KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | ACSL1 | Long-chain-fatty-acid--CoA ligase 1 | [1] | -1.98[2] | -4.33[3] | -3.74[4] | -4.31[5] | -1.20[6] | 0.95[7] |
2 | PCK1 | Phosphoenolpyruvate carboxykinase, cytosolic [GTP] | [8] | -9.00[9] | -4.63[10] | -12.35[11] | [12] | -16.16[13] | -0.26[14] |
3 | PCK2 | Phosphoenolpyruvate carboxykinase [GTP], mitochondrial | [15] | -0.52[16] | -1.82[17] | -1.18[18] | -4.75[19] | -2.77[20] | -1.59[21] |
4 | NFKBIA | NF-kappa-B inhibitor alpha | [22] | -1.00[23] | -2.68[24] | -3.10[25] | -2.88[26] | -1.05[27] | -2.45[28] |
5 | AKT1 | RAC-alpha serine/threonine-protein kinase | [29] | 0.13[30] | 0.01[31] | -1.11[32] | 0.59[33] | 0.56[34] | -1.56[35] |
6 | TNFRSF1A | Tumor necrosis factor receptor superfamily member 1A | [36] | -0.42[37] | -0.77[38] | -0.51[39] | 1.00[40] | 1.14[41] | -1.24[42] |
7 | STAT3 | Signal transducer and activator of transcription 3 | [43] | 0.60[44] | -0.79[45] | -0.09[46] | 0.88[47] | 0.10[48] | 1.09[49] |
8 | ACSL5 | Long-chain-fatty-acid--CoA ligase 5 | [50] | 0.30[51] | 0.32[52] | -3.15[53] | -2.77[54] | -5.36[55] | -0.22[56] |
9 | ADIPOR1 | Adiponectin receptor protein 1 | [57] | -0.32[58] | -0.22[59] | 0.18[60] | 0.82[61] | 0.67[62] | -1.06[63] |
10 | IKBKG | NF-kappa-B essential modulator | [64] | -0.84[65] | -0.58[66] | -2.87[67] | -0.21[68] | -1.47[69] | -1.92[70] |
11 | PTPN11 | Tyrosine-protein phosphatase non-receptor type 11 | [71] | 0.50[72] | 1.04[73] | 0.96[74] | 1.53[75] | 2.11[76] | -0.06[77] |
12 | PRKAG1 | 5'-AMP-activated protein kinase subunit gamma-1 | [78] | -1.37[79] | -0.72[80] | -0.64[81] | 0.29[82] | -0.04[83] | -2.96[84] |
13 | ACSL3 | Long-chain-fatty-acid--CoA ligase 3 | [85] | 0.15[86] | 2.40[87] | 1.55[88] | 0.85[89] | 0.29[90] | -0.59[91] |
14 | ADIPOR2 | Adiponectin receptor protein 2 | [92] | 0.51[93] | 0.96[94] | 1.20[95] | 0.24[96] | 0.67[97] | -0.76[98] |
15 | RELA | Transcription factor p65 | [99] | 0.18[100] | -0.21[101] | -0.11[102] | 0.58[103] | 0.44[104] | -2.19[105] |
16 | RXRA | Retinoic acid receptor RXR-alpha | [106] | 0.00[107] | -0.09[108] | 0.71[109] | 0.65[110] | 0.27[111] | 0.84[112] |
17 | PRKAG2 | 5'-AMP-activated protein kinase subunit gamma-2 | [113] | -4.01[114] | -8.99[115] | -2.60[116] | -1.10[117] | -1.01[118] | -1.79[119] |
18 | NFKBIB | NF-kappa-B inhibitor beta | [120] | -1.11[121] | -1.18[122] | -0.88[123] | -1.18[124] | -0.88[125] | -3.04[126] |
19 | STK11 | Serine/threonine-protein kinase STK11 | [127] | -0.04[128] | 0.02[129] | 0.23[130] | -0.07[131] | 0.23[132] | -2.18[133] |
20 | SOCS3 | Suppressor of cytokine signaling 3 | [134] | -4.09[135] | -4.39[136] | -2.71[137] | -0.16[138] | -1.28[139] | -1.18[140] |
21 | CPT1A | Carnitine O-palmitoyltransferase 1, liver isoform | [141] | 1.51[142] | 0.05[143] | 0.79[144] | 2.87[145] | 1.52[146] | 1.62[147] |
22 | AKT2 | RAC-beta serine/threonine-protein kinase | [148] | 1.01[149] | 1.40[150] | 1.49[151] | 1.50[152] | 1.24[153] | -0.18[154] |
