Links to Useful Resources
University of
Michigan
email Lists
Mouse Genome Sequence
Molecular Genetics Resources
DNA Cloning Services
Mouse Mutagenesis Projects
Mouse Databases
Mouse Biology
Resources
Vendors
Transgenic Web Sites
Entertaining Sites
Search the Web for Genetically
Engineered
Mice and Mouse Models
University of
Michigan
Core
Technology
Alliance of the Michigan
Life Sciences Corridor
email Lists
Transgenic
email List
International
Society for Transgenic Technologies
Comparative
Medicine
Embryo
Mail
Mouse
Genome Informatics email List
Rat Community Forum
Mouse Genome Sequence
Molecular Genetics Resources
Commercial Genotyping Services
DNA
and
Gene Cloning Services
Mouse Mutagenesis
Projects
- Has Your Gene Been Knocked Out?
Mouse Databases - Has Someone
Made
Your Mouse
Brian Condie's
Cre
Transgenic Database
International
Mouse Strain Resource
Mutant Mouse Regional Resource
Centers
The Jackson
Laboratory Induced
Mutant Resource
Mouse Biology Resources
Vendors
Transgenic
Web
Sites
- Baylor
College
of Medicine Genetically Engineered Mouse Core
- Beth
Israel
Deaconess Transgenic Facility
- Case Western
Reserve
University Transgenesis and Targeting Service
- Columbia-Presbyterian
Cancer Center Transgenic Mouse Research Center
- Duke University Trangenic
Mouse Facility
- Emory
University
Transgenic
Mouse Core Facility
- Johns
Hopkins University
Transgenic Core Laboratory
- Indiana
University School of Medicine Transgenic & Knockout Mouse
- Lexicon Genetics, Inc.
- Massachusetts
General Hospital Transgenic Core
- Medical
College of Georgia Mouse Embryonic Stem Cell and Transgenesis Core
Laboratories
- Medical
College of Wisconsin Transgenic Core Facility
- Medical
University of South Carolina in Charleston Transgenic Core
- Mount
Sinai School of Medicine, Brookdale Center Transgenic Mouse Core
- New
York
University Cancer Institute Transgenic Mouse/Embryonic Stem Cell
Chimera Facility
- NCI-Frederick
Transgenic
and Knock-out Services
- Northwestern
University Transgenic and Targeted Mutagenesis Core Facility
- Ohio
State
University Transgenic Animal Facility
- Oklahoma
Medical
Research Foundation Mouse Genome Manipulation Facility
- Oregon Health
and
Science
University Transgenics/Gene Targeting Facility
- Penn
State College of Medicine Transgenic Core Research Facility
- Princeton
University Transgenic Core Facility
- Purdue
University Transgenic Mouse Core Facility
- Roswell
Park Cancer Institute Gene Targeting and Transgenics Facility
- Stanford Transgenic
Research Facility Shared Resource
- SUNY-Stony
Brook Transgenic Mouse and ES-cell Facility
- Thomas
Jefferson University Transgenic and Gene Targeting Facility
- Tufts-New
England Medical Center Transgenic Core Facility
- Tulane
University Transgenic Mouse Facility
- University
of Alabama, Birmingham Transgenic Mouse Facility
- University
of Albany Transgenic Mouse Core
- University
of Arizona Cancer Center Genetically Engineered Mouse Shared Service
- University
of
California, Davis Murine Targeted Genomics Laboratory
- University
of California,
Irvine Transgenic Mouse Facility
- University
of
California, Los Angeles Transgenic Mouse Facility
- University
of California,
San
Diego Medical Center Moores
Cancer Center Transgenic Mouse and Gene Targeting Core
- University
of
California,
San Francisco Cancer Center Transgenic/Targeted Mutagensis Facilty
- University
of Chicago
Transgenic Core
- University
of Cincinnati
Gene Targeted Mouse Facility
- University
of
Cincinnati
Transgenic Mouse Facility
- University
of
Colorado, Boulder, Transgenic Facility
- University
of Colorado Health Science Center Transgenic and Gene Targeting Core
- University
of
Connecticut Health Center Gene Targeting and Transgenic Facility
- University of
Illinois, Chicago, Transgenic Production Service
- University
of
Iowa,
Transgenic Animal Facility
- University of Kansas
Transgenic
and
Gene Targeting Institutional Facility
- University
of
KentuckyTransgenic
Facility
- University of
Massachusetts
Transgenic Animal Modeling Core
- University
of Miami School of Medicine (Sylvester Comprehensive Cancer Center),
Transgenic
and Targeted Mutant Mouse Core Facility
- University of Michigan
Transgenic
Animal Model Core
- University
of Minnesota Mouse Genetics Laboratory
- University of
Missouri, Columbia
- University
of Medicine and Dentistry of New Jersey Transgenic Core Facility
- Universty
of Nevada Transgenic Center
- University
of
North Carolina
at Chapel Hill
- University of
Pennsylvania
Transgenic
and Chimeric Mouse Facility
- University
of Rochester Medical Center Transgenic Facility
- University
of Texas at Austin Mouse Genetic Engineering Facility
- University
of Texas Health Science Center at Houston
