KEGG_APOPTOSIS | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | NFKBIA | NF-kappa-B inhibitor alpha | [1] | -1.28[2] | -3.02[3] | -3.44[4] | -3.58[5] | -1.85[6] | -1.45[7] |
2 | PRKAR1A | cAMP-dependent protein kinase type I-alpha regulatory subunit | [8] | -0.15[9] | 0.03[10] | 0.13[11] | -0.15[12] | -0.41[13] | 0.28[14] |
3 | AIFM1 | Apoptosis-inducing factor 1, mitochondrial | [15] | -1.40[16] | -1.68[17] | -0.59[18] | -1.64[19] | -2.16[20] | -0.47[21] |
4 | AKT1 | RAC-alpha serine/threonine-protein kinase | [22] | -0.14[23] | -0.32[24] | -1.44[25] | -0.11[26] | -0.25[27] | -0.55[28] |
5 | TNFRSF1A | Tumor necrosis factor receptor superfamily member 1A | [29] | -0.69[30] | -1.10[31] | -0.85[32] | 0.30[33] | 0.33[34] | -0.23[35] |
6 | CAPN2 | Calpain-2 catalytic subunit | [36] | -1.00[37] | -2.34[38] | -5.01[39] | 1.16[40] | 0.57[41] | -1.48[42] |
7 | BCL2L1 | Bcl-2-like protein 1 | [43] | 1.92[44] | 1.36[45] | 2.27[46] | -0.68[47] | -0.44[48] | -1.13[49] |
8 | CAPN1 | Calpain-1 catalytic subunit | [50] | 0.31[51] | -0.82[52] | -0.27[53] | 0.31[54] | -0.19[55] | -0.66[56] |
9 | BAX | Apoptosis regulator BAX | [57] | 0.11[58] | -0.63[59] | -1.14[60] | -1.66[61] | -1.43[62] | -4.27[63] |
10 | IKBKG | NF-kappa-B essential modulator | [64] | -1.11[65] | -0.91[66] | -3.20[67] | -0.91[68] | -2.28[69] | -0.91[70] |
11 | IRAK1 | Interleukin-1 receptor-associated kinase 1 | [71] | 1.19[72] | 0.64[73] | -0.42[74] | 0.73[75] | 0.95[76] | -1.00[77] |
12 | TNFSF10 | Tumor necrosis factor ligand superfamily member 10 | [78] | -4.70[79] | -3.04[80] | -0.46[81] | -2.53[82] | -5.93[83] | -1.70[84] |
13 | BAD | Bcl2-associated agonist of cell death | [85] | -1.89[86] | -1.71[87] | -2.70[88] | -1.13[89] | -0.88[90] | -1.73[91] |
14 | CFLAR | CASP8 and FADD-like apoptosis regulator | [92] | -0.61[93] | 0.19[94] | -0.30[95] | -0.60[96] | -0.60[97] | 1.25[98] |
15 | IL1R1 | Interleukin-1 receptor type 1 | [99] | -0.79[100] | -1.10[101] | -1.79[102] | -0.88[103] | 1.63[104] | 0.46[105] |
16 | RELA | Transcription factor p65 | [106] | -0.09[107] | -0.54[108] | -0.45[109] | -0.12[110] | -0.36[111] | -1.19[112] |
17 | PRKACA | cAMP-dependent protein kinase catalytic subunit alpha | [113] | -0.39[114] | -0.51[115] | -0.55[116] | -0.53[117] | -0.10[118] | -1.09[119] |
18 | BIRC3 | Baculoviral IAP repeat-containing protein 3 | [120] | -3.34[121] | -2.26[122] | -4.70[123] | -3.18[124] | 0.43[125] | -2.39[126] |
19 | TNFRSF10 | Tumor necrosis factor receptor superfamily member 10B | [127] | 1.76[128] | 1.70[129] | 1.45[130] | -0.39[131] | 1.06[132] | -0.28[133] |
20 | CYCS | Cytochrome c | [134] | 1.11[135] | 1.36[136] | 1.39[137] | 1.27[138] | 1.52[139] | 1.01[140] |
21 | PPP3R1 | Calcineurin subunit B type 1 | [141] | -0.04[142] | 0.20[143] | 0.07[144] | 0.64[145] | 0.25[146] | -1.46[147] |
22 | CASP3 | Caspase-3 | [148] | -0.09[149] | 0.64[150] | -1.95[151] | -0.96[152] | -0.12[153] | -1.12[154] |
23 | ENDOG | Endonuclease G, mitochondrial | [155] | -2.90[156] | -2.59[157] | -3.34[158] | -3.90[159] | -3.90[160] | -3.37[161] |
24 | BID | BH3-interacting domain death agonist | [162] | -0.49[163] | -0.33[164] | -0.76[165] | -0.35[166] | -1.04[167] | -0.14[168] |
25 | MYD88 | Myeloid differentiation primary response protein MyD88 | [169] | -0.41[170] | -0.30[171] | -0.91[172] | -1.10[173] | -0.96[174] | 0.49[175] |
26 | DFFA | DNA fragmentation factor subunit alpha | [176] | -0.46[177] | -0.05[178] | -0.42[179] | -0.33[180] | -0.45[181] | -0.58[182] |
27 | IL1RAP | Interleukin-1 receptor accessory protein | [183] | -1.72[184] | 0.56[185] | 0.16[186] | -1.53[187] | -0.59[188] | 1.88[189] |
28 | FAS | Tumor necrosis factor receptor superfamily member 6 | [190] | -1.82[191] | -0.99[192] | -9.04[193] | -1.81[194] | -1.44[195] | -2.03[196] |
29 | AKT2 | RAC-beta serine/threonine-protein kinase | [197] | 0.73[198] | 1.07[199] | 1.15[200] | 0.80[201] | 0.43[202] | 0.82[203] |
30 | CASP7 | Caspase-7 | [204] | -0.53[205] | -0.84[206] | -0.44[207] | -0.96[208] | -0.91[209] | -0.79[210] |
31 | BIRC2 | Baculoviral IAP repeat-containing protein 2 | [211] | 0.02[212] | 1.03[213] | -0.07[214] | 0.36[215] | 0.99[216] | 0.42[217] |
32 | FADD | FAS-associated death domain protein | [218] | -0.19[219] | -0.84[220] | -0.16[221] | 1.87[222] | -0.47[223] | -2.08[224] |
33 | CASP8 | Caspase-8 | [225] | -0.20[226] | 0.42[227] | -0.45[228] | -0.14[229] | -1.04[230] | -1.73[231] |
34 | CASP6 | Caspase-6 | [232] | -1.49[233] | -1.23[234] | -0.91[235] | -1.01[236] | -1.49[237] | -1.19[238] |
35 | IRAK2 | Interleukin-1 receptor-associated kinase-like 2 | [239] | -0.30[240] | -0.14[241] | -0.41[242] | -2.49[243] | -1.10[244] | -1.33[245] |
36 | TNFRSF10 | Tumor necrosis factor receptor superfamily member 10A | [246] | -1.67[247] | -2.07[248] | -2.10[249] | -3.08[250] | -3.49[251] | -2.02[252] |
37 | PIK3R1 | Phosphatidylinositol 3-kinase regulatory subunit alpha | [253] | -0.70[254] | -0.52[255] | 0.52[256] | 2.01[257] | 1.35[258] | 2.69[259] |
38 | PRKAR2A | cAMP-dependent protein kinase type II-alpha regulatory subunit | [260] | -0.17[261] | -0.43[262] | 0.63[263] | -0.35[264] | -0.64[265] | -0.17[266] |
39 | NFKB1 | Nuclear factor NF-kappa-B p105 subunit | [267] | 0.45[268] | 0.18[269] | -0.08[270] | -0.31[271] | 0.45[272] | 0.14[273] |
40 | PRKAR1B | cAMP-dependent protein kinase type I-beta regulatory subunit | [274] | 0.75[275] | 0.26[276] | -1.58[277] | -4.16[278] | -1.52[279] | -0.48[280] |
41 | TNFRSF10 | Tumor necrosis factor receptor superfamily member 10D | [281] | 1.52[282] | 1.62[283] | 2.13[284] | 0.36[285] | -0.64[286] | -0.29[287] |
42 | TRADD | Tumor necrosis factor receptor type 1-associated DEATH domain protein | -0.48[288] | -0.59[289] | -1.80[290] | -1.05[291] | -1.35[292] | -0.90[293] | |
43 | TP53 | Cellular tumor antigen p53 | [294] | 1.41[295] | 1.03[296] | 1.75[297] | 1.23[298] | 0.74[299] | -0.35[300] |