23 | ACSL4 | Long-chain-fatty-acid--CoA ligase 4 | [155] | 2.77[156] | 4.61[157] | 4.87[158] | 2.19[159] | 2.97[160] | -0.35[161] |
24 | CAMKK2 | Calcium/calmodulin-dependent protein kinase kinase 2 | [162] | 0.62[163] | 1.07[164] | 0.21[165] | 0.80[166] | 0.65[167] | -0.36[168] |
25 | PRKAA1 | 5'-AMP-activated protein kinase catalytic subunit alpha-1 | [169] | -0.03[170] | 1.36[171] | 2.84[172] | 2.10[173] | 2.32[174] | 0.75[175] |
26 | PRKAB2 | 5'-AMP-activated protein kinase subunit beta-2 | [176] | 0.94[177] | 2.23[178] | 2.31[179] | 1.66[180] | 0.59[181] | 0.10[182] |
27 | MAPK8 | Mitogen-activated protein kinase 8 | [183] | -1.39[184] | 0.13[185] | -1.04[186] | -0.27[187] | -0.46[188] | -1.83[189] |
28 | NFKB1 | Nuclear factor NF-kappa-B p105 subunit | [190] | 0.72[191] | 0.51[192] | 0.26[193] | 0.39[194] | 1.25[195] | -0.86[196] |
29 | LEPR | Leptin receptor | [197] | -4.54[198] | -1.76[199] | 0.87[200] | -0.67[201] | -0.65[202] | 2.92[203] |
30 | TRADD | Tumor necrosis factor receptor type 1-associated DEATH domain protein | -0.21[204] | -0.26[205] | -1.47[206] | -0.35[207] | -0.55[208] | -1.90[209] | |
31 | ACACB | Acetyl-CoA carboxylase 2 | [210] | -0.82[211] | 0.27[212] | 0.35[213] | -1.13[214] | -0.89[215] | 2.87[216] |
32 | TRAF2 | TNF receptor-associated factor 2 | [217] | 0.28[218] | 0.45[219] | 0.15[220] | 0.76[221] | 0.72[222] | -2.11[223] |
33 | RXRB | Retinoic acid receptor RXR-beta | [224] | 1.06[225] | 1.50[226] | 0.39[227] | 2.22[228] | 1.05[229] | -1.20[230] |
34 | PRKAB1 | 5'-AMP-activated protein kinase subunit beta-1 | [231] | 0.76[232] | 1.41[233] | 0.52[234] | 0.57[235] | 0.63[236] | -1.31[237] |
35 | MAPK9 | Mitogen-activated protein kinase 9 | [238] | 1.28[239] | 1.62[240] | 1.64[241] | 2.35[242] | 1.76[243] | -0.80[244] |
36 | NFKBIE | NF-kappa-B inhibitor epsilon | [245] | 0.09[246] | 1.12[247] | -0.78[248] | -0.15[249] | 0.26[250] | -2.58[251] |
37 | PPARA | Peroxisome proliferator-activated receptor alpha | [252] | 0.72[253] | 1.81[254] | 2.63[255] | 0.67[256] | -0.21[257] | 2.84[258] |
38 | CHUK | Inhibitor of nuclear factor kappa-B kinase subunit alpha | [259] | 0.95[260] | 2.29[261] | 2.21[262] | 1.29[263] | 2.05[264] | 0.20[265] |
39 | TNFRSF1B | Tumor necrosis factor receptor superfamily member 1B | [266] | -2.07[267] | -6.07[268] | -6.77[269] | -2.74[270] | -1.14[271] | 0.14[272] |
40 | IKBKB | Inhibitor of nuclear factor kappa-B kinase subunit beta | [273] | 0.57[274] | 0.74[275] | 0.81[276] | 0.90[277] | 0.94[278] | -0.13[279] |
41 | MTOR | Serine/threonine-protein kinase mTOR | [280] | 2.58[281] | 3.71[282] | 3.24[283] | 3.32[284] | 3.35[285] | 2.14[286] |
42 | IRS1 | Insulin receptor substrate 1 | [287] | 2.14[288] | 1.70[289] | 3.09[290] | 2.34[291] | 1.87[292] | 0.80[293] |
43 | SLC2A1 | Solute carrier family 2, facilitated glucose transporter member 1 | [294] | 6.70[295] | 3.82[296] | 2.85[297] | 4.08[298] | 3.17[299] | -2.66[300] |
44 | IRS2 | Insulin receptor substrate 2 | [301] | -5.60[302] | [303] | -2.67[304] | -0.03[305] | 3.75[306] | 1.07[307] |
45 | PPARGC1 | Peroxisome proliferator-activated receptor gamma coactivator 1-alpha | -1.04[308] | 1.96[309] | -8.85[310] | 1.40[311] | -1.95[312] | 2.12[313] | |
46 | CD36 | Platelet glycoprotein 4 | [314] | 1.39[315] | 0.82[316] | -4.30[317] | 3.82[318] | -5.23[319] | 1.77[320] |
47 | CPT1B | Carnitine O-palmitoyltransferase 1, muscle isoform | [321] | -3.67[322] | -1.83[323] | -1.45[324] | -3.73[325] | -3.40[326] | -3.41[327] |
48 | POMC | Pro-opiomelanocortin | [328] | [329] | -8.20[330] | [331] | [332] | -6.53[333] | -3.50[334] |
49 | JAK2 | Tyrosine-protein kinase JAK2 | [335] | 0.28[336] | 0.38[337] | -0.10[338] | 1.40[339] | 1.95[340] | 1.39[341] |
50 | PRKAA2 | 5'-AMP-activated protein kinase catalytic subunit alpha-2 | [342] | 3.08[343] | 3.64[344] | 3.63[345] | 3.68[346] | 1.67[347] | 0.54[348] |
51 | SLC2A4 | Solute carrier family 2, facilitated glucose transporter member 4 | [349] | 1.88[350] | 2.23[351] | 2.81[352] | -1.50[353] | -2.27[354] | 0.12[355] |
52 | AKT3 | RAC-gamma serine/threonine-protein kinase | [356] | -1.79[357] | -4.24[358] | -3.59[359] | 6.48[360] | 5.38[361] | 2.29[362] |
53 | CAMKK1 | Calcium/calmodulin-dependent protein kinase kinase 1 | [363] | 1.30[364] | 0.71[365] | -1.04[366] | 3.48[367] | 1.88[368] | -1.23[369] |
54 | ACSL6 | Long-chain-fatty-acid--CoA ligase 6 | [370] | -0.02[371] | 2.47[372] | -0.19[373] | -0.63[374] | -1.24[375] | 1.71[376] |
55 | TNF | Tumor necrosis factor | [377] | 1.15[378] | -0.87[379] | -5.51[380] | -1.58[381] | -4.86[382] | -3.21[383] |
56 | CPT1C | Carnitine O-palmitoyltransferase 1, brain isoform | [384] | -0.22[385] | -1.16[386] | -1.08[387] | 2.18[388] | 6.65[389] | 0.29[390] |
57 | ADIPOQ | Adiponectin | [391] | -1.47[392] | -1.15[393] | -1.42[394] | -0.23[395] | -1.28[396] | -2.06[397] |
58 | PRKCQ | Protein kinase C theta type | [398] | 0.95[399] | -2.49[400] | [401] | 2.76[402] | 4.22[403] | 0.77[404] |
59 | LEP | Leptin | [405] | -1.28[406] | -0.19[407] | -0.77[408] | -0.22[409] | -1.59[410] | 0.99[411] |
60 | RXRG | Retinoic acid receptor RXR-gamma | [412] | -3.68[413] | [414] | [415] | -1.42[416] | [417] | 1.19[418] |
61 | PRKAG3 | 5'-AMP-activated protein kinase subunit gamma-3 | [419] | -1.69[420] | [421] | -1.94[422] | -0.38[423] | [424] | 1.81[425] |
62 | IRS4 | Insulin receptor substrate 4 | [426] | [427] | [428] | [429] | -0.92[430] | -2.06[431] | [432] |
63 | MAPK10 | Mitogen-activated protein kinase 10 | [433] | -1.43[434] | [435] | [436] | 9.55[437] | 5.23[438] | 5.93[439] |
64 | G6PC2 | Glucose-6-phosphatase 2 | [440] | [441] | [442] | [443] | [444] | [445] | [446] |
65 | AGRP | Agouti-related protein | [447] | [448] | [449] | [450] | [451] | [452] | [453] |
66 | G6PC1 | [454] | [455] | [456] | [457] | [458] | [459] | [460] | |
67 | NPY | Pro-neuropeptide Y | [461] | [462] | [463] | [464] | [465] | [466] | [467] |