KEGG_ACUTE_MYELOID_LEUKEMIA | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | EIF4EBP1 | Eukaryotic translation initiation factor 4E-binding protein 1 | [1] | -1.56[2] | -1.46[3] | -1.16[4] | -3.48[5] | -1.76[6] | -2.12[7] |
2 | AKT1 | RAC-alpha serine/threonine-protein kinase | [8] | -0.49[9] | -0.30[10] | -1.69[11] | -0.23[12] | -0.04[13] | -0.76[14] |
3 | CEBPA | CCAAT/enhancer-binding protein alpha | [15] | -0.23[16] | -1.02[17] | 0.90[18] | -7.20[19] | -7.37[20] | -0.56[21] |
4 | STAT3 | Signal transducer and activator of transcription 3 | [22] | -0.02[23] | -1.10[24] | -0.67[25] | 0.06[26] | -0.49[27] | 1.89[28] |
5 | MYC | Myc proto-oncogene protein | [29] | -0.14[30] | -0.06[31] | -2.39[32] | -2.97[33] | -0.43[34] | -2.52[35] |
6 | MAP2K1 | Dual specificity mitogen-activated protein kinase kinase 1 | [36] | -1.50[37] | -1.41[38] | -1.13[39] | -0.72[40] | -0.04[41] | -1.71[42] |
7 | MAP2K2 | Dual specificity mitogen-activated protein kinase kinase 2 | [43] | -0.51[44] | -0.42[45] | 0.14[46] | -1.02[47] | -0.37[48] | -2.22[49] |
8 | CCND1 | G1/S-specific cyclin-D1 | [50] | 2.48[51] | 0.40[52] | 0.92[53] | 1.70[54] | 0.39[55] | 0.53[56] |
9 | IKBKG | NF-kappa-B essential modulator | [57] | -1.46[58] | -0.89[59] | -3.45[60] | -1.03[61] | -2.07[62] | -1.12[63] |
10 | GRB2 | Growth factor receptor-bound protein 2 | [64] | 0.63[65] | 0.88[66] | 0.70[67] | 0.37[68] | 0.46[69] | -0.22[70] |
11 | JUP | Junction plakoglobin | [71] | 0.42[72] | -0.37[73] | -0.41[74] | -0.74[75] | -1.25[76] | -0.11[77] |
12 | RPS6KB2 | Ribosomal protein S6 kinase beta-2 | [78] | [79] | [80] | [81] | [82] | [83] | [84] |
13 | BAD | Bcl2-associated agonist of cell death | [85] | -2.24[86] | -1.69[87] | -2.94[88] | -1.25[89] | -0.67[90] | -1.94[91] |
14 | RELA | Transcription factor p65 | [92] | -0.43[93] | -0.52[94] | -0.69[95] | -0.24[96] | -0.16[97] | -1.40[98] |
15 | RAF1 | RAF proto-oncogene serine/threonine-protein kinase | [99] | -0.63[100] | 0.19[101] | 1.15[102] | -0.37[103] | 0.67[104] | 0.58[105] |
16 | NRAS | GTPase NRas | [106] | 0.06[107] | 0.91[108] | 1.02[109] | 0.82[110] | 0.56[111] | -0.77[112] |
17 | ARAF | Serine/threonine-protein kinase A-Raf | [113] | -1.02[114] | -0.91[115] | -0.95[116] | -0.27[117] | -0.07[118] | 0.36[119] |
18 | HRAS | GTPase HRas | [120] | -1.57[121] | -1.86[122] | -2.96[123] | -1.13[124] | -1.17[125] | -3.18[126] |
19 | MAPK1 | Mitogen-activated protein kinase 1 | [127] | 1.14[128] | 1.70[129] | 1.22[130] | 1.67[131] | 1.49[132] | 1.26[133] |
20 | AKT2 | RAC-beta serine/threonine-protein kinase | [134] | 0.39[135] | 1.09[136] | 0.91[137] | 0.68[138] | 0.64[139] | 0.61[140] |
21 | PPARD | Peroxisome proliferator-activated receptor delta | [141] | -0.93[142] | -1.06[143] | -1.63[144] | -0.10[145] | 0.48[146] | -2.15[147] |
22 | PIM1 | Serine/threonine-protein kinase pim-1 | [148] | -0.38[149] | -0.19[150] | -1.13[151] | 0.20[152] | -0.64[153] | -1.64[154] |
23 | KRAS | GTPase KRas | [155] | -1.08[156] | -0.68[157] | 0.61[158] | 0.62[159] | 0.45[160] | 0.15[161] |
24 | PIK3R1 | Phosphatidylinositol 3-kinase regulatory subunit alpha | [162] | -1.04[163] | -0.50[164] | 0.28[165] | 1.89[166] | 1.56[167] | 2.48[168] |
25 | SOS1 | Son of sevenless homolog 1 | [169] | -0.67[170] | 1.28[171] | 0.48[172] | 0.67[173] | 0.07[174] | 0.02[175] |
26 | NFKB1 | Nuclear factor NF-kappa-B p105 subunit | [176] | 0.10[177] | 0.20[178] | -0.32[179] | -0.43[180] | 0.65[181] | -0.07[182] |
27 | PIK3R2 | Phosphatidylinositol 3-kinase regulatory subunit beta | [183] | 1.31[184] | 1.95[185] | 2.25[186] | 0.53[187] | 1.26[188] | -0.81[189] |
28 | RARA | Retinoic acid receptor alpha | [190] | 0.04[191] | -0.97[192] | -0.73[193] | 0.99[194] | 0.62[195] | -0.37[196] |