44 | PIK3R2 | Phosphatidylinositol 3-kinase regulatory subunit beta | [301] | 1.65[302] | 1.93[303] | 2.49[304] | 0.65[305] | 1.05[306] | -0.60[307] |
45 | TRAF2 | TNF receptor-associated factor 2 | [308] | 0.00[309] | 0.12[310] | -0.19[311] | 0.06[312] | -0.09[313] | -1.11[314] |
46 | PPP3CB | Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform | 0.26[315] | 1.11[316] | 0.57[317] | 0.69[318] | 0.29[319] | -0.46[320] | |
47 | RIPK1 | Receptor-interacting serine/threonine-protein kinase 1 | [321] | 0.06[322] | 0.28[323] | -0.08[324] | 1.02[325] | 0.39[326] | 1.17[327] |
48 | CHUK | Inhibitor of nuclear factor kappa-B kinase subunit alpha | [328] | 0.68[329] | 1.95[330] | 1.87[331] | 0.59[332] | 1.25[333] | 1.21[334] |
49 | PPP3CC | Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform | -0.93[335] | -0.73[336] | -1.18[337] | -1.15[338] | -0.39[339] | -0.25[340] | |
50 | IKBKB | Inhibitor of nuclear factor kappa-B kinase subunit beta | [341] | 0.30[342] | 0.41[343] | 0.47[344] | 0.20[345] | 0.13[346] | 0.87[347] |
51 | PPP3CA | Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform | 0.50[348] | 0.32[349] | 0.08[350] | 1.88[351] | 1.47[352] | 1.50[353] | |
52 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | 0.99[354] | 1.55[355] | 1.67[356] | 0.99[357] | 0.99[358] | 0.85[359] | |
53 | IL1B | Interleukin-1 beta | [360] | -8.92[361] | -8.73[362] | -4.45[363] | -3.65[364] | 1.78[365] | -5.51[366] |
54 | PRKACB | cAMP-dependent protein kinase catalytic subunit beta | [367] | -1.06[368] | -0.23[369] | 1.01[370] | 2.17[371] | 0.88[372] | 1.40[373] |
55 | XIAP | E3 ubiquitin-protein ligase XIAP | [374] | 1.29[375] | 1.94[376] | 2.35[377] | 2.53[378] | 1.80[379] | 2.37[380] |
56 | CASP9 | Caspase-9 | [381] | -0.07[382] | 0.95[383] | 0.02[384] | 0.18[385] | -0.65[386] | -0.85[387] |
57 | MAP3K14 | Mitogen-activated protein kinase kinase kinase 14 | [388] | -0.62[389] | -0.11[390] | -1.32[391] | 2.01[392] | 0.84[393] | 0.57[394] |
58 | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | -0.60[395] | 1.09[396] | 1.23[397] | 1.07[398] | 1.12[399] | 1.60[400] | |
59 | PIK3CD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform | 1.66[401] | 2.81[402] | -1.05[403] | 0.22[404] | 0.83[405] | -0.01[406] | |
60 | CASP10 | Caspase-10 | [407] | 1.00[408] | 2.34[409] | 1.25[410] | 0.36[411] | 0.26[412] | 0.76[413] |
61 | ENDOD1 | Endonuclease domain-containing 1 protein | [414] | 1.20[415] | 0.60[416] | -1.92[417] | 2.60[418] | 1.41[419] | 1.26[420] |
62 | IRAK4 | Interleukin-1 receptor-associated kinase 4 | [421] | 0.03[422] | 1.45[423] | 1.69[424] | 1.36[425] | 0.96[426] | 1.47[427] |
63 | EXOG | Nuclease EXOG, mitochondrial | [428] | 0.31[429] | 0.22[430] | -0.49[431] | -0.06[432] | 1.02[433] | -0.36[434] |
64 | APAF1 | Apoptotic protease-activating factor 1 | [435] | 1.43[436] | 1.92[437] | 2.12[438] | 2.56[439] | 1.51[440] | 1.18[441] |
65 | ATM | Serine-protein kinase ATM | [442] | 2.80[443] | 4.47[444] | 4.15[445] | 4.09[446] | 3.42[447] | 4.68[448] |
66 | DFFB | DNA fragmentation factor subunit beta | [449] | 0.66[450] | 1.64[451] | 0.96[452] | 0.71[453] | 0.23[454] | 0.33[455] |
67 | PRKX | cAMP-dependent protein kinase catalytic subunit PRKX | [456] | -1.87[457] | -2.04[458] | 2.84[459] | 1.19[460] | 2.57[461] | 1.13[462] |
68 | TNFRSF10 | Tumor necrosis factor receptor superfamily member 10C | [463] | -2.25[464] | -1.28[465] | -2.91[466] | -3.38[467] | -4.17[468] | 0.09[469] |
69 | PIK3R3 | Phosphatidylinositol 3-kinase regulatory subunit gamma | [470] | 1.50[471] | 1.56[472] | 2.36[473] | 3.11[474] | 1.97[475] | 2.37[476] |
70 | AKT3 | RAC-gamma serine/threonine-protein kinase | [477] | -2.07[478] | -4.57[479] | -3.93[480] | 5.78[481] | 4.58[482] | 3.30[483] |
71 | PIK3R5 | Phosphoinositide 3-kinase regulatory subunit 5 | [484] | -7.39[485] | [486] | -2.75[487] | -3.98[488] | -3.80[489] | 2.03[490] |
72 | IL3RA | Interleukin-3 receptor subunit alpha | [491] | [492] | [493] | [494] | [495] | [496] | [497] |
73 | CSF2RB | Cytokine receptor common subunit beta | [498] | [499] | [500] | [501] | -6.21[502] | -4.05[503] | 2.56[504] |
74 | CHP2 | Calcineurin B homologous protein 2 | [505] | -0.77[506] | -1.15[507] | -2.05[508] | -1.65[509] | -2.21[510] | -2.21[511] |
75 | PRKAR2B | cAMP-dependent protein kinase type II-beta regulatory subunit | [512] | -2.56[513] | -0.68[514] | 3.55[515] | 5.02[516] | 3.38[517] | 3.00[518] |
76 | TNF | Tumor necrosis factor | [519] | 0.88[520] | -1.20[521] | -5.85[522] | -2.28[523] | -5.66[524] | -2.20[525] |
77 | BCL2 | Apoptosis regulator Bcl-2 | [526] | -3.08[527] | 2.38[528] | -5.07[529] | 1.71[530] | 1.27[531] | 2.92[532] |
78 | IRAK3 | Interleukin-1 receptor-associated kinase 3 | [533] | -1.67[534] | -0.63[535] | 1.19[536] | 5.98[537] | 8.07[538] | 5.58[539] |
79 | FASLG | Tumor necrosis factor ligand superfamily member 6 | [540] | -4.04[541] | -2.11[542] | -6.12[543] | [544] | [545] | 0.27[546] |
80 | PIK3CG | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | [547] | [548] | [549] | 1.28[550] | -3.76[551] | 3.79[552] | |
81 | IL1A | Interleukin-1 alpha | [553] | -0.65[554] | -0.99[555] | -2.22[556] | -0.70[557] | 5.89[558] | -1.89[559] |
82 | IL3 | Interleukin-3 | [560] | [561] | [562] | [563] | [564] | [565] | [566] |
83 | NGF | Beta-nerve growth factor | [567] | [568] | [569] | [570] | [571] | [572] | [573] |
84 | NTRK1 | High affinity nerve growth factor receptor | [574] | [575] | [576] | [577] | [578] | [579] | [580] |
85 | CHP1 | Calcineurin B homologous protein 1 | [581] | [582] | [583] | [584] | [585] | [586] | [587] |
86 | PRKACG | cAMP-dependent protein kinase catalytic subunit gamma | [588] | [589] | [590] | [591] | [592] | [593] | [594] |
87 | PPP3R2 | Calcineurin subunit B type 2 | [595] | [596] | [597] | [598] | [599] | [600] | [601] |