Misc

The number of genetically engineered mice available for study is rapidly increasing. Considerable savings in animal life and research dollars are possible when existing transgenic or gene targeted mouse strains can be used for experimental studies. In addition, investigators may find that a spontaneous mouse mutant may provide insight into their research questions. Unfortunately, there is no single comprehensive repository for all genetically altered mice.We list vendors that have mice for sale. In addition, there are information databases which describe mouse models.

The Jackson Laboratory in Bar Harbor, Maine, has a large number of mouse strains for distribution. Lines with specific genetic alterations can be found by searching various databases for the Induced Mutant Resource, the Mouse Mutant Resource, and the Lane List of Named Mutations Maintained at the Jackson Laboratory.
http://www.jax.org/imr/imr_info.html.

The Jackson Laboratory Induced Mutant Resource of genetically engineered mice can be searched over the internet. The database lists several disease model categories. For example, there are 47 listings in the Strain Category of Breast Cancer of the search form (http://www.jax.org/pub-cgi/imrpub.sh?objtype=rptquery). Linking to the first listing takes us to information on a mouse with an experimentally induced mutation in the ataxia telangiectasia gene. Another takes us to the Mouse Locus Catalog entry and a detailed comparison of human disease and the phenotype of this mouse model, including 10 references.

The Jackson Laboratory also maintains the Mouse Genome Database. This excellent source of information includes information on spontaneous mouse mutants. When spina bifida is entered as a search term in the phenotype field of the "Genes, Markers and Phenotypes Query Form" (http://www.informatics.jax.org/locus.html), 8 known mouse genes are returned. Linking to the first gene in the list returns a description of mice with the "curly tail" mutation and 18 research papers.

The Transgenic/Targeted Mutation Database (TBase) hosted at The Jackson Laboratory. Selecting mouse in the common name of organism filed and entering muscular dystrophy as the search term in the phenotype field of the search form (http://tbase.jax.org/docs/tb.html) returns a list of mouse lines related to this disease. Linking to the first mouse line on the list provides a detailed description of the line and links to other related lines.

Access to the Mouse Knock-Out and Mutation database is obtained through BioMedNet (http://biomednet.com/db/mkmd). Enter arthritis into the search filed and 8 published studies of arthritis models that use gene targeted mice are retrieved.

Frontiers in Bioscience also maintains a database of gene knockout mice at http://www.bioscience.org/knockout/knochome.htm. Genes are listed in alphabetical order, with links to published research papers.

The Medical Research Council's Mammalian Genetics Unit at Harwell, UK, has more than 200 mouse strains available for distribution. These include both genetically engineered mice and spontaneous mutants. A searchable database is available at http://www.mgu.har.mrc.ac.uk/facilities/stocklist/

The National Institute of Genetics of Japan lists more than 100 strains of mice available for study at http://www.shigen.nig.ac.jp/mouse/strain/index_e.php

A more limited number of transgenic, gene targeted, and mutant mouse lines are also available from commercial vendors such as: Charles River Laboratory , Taconic, and Harlan Sprague Dawley. B & K Universal offer a partial listing of their available mice.


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