29 | MAPK3 | Mitogen-activated protein kinase 3 | [197] | 1.28[198] | 1.75[199] | 1.48[200] | 0.24[201] | 0.44[202] | -1.56[203] |
30 | STAT5B | Signal transducer and activator of transcription 5B | [204] | 0.79[205] | 0.83[206] | 1.23[207] | 1.37[208] | 0.68[209] | 1.10[210] |
31 | CHUK | Inhibitor of nuclear factor kappa-B kinase subunit alpha | [211] | 0.34[212] | 1.97[213] | 1.63[214] | 0.47[215] | 1.45[216] | 1.00[217] |
32 | PML | Protein PML | [218] | -0.33[219] | -0.92[220] | 0.47[221] | 1.71[222] | 1.37[223] | -0.28[224] |
33 | IKBKB | Inhibitor of nuclear factor kappa-B kinase subunit beta | [225] | -0.05[226] | 0.43[227] | 0.23[228] | 0.08[229] | 0.34[230] | 0.66[231] |
34 | PIM2 | Serine/threonine-protein kinase pim-2 | [232] | -0.97[233] | -0.04[234] | 0.18[235] | -0.87[236] | -0.38[237] | -0.90[238] |
35 | MTOR | Serine/threonine-protein kinase mTOR | [239] | 1.97[240] | 3.40[241] | 2.66[242] | 2.50[243] | 2.75[244] | 2.93[245] |
36 | RPS6KB1 | Ribosomal protein S6 kinase beta-1 | [246] | [247] | [248] | [249] | [250] | [251] | [252] |
37 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | 0.64[253] | 1.57[254] | 1.42[255] | 0.87[256] | 1.20[257] | 0.64[258] | |
38 | SOS2 | Son of sevenless homolog 2 | [259] | -0.59[260] | 0.95[261] | -0.13[262] | 1.51[263] | 1.54[264] | 1.32[265] |
39 | STAT5A | Signal transducer and activator of transcription 5A | [266] | -2.52[267] | -0.92[268] | -2.16[269] | -1.03[270] | -0.10[271] | -0.28[272] |
40 | TCF7L2 | Transcription factor 7-like 2 | [273] | 0.30[274] | 1.48[275] | 1.38[276] | 0.51[277] | 0.67[278] | 1.20[279] |
41 | RUNX1 | Runt-related transcription factor 1 | [280] | 0.64[281] | -0.16[282] | -0.36[283] | 2.00[284] | 1.88[285] | -1.16[286] |
42 | ZBTB16 | Zinc finger and BTB domain-containing protein 16 | [287] | -10.03[288] | -10.01[289] | -1.19[290] | [291] | 0.55[292] | 3.37[293] |
43 | SPI1 | Transcription factor PU.1 | [294] | -9.72[295] | [296] | -10.72[297] | -9.83[298] | -10.47[299] | -1.09[300] |
44 | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | -0.95[301] | 1.11[302] | 0.99[303] | 0.95[304] | 1.32[305] | 1.39[306] | |
45 | PIK3CD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform | 1.32[307] | 2.82[308] | -1.29[309] | 0.10[310] | 1.04[311] | -0.22[312] | |
46 | TCF7L1 | Transcription factor 7-like 1 | [313] | -3.62[314] | -1.40[315] | 0.49[316] | -2.00[317] | -1.71[318] | -0.23[319] |
47 | TCF7 | Transcription factor 7 | [320] | 1.87[321] | 0.94[322] | -0.31[323] | -0.02[324] | -0.15[325] | -0.89[326] |
48 | BRAF | Serine/threonine-protein kinase B-raf | [327] | -0.32[328] | -0.17[329] | 1.55[330] | 0.56[331] | 0.43[332] | 1.33[333] |
49 | PIK3R3 | Phosphatidylinositol 3-kinase regulatory subunit gamma | [334] | 1.15[335] | 1.58[336] | 2.12[337] | 2.99[338] | 2.18[339] | 2.16[340] |
50 | AKT3 | RAC-gamma serine/threonine-protein kinase | [341] | -2.41[342] | -4.55[343] | -4.17[344] | 5.66[345] | 4.79[346] | 3.09[347] |
51 | PIK3R5 | Phosphoinositide 3-kinase regulatory subunit 5 | [348] | -7.73[349] | [350] | -2.99[351] | -4.10[352] | -3.59[353] | 1.82[354] |
52 | KIT | Mast/stem cell growth factor receptor Kit | [355] | -3.56[356] | -5.02[357] | [358] | 2.32[359] | -3.04[360] | 3.12[361] |
53 | PIK3CG | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | [362] | [363] | [364] | 1.16[365] | -3.55[366] | 3.58[367] | |
54 | LEF1 | Lymphoid enhancer-binding factor 1 | [368] | 2.09[369] | -4.42[370] | 3.19[371] | 0.90[372] | -0.63[373] | 0.56[374] |
55 | FLT3 | Receptor-type tyrosine-protein kinase FLT3 | [375] | [376] | [377] | -3.95[378] | -2.97[379] | [380] | 2.40[381] |
56 | CCNA1 | Cyclin-A1 | [382] | [383] | -3.54[384] | [385] | -0.97[386] | 6.61[387] | [388] |
57 | RUNX1T1 | Protein CBFA2T1 | [389] | [390] | -1.69[391] | -3.75[392] | 1.90[393] | 3.27[394] | 5.11[395] |