 | Cytochrome P450 2U1 | [190] | 3.21[191] | -0.40[192] | 0.31[193] | 4.39[194] | 6.22[195] | 2.22[196] |
29 | TBXAS1 | Thromboxane-A synthase | [197] | 0.06[198] | 2.32[199] | -0.37[200] | 3.80[201] | 3.38[202] | 1.80[203] |
30 | PLA2G6 | 85/88 kDa calcium-independent phospholipase A2 | [204] | 3.08[205] | 5.72[206] | 6.56[207] | 3.00[208] | 4.10[209] | 1.79[210] |
31 | PLA2G4B | Cytosolic phospholipase A2 beta | [211] | -3.53[212] | -4.34[213] | -1.26[214] | -1.49[215] | -0.78[216] | [217] |
32 | PTGDS | Prostaglandin-H2 D-isomerase | [218] | 3.52[219] | 3.91[220] | -4.46[221] | 2.98[222] | 4.13[223] | 1.04[224] |
33 | ALOX5 | Arachidonate 5-lipoxygenase | [225] | 2.16[226] | -2.99[227] | -2.41[228] | -3.97[229] | -1.68[230] | 2.96[231] |
34 | PLA2G1B | Phospholipase A2 | [232] | 1.03[233] | 0.55[234] | 0.05[235] | -1.02[236] | -2.76[237] | -0.53[238] |
35 | JMJD7-PL | JMJD7-PLA2G4B readthrough (Fragment) | [239] | -3.10[240] | -1.55[241] | -1.08[242] | -3.29[243] | -3.85[244] | -4.46[245] |
36 | GGT6 | Glutathione hydrolase 6 | [246] | 3.35[247] | 4.10[248] | 2.86[249] | 2.17[250] | 2.49[251] | 0.14[252] |
37 | LTC4S | Leukotriene C4 synthase | [253] | 0.11[254] | 1.81[255] | 0.94[256] | -2.66[257] | 1.71[258] | 0.69[259] |
38 | PTGIS | Prostacyclin synthase | [260] | 1.47[261] | 2.79[262] | 7.27[263] | 4.28[264] | 11.26[265] | 4.99[266] |
39 | PTGES | Prostaglandin E synthase | [267] | 4.32[268] | 0.67[269] | 1.29[270] | 6.48[271] | 10.02[272] | -1.22[273] |
40 | ALOX15B | Arachidonate 15-lipoxygenase B | [274] | -2.45[275] | [276] | 4.71[277] | -3.95[278] | 4.94[279] | 0.11[280] |
41 | GGT5 | Glutathione hydrolase 5 proenzyme | [281] | 7.60[282] | 5.19[283] | 0.81[284] | 7.07[285] | 8.24[286] | 5.78[287] |
42 | ALOX12 | Arachidonate 12-lipoxygenase, 12S-type | [288] | 3.66[289] | 3.80[290] | 3.27[291] | 4.00[292] | 4.43[293] | 0.97[294] |
43 | PTGS1 | Prostaglandin G/H synthase 1 | [295] | 4.38[296] | -2.33[297] | -0.09[298] | 5.84[299] | 9.71[300] | 3.12[301] |
44 | HPGDS | Hematopoietic prostaglandin D synthase | [302] | [303] | [304] | [305] | -2.87[306] | 0.31[307] | 0.11[308] |
45 | PLA2G2D | Group IID secretory phospholipase A2 | [309] | -0.25[310] | [311] | [312] | [313] | [314] | -2.20[315] |
46 | PLA2G3 | Group 3 secretory phospholipase A2 | [316] | 1.70[317] | 5.48[318] | -1.79[319] | -2.08[320] | 2.01[321] | -3.34[322] |
47 | PTGS2 | Prostaglandin G/H synthase 2 | [323] | [324] | 0.61[325] | 1.37[326] | 6.02[327] | 12.88[328] | 2.98[329] |
48 | PLA2G10 | Group 10 secretory phospholipase A2 | [330] | 3.75[331] | 3.79[332] | 3.26[333] | 2.28[334] | 0.84[335] | 0.91[336] |
49 | ALOX15 | Arachidonate 15-lipoxygenase | [337] | 4.64[338] | 0.77[339] | 5.86[340] | 1.40[341] | 2.88[342] | -0.79[343] |
50 | PLA2G4A | Cytosolic phospholipase A2 | [344] | 3.30[345] | 0.95[346] | 9.56[347] | 6.66[348] | 11.46[349] | 4.50[350] |
51 | PLA2G4E | Cytosolic phospholipase A2 epsilon | [351] | 6.03[352] | 6.57[353] | 7.71[354] | 6.44[355] | 7.30[356] | 1.26[357] |
52 | GPX5 | Epididymal secretory glutathione peroxidase | [358] | [359] | [360] | [361] | [362] | [363] | [364] |
53 | PLA2G2F | Group IIF secretory phospholipase A2 | [365] | [366] | [367] | [368] | [369] | [370] | [371] |
54 | PLA2G2C | Putative inactive group IIC secretory phospholipase A2 | [372] | [373] | [374] | [375] | [376] | [377] | [378] |
55 | GPX6 | Glutathione peroxidase 6 | [379] | [380] | [381] | [382] | [383] | [384] | [385] |
56 | ALOX12B | Arachidonate 12-lipoxygenase, 12R-type | [386] | [387] | [388] | [389] | [390] | [391] | [392] |
57 | PLA2G2E | Group IIE secretory phospholipase A2 | [393] | [394] | [395] | [396] | [397] | [398] | [399] |
58 | PLA2G5 | Calcium-dependent phospholipase A2 | [400] | [401] | [402] | [403] | [404] | [405] | [406] |