- University
of Texas Health Science Center at San Antonio
- University
of
Texas
M.D. Anderson Cancer Center
- University of Texas
Medical
Branch Transgenic Mouse Facility
- Universtity
of Texas Southwestern Medical Center at Dallas Transgenic Core Facility
- University
of Utah Transgenic/Gene Targeting Facility
- University
of Virginia Gene Targeting and Transgenic Facility
- University
of Washington Transgenic Animal Resources
- University
of Wisconsin Biotechnology Center, Transgenic Animal Facility
- Vanderbilt
University Transgenic Mouse/ES Cell Shared Resource
- Virginia
Commonwealth University Transgenic Mouse Core Facility
- Wadsworth
Center,
New York State Department of Health, Transgenic and Gene-Knockout
Mouse Facility
- Washington University School of
Medicine Mouse Genetics Core
- Yale University Animal
Resources
Center
Australia
Estonia
Canada
Norway
Sweden
Entertaining
Sites
Searching the Web
for
Mouse Models of Human Disease and
Genetically Altered Mouse Strains.
The number of genetically engineered mice available for study is
rapidly
increasing. Considerable savings in animal life and research dollars
are
possible when existing transgenic or gene targeted mouse strains can be
used for experimental studies. In addition, investigators may find that
a spontaneous mouse mutant may provide insight into their research
questions.
Unfortunately, there is no single comprehensive repository for all
genetically
altered mice.We list vendors that have mice for sale. In addition,
there
are information databases which describe mouse models.
The Jackson Laboratory in Bar Harbor, Maine, has a large number of
mouse
strains for distribution. Lines with specific genetic alterations can
be
found by searching various databases for the Induced Mutant Resource,
the
Mouse Mutant Resource, and the Lane List of Named Mutations Maintained
at the Jackson Laboratory.
http://www.jax.org/imr/imr_info.html.
The Jackson Laboratory Induced Mutant Resource of genetically
engineered
mice can be searched over the internet. The database lists several
disease
model categories. For example, there are 47 listings in the Strain
Category
of Breast Cancer of the search form (http://www.jax.org/pub-cgi/imrpub.sh?objtype=rptquery).
Linking to the first listing takes us to information on a mouse with an
experimentally induced mutation in the ataxia telangiectasia gene.
Another
takes us to the Mouse Locus Catalog entry and a detailed comparison of
human disease and the phenotype of this mouse model, including 10
references.
The Jackson Laboratory also maintains the Mouse Genome Database.
This
excellent source of information includes information on spontaneous
mouse
mutants. When spina bifida is entered as a search term in the phenotype
field of the "Genes, Markers and Phenotypes Query Form" (http://www.informatics.jax.org/locus.html),
8 known mouse genes are returned. Linking to the first gene in the list
returns a description of mice with the "curly tail" mutation and 18
research
papers.
The Transgenic/Targeted Mutation Database (TBase) hosted at The
Jackson
Laboratory. Selecting mouse in the common name of organism filed and
entering
muscular dystrophy as the search term in the phenotype field of the
search
form (http://tbase.jax.org/docs/tb.html)
returns a list of mouse lines related to this disease. Linking to the
first
mouse line on the list provides a detailed description of the line and
links to other related lines.
Access to the Mouse Knock-Out and Mutation database is obtained
through
BioMedNet (http://biomednet.com/db/mkmd).
Enter arthritis into the search filed and 8 published studies of
arthritis
models that use gene targeted mice are retrieved.
Frontiers in Bioscience also maintains a database of gene knockout
mice
at http://www.bioscience.org/knockout/knochome.htm.
Genes are listed in alphabetical order, with links to published
research
papers.
The Medical Research Council's Mammalian Genetics Unit at Harwell,
UK,
has more than 200 mouse strains available for distribution. These
include
both genetically engineered mice and spontaneous mutants. A searchable
database is available at http://www.mgu.har.mrc.ac.uk/facilities/stocklist/
The National Institute of Genetics of Japan lists more than 100
strains
of mice available for study at http://www.shigen.nig.ac.jp/mouse/strain/index_e.php
A more limited number of transgenic, gene targeted, and mutant mouse
lines are also available from commercial vendors such as: Charles
River Laboratory , Taconic,
and Harlan Sprague Dawley.
B
& K Universal offer a partial listing of their available mice.
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comments to:
tsaunder@umich.edu