Research Publications that Used Animals Produced in the University of Michigan Transgenic Core

·  2014

·  2013

·  2012

·  2011
·  2010

·  2009

·  2008

·  2007

·  2006

·  2005

·  2004

·  2003

·  2002

·  2001

·  2000

·  1999

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·  1997

·  1996

·  1995

·  1994

·  1993

·  1992

·  1991

 


2014


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Hu Y, Xie Y, Wang Y, Chen X, Smith DE. 2014. Development and Characterization of a Novel Mouse Line Humanized for the Intestinal Peptide Transporter PEPT1. Mol Pharm. 11:3737-3746.

Jones JM, Meisler MH. 2014. Modeling human epilepsy by TALEN targeting of mouse sodium channel Scn8a. Genesis. 52:141-148.

Kehrl JM, Sahaya K, Dalton HM, Charbeneau RA, Kohut KT, Gilbert K, Pelz MC, Parent J, Neubig RR. 2014. Gain-of-function mutation in Gnao1: A murine model of epileptiform encephalopathy (EIEE17)? Mamm Genome. 25:202-210.

Lenk GM, Meisler MH. 2014. Mouse models of PI(3,5)P2 deficiency with impaired lysosome function. Methods Enzymol. 534:245-260.

Li H, Tan M, Jia L, Wei D, Zhao Y, Chen G, Xu J, Zhao L, Thomas D, Beer DG, Sun Y. 2014. Inactivation of SAG/RBX2 E3 ubiquitin ligase suppresses KrasG12D-driven lung tumorigenesis. J Clin Invest. 124:835-846.

Merchant JL, Saqui-Salces M. 2014. Inhibition of Hedgehog signaling in the gastrointestinal tract: targeting the cancer microenvironment. Cancer Treat Rev. 40:12-21.

Meng ZX, Wang L, Xiao Y, Lin JD. 2014. The Baf60c/Deptor Pathway Links Skeletal Muscle Inflammation to Glucose Homeostasis in Obesity. Diabetes. 2014 Jan 23. [Epub ahead of print]

Rajala MW, Patterson CM, Opp JS, Foltin SK, Young VB, Myers MG Jr. 2014. Leptin acts independently of food intake to modulate gut microbial composition in male mice. Endocrinology. 2014 Jan 1 [Epub ahead of print]

Roger JE, Hiriyanna A, Gotoh N, Hao H, Cheng DF, Ratnapriya R, Kautzmann MA, Chang B, Swaroop A. 2014. OTX2 loss causes rod differentiation defect in CRX-associated congenital blindness. J Clin Invest. 124:631-643.

Tian X, Kim JJ, Monkley SM, Gotoh N, Nandez R, Soda K, Inoue K, Balkin DM, Hassan H, Son SH, Lee Y, Moeckel G, Calderwood DA, Holzman LB, Critchley DR, Zent R, Reiser J, Ishibe S. 2014. Podocyte-associated talin1 is critical for glomerular filtration barrier maintenance. J Clin Invest. 2014 Feb 17. pii: 69778. doi: 10.1172/JCI69778. [Epub ahead of print]

Whiteman EL, Fan S, Harder JL, Walton KD, Liu CJ, Soofi A, Fogg VC, Hershenson MB, Dressler GR, Deutsch GH, Gumucio DL, Margolis B. 2014. Crumbs3 is essential for proper epithelial development and viability. Mol Cell Biol. 34:43-56.


2013


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Abe A, Rzepecki PW, Shayman JA. 2013. A fluorogenic phospholipid for the detection of lysosomal phospholipase A2 activity. Anal Biochem. 434:78-83.

Baines AC, Adams EJ, Zhang B, Ginsburg D. 2013. Disruption of the Sec24d gene results in early embryonic lethality in the mouse. PLoS One. 8:e61114.

Brackenbury WJ, Yuan Y, O'Malley HA, Parent JM, Isom LL.2013. Abnormal neuronal patterning occurs during early postnatal brain development of Scn1b-null mice and precedes hyperexcitability. Proc Natl Acad Sci U S A. 110:1089-1094

Broder C, Arnold P, Vadon-Le Goff S, Konerding MA, Bahr K, Müller S, Overall CM, Bond JS, Koudelka T, Tholey A, Hulmes DJ, Moali C, Becker-Pauly C. 2013. Metalloproteases meprin alpha and meprin beta are C- and N-procollagen proteinases important for collagen assembly and tensile strength. Proc Natl Acad Sci U S A. 110:14219-14224.

Campeau PM, Lenk GM, Lu JT, Bae Y, Burrage L, Turnpenny P, Román Corona-Rivera J, Morandi L, Mora M, Reutter H, Vulto-van Silfhout AT, Faivre L, Haan E, Gibbs RA, Meisler MH, Lee BH. 2013. Yunis-Varón syndrome is caused by mutations in FIG4, encoding a phosphoinositide phosphatase. Am J Hum Genet. 292:781-791.

Cannon JR, Geghman KD, Tapias V, Sew T, Dail MK, Li C, Greenamyre JT. 2013. Expression of human E46K-mutated α-synuclein in BAC-transgenic rats replicates early-stage Parkinson's disease features and enhances vulnerability to mitochondrial impairment. Exp Neurol. 240:44-56.

Chen XW, Wang H, Bajaj K, Zhang P, Meng ZX, Ma D, Bai Y, Liu HH, Adams E, Baines A, Yu G, Sartor MA, Zhang B, Yi Z, Lin J, Young SG, Schekman R, Ginsburg D. 2013. SEC24A deficiency lowers plasma cholesterol through reduced PCSK9 secretion. Elife. 2:e00444.

Ding L, Morrison SJ. 2013. Haematopoietic stem cells and early lymphoid progenitors occupy distinct bone marrow niches. Ding L, Morrison SJ. Nature. 495:231-235.

Dunnick WA, Shi J, Fontaine C, Collins J T. 2013. Transgenes of the Mouse Immunoglobulin Heavy Chain Locus, Lacking Distal Elements in the 3’ Regulatory Region, are Impaired for Class Switch Recombination. PLoS ONE 8: e55842.

Dutton SB, Makinson CD, Papale LA, Shankar A, Balakrishnan B, Nakazawa K, Escayg A. 2013. Preferential inactivation of Scn1a in parvalbumin interneurons increases seizure susceptibility. Neurobiol Dis. 49:211–220.


Feng Y, Sentani K, Wiese A, Sands E, Green M, Bommer GT, Cho KR, Fearon ER. 2013. Sox9 induction, ectopic paneth cells, and mitotic spindle axis defects in mouse colon adenomatous epithelium arising from conditional biallelic apc inactivation. Am J Pathol. 183:493-503.

Harms KL, Dlugosz AA. 2013. Harnessing hedgehog for the treatment of basal cell carcinoma. JAMA Dermatol. 149:607-608

Johnstone DB, Ikizler O, Zhang J, Holzman LB. 2013. Background strain and the differential susceptibility of podocyte-specific deletion of Myh9 on murine models of experimental glomerulosclerosis and HIV nephropathy. PLoS One. 10;8(7):e67839.

Lehoczky JA, Thomas PE, Patrie KM, Owens KM, Villarreal LM, Galbraith K, Washburn J, Johnson CN, Gavino B, Borowsky AD, Millen KJ, Wakenight P, Law W, Van Keuren ML, Gavrilina G, Hughes ED, Saunders TL, Brihn L, Nadeau JH, Innis JW. 2013. A Novel Intergenic ETnII-β Insertion Mutation Causes Multiple Malformations in Polypodia Mice. PLoS Genet. 9(12):e1003967.

Liu HX, Ermilov A, Grachtchouk M, Li L, Gumucio DL, Dlugosz AA, Mistretta CM. 2013. Multiple Shh signaling centers participate in fungiform papilla and taste bud formation and maintenance. Dev Biol. 382:82-97.

Meng ZX, Li S, Wang L, Ko HJ, Lee Y, Jung DY, Okutsu M, Yan Z, Kim JK, Lin JD. 2013. Baf60c drives glycolytic metabolism in the muscle and improves systemic glucose homeostasis through Deptor-mediated Akt activation. Nat Med. 19:640-645.

Ming X, Chew LJ, Gallo V. 2013. Transgenic overexpression of Sox17 promotes oligodendrocyte development and attenuates demyelination. J Neurosci. 33:12528-12542.

Nayak G, Lee SI, Yousaf R, Edelmann SE, Trincot C, Van Itallie CM, Sinha GP, Rafeeq M, Jones SM, Belyantseva IA, Anderson JM, Forge A, Frolenkov GI, Riazuddin S. 2013. Tricellulin deficiency affects tight junction architecture and cochlear hair cells. J Clin Invest. 123:4036-4049.

O'Brien JE, Meisler MH. 2013. Sodium channel SCN8A (Nav1.6): properties and de novo mutations in epileptic encephalopathy and intellectual disability. Front Genet. 4:213.

Paduraru C, Bezbradica JS, Kunte A, Kelly R, Shayman JA, Veerapen N, Cox LR, Besra GS, Cresswell P. 2013.Role for lysosomal phospholipase A2 in iNKT cell-mediated CD1d recognition. Proc Natl Acad Sci U S A. 110:5097-5102.

Pérez-Millán MI, Zeidler MG, Saunders TL, Camper SA, Davis SW. 2013. Efficient, specific, developmentally appropriate cre-mediated recombination in anterior pituitary gonadotropes and thyrotropes. Genesis. 51:785-792.


Reifler A, Lenk GM, Li X, Groom L, Brooks SV, Wilson D, Bowerson M, Dirksen RT, Meisler MH, Dowling JJ. 2013. Murine Fig4 is dispensable for muscle development but required for muscle function. Skelet Muscle. 3:21.

Schwab KR, Smith GD, Dressler GR. 2013. Arrested spermatogenesis and evidence for DNA damage in PTIP mutant testes. Dev Biol. 373:64-71.

Soofi A, Zhang P, Dressler GR. 2013. Kielin/chordin-like protein attenuates both acute and chronic renal injury. J Am Soc Nephrol. 224:897-905.

Strickland FM, Hewagama A, Wu A, Sawalha AH, Delaney C, Hoeltzel MF, Yung R, Johnson K, Mickelson B, Richardson BC. 2013. Diet influences expression of autoimmune-associated genes and disease severity by epigenetic mechanisms in a transgenic mouse model of lupus. Arthritis Rheum. 65:1872-1881.

Tang Y, Rowe RG, Botvinick EL, Kurup A, Putnam AJ, Seiki M, Weaver VM, Keller ET, Goldstein S, Dai J, Begun D, Saunders T, Weiss S 2013.MT1-MMP-Dependent Control of Skeletal Stem Cell Commitment via a β1-Integrin/YAP/TAZ Signaling Axis. Dev Cell. 25:402-416.

Ting JT, Feng G. 2013. Development of transgenic animals for optogenetic manipulation of mammalian nervous system function: progress and prospects for behavioral neuroscience. Behav Brain Res. 255:3-18.

Tye KM, Mirzabekov JJ, Warden MR, Ferenczi EA, Tsai HC, Finkelstein J, Kim SY, Adhikari A, Thompson KR, Andalman AS, Gunaydin LA, Witten IB, Deisseroth K. 2013. Dopamine neurons modulate neural encoding and expression of depression-related behaviour. Nature. 493:537-541.


Wiese CB, Fleming N, Buehler DP, Southard-Smith EM. 2013. A Uchl1-Histone2BmCherry:GFP-gpi BAC transgene for imaging neuronal progenitors. Genesis. 51:852-861.


Worthington JJ, Samuelson LC, Grencis RK, McLaughlin JT. 2013. Adaptive immunity alters distinct host feeding pathways during nematode induced inflammation, a novel mechanism in parasite expulsion. PLoS Pathog. 9(1):e1003122.

Wright J, Wang X, Haataja L, Kellogg AP, Lee J, Liu M, Arvan P. 2013. Dominant protein interactions that influence the pathogenesis of conformational diseases. J Clin Invest. 123: 3124-3134.

Xu Y, Kim ER, Zhao R, Myers MG Jr, Munzberg H, Tong Q. 2013. Glutamate release mediates leptin action on energy expenditure. Mol Metab. 2:109-115.

Xu J, Morris L, Thapa A, Ma H, Michalakis S, Biel M, Baehr W, Peshenko IV, Dizhoor AM, Ding XQ. 2013. cGMP Accumulation Causes Photoreceptor Degeneration in CNG Channel Deficiency: Evidence of cGMP Cytotoxicity Independently of Enhanced CNG Channel Function. J Neurosci. 33:14939-14948.

Xue X, Ramakrishnan S, Anderson E, Taylor M, Zimmermann EM, Spence JR, Huang S, Greenson JK, Shah YM. 2013. Endothelial PAS Domain Protein 1 Activates the Inflammatory Response in the Intestinal Epithelium to Promote Colitis in Mice. Gastroenterology. 145:831-841.


2012


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Akhmetshina A, Palumbo K, Dees C, Bergmann C, Venalis P, Zerr P, Horn A, Kireva T, Beyer C, Zwerina J, Schneider H, Sadowski A, Riener MO, MacDougald OA, Distler O, Schett G, Distler JH. 2012. Activation of canonical Wnt signalling is required for TGF-β-mediated fibrosis. Nat Commun. 13;3:735.

Blij S, Frum T, Akyol A, Fearon E, Ralston A. 2012. Maternal Cdx2 is dispensable for mouse development. Development. 139:3969-3972.

Blumer JB, Oner SS, Lanier SM. 2012. Group II activators of G-protein signalling and proteins containing a G-protein regulatory motif. Acta Physiol (Oxf). 204:201-218.


Burrows PE, Gonzalez-Garay ML, Rasmussen JC, Aldrich MB, Guilliod R, Maus EA, Fife CE, Kwon S, Lapinski PE, King PD, Sevick-Muraca EM. 2013.Lymphatic abnormalities are associated with RASA1 gene mutations in mouse and man. Proc Natl Acad Sci U S A. 110:8621-8626.

Cho H, Kamenyeva O, Yung S, Gao JL, Hwang IY, Park C, Murphy PM, Neubig RR, Kehrl JH. 2012. The Loss of RGS Protein-Gαi2 Interactions Results in Markedly Impaired Mouse Neutrophil Trafficking to Inflammatory Sites.
Mol Cell Biol. 2012 Sep 10. [Epub ahead of print]

Ding L, Saunders TL, Enikolopov G, Morrison SJ. 2012. Endothelial and perivascular cells maintain haematopoietic stem cells. Nature. 481:457-462.

Eberl M, Klingler S, Mangelberger D, Loipetzberger A, Damhofer H, Zoidl K, Schnidar H, Hache H, Bauer HC, Solca F, Hauser-Kronberger C, Ermilov AN, Verhaegen ME, Bichakjian CK, Dlugosz AA, Nietfeld W, Sibilia M, Lehrach H, Wierling C, Aberger F. 2012. Hedgehog-EGFR cooperation response genes determine the oncogenic phenotype of basal cell carcinoma and tumour-initiating pancreatic cancer cells. EMBO Mol Med. 4:218-233.

El-Zaatari M, Kao JY, Tessier A, Bai L, Hayes MM, Fontaine C, Eaton KA, Merchant JL. 2013. Gli1 deletion prevents Helicobacter-induced gastric metaplasia and expansion of myeloid cell subsets. PLoS One. 8(3):e58935

Emmett LS, O'Shea KS. 2012. Geminin is required for epithelial to mesenchymal transition at gastrulation. Stem Cells Dev. 21:2395-2409.

Essien BE, Grasberger H, Romain RD, Law DJ, Veniaminova NA, Saqui-Salces M, El-Zaatari M, Tessier A, Hayes MM, Yang AC, Merchant JL. 2013. ZBP-89 regulates expression of tryptophan hydroxylase I and mucosal defense against Salmonella typhimurium in mice. Gastroenterology. 144:1466-1477.

Fang Q, Giordimaina AM, Dolan DF, Camper SA, Mustapha M. Genetic background of Prop1(df) mutants provides remarkable protection against hypothyroidism-induced hearing impairment. J Assoc Res Otolaryngol. 13:173-184.

Ferguson CJ, Lenk GM, Jones JM, Grant AE, Winters JJ, Dowling JJ, Giger RJ, Meisler MH. 2012. Neuronal expression of Fig4 is both necessary and sufficient to prevent spongiform neurodegeneration. Hum Mol Genet. 21:3525-3534.

Fukuda A, Chowdhury MA, Venkatareddy MP, Wang SQ, Nishizono R, Suzuki T, Wickman LT, Wiggins JE, Muchayi T, Fingar D, Shedden KA, Inoki K, Wiggins RC.2012. Growth-dependent podocyte failure causes glomerulosclerosis. J Am Soc Nephrol. 23:1351-1363.

Fukuda A, Wickman LT, Venkatareddy MP, Sato Y, Chowdhury MA, Wang SQ, Shedden KA, Dysko RC, Wiggins JE, Wiggins RC. Kidney Int. 2012. Angiotensin II-dependent persistent podocyte loss from destabilized glomeruli causes progression of end stage kidney disease. 81:40-55.

Fukuda A, Wickman LT, Venkatareddy MP, Wang SQ, Chowdhury MA, Wiggins JE, Shedden KA, Wiggins RC. 2012. Urine podocin:nephrin mRNA ratio (PNR) as a podocyte stress biomarker. Nephrol Dial Transplant. 27:4079-4087.

Gopalakrishnan K, Kumarasamy S, Abdul-Majeed S, Kalinoski AL, Morgan EE, Gohara AF, Nauli SM, Filipiak WE, Saunders TL, Joe B. 2012. Targeted disruption of Adamts16 gene in a rat genetic model of hypertension.  Proc Natl Acad Sci U S A. 109:20555-20559.

Hurd EA, Micucci JA, Reamer EN, Martin DM. 2012. Delayed fusion and altered gene expression contribute to semicircular canal defects in Chd7 deficient mice. Mech Dev. 129:308-323.

Hüttemann M, Klewer S, Lee I, Pecinova A, Pecina P, Liu J, Lee M, Doan JW, Larson D, Slack E, Maghsoodi B, Erickson RP, Grossman LI.. 2012. Mice deleted for heart-type cytochrome c oxidase subunit 7a1 develop dilated cardiomyopathy. Mitochondrion.12:294-304.


Kaur K, Parra S, Chen R, Charbeneau RA, Wade SM, Jay PY, Neubig RR. 2012. Gαi2 signaling: friend or foe in cardiac injury and heart failure? Naunyn Schmiedebergs Arch Pharmacol. 385:443-453.

Kenneth NS, Younger JM, Hughes ED, Marcotte D, Barker PA, Saunders TL, Duckett CS. 2012. An Inactivating Caspase-11 Passenger Mutation Originating from the 129 Murine Strain in Mice Targeted for c-Iap1. Biochem J. 443:355-359.

Khoriaty R, Vasievich MP, Ginsburg D. 2012. The COPII pathway and hematologic disease. Blood. 120:31-38.

King PD, Lubeck BA, Lapinski PE. 2013. Nonredundant functions for Ras GTPase-activating proteins in tissue homeostasis. Sci Signal. 6:re1.

Krebs CJ, Schultz DC, Robins DM. 2012. The KRAB zinc finger protein RSL1 regulates sex- and tissue-specific promoter methylation and dynamic hormone-responsive chromatin configuration. Mol Cell Biol. 32:3732-3742.

Kwon M, Pavlov TS, Nozu K, Rasmussen SA, Ilatovskaya DV, Lerch-Gaggl A, North LM, Kim H, Qian F, Sweeney WE Jr, Avner ED, Blumer JB, Staruschenko A, Park F. 2012. G-protein signaling modulator 1 deficiency accelerates cystic disease in an orthologous mouse model of autosomal dominant polycystic kidney disease. Proc Natl Acad Sci U S A. 109:21462-21467.

Lapinski PE, Kwon S, Lubeck BA, Wilkinson JE, Srinivasan RS, Sevick-Muraca E, King PD. 2012. RASA1 maintains the lymphatic vasculature in a quiescent functional state in mice. J Clin Invest. 122:733-747.


Leshan RL, Greenwald-Yarnell M, Patterson CM, Gonzalez IE, Myers MG Jr. 2012. Leptin action through hypothalamic nitric oxide synthase-1-expressing neurons controls energy balance. Nat Med. 18:820-823.

Li X, Li L, Pandey R, Byun JS, Gardner K, Qin Z, Dou Y. 2012. The histone acetyltransferase MOF is a key regulator of the embryonic stem cell core transcriptional network. Cell Stem Cell. 11:163-178.

Li P, Neubig RR, Zingarelli B, Borg K, Halushka PV, Cook JA, Fan H. 2012. Toll-like Receptor-Induced Inflammatory Cytokines are Suppressed by Gain of Function or Overexpression of Gα (i2) Protein. Inflammation. 35:1611-1617.

Lim KC, Hosoya T, Brandt W, Ku CJ, Hosoya-Ohmura S, Camper SA, Yamamoto M, Engel JD. 2012. Conditional Gata2 inactivation results in HSC loss and lymphatic mispatterning. J Clin Invest. 122:3705-3717.

Liu Z, Demitrack ES, Keeley TM, Eaton KA, El-Zaatari M, Merchant JL, Samuelson LC. 2012. IFNγ contributes to the development of gastric epithelial cell metaplasia in Huntingtin interacting protein 1 related (Hip1r)-deficient mice. Lab Invest. 92:1045-1057.

Miller SJ, Heist KA, Feng Y, Galbán CJ, Rehemtulla A, Ross BD, Fearon ER, Wang TD. 2012. Multimodal imaging of growth and rapamycin-induced regression of colonic adenomas in apc mutation-dependent mouse. Transl Oncol. 5:313-320.

Marionneau C, Carrasquillo Y, Norris AJ, Townsend RR, Isom LL, Link AJ, Nerbonne JM. 2012. The sodium channel accessory subunit Navβ1 regulates neuronal excitability through modulation of repolarizing voltage-gated K+ channels. J Neurosci. 32:5716-5727.


Myers MG Jr, Olson DP. 2012. Central nervous system control of metabolism. Nature. 491:357-363.

Patterson CM, Villanueva EC, Greenwald-Yarnell M, Rajala M, Gonzalez IE, Saini N, Jones J, Myers MG Jr. 2012. Leptin action via LepR-b Tyr1077 contributes to the control of energy balance and female reproduction. Mol Metab. 1:61-69.

Prasov L, Nagy M, Rudolph DD, Glaser T. 2012. Math5 (Atoh7) gene dosage limits retinal ganglion cell genesis. Neuroreport. 23:631-634.

Roger JE, Ranganath K, Zhao L, Cojocaru RI, Brooks M, Gotoh N, Veleri S, Hiriyanna A, Rachel RA, Campos MM, Fariss RN, Wong WT, Swaroop A. 2012. Preservation of cone photoreceptors after a rapid yet transient degeneration and remodeling in cone-only Nrl-/- mouse retina. J Neurosci. 32:528-541.


Qiao Y, Zhu L, Sofi H, Lapinski PE, Horai R, Mueller K, Stritesky GL, He X, Teh HS, Wiest DL, Kappes DJ, King PD, Hogquist KA, Schwartzberg PL, Sant'Angelo DB, Chang CH. 2012. Development of promyelocytic leukemia zinc finger-expressing innate CD4 T cells requires stronger T-cell receptor signals than conventional CD4 T cells. Proc Natl Acad Sci U S A.109:16264-16269.

Rother E, Belgardt BF, Tsaousidou E, Hampel B, Waisman A, Myers MG Jr, Brüning JC. 2012. Acute selective ablation of rat insulin promoter-expressing (RIPHER) neurons defines their orexigenic nature. Proc Natl Acad Sci U S A. 109):18132-18137.

Sadagurski M, Leshan RL, Patterson C, Rozzo A, Kuznetsova A, Skorupski J, Jones JC, Depinho RA, Myers MG Jr, White MF. 2012. IRS2 signaling in LepR-b neurons suppresses FoxO1 to control energy balance independently of leptin action. Cell Metab. 15:703-712.

Saqui-Salces M, Covés-Datson E, Veniaminova NA, Waghray M, Syu LJ, Dlugosz AA, Merchant JL. 2012. Inflammation and Gli2 suppress gastrin gene expression in a murine model of antral hyperplasia. PLoS One.7(10):e48039.

Sevick-Muraca EM, King PD. 2013. Lymphatic vessel abnormalities arising from disorders of Ras signal transduction. Trends Cardiovasc Med. 2013 Oct 31. [Epub ahead of print]

Schumacher MA, Donnelly JM, Engevik AC, Xiao C, Yang L, Kenny S, Varro A, Hollande F, Samuelson LC, Zavros Y. 2012. Gastric Sonic Hedgehog acts as a macrophage chemoattractant during the immune response to Helicobacter pylori. Gastroenterology. 142:1150-1159.


Skidmore JM, Waite MR, Alvarez-Bolado G, Puelles L, Martin DM. 2012. A novel TaulacZ allele reveals a requirement for Pitx2 in formation of the mammillothalamic tract. Genesis. 50:67-73.

Soofi A, Levitan I, Dressler GR. 2012. Two novel EGFP insertion alleles reveal unique aspects of Pax2 function in embryonic and adult kidneys. Dev Biol. 36: 241-250.

Spehalski E, Kovalchuk AL, Collins JT, Liang G, Dubois W, Morse HC 3rd, Ferguson DO, Casellas R, Dunnick WA. 2012. Oncogenic Myc translocations are independent of chromosomal location and orientation of the immunoglobulin heavy chain locus. Proc Natl Acad Sci U S A. 109:13716-13721.

Strickland FM, Hewagama A, Lu Q, Wu A, Hinderer R, Webb R, Johnson K, Sawalha AH, Delaney C, Yung R, Richardson BC. 2012. Environmental exposure, estrogen and two X chromosomes are required for disease development in an epigenetic model of lupus. J Autoimmun. 38:J135-143.

Sun H, Xu Y, Sitkiewicz I, Ma Y, Wang X, Yestrepsky BD, Huang Y, Lapadatescu MC, Larsen MJ, Larsen SD, Musser JM, Ginsburg D. 2012. Inhibitor of streptokinase gene expression improves survival after group A streptococcus infection in mice. Proc Natl Acad Sci U S A 109:3469-3474.

Syu LJ, El-Zaatari M, Eaton KA, Liu Z, Tetarbe M, Keeley TM, Pero J, Ferris J, Wilbert D, Kaatz A, Zheng X, Qiao X, Grachtchouk M, Gumucio DL, Merchant JL, Samuelson LC, Dlugosz AA. 2012. Transgenic expression of interferon-γ in mouse stomach leads to inflammation, metaplasia, and dysplasia. Am J Pathol. 181:2114-2125.

Tao J, Zhu M, Wang H, Afelik S, Vasievich MP, Chen XW, Zhu G, Jensen J, Ginsburg D, Zhang B. 2012. SEC23B is required for the maintenance of murine professional secretory tissues. Proc Natl Acad Sci U S A. 109:E2001-2009.

Veniaminova NA, Hayes MM, Varney JM, Merchant JL. 2012. Conditional deletion of menin results in antral G cell hyperplasia and hypergastrinemia. Am J Physiol Gastrointest Liver Physiol. 303:G752-G764.

Warren SA, Briggs LE, Zeng H, Chuang J, Chang EI, Terada R, Li M, Swanson MS, Lecker SH, Willis MS, Spinale FG, Maupin-Furlowe J, McMullen JR, Moss RL, Kasahara H. 2012. Myosin light chain phosphorylation is critical for adaptation to cardiac stress. Circulation. 126:2575-2588.

Wei Q, Fentress HM, Hoversten MT, Zhang L, Hebda-Bauer EK, Watson SJ, Seasholtz AF, Akil H. 2012. Early-Life Forebrain Glucocorticoid Receptor Overexpression Increases Anxiety Behavior and Cocaine Sensitization. Biol Psychiatry. 71:224-31.

Wu J, Liu C, Chen J, Yu X. 2012. RAP80 protein is important for genomic stability and is required for stabilizing BRCA1-A complex at DNA damage sites in vivo. J Biol Chem. 287:22919-22926.

Wu X, Peppi M, Vengalil MJ, Maheras KJ, Southwood CM, Bradley M, Gow A 2012..Transgene-mediated rescue of spermatogenesis in Cldn11-null mice. Biol Reprod. 86: 1-11.

Xiao H, Yu Z, Wu Y, Nan J, Merry DE, Sekiguchi JM, Ferguson DO, Lieberman AP, Dressler GR. 2012. A polyglutamine expansion disease protein sequesters PTIP to attenuate DNA repair and increase genomic instability. Hum Mol Genet. 21:4225-4236.

Xu Y, O'Brien WG 3rd, Lee CC, Myers MG Jr, Tong Q. 2012. Role of GABA release from leptin receptor-expressing neurons in body weight regulation. Endocrinology. 153:2223-2233.

Yu S, Zhou X, Hsiao JJ, Yu D, Saunders TL, Xue HH. 2012. Fidelity of a BAC-EGFP transgene in reporting dynamic expression of IL-7Rα in T cells. Transgenic Res.21:201-15.

Yin KJ, Olsen K, Hamblin M, Zhang J, Schwendeman SP, Chen YE. 2012. Vascular endothelial cell-specific microRNA-15a inhibits angiogenesis in hindlimb ischemia. J Biol Chem. 287:27055-27064.

Zhang Y, McCartney AJ, Zolov SN, Ferguson CJ, Meisler MH, Sutton MA, Weisman LS. 2012. Modulation of synaptic function by VAC14, a protein that regulates the phosphoinositides PI(3,5)P? and PI(5)P. EMBO J. 31:3442-3456.

Zolov SN, Bridges D, Zhang Y, Lee WW, Riehle E, Verma R, Lenk GM, Converso-Baran K, Weide T, Albin RL, Saltiel AR, Meisler MH, Russell MW, Weisman LS. 2012. In vivo, Pikfyve generates PI(3,5)P2, which serves as both a signaling lipid and the major precursor for PI5P. Proc Natl Acad Sci U S A. 109:17472-17477.


2011


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Barthson J, Germano CM, Moore F, Maida A, Drucker DJ, Marchetti P, Gysemans C, Mathieu C, Nuñez G, Jurisicova A, Eizirik DL, Gurzov EN. 2011. Cytokines tumor necrosis factor-α and interferon-γ induce pancreatic β-cell apoptosis through STAT1-mediated Bim protein activation. J Biol Chem. 286:39632-39643.

Castinetti F, Brinkmeier ML, Gordon DF, Vella KR, Kerr JM, Mortensen AH, Hollenberg A, Brue T, Ridgway EC, Camper SA. 2011. PITX2 AND PITX1 Regulate Thyrotroph Function and Response to Hypothyroidism. Mol Endocrinol.25:1950-1960.

Cho KW, Zhou Y, Sheng L, Rui L. 2011. Lipocalin-13 Regulates Glucose Metabolism by Both Insulin-dependent and Insulin-independent Mechanisms. Mol Cell Biol. 31:450-457.

Choi BY, Kim HM, Ito T, Lee KY, Li X, Monahan K, Wen Y, Wilson E, Kurima K, Saunders TL, Petralia RS, Wangemann P, Friedman TB, Griffith AJ. 2011. Mouse model of enlarged vestibular aqueducts defines temporal requirement of Slc26a4 expression for hearing acquisition. J Clin Invest. 121:4516-4525.

Clement LC, Avila-Casado C, Macé C, Soria E, Bakker WW, Kersten S, Chugh SS. 2011. Podocyte-secreted angiopoietin-like-4 mediates proteinuria in glucocorticoid-sensitive nephrotic syndrome. Nat Med. 17:117-122.

Dobson ME, Diallo-Krou E, Grachtchouk V, Yu J, Colby LA, Wilkinson JE, Giordano TJ, Koenig RJ. 2011. Pioglitazone induces a proadipogenic antitumor response in mice with PAX8-PPARgamma fusion protein thyroid carcinoma. Endocrinology. 152:4455-4465.

Dunnick WA, Shi J, Holden V, Fontaine C, Collins JT. 2011. The role of germline promoters and I exons in cytokine-induced gene-specific class switch recombination. J Immunol. 186:350-358.

Dunnick WA, Shi J, Zerbato JM, Fontaine CA, Collins JT. 2011. Enhancement of antibody class-switch recombination by the cumulative activity of four separate elements. J Immunol. 187:4733-4743.

Corpening JC, Deal KK, Cantrell VA, Skelton SB, Buehler DP, Southard-Smith EM. 2011. Isolation and live imaging of enteric progenitors based on Sox10-histone2bvenus transgene expression. Genesis. 49: 599-618.

Ghiasvand NM, Rudolph DD, Mashayekhi M, Brzezinski JA 4th, Goldman D, Glaser T. 2011. Deletion of a remote enhancer near ATOH7 disrupts retinal neurogenesis, causing NCRNA disease. Nat Neurosci. 14:578-586

Grachtchouk M, Pero J, Yang SH, Ermilov AN, Michael LE, Wang A, Wilbert D, Patel RM, Ferris J, Diener J, Allen M, Lim S, Syu LJ, Verhaegen M, Dlugosz AA. 2011. Basal cell carcinomas in mice arise from hair follicle stem cells and multiple epithelial progenitor populations. J Clin Invest. 121:1768-81.


Hodish I, Absood A, Liu L, Liu M, Haataja L, Larkin D, Al-Khafaji A, Zaki A, Arvan P. 2011. In vivo misfolding of proinsulin below the threshold of frank diabetes. Diabetes.60:2092-2101.

Johnstone DB, Zhang J, George B, Léon C, Gachet C, Wong H, Parekh R, Holzman LB. 2011. Podocyte-specific deletion of Myh9 encoding non-muscle myosin heavy chain 2A predisposes mice to glomerulopathy. Mol Cell Biol. 31:2162-2170.

Jorge BS, Campbell CM, Miller AR, Rutter ED, Gurnett CA,Vanoye CG, George AL, Jr, Kearney JA. 2011. Voltage-gated potassium channel KCNV2 (Kv8.2) contributes to epilepsy susceptibility.  Proc Natl Acad Sci U S A. 108:5443-5448.

Kaur K, Kehrl JM, Charbeneau RA, Neubig RR. 2011. RGS-Insensitive Gα Subunits: Probes of Gα Subtype-Selective Signaling and Physiological Functions of RGS Proteins. Methods Mol Biol.756:75-98.

Kawashima Y, Géléoc GS, Kurima K, Labay V, Lelli A, Asai Y, Makishima T, Wu DK, Della Santina CC, Holt JR, Griffith AJ. 201. Mechanotransduction in mouse inner ear hair cells requires transmembrane channel-like genes. J Clin Invest. 121:4796-4809.

Kurima K, Hertzano R, Gavrilova O, Monahan K, Shpargel KB, Nadaraja G, Kawashima Y, Lee KY, Ito T, Higashi Y, Eisenman DJ, Strome SE, Griffith AJ. 2011. A Noncoding Point Mutation of Zeb1 Causes Multiple Developmental Malformations and Obesity in Twirler Mice. PLoS Genetics. 7(9):e1002307.

Lapinski PE, Qiao Y, Chang CH, King PD. 2011. A role for p120 RasGAP in thymocyte positive selection and survival of naive T cells. J Immunol. 187:151-163.

Layman WS, Hurd EA, Martin DM.
2011. Reproductive dysfunction and decreased GnRH neurogenesis in a mouse model of CHARGE syndrome. Hum Mol Genet. 20:3138-1350

Leinninger GM, Opland DM, Jo YH, Faouzi M, Christensen L, Cappellucci LA, Rhodes CJ, Gnegy ME, Becker JB, Pothos EN, Seasholtz AF, Thompson RC, Myers MG Jr. 2011. Leptin Action via Neurotensin Neurons Controls Orexin, the Mesolimbic Dopamine System and Energy Balance. Cell Metab. 14:313-323.

Li X, Li L, Pandey R, Byun JS, Gardner K, Qin Z, Dou Y. 2012. The Histone Acetyltransferase MOF Is a Key Regulator of the Embryonic Stem Cell Core Transcriptional Network.Cell Stem Cell. 11:163-178.

Lopez-Santiago LF, Brackenbury WJ, Chen C, Isom LL. 2011.
Na+ channel SCN1B regulates dorsal root ganglion nociceptor excitability in vivo. J Biol Chem. 286:22913-22923.

Ma T, Keller JA, Yu X. 2011.
RNF8-dependent histone ubiquitination during DNA damage response and spermatogenesis. Acta Biochim Biophys Sin (Shanghai). 43:339-345.

McCormick JA, Nelson JH, Yang CL, Curry JN, Ellison DH. 2011. Overexpression of the sodium chloride cotransporter is not sufficient to cause familial hyperkalemic hypertension. .Hypertension. 58:888-894.


Mendez MP, Monroy YK, Du M, Preston AM, Tolle L, Lin Y, VanDussen KL, Samuelson LC, Standiford TJ, Curtis JL, Beck JM, Christensen PJ, Paine R 3rd. 2011. Overexpression of sICAM-1 in the alveolar epithelial space results in an exaggerated inflammatory response and early death in Gram negative pneumonia. Respir Res. 12:12.

Miller SJ, Joshi BP, Feng Y, Gaustad A, Fearon ER, Wang TD.
2011. In vivo fluorescence-based endoscopic detection of colon dysplasia in the mouse using a novel Peptide probe. PLoS One. 6:e17384.

Nasonkin IO, Ward RD, Bavers DL, Beuschlein F, Mortensen AH, Keegan CE, Hammer GD, Camper SA. 2011. Aged PROP1 deficient dwarf mice maintain ACTH production. PLoS One. 6:e28355.

Patino GA, Brackenbury WJ, Bao Y, Lopez-Santiago LF, O'Malley HA, Chen C, Calhoun JD, Lafrenière RG, Cossette P, Rouleau GA, Isom LL. 2011. Voltage-gated Na+ channel β1B: a secreted cell adhesion molecule involved in human epilepsy. J Neurosci. 31:14577-14591.

Pipe SW, Miao H, Butler SP, Calcaterra J, Velander WH. 2011. Functional factor VIII made with von Willebrand factor at high levels in transgenic milk. J Thromb Haemost. 9:2235-2242.

Qiao XT, Gumucio DL. 2011. Current molecular markers for gastric progenitor cells and gastric cancer stem cells. J Gastroenterol. 46:855-865.

Regner KR, Nozu K, Lanier SM, Blumer JB, Avner ED, Sweeney WE Jr, Park F. 2011. Loss of activator of G-protein signaling 3 impairs renal tubular regeneration following acute kidney injury in rodents. FASEB J. 25:1844-55.

Rowe RG, Keena D, Sabeh F, Willis AL, Weiss SJ. 2011. Pulmonary fibroblasts mobilize the membrane-tethered matrix metalloprotease, MT1-MMP, to destructively remodel and invade interstitial type I collagen barriers. Am J Physiol Lung Cell Mol Physiol. 301:L683-L692.

Rowe RG, Lin Y, Shimizu-Hirota R, Hanada S, Neilson EG, Greenson JK, Weiss SJ. 2011. Hepatocyte-derived Snail1 propagates liver fibrosis progression. Mol Cell Biol. 31:2392-2403.

Saqui-Salces M, Keeley TM, Grosse AS, Qiao XT, El-Zaatari M, Gumucio DL, Samuelson LC, Merchant JL. 2011. Gastric tuft cells express DCLK1 and are expanded in hyperplasia. Histochem Cell Biol. 136:191-204.

Schwab KR, Patel SR, Dressler GR. 2011. Role of PTIP in class switch recombination and long-range chromatin interactions at the immunoglobulin heavy chain locus. Mol Cell Biol. 31:1503-1511.

Sheng L, Cho KW, Zhou Y, Shen H, Rui L. 2011. Lipocalin 13 protein protects against hepatic steatosis by both inhibiting lipogenesis and stimulating fatty acid β-oxidation. J Biol Chem. 286:38128-38135.


Singer BH, Gamelli AE, Fuller CL, Temme SJ, Parent JM, Murphy GG. 2011. Compensatory network changes in the dentate gyrus restore long-term potentiation following ablation of neurogenesis in young-adult mice. Proc Natl Acad Sci U S A. 108:5437-5442.

Stein AB, Jones TA, Herron TJ, Patel SR, Day SM, Noujaim SF, Milstein ML, Klos M, Furspan PB, Jalife J, Dressler GR. 2011.Loss of H3K4 methylation destabilizes gene expression patterns and physiological functions in adult murine cardiomyocytes. J Clin Invest. 2641-2650.

Strickland FM, Hewagama A, Lu Q, Wu A, Hinderer R, Webb R, Johnson K, Sawalha AH, Delaney C, Yung R, Richardson BC. 2011. Environmental exposure, estrogen and two X chromosomes are required for disease development in an epigenetic model of lupus. J Autoimmun. J Autoimmun. 38):J135-143.

Tan M, Zhao Y, Kim S-J, Liu M, Jia L, Saunders TL, Zhu U, Sun Y. 2011. SAG/RBX2/ROC2 E3 Ubiquitin Ligase Is Essential for Vascular and Neural Development by Targeting NF1 for Degradation. Dev Cell. 21:1062-1076.

Terahara K, Nochi T, Yoshida M, Takahashi Y, Goto Y, Hatai H, Kurokawa S, Jang MH, Kweon MN, Domino SE, Hiroi T, Yuki Y, Tsunetsugu-Yokota Y, Kobayashi K, Kiyono H. 2011. Distinct fucosylation of M cells and epithelial cells by Fut1 and Fut2, respectively, in response to intestinal environmental stress. Biochem Biophys Res Commun. 404:822-828.


Waterson RE, Thompson CG, Mabe NW, Kaur K, Talbot JN, Neubig RR, Rorabaugh BR. 2011. G{alpha}i2-mediated protection from ischaemic injury is modulated by endogenous RGS proteins in the mouse heart. Cardiovasc Res. 91: 45-52.

Wei J, Melichian D, Komura K, Hinchcliff M, Lam AP, Lafyatis R, Gottardi CJ, MacDougald OA, Varga J. 2011. Canonical Wnt signaling induces skin fibrosis and subcutaneous lipoatrophy: a novel mouse model for scleroderma? Arthritis Rheum. 63:1707-1717.

Witten IB, Steinberg EE, Lee SY, Davidson TJ, Zalocusky KA, Brodsky M, Yizhar O, Cho SL, Gong S, Ramakrishnan C, Stuber GD, Tye KM, Janak PH, Deisseroth K. 2011. Recombinase-driver rat lines: tools, techniques, and optogenetic application to dopamine-mediated reinforcement. Neuron. 72:721-733.

Wu J, Chen Y, Lu LY, Wu Y, Paulsen MT, Ljungman M, Ferguson DO, Yu X. 2011. Chfr and RNF8 synergistically regulate ATM activation. Nat Struct Mol Biol. 18:761-768.

Yasuda M, Johnson-Venkatesh EM, Zhang H, Parent JM, Sutton MA, Umemori H. 2011. Multiple forms of activity-dependent competition refine hippocampal circuits in vivo. Neuron. 70:1128-1142.

Yu T, Shakkottai VG, Chung C, Lieberman AP. 2011. Temporal and cell-specific deletion establishes that neuronal Npc1 deficiency is sufficient to mediate neurodegeneration.. Hum Mol Genet. 20: 4440-4451.

Zacharias AL, Lewandoski M, Rudnicki MA, Gage PJ. 2011.
Pitx2 is an upstream activator of extraocular myogenesis and survival. Dev Biol. 349:395-405.

Zacharias WJ, Madison BB, Kretovich KE, Walton KD, Richards N, Udager AM, Li X, Gumucio DL. 2011. Hedgehog signaling controls homeostasis of adult intestinal smooth muscle. Dev Biol. 355:152-162.


Zhang K, Wang S, Malhotra J, Hassler JR, Back SH, Wang G, Chang L, Xu W, Miao H, Leonardi R, Chen YE, Jackowski S, Kaufman RJ. 2011.
The unfolded protein response transducer IRE1α prevents ER stress-induced hepatic steatosis. EMBO J. 30:1357-1375.

Zhang B, Zheng C, Zhu M, Tao J, Vasievich MP, Baines A, Kim J, Schekman R, Kaufman RJ, Ginsburg D. 2011. Mice deficient in LMAN1 exhibit FV and FVIII deficiencies and liver accumulation of {alpha}1-antitrypsin. Blood. 118: 3384-3391.

Zhdanova O, Srivastava S, Di L, Li Z, Tchelebi L, Dworkin S, Johnstone DB, Zavadil J, Chong MM, Littman DR, Holzman LB, Barisoni L, Skolnik EY. 2011. The inducible deletion of Drosha and microRNAs in mature podocytes results in a collapsing glomerulopathy. Kidney Int. 80:719-730.

Zhu L, Chang C-H, Dunnick WA. 2011. Excessive amounts of mu heavy chain block B cell development. Int Immunol. 23: 545-551.


2010


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Abe A, Kelly R, Shayman JA. 2010. The measurement of lysosomal phospholipase A2 activity in plasma. J Lipid Res. 51:2464-2470.

Anand S, Majeti BK, Acevedo LM, Murphy EA, Mukthavaram R, Scheppke L, Huang M, Shields DJ, Lindquist JN, Lapinski PE, King PD, Weis SM, Cheresh DA. 2010. MicroRNA-132-mediated loss of p120RasGAP activates the endothelium to facilitate pathological angiogenesis. Nat Med. 16:909-14.


Bjork BC, Fujiwara Y, Davis SW, Qiu H, Saunders TL, Sandy P, Orkin S, Camper SA, Beier DR. 2010. A Transient Transgenic RNAi Strategy for Rapid Characterization of Gene Function during Embryonic Development. PLoS One. 5:e14375.

Brackenbury WJ, Calhoun JD, Chen C, Miyazaki H, Nukina N, Oyama F, Ranscht B, Isom LL. 2010. Functional reciprocity between Na+ channel Nav1.6 and beta1 subunits in the coordinated regulation of excitability and neurite outgrowth. Proc Natl Acad Sci U S A. 107:2283-2288.

Carvalho LR, Brinkmeier ML, Castinetti F, Ellsworth BS, Camper SA. 2010. Corepressors TLE1 and TLE3 interact with HESX1 and PROP1. Mol Endocrinol. 24:754-65.

Chun YH, Lu Y, Hu Y, Krebsbach PH, Yamada Y, Hu JC, Simmer JP. 2010. Transgenic rescue of enamel phenotype in Ambn null mice. J Dent Res. 89:1414-1420.


Daniel JA, Santos MA, Wang Z, Zang C, Schwab KR, Jankovic M, Filsuf D, Chen HT, Gazumyan A, Yamane A, Cho YW, Sun HW, Ge K, Peng W, Nussenzweig MC, Casellas R, Dressler GR, Zhao K, Nussenzweig A. 2010. PTIP promotes chromatin changes critical for immunoglobulin class switch recombination. Science. 329:917-923.

Davis SW, Castinetti F, Carvalho LR, Ellsworth BS, Potok MA, Lyons RH, Brinkmeier ML, Raetzman LT, Carninci P, Mortense AH, Hayashizaki Y, Arnhold IJ, Mendonça BB, Brue T, Camper SA. 2010. Molecular mechanisms of pituitary organogenesis: In search of novel regulatory genes. Mol Cell Endocrinol. 323:4-19.

Depianto D, Kerns ML, Dlugosz AA, Coulombe PA. 2010. Keratin 17 promotes epithelial proliferation and tumor growth by polarizing the immune response in skin. Nat Genet. 42:910-914.


Elrick MJ, Pacheco CD, Yu T, Dadgar N, Shakkottai VG, Ware C, Paulson HL, Lieberman AP. 2010. Conditional Niemann-Pick C mice demonstrate cell autonomous Purkinje cell neurodegeneration. Hum Mol Genet.19:837-847.

El-Zaatari M, Zavros Y, Tessier A, Waghray M, Lentz S, Gumucio D, Todisco A, Merchant JL. 2010. Intracellular calcium-release and protein kinase C-activation stimulate sonic hedgehog gene expression during gastric acid secretion. Gastroenterology. 139:2061-2071.

Hebda-Bauer EK, Pletsch A, Darwish H, Fentress H, Simmons TA, Wei Q, Watson SJ, Akil H. Forebrain glucocorticoid receptor overexpression increases environmental reactivity and produces a stress-induced spatial discrimination deficit. Neuroscience. 169:645-653.

Hodish I, Liu M, Rajpal G, Larkin D, Holz RW, Adams A, Liu L, Arvan P. 2010. Misfolded proinsulin affects bystander proinsulin in neonatal diabetes. J Biol Chem. 285:685-94.

Hurd EA, Poucher HK, Cheng K, Raphael Y, Martin DM. 2010. The ATP-dependent chromatin remodeling enzyme CHD7 regulates pro-neural gene expression and neurogenesis in the inner ear. Development. 137:3139-3150.

Jappar D, Wu SP, Hu Y, Smith DE. 2010 Significance and regional dependency of peptide transporter (PEPT) 1 in the intestinal permeability of glycylsarcosine: in situ single-pass perfusion studies in wild-type and Pept1 knockout mice. Drug Metab Dispos. 38:1740-6.

Kaufman RJ, Back SH, Song B, Han J, Hassler J. 2010. The unfolded protein response is required to maintain the integrity of the endoplasmic reticulum, prevent oxidative stress and preserve differentiation in β-cells. Diabetes Obes Metab. 12 Suppl 2:99-107.

Kitajiri SI, Sakamoto T, Belyantseva IA, Goodyear RJ, Stepanyan R, Fujiwara I, Bird JE, Riazuddin S, Riazuddin S, Ahmed ZM, Hinshaw JE, Sellers J, Bartles JR, Hammer JA 3rd, Richardson GP, Griffith AJ, Frolenkov GI, Friedman TB. 2010. Actin-Bundling Protein TRIOBP Forms Resilient Rootlets of Hair Cell Stereocilia Essential for Hearing. Cell. 141:786 - 798.

Krebs CJ, Robins DM. 2010. A pair of mouse KRAB zinc finger proteins modulates multiple indicators of female reproduction. Biol Reprod. 82:662-668.

Lefevre GM, Patel SR, Kim D, Tessarollo L, Dressler GR. 2010. Altering a histone H3K4 methylation pathway in glomerular podocytes promotes a chronic disease phenotype. PLoS Genet. 6:e1001142.

Leshan RL, Opland DM, Louis GW, Leinninger GM, Patterson CM, Rhodes CJ, Münzberg H, Myers MG Jr. 2010. Ventral tegmental area leptin receptor neurons specifically project to and regulate cocaine- and amphetamine-regulated transcript neurons of the extended central amygdala. J Neurosci. 30:5713-23.

Li JY, Chai BX, Zhang W, Wang H, Mulholland MW. 2010.Expression of ankyrin repeat and suppressor of cytokine signaling box protein 4 (Asb-4) in proopiomelanocortin neurons of the arcuate nucleus of mice produces a hyperphagic, lean phenotype.Endocrinology.151:134-142.


Li X, Corsa CA, Pan PW, Wu L, Ferguson D, Yu X, Min J, Dou Y. 2010. MOF and H4 K16 acetylation play important roles in DNA damage repair by modulating recruitment of DNA damage repair protein Mdc1. Mol Cell Biol. 30:5335-5347.

Lo CM, King A, Samuelson LC, Kindel TL, Rider T, Jandacek RJ, Raybould HE, Woods SC, Tso P. 2010. Cholecystokinin knockout mice are resistant to high-fat diet-induced obesity. Gastroenterology. 138:1997-2005.

Louis GW, Leinninger GM, Rhodes CJ, Myers MG Jr. 2010. Direct innervation and modulation of orexin neurons by lateral hypothalamic LepRb neurons. J Neurosci. 30:11278-11287.

Lu LY, Wu J, Ye L, Gavrilina G, Saunders TL, Yu X. 2010. RNF8-Dependent Histone Modifications Regulate Nucleosome Removal during Spermatogenesis, Dev. Cell. 18:371-384.

Ma H, Togawa A, Soda K, Zhang J, Lee S, Ma M, Yu Z, Ardito T, Czyzyk J, Diggs L, Joly D, Hatakeyama S, Kawahara E, Holzman L, Guan JL, Ishibe S. 2010. Inhibition of Podocyte FAK Protects against Proteinuria and Foot Process Effacement. J Am Soc Nephrol. 21:1145-1156.

Ma K, Hu Y, Smith DE. 2011. Peptide transporter 1 is responsible for intestinal uptake of the dipeptide glycylsarcosine: Studies in everted jejunal rings from wild-type and Pept1 null mice. J Pharm Sci. 100:767-774.

Martin MS, Dutt K, Papale LA, Dubé CM, Dutton SB, de Haan G, Shankar A, Tufik S, Meisler MH, Baram TZ, Goldin AL, Escayg A. 2010. Altered function of the SCN1A voltage-gated sodium channel leads to gamma-aminobutyric acid-ergic (GABAergic) interneuron abnormalities. J Biol Chem. 285:9823-9834.

Mo K, Razak Z, Rao P, Yu Z, Adachi H, Katsuno M, Sobue G, Lieberman AP, Westwood JT, Monks DA. 2010. Microarray analysis of gene expression by skeletal muscle of three mouse models of Kennedy disease/spinal bulbar muscular atrophy. PLoS One. 5:e12922.

Morris DL, Cho KW, Rui L 2010. Critical Role of the Src Homology 2 (SH2) Domain of Neuronal SH2B1 in the Regulation of Body Weight and Glucose Homeostasis in Mice. Endocrinology. 151:3643-3451.

Murai K, Qiu R, Zhang H, Wang J, Wu C, Neubig RR, Lu Q. 2010. Gα subunit coordinates with ephrin-B to balance self-renewal and differentiation in neural progenitor cells.Stem Cells. 28:1581-1589.

Nakada D, Saunders TL, Morrison SJ. 2010. Lkb1 regulates cell cycle and energy metabolism in haematopoietic stem cells. Nature. 468:653-658.

Nishino J, Saunders TL, Sagane K, Morrison SJ. 2010. Lgi4 promotes the proliferation and differentiation of glial lineage cells throughout the developing peripheral nervous system. J Neurosci. 30:15228-15240.

Osorio N, Cathala L, Meisler MH, Crest M, Magistretti J, Delmas P. 2010. Persistent Nav1.6 current at axon initial segments tunes spike timing of cerebellar granule cells. J Physiol. 588:651-670.

Pierce A, Wei R, Halade D, Yoo SE, Ran Q, Richardson A. 2010. A Novel mouse model of enhanced proteostasis: Full-length human heat shock factor 1 transgenic mice. Biochem Biophys Res Commun. 402:59-65.

Robertson S, Ishida-Takahashi R, Tawara I, Hu J, Patterson CM, Jones JC, Kulkarni RN, Myers MG Jr. 2010. Insufficiency of Janus kinase 2-autonomous leptin receptor signals for most physiologic leptin actions. Diabetes. 59:782-90.

Saqui-Salces M, Merchant JL. 2010. Hedgehog signaling and gastrointestinal cancer. Biochim Biophys Acta. 1803:786-795.


Saunders TL. 2010. A survey of internet resources for mouse development. Methods Enzymol. 476:3-21.

Saunders TL, Sobieszczuk P. 2010. 9th transgenic technology meeting (TT2010) in Berlin, Germany: a meeting report. Transgenic Res. 19:1145-1148.

Shinohara M, Mao M, Keeley TM, El-Zaatari M, Lee HJ, Eaton KA, Samuelson LC, Merchant JL, Goldenring JR, Todisco A. 2010. Bone Morphogenetic Protein signaling Regulates Gastric Epithelial Cell Development and Proliferation in Mice. Gastroenterology. 139:2050-2060.

Signarvic RS, Cierniewska A, Stalker TJ, Fong KP, Chatterjee MS, Hess PR, Ma P, Diamond SL, Neubig RR, Brass LF. 2010. RGS/Gi2alpha interactions modulate platelet accumulation and thrombus formation at sites of vascular injury. Blood. 116:6092-6100.

Sisson TH, Mendez M, Choi K, Subbotina N, Courey A, Cunningham A, Dave A, Engelhardt JF, Liu X, White ES, Thannickal VJ, Moore BB, Christensen PJ, Simon RH. 2010. Targeted injury of type II alveolar epithelial cells induces pulmonary fibrosis. Am J Respir Crit Care Med. 181:254-263.

Smalley-Freed WG, Efimov A, Burnett PE, Short SP, Davis MA, Gumucio DL, Washington MK, Coffey RJ, Reynolds AB. 2010. p120-catenin is essential for maintenance of barrier function and intestinal homeostasis in mice. J Clin Invest. 120:1824-1835.

Smith DE, Hu Y, Shen H, Nagaraja TN, Fenstermacher JD, Keep RF. 2011. Distribution of glycylsarcosine and cefadroxil among cerebrospinal fluid, choroid plexus, and brain parenchyma after intracerebroventricular injection is markedly different between wild-type and Pept2 null mice. J Cereb Blood Flow Metab. 31:250-261.


Song W, Ren D, Li W, Jiang L, Cho KW, Huang P, Fan C, Song Y, Liu Y, Rui L. 2010. SH2B regulation of growth, metabolism, and longevity in both insects and mammals. Cell Metab. 11:427-437.


Steenhard BM, Isom K, Stroganova L, St John PL, Zelenchuk A, Freeburg PB, Holzman LB, Abrahamson DR. 2010. Deletion of von Hippel-Lindau in glomerular podocytes results in glomerular basement membrane thickening, ectopic subepithelial deposition of collagen {alpha}1{alpha}2{alpha}1(IV), expression of neuroglobin, and proteinuria. Am J Pathol.177:84-96.

Swaroop A, Kim D, Forrest D. 2010. Transcriptional regulation of photoreceptor development and homeostasis in the mammalian retina. Nat Rev Neurosci. 11:563-576.


Talbot JN, Jutkiewicz EM, Graves SM, Clemans CF, Nicol MR, Mortensen RM, Huang X, Neubig RR, Traynor JR. 2010. RGS inhibition at G(alpha)i2 selectively potentiates 5-HT1A-mediated antidepressant effects. Proc Natl Acad Sci U S A107:11086-91.

Tan M, Zhu Y, Kovacev J, Zhao Y, Pan ZQ, Spitz DR, Sun Y. 2010. Disruption of Sag/Rbx2/Roc2 induces radiosensitization by increasing ROS levels and blocking NF-kappaB activation in mouse embryonic stem cells. Free Radic Biol Med. 49:976-83.

Uebachs M, Opitz T, Royeck M, Dickhof G, Horstmann MT, Isom LL, Beck H.
2010. Efficacy loss of the anticonvulsant carbamazepine in mice lacking sodium channel beta subunits via paradoxical effects on persistent sodium currents. J Neurosci. 30:8489-501.

VanDussen KL, Samuelson LC. 2010. Mouse atonal homolog 1 directs intestinal progenitors to secretory cell rather than absorptive cell fate. Dev Biol. 346:215-223.

Wang HH, Portincasa P, Liu M, Tso P, Samuelson LC, Wang DQ. 2010. Effect of gallbladder hypomotility on cholesterol crystallization and growth in CCK-deficient mice. Biochim Biophys Acta. 1801:138-146.

Wang Y, Heilig KO, Saunders T, Minto AW, Deb DK, Chang A, Brosius FC 3rd, Monteiro C, Heilig CW. 2010.Transgenic Overexpression of GLUT1 in Mouse Glomeruli Produces Renal Disease Resembling Diabetic Glomerulosclerosis. Am J Physiol Renal Physiol. 299:F99-F111.

Westrick RJ, Mohlke KL, Korepta LM, Yang AY, Zhu G, Manning SL, Winn ME, Dougherty KM, Ginsburg D. 2010. Spontaneous Irs1 passenger mutation linked to a gene-targeted SerpinB2 allele. Proc Natl Acad Sci U S A. 107:16904-16909.

Zacharias WJ, Li X, Madison BB, Kretovich K, Kao JY, Merchant JL, Gumucio DL. 2010. Hedgehog Is an Anti-Inflammatory  Epithelial Signal for the Intestinal Lamina Propria. Gastroenterology. 138:2368-77.

Zhang H, Schin M, Saha J, Burke K, Holzman LB, Filipiak WE, Saunders T, Heilig CW, Brosius FC 3rd. 2010. Podocyte Specific Overexpression of GLUT1 Surprisingly Reduces Mesangial Matrix Expansion in Diabetic Nephropathy in Mice. Am J Physiol Renal Physiol.  299:F91-98.

Zhao X, Peng X, Sun S, Park AY, Guan JL. 2010. Role of kinase-independent and -dependent functions of FAK in endothelial cell survival and barrier function during embryonic development. J Cell Biol. 189:955-965.


2009


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Aman TK, Grieco-Calub TM, Chen C, Rusconi R, Slat EA, Isom LL, Raman IM. 2009. Regulation of persistent Na current by interactions between beta subunits of voltage-gated Na channels.J Neurosci. 29:2027-2042.

Back SH, Scheuner D, Han J, Song B, Ribick M, Wang J, Gildersleeve RD, Pennathur S, Kaufman RJ. 2009. Translation attenuation through eIF2alpha phosphorylation prevents oxidateive stress and maintains the differentiated state in beta cells. Cell Metab. 10:13-26.

Belyantseva IA, Perrin BJ, Sonnemann KJ, Zhu M, Stepanyan R, McGee J, Frolenkov GI, Walsh EJ, Friderici KH, Friedman TB, Ervasti JM. 2009. Gamma-actin is required for cytoskeletal maintenance but not development. Proc Natl Acad Sci U S A. 106:9703-9708.

Chang J, Wang Z, Tan, E, Fan Z, McCauley L, Franceschi R, Guan K, Krebsbach PH, Wang CY. 2009. Inhibition of osteoblastic bone formation by nuclear factor-kappaB. Nat. Med. 15: 682-689.

Chrispell JD, Feathers KL, Kane MA, Kim CY, Brooks M, Khanna R, Kurth I, Hübner CA, Gal A, Mears AJ, Swaroop A,Napoli JL, Sparrow JR, Thompson DA. 2009. Rdh12 activity and effects on retinoid processing in the murine retina. J Biol Chem. 284:21468-77.

Coonce MM, Rabideau AC, McGee S, Smith K, Narayan P. 2009. Impact of a constitutively active luteinizing hormone receptor on testicular gene expression and postnatal Leydig cell development.Mol Cell Endocrinol. 298:33-41.

Dai C, Stolz DB, Kiss LP, Monga SP, Holzman LB, Liu Y. 2009. Wnt/beta-catenin signaling promotes podocyte dysfunction and albuminuria. J Am Soc Nephrol. 20:1997-2008.

Diallo-Krou E, Yu J, Colby LA, Inoki K, Wilkinson JE, Thomas DG, Giordano TJ, Koenig RJ. 2009. Paired box gene 8-peroxisome proliferator-activated receptor-gamma fusion protein and loss of phosphatase and tensin homolog synergistically cause thyroid hyperplasia in transgenic mice. Endocrinology. 150:5181-90.

Domino, S. E., Hurd, E. A., Thomsson, K. A., Karnak, D. M., Holmen Larsson, J. M., Thomsson, E., Backstrom, M., Hansson, G. C. 2009. Cervical mucins carry alpha(1,2)fucosylated glycans that partly protect from experimental vaginal candidiasis. Glycoconj. J. 26:1125-1134.

Dunnick WA, Collins JT, Shi J, Westfield G, Fontaine C, Hakimpour P, Papavasiliou FN. 2009. Switch recombination and somatic hypermutation are controlled by the heavy chain 3' enhancer region. J Exp Med. 206:2613-2623.


Fahim, A. T., Wang, H., Feng, J., and Ginsburg, D. 2009. Transgenic overexpression of a stable Plasminogen Activator Inhibitor-1 variant. Thromb. Res. 123: 785-792.

Franceschi, R. T., Ge, C., Xiao, G., Roca, H., and Jiang, D. 2009. Transcriptional regulation of osteoblasts. Cells Tissues Organs 189: 144-152.


Goldenstein BL, Nelson BW, Xu K, Luger EJ, Pribula JA, Wald JM, O'Shea LA, Weinshenker D, Charbeneau RA, Huang X, Neubig RR, Doze VA. 2009. Regulator of G protein signaling protein suppression of Galphao protein-mediated alpha2A adrenergic receptor inhibition of mouse hippocampal CA3 epileptiform activity.Mol Pharmacol. 75:1222-1230.

Girirajan S, Elsea SH. 2009. Abnormal maternal behavior, altered sociability, and impaired serotonin metabolism in Rai1-transgeni c mice. Mamm Genome. 20:247-255.

Harding HP, Zhang Y, Scheuner D, Chen JJ, Kaufman RJ, Ron D. 2009. Ppp1r15 gene knockout reveals an essential role for translation initiation factor 2 alpha (eIF2alpha) dephosphorylation in mammalian development. Proc Natl Acad Sci U S A. 106:1832-7.

He S, Iwashita T, Buchstaller J, Molofsky AV, Thomas D, Morrison SJ. 2009. Bmi-1 over-expression in neural stem/progenitor cells increases proliferation and neurogenesis in culture but has little effect on these functions in vivo. Dev Biol. 328:257-272.

Huang X, Fu Y, Charbeneau RA, Neubig RR. 2009. GNAI2 and regulators of G protein signaling as a potential Noonan syndrome mechanism. Med Hypotheses. 73:56-59.

Icaza EE, Huang X, Fu Y, Neubig RR, Baghdoyan HA, Lydic R. 2009. Isoflurane-induced changes in righting response and breathing are modulated by RGS proteins. Anesth Analg. 109:1500-1500.

Jia L, Oh EC, Ng L, Srinivas M, Brooks M, Swaroop A, Forrest D. 2009. Retinoid-related orphan nuclear receptor ROR{beta} is an early-acting factor in rod photoreceptor development. Proc Natl Acad Sci U S A. 1061:7534-7539.

Jia L, Sun Y. 2009. RBX1/ROC1-SCF E3 ubiquitin ligase is required for mouse embryogenesis and cancer cell survival. Cell Div. 4:16

Jiang H, Hu Y, Keep RF, Smith DE. 2009.  Enhanced antinociceptive response to intracerebroventricular kyotorphin in Pept2 null mice. J Neurochem. 109:1536-43.

Kamal MA, Jiang H, Hu Y, Keep RF, Smith D. 2009. Influence of genetic knockout of Pept2 on the in vivo disposition of endogenous and exogenous carnosine in wild-type and Pept2 null mice.Am J Physiol Regul Integr Comp Physiol. 296:R986-91.

Kim D, Patel SR, Xiao H, Dressler GR. 2009. The role of PTIP in maintaining embryonic stem cell pluripotency. Stem Cells.27:1516-1523.

Kolterud A, Grosse AS, Zacharias WJ, Walton KD, Kretovich KE, Madison BB, Waghray M, Ferris JE, Hu C, Merchant JL, Dlugosz AA, Kottmann AH, Gumucio DL. 2009. Paracrine Hedgehog Signaling in Stomach and Intestine: New Roles for Hedgehog in Gastrointestinal Patterning. Gastroenterology 137:618-628.

Krebs, C. J., Khan, S., MacDonald, J. W., Sorenson, M., and Robins, D. M. 2009. Regulator of sex-limitation KRAB zinc finger proteins modulate sex-dependent and -independent liver metabolism. Physiol. Genomics 38: 16-28.


Kurachi, S., Huo, J. S., Ameri, A., Zhang, K., Yoshizawa, A. C., and Kurachi, K. 2009. An age-related homeostasis mechanism is essential for spontaneous amelioration of hemophilia B Leyden. Proc. Natl. Acad. Sci. U. S. A. 106: 7921-7926.


Lapinski PE, Oliver JA, Bodie JN, Marti F, King PD. 2009. The T-cell-specific adapter protein family: TSAd, ALX, and SH2D4A/SH2D4B. Immunol Rev. 232:240-54.

Layman, W. S., McEwen, D. P., Beyer, L. A., Lalani, S. R., Fernbach, S. D., Oh, E., Swaroop, A., Hegg, C. C., Raphael, Y., Martens, J. R., et al. 2009. Defects in neural stem cell proliferation and olfaction in Chd7 deficient mice indicate a mechanism for hyposmia in human CHARGE syndrome. Hum. Mol. Genet. 18: 1909-1923.

Leshan RL, Louis GW, Jo YH, Rhodes CJ, Münzberg H, Myers MG Jr. 2009. Direct innervation of GnRH neurons by metabolic- and sexual odorant-sensing leptin receptor neurons in the hypothalamic ventral premammillary nucleus. J Neurosci. 29:3138-3147.

Li X, Gonzalez ME, Toy K, Filzen T, Merajver SD, Kleer CG. 2009. Targeted overexpression of EZH2 in the mammary gland disrupts ductal morphogenesis and causes epithelial hyperplasia. Am J Pathol. 175:1246-1254.

Li X, Udager AM, Hu C, Qiao XT, Richards N, Gumucio DL.2009. Dynamic patterning at the pylorus: formation of an epithelial intestine-stomach boundary in late fetal life. Dev Dyn. 238:3205-3217.

Li Y, Gudjonsson, J E, Woods TL, Zhang T, Johnston A, Stoll, SW, Elder JT. 2009. Transgenic expression of S100A2 in hairless mouse skin enhances Cxcl13 mRNA in response to solar-simulated radiation. Arch. Dermatol. Res. 301: 205-217.


Liang H, Balas B, Tantiwong P, Dube J, Goodpaster BH, O'Doherty RM, DeFronzo RA, Richardson A, Musi N, Ward WF. 2009. Whole body overexpression of PGC-1alpha has opposite effects on hepatic and muscle insulin sensitivity. Am J Physiol Endocrinol Metab. 296: E945-E954.

Liang H, Yoo SE, Na R, Walter CA, Richardson A, Ran Q. 2009. Short form glutathione peroxidase 4 is the essential isoform required for survival and somatic mitochondrial functions. J Biol Chem. 284: 30836-30844.


Liu T, Hu B, Choi YY, Chung M, Ullenbruch M, Yu H, Lowe JB, Phan SH. 2009. Notch1 signaling in FIZZ1 induction of myofibroblast differentiation. Am J Pathol. 174: 1745-1755.

Morris DL, Cho KW, Zhou Y, Rui L. 2009. SH2B1 enhances insulin sensitivity by both stimulating the insulin receptor and inhibiting tyrosine dephosphorylation of insulin receptor substrate proteins. Diabetes. 58:2039-2047.


Murrey, H. E., Ficarro, S. B., Krishnamurthy, C., Domino, S. E., Peters, E. C., and Hsieh-Wilson, L. C. 2009. Identification of the Plasticity-Relevant Fucose-(1-2)-Galactose Proteome from Mouse Olfactory Bulb. Biochemistry. 48:7261-7270.

Nasonkin IO, Potok MA, Camper SA. 2009. Cre-mediated recombination in pituitary somatotropes. Genesis. 47: 55-60.

Nelson, L. T., Rakshit, S., Sun, H., and Wellik, D. M. 2008. Generation and expression of a Hoxa11eGFP targeted allele in mice. Dev. Dyn. 237: 3410-3416.

O'Malley HA, Shreiner AB, Chen GH, Huffnagle GB, Isom LL. 2009. Loss of Na+ channel beta2 subunits is neuroprotective in a mouse model of multiple sclerosis. Mol Cell Neurosci. 40:143-155.

Papagerakis P, Hu Y, Ye L, Feng JQ, Simmer JP, Hu JC. 2009. Identifying promoter elements necessary for enamelin tissue-specific expression. Cells Tissues Organs. 189:98-104.


Ragland, R. L., Arlt, M. F., Hughes, E. D., Saunders, T. L., and Glover, T. W. 2009. Mice hypomorphic for Atr have increased DNA damage and abnormal checkpoint response. Mamm. Genome 20:375-385 .

Rosenzweig DH, Nair KS, Levay K, Peshenko IV, Crabb JW, Dizhoor AM, Slepak VZ. 2009. Interaction of retinal guanylate cyclase with the alpha subunit of transducin: potential role in transducin localization. Biochem J. 417:803-812.

Rowe RG, Li XY, Hu Y, Saunders TL, Virtanen I, Garcia de Herreros A, Becker KF, Ingvarsen S, Engelholm LH, Bommer GT, Fearon ER, Weiss SJ. 2009. Mesenchymal cells reactivate Snail1 expression to drive three-dimensional invasion programs. J Cell Biol.184:399-408.
 
Sato Y, Wharram BL, Lee SK, Wickman L, Goyal M, Venkatareddy M, Chang JW, Wiggins JE, Lienczewski C, Kretzler M, Wiggins RC. 2009. Urine podocyte mRNAs mark progression of renal disease. J Am Soc Nephrol. 20:1041-52.

Sabeh, F., Li, X. Y., Saunders, T. L., Rowe, R. G., and Weiss, S. J. 2009. Secreted versus membrane-anchored collagenases: Relative roles in fibroblast-dependent collagenolysis and invasion. J. Biol. Chem. 284:23001-11.
 
Singer BH, Jutkiewicz EM, Fuller CL, Lichtenwalner RJ, Zhang H, Velander A J, Li X, Gnegy ME, Burant CF ,Parent JM. 2009. Conditional ablation and recovery of forebrain neurogenesis in the mouse. J. Comp. Neurol. 514: 567-582.

Sun H. Wang X, Degen JL, Ginsburg D. 2009. Reduced thrombin generation increases host susceptibility to group A streptococcal infection.Blood. 113:1358-64.

Tan M, Davis SW, Saunders TL, Zhu Y, Sun Y. 2009. RBX1/ROC1 disruption results in early embryonic lethality due to proliferation failure, partially rescued by simultaneous loss of p27. Proc Natl Acad Sci U S A. 106:6203-6208.

Van Keuren ML, Gavrilina GB, Filipiak WE, Zeidler MG, Saunders TL. 2009.  Generating transgenic mice from bacterial artificial chromosomes: transgenesis efficiency, integration and expression outcomes. Transgenic Res. 18:769-85.


Vesely ED, Heilig CW, Brosius FC 3rd. 2009. GLUT1-induced cFLIP expression promotes proliferation and prevents apoptosis in vascular smooth muscle cells. Am J Physiol Cell Physiol. 297:C759-765.


Wada M, Saunders TL, Morrow J, Milne GL, Walker KP, Dey SK, Brock TG, Opp MR, Aronoff DM, Smith WL. 2009. Two pathways for cyclooxygenase-2 protein degradation in vivo.J Biol Chem. 284:30742-30753.

Wang HH, Portincasa P, Liu M, Tso P, Samuelson LC, Wang DQ. 2009. Effect of gallbladder hypomotility on cholesterol crystallization and growth in CCK-deficient mice. Biochim Biophys Acta. 1801:138-146.

Wong SY, Seol AD, So PL, Ermilov AN, Bichakjian CK, Epstein EH Jr, Dlugosz AA, Reiter JF. 2009. Primary cilia can both mediate and suppress Hedgehog pathway-dependent tumorigenesis. Nat Med. 15:1055-1061.

 

Yu Z, Wang AM, Robins DM, Lieberman AP. 2009. Altered RNA splicing contributes to skeletal muscle pathology in Kennedy disease knock-in mice. Dis Model Mech. 2:500-507.

Zhou H, Huang C, Yang M, Landel CP, Xia PY, Liu, YJ, Xia, XG. 2009. Developing tTA transgenic rats for inducible and reversible gene expression. Int. J. Biol. Sci. 5: 171-181.


2008


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Akyol A, Hinoi T, Feng Y, Bommer GT, Glaser TM, Fearon ER. 2008. Generating somatic mosaicism with a Cre recombinase-microsatellite sequence transgene. Nat Methods. 5:231-233.

Albertelli MA, O'Mahony OA, Brogley M, Tosoian J, Steinkamp M, Daignault S, Wojno K, Robins DM. 2008. Glutamine tract length of human androgen receptors affects hormone-dependent and -independent prostate cancer in mice. Hum Mol Genet.17:98-110.

Bauler TJ, Hendriks WJ, King PD. 2008. The FERM and PDZ domain-containing protein tyrosine phosphatases, PTPN4 and PTPN3, are both dispensable for T cell receptor signal transduction. PLoS ONE. 2008;3(12):e4014.

Blumer JB, Lord K, Saunders TL, Pacchioni A, Black C, Lazartigues E, Varner KJ, Gettys TW, Lanier SM. 2008. Activator of G protein signaling 3 null mice: I. Unexpected alterations in metabolic and cardiovascular function. Endocrinology. 149:3842-3849.

Blauwkamp MN, Yu J, Schin MA, Burke KA, Berry MJ, Carlson BA, Brosius FC 3rd, Koenig RJ. 2008. Podocyte specific knock out of selenoproteins does not enhance nephropathy in streptozotocin diabetic C57BL/6 mice.  BMC Nephrol. 2008; 9: 7.

Brackenbury WJ, Davis TH, Chen C, Slat EA, Detrow MJ, Dickendesher TL, Ranscht B, Isom LL. 2008. Voltage-gated Na+ channel beta1 subunit-mediated neurite outgrowth requires Fyn kinase and contributes to postnatal CNS development in vivo. J Neurosci. 28:3246-3256.

Charles MA, Mortensen AH, Potok MA, Camper SA. 2008. Pitx2 deletion in pituitary gonadotropes is compatible with gonadal development, puberty, and fertility. Genesis. 46:507-514.

Chauhan AK, Walsh MT, Zhu G, Ginsburg D, Wagner DD, Motto DG. 2008. The combined roles of ADAMTS13 and VWF in murine models of TTP, endotoxemia, and thrombosis.  Blood. 111:3452-7.

Chen L, Na R, Gu M, Salmon AB, Liu Y, Liang H, Qi W, Van Remmen H, Richardson A, Ran Q. 2008. Reduction of mitochondrial H2O2 by overexpressing peroxiredoxin 3 improves glucose tolerance in mice. Aging Cell. 7:866-878.

Chen S, Wassenhove-McCarthy DJ, Yamaguchi Y, Holzman LB, van Kuppevelt TH, Jenniskens GJ, Wijnhoven TJ, Woods AC, McCarthy KJ. 2008. Loss of heparan sulfate glycosaminoglycan assembly in podocytes does not lead to proteinuria. Kidney Int. 74:28-99.

Corpening JC, Cantrell VA, Deal KK, Southard-Smith EM. 2008. A Histone2BCerulean BAC transgene identifies differential expression of Phox2b in migrating enteric neural crest derivatives and enteric glia.Dev Dyn. 237:1119-1132.

Day SM, Coutu P, Wang W, Herron TJ, Turner I, Shillingford M, Lacross NC, Converso KL, Piao L, Li J, Lopatin AN, Metzger JM. 2008. Cardiac-directed parvalbumin transgene expression in mice shows marked heart rate dependence of delayed Ca++ buffering action. Physiol Genomics. 33:312-322.

Elkouby-Naor, L., Abassi, Z., Lagziel, A., Gow, A., and Ben-Yosef, T. 2008. Double gene deletion reveals lack of cooperation between claudin 11 and claudin 14 tight junction proteins. Cell Tissue Res. 333: 427-438.

Egashira N, Minematsu T, Miyai S, Takekoshi S, Camper SA, Osamura RY. 2008. Pituitary Changes in Prop1 Transgenic Mice: Hormone Producing Tumors and Signet-ring Type Gonadotropes. Acta Histochem Cytochem.41:47-57.

Feathers KL, Lyubarsky AL, Khan NW, Teofilo K, Swaroop A, Williams DS, Pugh EN Jr, Thompson DA. 2008. Nrl-Knockout Mice Deficient in Rpe65 Fail to Synthesize 11-cis Retinal and Cone Outer Segments. Invest Ophthalmol Vis Sci. 49: 1126-35.

Gage PJ, Qian M, Wu D, Rosenberg KI. 2008. The canonical Wnt signaling antagonist DKK2 is an essential effector of PITX2 function during normal eye development. Dev Biol.317:310-324.

Gammie SC, Seasholtz AF, Stevenson SA. 2008. Deletion of corticotropin-releasing factor binding protein selectively impairs maternal, but not intermale aggression. Neuroscience. 157:502-512.

Galli C, Zella LA, Fretz JA, Fu Q, Pike JW, Weinstein RS, Manolagas SC, O'Brien CA. 2008. Targeted deletion of a distant transcriptional enhancer of the receptor activator of nuclear factor-kappaB ligand gene reduces bone remodeling and increases bone mass. Endocrinology. 149:146-53.


Girirajan S, Hauck PM, Williams S, Vlangos CN, Szomju BB, Solaymani-Kohal S, Mosier PD, White KL Jr, McCoy K, Elsea SH. 2008. Tom1l2 hypomorphic mice exhibit increased incidence of infections and tumors and abnormal immunologic response. Mamm Genome. 19:246-262.


Girirajan, S., Patel, N., Slager, R. E., Tokarz, M. E., Bucan, M., Wiley, J. L., and Elsea, S. H. 2008. How much is too much? Phenotypic consequences of Rai1 overexpression in mice. Eur. J. Hum. Genet. 16: 941-954.

Gammie SC, Seasholtz AF, Stevenson SA. 2008. Deletion of corticotropin-releasing factor binding protein selectively impairs maternal, but not intermale aggression. Neuroscience. 157:502-12.

Howell VM, de Haan G, Bergren S, Jones JM, Culiat CT, Michaud EJ, Frankel WN, Meisler MH. 2008. A targeted deleterious allele of the splicing factor SCNM1 in the mouse. Genetics. 180:1419-1427.

Hu, Y., Papagerakis, P., Ye, L., Feng, J. Q., Simmer, J. P., and Hu, J. C. 2008. Distal cis-regulatory elements are required for tissue-specific expression of enamelin (Enam). Eur. J. Oral Sci. 116: 113-123

Hu, Y., Smith, D. E., Ma, K., Jappar, D., Thomas, W., and Hillgren, K. M. 2008. Targeted disruption of peptide transporter Pept1 gene in mice significantly reduces dipeptide absorption in intestine. Mol. Pharm. 5: 1122-1130. .

Huang X, Charbeneau RA, Fu Y, Kaur K, Gerin I, MacDougald OA, Neubig RR. 2008. Resistance to diet-induced obesity and improved insulin sensitivity in mice with a regulator of G protein signaling-insensitive G184S Gnai2 allele. Diabetes. 57:77-85.

Jain RN, Al-Menhali AA, Keeley TM, Ren J, El-Zaatari M, Chen X, Merchant JL, Ross TS, Chew CS, Samuelson LC. 2008. Hip1r is expressed in gastric parietal cells and is required for tubulovesicle formation and cell survival in mice. J Clin Invest. 118:2459-70.

Ji B, Song J, Tsou L, Bi Y, Gaiser S, Mortensen R, Logsdon C. 2008. Robust acinar cell transgene expression of CreErT via BAC recombineering. Genesis. 46:390-395.

Jia Q, McDill BW, Sankarapandian B, Wu S, Liapis H, Holzman LB, Capecchi MR, Miner JH, Chen F. 2008. Ablation of developing podocytes disrupts cellular interactions and nephrogenesis both inside and outside the glomerulus. Am J Physiol Renal Physiol. 295:F1790-F1798.


Johnsen JM, Levy GG, Westrick RJ, Tucker PK, Ginsburg D. 2008. The endothelial-specific regulatory mutation, Mvwf1, is a common mouse founder allele. Mamm Genome.  19:32-40.

Kang W, Saqui-Salces M, Zavros Y, Merchant JL. 2008.Induction of follistatin precedes gastric transformation in gastrin deficient mice. Biochem Biophys Res Commun. 376:573-577.

Kim J, Lauderdale JD. 2008. Overexpression of pairedless Pax6 in the retina disrupts corneal development and affects lens cell survival. Dev Biol. 313:434-454.

Lapinski PE, Oliver JA, Kamen LA, Hughes ED, Saunders TL, King PD. 2008. Genetic analysis of SH2D4A, a novel adapter protein related to T cell-specific adapter and adapter protein in lymphocytes of unknown function, reveals a redundant function in T cells. J Immunol. 181:2019-2027.

Lehoczky JA, Innis JW. 2008. BAC transgenic analysis reveals enhancers sufficient for Hoxa13 and neighborhood gene expression in mouse embryonic distal limbs and genital bud. Evol Dev.10:421-432.

Luebke-Wheeler J, Zhang K, Battle M, Si-Tayeb K, Garrison W, Chhinder S, Li J, Kaufman RJ, Duncan SA.2008. Hepatocyte nuclear factor 4alpha is implicated in endoplasmic reticulum stress-induced acute phase response by regulating expression of cyclic adenosine monophosphate responsive element binding protein H. Hepatology. 48:1242-1250.


Lieberman AP, Robins DM. 2008.  The androgen receptor's CAG/glutamine tract in mouse models of neurological disease and cancer. J Alzheimers Dis. 14:247-55.

Lo CM, Samuelson LC, Chambers JB, King A, Heiman J, Jandacek RJ, Sakai RR, Benoit SC, Raybould HE, Woods SC, Tso P. 2008. Characterization of mice lacking the gene for cholecystokinin. Am J Physiol Regul Integr Comp Physiol. 294:R803-10.

Lu LY, Wood JL, Ye L, Minter-Dykhouse K, Saunders TL, Yu X, Chen J. 2008. Aurora A is essential for early embryonic development and tumor suppression. J Biol Chem. 283:31785-31790.

Lu LY, Wood JL, Minter-Dykhouse K, Ye L, Saunders TL, Yu X, Chen J. 2008. Polo-like kinase 1 is essential for early embryonic development and tumor suppression. Mol Cell Biol.28:6870-6876.

Luebke-Wheeler J, Zhang K, Battle M, Si-Tayeb K, Garrison W, Chhinder S, Li J, Kaufman RJ, Duncan SA. 2008. Hepatocyte nuclear factor 4alpha is implicated in endoplasmic reticulum stress-induced acute phase response by regulating expression of cyclic adenosine monophosphate responsive element binding protein H. Hepatology. 48:1242-1250.

McKinney BC, Chow CY, Meisler MH, Murphy GG. 2008, Exaggerated emotional behavior in mice heterozygous null for the sodium channel Scn8a (Nav1.6). Genes Brain Behav. 7:629-638.

Mensah-Osman E, Labut E, Zavros Y, El-Zaatari M, Law DJ, Merchant JL. 2008. Regulated expression of the human gastrin gene in mice. Regul Pept. 151:115-122.

Michael LE, Westerman BA, Ermilov AN, Wang A, Ferris J, Liu J, Blom M, Ellison DW, van Lohuizen M, Dlugosz AA. 2008. Bmi1 is required for Hedgehog pathway-driven medulloblastoma expansion. Neoplasia. 10:1343-1349.

Nelson LT, Rakshit S, Sun H, Wellik DM. 2008. Generation and expression of a Hoxa11eGFP targeted allele in mice. Dev Dyn. 237:3410-3416.

O'Mahony OA, Steinkamp MP, Albertelli MA, Brogley M, Rehman H, Robins DM. 2008. Profiling human androgen receptor mutations reveals treatment effects in a mouse model of prostate cancer.  Mol Cancer Res. 6:1691-1701.

Oh EC, Cheng H, Hao H, Jia L, Khan NW, Swaroop A. Rod differentiation factor NRL activates the expression of nuclear receptor NR2E3 to suppress the development of cone photoreceptors. Brain Res. 1236:16-29.

Palpant NJ, Day SM, Herron TJ, Converso KL, Metzger JM. 2008., Single histidine substituted cardiac troponin I confers protection from age-related systolic and diastolic dysfunction. Cardiovasc Res. 80:209-218.

Pozzi A, Jarad G, Moeckel GW, Coffa S, Zhang X, Gewin L, Eremina V, Hudson BG, Borza DB, Harris RC, Holzman LB, Phillips CL, Fassler R, Quaggin SE, Miner JH, Zent R. 2008. Beta1 integrin expression by podocytes is required to maintain glomerular structural integrity. Dev Biol. 316:288-301.

Robins DM, Albertelli MA, O’Mahony OA. Androgen receptor variants and prostate cancer in humanized AR mice. J Steroid Biochem Mol Biol. 2008 Feb; 108: 230-236.

Rousso DL, Gaber ZB, Wellik D, Morrisey EE, Novitch BG. 2008. Coordinated actions of the forkhead protein Foxp1 and Hox proteins in the columnar organization of spinal motor neurons. Neuron. 59:226-240.


Saul SM, Brzezinski JA 4th, Altschuler RA, Shore SE, Rudolph DD, Kabara LL, Halsey KE, Hufnagel RB, Zhou J, Dolan DF, Glaser T. 2008. Math5 expression and function in the central auditory system. Mol Cell Neurosci. 37:153-169.

Sawalha AH, Jeffries M, Webb R, Lu Q, Gorelik G, Ray D, Osban J, Knowlton N, Johnson K, Richardson B. 2008. Defective T-cell ERK signaling induces interferon-regulated gene expression and overexpression of methylation-sensitive genes similar to lupus patients. Genes Immun. 9:368-378.

Shi S, Yu L, Chiu C, Sun Y, Chen J, Khitrov G, Merkenschlager M, Holzman LB, Zhang W, Mundel P, Bottinger EP. Podocyte-selective deletion of dicer induces proteinuria and glomerulosclerosis. J Am Soc Nephrol. 19:2159-2169.

Skidmore JM, Cramer JD, Martin JF, Martin DM. 2008. Cre fate mapping reveals lineage specific defects in neuronal migration with loss of Pitx2 function in the developing mouse hypothalamus and subthalamic nucleus. Mol Cell Neurosci. 37:696-707.

Tessari A, Pietrobon M, Notte A, Cifelli G, Gage PJ, Schneider MD, Lembo G, Campione M. Myocardial Pitx2 Differentially Regulates the Left Atrial Identity and Ventricular Asymmetric Remodeling Programs. Circ Res 102:813-822.

Tomlins SA, Laxman B, Varambally S, Cao X, Yu J, Helgeson BE, Cao Q, Prensner JR, Rubin MA, Shah RB, Mehra R, Chinnaiyan AM. 2008. Role of the TMPRSS2-ERG gene fusion in prostate cancer.  Neoplasia. 10:177-188.

Yang SH, Andl T, Grachtchouk V, Wang A, Liu J, Syu LJ, Ferris J, Wang TS, Glick AB, Millar SE, Dlugosz AA. 2008. Pathological responses to oncogenic Hedgehog signaling in skin are dependent on canonical Wnt/beta3-catenin signaling. Nat Genet. 40:1130-5.

Yang H, Gumucio DL, Teitelbaum DH. 2008. Intestinal specific overexpression of interleukin-7 attenuates the alternation of intestinal intraepithelial lymphocytes after total parenteral nutrition administration.  Ann Surg. 248:849-856.

Yang H, Madison B, Gumucio DL, Teitelbaum DH. 2008. Specific overexpression of IL-7 in the intestinal mucosa: the role in intestinal intraepithelial lymphocyte development. Am J Physiol Gastrointest Liver Physiol.  294:G1421-30.

Zhang W, Chai B, Li JY, Wang H, Mulholland MW. 2008. Effect of des-acyl ghrelin on adiposity and glucose metabolism. Endocrinology. 149:4710-4716.


2007


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Adams ME, Hurd EA, Beyer LA, Swiderski DL, Raphael Y, Martin DM. 2007. Defects in vestibular sensory epithelia and innervation in mice with loss of Chd7 function: implications for human CHARGE syndrome. J Comp Neurol.  504: 519-32.

Bauler TJ, Hughes ED, Arimura Y,Mustelin T,Saunders TL, King PD.2007. Normal TCR signal transduction in mice that lack catalytically active PTPN3 protein tyrosine phosphatase.  J Immunol. 178:3680-3687.

Bennett CN, Ouyang H, Ma YL, Zeng Q, Gerin I, Sousa KM, Lane TF, Krishnan V, Hankenson KD, MacDougald OA. 2007. Wnt10b increases postnatal bone formation by enhancing osteoblast differentiation. J Bone Miner Res.22:1924-32.

Bommer GT, Gerin I, Feng Y, Kaczorowski AJ, Kuick R, Love RE, Zhai Y, Giordano TJ, Qin ZS, Moore BB, Macdougald OA, Cho KR, Fearon ER. 2007. p53-Mediated Activation of miRNA34 Candidate Tumor-Suppressor Genes. Curr Biol.17:1298-307.

Bradley SV. Hyun TS. Oravecz-Wilson KI. Li L. Waldorff EI. Ermilov AN. Goldstein SA. Zhang CX. Drubin DG. Varela K. Parlow A. Dlugosz AA. Ross TS. 2007. Degenerative phenotypes caused by the combined deficiency of murine HIP1 and HIP1r are rescued by human HIP1.  Human Molecular Genetics. 16:1279-92,

Chen C, Dickendesher DL, Oyama F, Miyazaki H, Nukina N, Isom LL. 2007. Floxed allele for conditional inactivation of the voltage-gated sodium channel 1 subunit Scn1b. Genesis. 45:547-553.

Costa-Mattioli M, Gobert D, Stern E, Gamache K, Colina R, Cuello C, Sossin W, Kaufman R, Pelletier J, Rosenblum K, Krnjević K, Lacaille JC, Nader K, Sonenberg N. 2007. eIF2alpha phosphorylation bidirectionally regulates the switch from short- to long-term synaptic plasticity and memory. Cell.129:195-206.

Davis SW, Camper SA. 2007. Noggin regulates Bmp4 activity during pituitary induction.Dev Biol. 305:145-160.

Dentice M, Luongo C, Huang S, Ambrosio R, Elefante A, Mirebeau-Prunier D, Zavacki AM, Fenzi G, Grachtchouk M, Hutchin M, Dlugosz AA, Bianco AC, Missero C, Larsen PR, Salvatore D.  2007. Sonic hedgehog-induced type 3 deiodinase blocks thyroid hormone action enhancing proliferation of normal and malignant keratinocytes. Proc Natl Acad Sci U S A. 104:14466-14471.

Domino SE, Karnak DM, Hurd EA. 2007. Cell surface fucosylation does not affect development of colon tumors in mice with germline Smad3 mutation. Tumour Biol. 28:77-83.

Drews VL, Shi K, de Haan G, Meisler MH. 2007. Identification of evolutionarily conserved, functional noncoding elements in the promoter region of the sodium channel gene SCN8A. Mamm Genome. 18:723-731.

Elmore CL, Matthews RG. 2007. The many flavors of hyperhomocyst(e)inemia: insights from transgenic and inhibitor-based mouse models of disrupted one-carbon metabolism. Antioxid Redox Signal.9:1911-1921.

Elmore CL, Wu X, Leclerc D, Watson ED, Bottiglieri T, Krupenko NI, Krupenko SA, Cross JC, Rozen R, Gravel RA, Matthews RG. 2007. Metabolic derangement of methionine and folate metabolism in mice deficient in methionine synthase reductase. Mol Genet Metab. 91:85-97.

Fu Y, Huang X, Piao L, Lopatin AN, Neubig RR. 2007. Endogenous RGS proteins modulate SA and AV nodal functions in isolated heart: implications for sick sinus syndrome and AV block. Am J Physiol Heart Circ Physiol. 292:H2532-9.

Ge C, Xiao G, Jiang D, Franceschi RT. 2007. Critical role of the extracellular signal-regulated kinase-MAPK pathway in osteoblast differentiation and skeletal development. J Cell Biol. 176:709-718.

Gong KQ, Yallowitz AR, Sun H, Dressler GR, Wellik DM. 2007.  A Hox-Eya-Pax complex regulates early kidney developmental gene expression. Mol Cell Biol. 27:7661-668.


Gu Q, Bowden GT, Normolle D, Sun Y. 2007. SAG/ROC2 E3 ligase regulates skin carcinogenesis by stage-dependent targeting of c-Jun/AP1 and IkappaB-alpha/NF-kappaB. J Cell Biol. 178:1009-1023.

Haremaki T, Fraser ST, Kuo YM, Baron MH, Weinstein DC. 2007. Vertebrate Ctr1 coordinates morphogenesis and progenitor cell fate and regulates embryonic stem cell differentiation. Proc Natl Acad Sci U S A.104:12029-34.

Harvey SJ, Jarad G, Cunningham J, Rops AL, van der Vlag J, Berden JH, Moeller MJ, Holzman LB, Burgess RW, Miner JH. 2007. Disruption of Glomerular Basement Membrane Charge through Podocyte-Specific Mutation of Agrin Does Not Alter Glomerular Permselectivity. Am J Pathol. 171:139–152.

Hinoi T, A, Theisen BK, Ferguson DO, Greenson JK, Williams BO, Cho KR, Fearon ER. 2007. Mouse model of colonic adenoma-carcinoma progression based on somatic apc inactivation. Cancer Res. 67: 9721-30.

Hu Y, Shen H, Keep RF, Smith DE. 2007. Peptide transporter 2 (PEPT2) expression in brain protects against 5-aminolevulinic acid neurotoxicity. J Neurochem. 103:2058-2065.

Huang X, Charbeneau RA, Fu Y, Kaur K, Gerin I, Macdougald OA, Neubig RR. 2007. Resistance to diet-induced obesity and improved insulin sensitivity in mice with an RGS insensitive G184S Gnai2 allele. Diabetes. 57:77-85.

Hughes ED, Qu YY, Genik SJ, Lyons RH, Pacheco CD, Lieberman AP, Samuelson LC, Nasonkin IO, Camper SA, Van Keuren ML, Saunders TL. 2007. Genetic variation in C57BL/6 ES cell lines and genetic instability in the Bruce4 C57BL/6 ES cell line. Mamm Genome. 18:549-558.

Hurd EA, Capers PL, Blauwkamp MN, Adams ME,  Raphael T, Poucher HK, Martin DM. 2007. Loss of Chd7 function in gene-trapped reporter mice is embryonic lethal and associated with severe defects in multiple developing tissues. Mamm. Genome. 18:94-104.

Jain RN, Samuelson LC. 2007. Transcriptional Profiling of Gastrin-Regulated Genes in Mouse Stomach. Physiol Genomics. 29;1-12.

Kim I, Saunders TL, Morrison SJ. 2007.  Sox17 dependence distinguishes the transcriptional regulation of fetal from adult hematopoietic stem cells. Cell.130:470-483.

Kim D. Wang M. Cai Q. Brooks H. Dressler GR. 2007. Pax transactivation-domain interacting protein is required for urine concentration and osmotolerance in collecting duct epithelia. Journal of the American Society of Nephrology. 18:1458-1465.

Lapinski PE, Bauler TJ, Brown EJ, Hughes ED, Saunders TL, King PD. 2007. Generation of mice with a conditional allele of the p120 Ras GTPase-activating protein. Genesis. 45:762-767.

Lehoczky JA, Innis JW. 2007. A mouse transgene drives embryonic dorsal posterior commissure expression. Transgenic Res. 16:823-8.

López-Díaz L, Jain RN, Keeley TM, VanDussen KL, Brunkan CS, Gumucio DL, Samuelson LC. 2007. Intestinal Neurogenin 3 directs differentiation of a bipotential secretory progenitor to endocrine cell rather than goblet cell fate. Dev Biol. 309:298-305.

Lopez-Santiago LF, Meadows LS, Ernst SJ, Chen C, Malhotra JD, McEwen DP, Speelman A, Noebels JL, Maier SK, Lopatin AN, Isom LL. 2007. Sodium channel Scn1b null mice exhibit prolonged QT and RR intervals. J Mol Cell Cardiol. 43:636-647.

Lu B, Geurts AM, Poirier C, Petit DC, Harrison W, Overbeek PA, Bishop CE. 2007. Generation of rat mutants using a coat color-tagged Sleeping Beauty transposon system. Mamm Genome. 18:338-46.

Matthews RG, Elmore CL. 2007. Defects in homocysteine metabolism: diversity among hyperhomocyst(e)inemias. Clin Chem Lab Med. 45:1700-1703.

Nenci A, Becker C, Wullaert A, Gareus R, van Loo G, Danese S, Huth M, Nikolaev A, Neufert C, Madison B, Gumucio D, Neurath MF, Pasparakis M. 2007. Epithelial NEMO links innate immunity to chronic intestinal inflammation. Nature. 446:557-61.

Newell-Litwa K, Seong E, Burmeister M, Faundez V. 2007. Neuronal and non-neuronal functions of the AP-3 sorting machinery. J Cell Sci. 120(Pt 4):531-541.

Noujaim SF, Pandit SV, Berenfeld O, Vikstrom K, Cerrone M, Mironov S, Zugermayr M, Lopatin AN, Jalife J. 2007. Up-regulation of the inward rectifier K+ current (IK1) in the mouse heart accelerates and stabilizes rotors. J Physiol. 578(Pt 1):315-26.

Oh EC, Khan N, Novelli E, Khanna H, Strettoi E, Swaroop A. 2007. Transformation of cone precursors to functional rod photoreceptors by bZIP transcription factor NRL. PNAS (USA) 104:1679–1684.

Panama BK, McLerie M, Lopatin AN. 2007.  Heterogeneity of IK1 in the mouse heart. Am J Physiol Heart Circ Physiol. 293:H3558-67.

Patel SR, Kim D, Levitan I, Dressler GR. 2007. The BRCT-domain containing protein PTIP links PAX2 to a histone H3, lysine 4 methyltransferase complex.Dev Cell. 13:580-592.


Piao L, Li J, McLerie M, Lopatin AN. 2007.  Transgenic upregulation of IK1 in the mouse heart is proarrhythmic. Basic Res Cardiol. 102:416-28.

Piao L, Li J, McLerie M, Lopatin AN. 2007.Cardiac IK1 underlies early action potential shortening during hypoxia in the mouse heart. J Mol Cell Cardiol. 43:27-38.

Qiao XT. Ziel JW. McKimpson W. Madison BB. Todisco A. Merchant JL. Samuelson LC. Gumucio DL. 2007. Prospective identification of a multilineage progenitor in murine stomach epithelium. Gastroenterology. 133:1989-1998,

Raven MA, Oh EC, Swaroop A, Reese BE. 2007. Afferent control of horizontal cell morphology revealed by genetic respecification of rods and cones. J Neurosci. 27:3540-3547.

Raetzman LT, Cai JX, Camper SA.  2007. Hes1 is required for pituitary growth and melanotrope specification. Dev Biol. 304:455-466.

Ren D, Zhou Y, Morris D, Li M, Li Z, Rui L. 2007. Neuronal SH2B1 is essential for controlling energy and glucose homeostasis. J Clin Invest. 117:397-406.

Rozeboom AM, Akil H, Seasholtz AF. 2007.  Mineralocorticoid receptor overexpression in forebrain decreases anxiety-like behavior and alters the stress response in mice. Proc Natl Acad Sci U S A.104:4688-4693.

Savage JJ, Mullen RD, Sloop KW, Colvin SC, Camper SA, Franklin CL, Rhodes SJ. 2007. Transgenic mice expressing LHX3 transcription factor isoforms in the pituitary: effects on the gonadotrope axis and sex-specific reproductive disease. J Cell Physiol. 212:105-17.

Shen H, Ocheltree SM, Hu Y, Kee, RF, Smith DE. 2007. Impact of genetic knockout of PEPT2 on cefadroxil pharmacokinetics, renal tubular reabsorption and brain penetration in mice. Drug Metabolism and Disposition.  35: 1209-1216.

Soliman GA, Ishida-Takahashi R, Gong Y, Jones JC, Leshan RL, Saunders TL, Fingar DC, Myers MG Jr. 2007. A simple qPCR-based method to detect correct insertion of homologous targeting vectors in murine ES cells. Transgenic Res. 16:665-70.

Suleiman H, Heudobler D, Raschta AS, Zhao Y, Zhao Q, Hertting I, Vitzthum H, Moeller MJ, Holzman LB, Rachel R, Johnson R, Westphal H, Rascle A, Witzgall R. 2007. The podocyte-specific inactivation of Lmx1b, Ldb1 and E2a yields new insight into a transcriptional network in podocytes. Dev Biol. 304:701-12.

Wang SH, Arscott P, Wu P, Baker JR Jr. 2006. No apparent damage in the thyroid of transgenic mice expressing antiapoptotic FLIP. Thyroid. 16:1-8.

Wei Q, Hebda-Bauer EK, Pletsch A, Luo J, Hoversten MT, Osetek AJ, Evans SJ, Watson SJ, Seasholtz AF, Akil H. 2007. Overexpressing the glucocorticoid receptor in forebrain causes an aging-like neuroendocrine phenotype and mild cognitive dysfunction. J Neurosci. 37:8836-8844.

Wiggins RC. 2007. The spectrum of podocytopathies: A unifying view of glomerular diseases. Kidney Int. 71:1205-14.

Wright WS, Longo KA, Dolinsky VW, Gerin I, Kang S, Bennett CN, Chiang SH, Prestwich TC, Gress C, Burant CF, Susulic VS, MacDougald OA. 2007. Wnt10b inhibits obesity in ob/ob and agouti mice. Diabetes. 56:295-303.

Wu J, Rutkowski DT, Dubois M, Swathirajan J, Saunders T, Wang J, Song B, Yau GD, Kaufman RJ. 2007. ATF6alpha Optimizes Long-Term Endoplasmic Reticulum Function to Protect Cells from Chronic Stress. Dev Cell. 13:351-64.

Zavros Y, Waghray M, Tessier A, Bai L, Todisco A, L Gumucio D, Samuelson LC, Dlugosz A, Merchant JL. 2007. Reduced pepsin A processing of sonic hedgehog in parietal cells precedes gastric atrophy and transformation. J Biol Chem. 282:33265-33274.

Zhu A, Sun H, Raymond RM Jr, Furie BC, Furie B, Bronstein M, Kaufman RJ, Westrick R, Ginsburg D.  2007. Fatal hemorrhage in mice lacking {gamma}-glutamyl carboxylase. Blood. 109:5270-5.


 

2006


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Adachi M, Kurotani R, Morimura K, Shah Y, Sanford M, Madison BB, Gumucio DL, Marin HE, Peters JM, Young HA, Gonzalez FJ. 2006. PPAR{gamma} in colonic epithelial cells protects against experimental inflammatory bowel disease. Gut. 55:1104-13.


Ai D, Liu W, Ma L, Dong F, Lu MF, Wang D, Verzi MP, Cai C, Gage PJ, Evans S, Black BL, Brown NA, Martin JF. 2006. Pitx2 regulates cardiac left-right asymmetry by patterning second cardiac lineage-derived myocardium. Dev Biol. 47:4905-9.

Akimoto M, Cheng H, Zhu D; Brzezinski JA, Khanna R, Filippova E, Oh EC, Jing Y, Linares JL, Brooks M, Zareparsi S, Mears AJ, Hero A, Glaser T, Swaroop A, 2006. Targeting of GFP to newborn rods by Nrl promoter and temporal expression profiling of flow-sorted photoreceptors., Proc Natl Acad Sci U S A. 103:3890-3895.

Albertelli MA, Scheller A, Brogley M, Robins DM. 2006. Replacing the mouse androgen receptor with human alleles demonstrates glutamine tract length-dependent effects on physiology and tumorigenesis in mice. Mol Endocrinol. 20):1248-1260.


Cai YH, Alvarez A, Alcaide P, Duramad P, Lim YC, Jarolim P, Lowe JB, Luscinskas FW, Lichtman AH. 2006. Abrogation of functional selectin-ligand expression reduces migration of pathogenic CD8+ T cells into heart. J Immunol. 176:6568-75.

Charles MA, Saunders TL, Wood WM, Owens K, Parlow AF, Camper SA, Ridgway EC, Gordon DF. 2006. Pituitary-specific gata2 knockout: effects on gonadotrope and thyrotrope function. Mol Endocrinol. 20:1366-1377.

Chauhan AK, Motto DG, Lamb CB, Bergmeier W, Dockal M, Plaimauer B, Scheiflinger F, Ginsburg D, Wagner DD. 2006. Systemic antithrombotic effects of ADAMTS13. J Exp Med. 203:767-776.

Cheng H, Aleman TS, Cideciyan AV, Khanna R, Jacobson SG, Swaroop A. 2006. In vivo function of the orphan nuclear receptor NR2E3 in establishing photoreceptor identity during mammalian retinal development. Hum Mol Genet. 15:2588-602.

Cole JN. McArthur JD. McKay FC. Sanderson-Smith ML. Cork AJ. Ranson M. Rohde M. Itzek A. Sun H. Ginsburg D. Kotb M. Nizet V. Chhatwal GS. Walker MJ. 2006. Trigger for group A streptococcal M1T1 invasive disease.  FASEB Journal. 20:1745-1747,

Day SM, Westfall MV, Fomicheva EV, Hoyer K, Yasuda S, La Cross NC, D'Alecy LG, Ingwall JS, Metzger JM. 2006. Histidine button engineered into cardiac troponin I protects the ischemic and failing heart. Nat Med. 12:181-189.

Deal KK, Cantrell VA, Chandler RL, Saunders TL, Mortlock DP, Southard-Smith EM. 2006. Distant regulatory elements in a Sox10-betaGEO BAC transgene are required for expression of Sox10 in the enteric nervous system and other neural crest-derived tissues. Dev Dyn.  235:1413-1432.


Fu Q, Manolagas SC, O'Brien CA. 2006. Parathyroid hormone controls receptor activator of NF-kappaB ligand gene expression via a distant transcriptional enhancer. Mol Cell Biol. 26:6453-68.

Diehl AG, Zareparsi S, Qian M, Khanna R, Angeles R, Gage PJ. 2006. Extraocular muscle morphogenesis and gene expression are regulated by Pitx2 gene dose.Invest Ophthalmol Vis Sci.47:1785-1793.

Dobrzynski H, Billeter R, Greener ID, Tellez JO, Chandler NJ, Flagg TP, Nichols CG, Lopatin AN, Boyett MR. 2006. Expression of Kir2.1 and Kir6.2 transgenes under the control of the alpha-MHC promoter in the sinoatrial and atrioventricular nodes in transgenic mice. J Mol Cell Cardiol. J Mol Cell Cardiol. 41:855-67.

El-Aouni C, Herbach N, Blattner SM, Henger A, Rastaldi MP, Jarad G, Miner JH, Moeller MJ, St-Arnaud R, Dedhar S, Holzman LB, Wanke R, Kretzler M. 2006.  Podocyte-specific deletion of integrin-linked kinase results in severe glomerular basement membrane alterations and progressive glomerulosclerosis. J Am Soc Nephrol. 17:1334-44.

Ellsworth BS, Egashira N, Haller JL, Butts DL, Cocquet J, Clay CM, Osamura RY, Camper SA.  2006. FOXL2 in the Pituitary: Molecular, Genetic and Developmental Analysis. Mol Endocrinol. 20:2796-805.

Filipiak WE, Saunders TL. 2006. Advances in transgenic rat production. Transgenic Res. 15:673-686.

Foulkes T, Nassar MA, Lane T, Matthews EA, Baker MD, Gerke V, Okuse K, Dickenson AH, Wood JN. 2006. Deletion of annexin 2 light chain p11 in nociceptors causes deficits in somatosensory coding and pain behavior. J Neurosci. 26:10499-10507.
Fu Y, Huang X, Zhong H, Mortensen RM, D'Alecy LG, Neubig RR. 2006. Endogenous RGS Proteins and G{alpha} Subtypes Differentially Control Muscarinic and Adenosine-Mediated Chronotropic Effects. Circ Res. 98:659-666.


Godovikova V, Li XR, Saunders TL, Ritchie HH. 2006. A rat 8 kb dentin sialoprotein-phosphophoryn (DSP-PP) promoter directs spatial and temporal LacZ activity in mouse tissues. Dev Biol. 289:507-16.

Grachtchouk M, Liu J, Wang A, Wei L, Bichakjian CK, Garlick J, Paulino AF, Giordano T, Dlugosz AA. 2006. Odontogenic keratocysts arise from quiescent epithelial rests and are associated with deregulated hedgehog signaling in mice and humans. Am J Pathol. 169:806-14.

Hamstra DA, Bhojani MS, Griffin LB, Laxman B, Ross BD, Rehemtulla A. 2006. Real-time evaluation of p53 oscillatory behavior in vivo using bioluminescent imaging. Cancer Res. 66:7482-7489.

Heilig CW, Brosius FC, Cunningham C. 2006. Role for GLUT1 in diabetic glomerulosclerosis. Expert Rev Mol Med. 8:1-18.

 

Hiraoka M, Abe A, Lu Y, Yang K, Han X, Gross RW, Shayman JA. 2006. Lysosomal phospholipase A2 and phospholipidosis. Mol Cell Biol. 26:6139-48.

Huang X, Fu Y, Charbeneau RA, Saunders TL, Taylor DK, Hankenson KD, Russell MW, D'Alecy LG, Neubig RR. 2006. Pleiotropic phenotype of a genomic knock-in of an RGS-insensitive G184S Gnai2 allele. Mol Cell Biol. 26:6870-9.

Jain RN, Samuelson LC. 2006. Differentiation of the gastric mucosa. II. Role of gastrin in gastric epithelial cell proliferation and maturation. Am J Physiol Gastrointest Liver Physiol. 291:G762-5.

Jones RG, Li X, Gray PD, Kuang J, Clayton F, Samowitz WS, Madison BB, Gumucio DL, Kuwada SK. 2006. Conditional deletion of beta1 integrins in the intestinal epithelium causes a loss of Hedgehog expression, intestinal hyperplasia, and early postnatal lethality. J Cell Biol.  175:505-14.

Kanzaki S, Beyer L, Karolyi IJ, Dolan DF, Fang Q, Probst FJ, Camper SA, Raphael Y. 2006. Transgene correction maintains normal cochlear structure and function in 6-month-old Myo15a mutant mice. Hear Res. 214:37-44.

Law DJ, Labut EM, Adams RD, Merchant JL. 2006. An isoform of ZBP-89 predisposes the colon to colitis. Nucleic Acids Res. 34:1342-1350.

Law DJ, Labut EM, Merchant JL. 2006.  Intestinal overexpression of ZNF148 suppresses Apc(Min)/+ neoplasia. Mamm Genome.17:999-1004.

Lehoczky JA, Cai WW, Douglas JA, Moran JL, Beier DR, Innis JW. 2006. Description and genetic mapping of Polypodia: an X-linked dominant mouse mutant with ectopic caudal limbs and other malformations. Mamm Genome. 17:903-13.

Leshan RL, Björnholm M, Münzberg H, Myers MG Jr. 2006. Leptin receptor signaling and action in the central nervous system. Obesity (Silver Spring). 14 Suppl 5:208S-212S.

Levin SI, Khaliq ZM, Aman TK, Grieco TM, Kearney JA, Raman IM, Meisler MH. 2006. Impaired motor function in mice with cell-specific knockout of Na channel Scn8a (NaV1.6) in cerebellar Purkinje neurons and granule cells. J Neurophysiol. 96:785-93.

Li B, Duysen EG, Saunders TL, Lockridge O. 2006. Production of the butyrylcholinesterase knockout mouse. J Mol Neurosci. 30:193-6.

Li M, Ren D, Iseki M, Takaki S, Rui L. 2006. Differential Role of SH2-B and APS in Regulating Energy and Glucose Homeostasis. Endocrinology. 147:2163-2170.

Lin J, Patel SLin J, Patel SR, Wang M, Dressler GR. 2006. The cysteine-rich domain protein KCP is a suppressor of transforming growth factor beta/activin signaling in renal epithelia. Mol Cell Biol. 26:4577-85.

 

Lopez-Diaz L, Hinkle KL, Jain RN, Zavros Y, Brunkan CS, Keeley T, Eaton KA, Merchant JL, Chew CS, Samuelson LC. 2006. Parietal Cell Hyperstimulation and Autoimmune Gastritis in Cholera Toxin Transgenic Mice.  Am J Physiol Gastrointest Liver Physiol. 290:G970-979.

Lopez-Santiago LF, Pertin M, Morisod X, Chen C, Hong S, Wiley J, Decosterd I, Isom LL. 2006. Sodium channel beta2 subunits regulate tetrodotoxin-sensitive sodium channels in small dorsal root ganglion neurons and modulate the response to pain. J Neurosci. 26:7984-94.

 

Ma J, Zeng F, Schultz RM, Tseng H. 2006.  Basonuclin: a novel mammalian maternal-effect gene. Development. 133:2053-2062.

MacLaren RE, Pearson RA, MacNeil A, Douglas RH, Salt TE, Akimoto M, Swaroop A, Sowden JC, Ali RR. 2006. Retinal repair by transplantation of photoreceptor precursors. Nature. 444:203-7.

 
Nose Y, Kim BE, Thiele DJ. 2006. Ctr1 drives intestinal copper absorption and is essential for growth, iron metabolism, and neonatal cardiac function. Cell Metab. 4:235-44.

Nowotschin S, Liao J, Gage PJ, Epstein JA, Campione M, Morrow BE. 2006. Tbx1 affects asymmetric cardiac morphogenesis by regulating Pitx2 in the secondary heart field. Development. 133:1565-73.

Pasca di Magliano M, Sekine S, Ermilov A, Ferris J, Dlugosz AA, Hebrok M. 2006. Hedgehog/Ras interactions regulate early stages of pancreatic cancer. Genes Dev. 20:3161-3173.


Raetzman LT, Wheeler BS, Ross SA, Thomas PQ, Camper SA.  2006. Persistent expression of Notch2 delays gonadotrope differentiation. Mol Endocrinol. 20:2898-90.

 

Reiley WW, Zhang M, Jin W, Losiewicz M, Donohue KB, Norbury CC, