KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | HSD11B1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | [1] | -14.17[2] | -13.75[3] | -16.16[4] | -8.77[5] | -3.00[6] | -0.62[7] |
2 | SFN | 14-3-3 protein sigma | [8] | -2.73[9] | -2.81[10] | -2.63[11] | -7.23[12] | -8.40[13] | -10.45[14] |
3 | ATP1A1 | Sodium/potassium-transporting ATPase subunit alpha-1 | [15] | 1.99[16] | 1.37[17] | 1.36[18] | 0.85[19] | 1.02[20] | -0.31[21] |
4 | SLC9A3R2 | Na(+)/H(+) exchange regulatory cofactor NHE-RF2 | [22] | -2.61[23] | -2.67[24] | -4.32[25] | -2.65[26] | -4.56[27] | -1.55[28] |
5 | ATP1B1 | Sodium/potassium-transporting ATPase subunit beta-1 | [29] | -0.69[30] | 0.03[31] | -0.17[32] | -0.07[33] | -1.60[34] | -1.13[35] |
6 | IGF1 | Insulin-like growth factor I | [36] | -8.79[37] | -9.45[38] | -7.88[39] | -0.93[40] | -9.02[41] | 0.56[42] |
7 | ATP1B3 | Sodium/potassium-transporting ATPase subunit beta-3 | [43] | 0.59[44] | 0.14[45] | 0.09[46] | 1.41[47] | 1.85[48] | -2.37[49] |
8 | MAPK1 | Mitogen-activated protein kinase 1 | [50] | 1.34[51] | 1.76[52] | 1.37[53] | 2.46[54] | 1.85[55] | 1.42[56] |
9 | SGK1 | Serine/threonine-protein kinase Sgk1 | [57] | -1.42[58] | -2.10[59] | 1.74[60] | 0.23[61] | 1.62[62] | 0.73[63] |
10 | KRAS | GTPase KRas | [64] | -0.89[65] | -0.62[66] | 0.76[67] | 1.41[68] | 0.81[69] | 0.32[70] |
11 | PIK3R1 | Phosphatidylinositol 3-kinase regulatory subunit alpha | [71] | -0.84[72] | -0.44[73] | 0.43[74] | 2.67[75] | 1.92[76] | 2.64[77] |
12 | INSR | Insulin receptor | [78] | 0.09[79] | 1.02[80] | 2.24[81] | -2.47[82] | -0.13[83] | 3.65[84] |
13 | PIK3R2 | Phosphatidylinositol 3-kinase regulatory subunit beta | [85] | 1.50[86] | 2.01[87] | 2.40[88] | 1.31[89] | 1.62[90] | -0.65[91] |
14 | NEDD4L | E3 ubiquitin-protein ligase NEDD4-like | [92] | 2.16[93] | 2.36[94] | 1.96[95] | 0.68[96] | 1.34[97] | 0.38[98] |
15 | MAPK3 | Mitogen-activated protein kinase 3 | [99] | 1.48[100] | 1.81[101] | 1.63[102] | 1.03[103] | 0.80[104] | -1.40[105] |
16 | PDPK1 | 3-phosphoinositide-dependent protein kinase 1 | [106] | 1.96[107] | 3.44[108] | 1.93[109] | 2.04[110] | 2.19[111] | 2.15[112] |
17 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | 0.84[113] | 1.63[114] | 1.57[115] | 1.66[116] | 1.56[117] | 0.80[118] | |
18 | IRS1 | Insulin receptor substrate 1 | [119] | 1.72[120] | 1.45[121] | 2.66[122] | 2.31[123] | 1.64[124] | 1.76[125] |
19 | PRKCA | Protein kinase C alpha type | [126] | 2.47[127] | 2.79[128] | 2.93[129] | 2.76[130] | 2.86[131] | 1.56[132] |
20 | IRS2 | Insulin receptor substrate 2 | [133] | -6.02[134] | [135] | -3.10[136] | -0.06[137] | 3.52[138] | 2.03[139] |
21 | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | -0.75[140] | 1.17[141] | 1.14[142] | 1.74[143] | 1.69[144] | 1.56[145] | |
22 | PIK3CD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform | 1.52[146] | 2.89[147] | -1.14[148] | 0.89[149] | 1.40[150] | -0.06[151] | |
23 | FXYD2 | Sodium/potassium-transporting ATPase subunit gamma | [152] | -0.94[153] | -2.57[154] | [155] | [156] | [157] | -0.53[158] |
24 | NR3C2 | Mineralocorticoid receptor | [159] | -3.90[160] | -2.33[161] | -1.80[162] | -4.67[163] | -0.88[164] | 2.66[165] |
25 | SCNN1A | Amiloride-sensitive sodium channel subunit alpha | [166] | 4.97[167] | 4.82[168] | -0.06[169] | 3.82[170] | 4.58[171] | 1.69[172] |
26 | HSD11B2 | Corticosteroid 11-beta-dehydrogenase isozyme 2 | [173] | 1.83[174] | 2.16[175] | 1.10[176] | -1.67[177] | -4.27[178] | 0.29[179] |
27 | PIK3R3 | Phosphatidylinositol 3-kinase regulatory subunit gamma | [180] | 1.35[181] | 1.64[182] | 2.27[183] | 3.77[184] | 2.54[185] | 2.32[186] |
28 | PIK3R5 | Phosphoinositide 3-kinase regulatory subunit 5 | [187] | -7.54[188] | [189] | -2.84[190] | -3.32[191] | -3.23[192] | 1.98[193] |
29 | ATP1B2 | Sodium/potassium-transporting ATPase subunit beta-2 | [194] | -2.71[195] | -1.69[196] | -0.69[197] | -0.08[198] | -1.17[199] | 1.45[200] |
30 | PRKCB | Protein kinase C beta type | [201] | -7.18[202] | -5.70[203] | [204] | 3.09[205] | -2.47[206] | 3.18[207] |
31 | ATP1A3 | Sodium/potassium-transporting ATPase subunit alpha-3 | [208] | 0.47[209] | [210] | -4.51[211] | -0.15[212] | -0.57[213] | -1.57[214] |
32 | ATP1B4 | Protein ATP1B4 | [215] | -0.63[216] | 0.98[217] | 0.12[218] | 0.76[219] | 0.88[220] | -1.60[221] |
33 | ATP1A2 | Sodium/potassium-transporting ATPase subunit alpha-2 | [222] | 2.12[223] | 0.89[224] | -0.16[225] | 3.03[226] | 0.59[227] | 2.13[228] |
34 | PIK3CG | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | [229] | [230] | [231] | 1.95[232] | -3.19[233] | 3.74[234] | |
35 | PRKCG | Protein kinase C gamma type | [235] | -1.19[236] | -0.24[237] | -2.83[238] | -0.46[239] | -0.80[240] | [241] |
36 | SCNN1G | Amiloride-sensitive sodium channel subunit gamma | [242] | -5.26[243] | -3.63[244] | [245] | [246] | -3.97[247] | -2.39[248] |
37 | IRS4 | Insulin receptor substrate 4 | [249] | [250] | [251] | [252] | -0.95[253] | -2.30[254] | [255] |
38 | ATP1A4 | Sodium/potassium-transporting ATPase subunit alpha-4 | [256] | [257] | [258] | [259] | [260] | [261] | [262] |
39 | SCNN1B | Amiloride-sensitive sodium channel subunit beta | [263] | [264] | [265] | [266] | [267] | [268] | [269] |
40 | FXYD4 | FXYD domain-containing ion transport regulator 4 | [270] | [271] | [272] | [273] | [274] | [275] | [276] |
41 | KCNJ1 | ATP-sensitive inward rectifier potassium channel 1 | [277] | [278] | [279] | [280] | [281] | [282] | [283] |
42 | INS | Insulin | [284] | [285] | [286] | [287] | [288] | [289] | [290] |