Dr. Dlugosz is the Poth Professor of Cutaneous Oncology and Professor in the Departments of Dermatology and Cell & Developmental Biology at the University of Michigan. He is Director of the Cancer Biology Program in Dermatology, and Co-director of the Cancer Cell Biology Program and Scientific Director of the Cutaneous Oncology Program at the University of Michigan Comprehensive Cancer Center. Dr. Dlugosz received his BA from Franklin and Marshall College, his MD from Penn State, did his Internship at the Roger Williams General Hospital, and completed a dermatology residency at the University of Pennsylvania. He did post-doctoral training at the NCI in Dr. Stuart Yuspa's laboratory and initiated an independent research program in Carl Baker's lab prior his recruitment to Michigan in 1997. He runs an active immunobullous clinic and sees general dermatology patients.
In addition to training fellows, dermatology residents, and medical students, Dr. Dlugosz actively participates in formal courses run by several departments in the medical school and plays an active role in training graduate students as thesis mentor and member of multiple thesis committees. Dr. Dlugosz has received numerous grants, fellowships, and awards, including the Marion B. Sulzberger, MD, Memorial Award and Lectureship, and election to the American Society for Clinical Investigation and the Association of American Physicians. His service activities include membership on multiple scientific review panels and NIH study sections.
Research in the Dlugosz lab is centered on defining the functions of the Hedgehog signaling pathway in hair follicle biology and tumorigenesis, with a major emphasis on basal cell carcinoma (BCC), medulloblastoma, and gastric cancer. Using genetically-engineered mouse models developed in his laboratory, Dr. Dlugosz helped establish a central role for deregulated Hedgehog signaling in BCC initiation, expansion, and maintenance; defined critical interactions between Hedgehog and other signaling pathways in tumorigenesis; and elucidated the importance of cell of origin, timing of oncogene activation, and magnitude of Hedgehog signaling as key determinants of skin tumor phenotype. Dr. Dlugosz has authored over 115 publications, including peer-reviewed papers, review articles, commentaries, and book chapters.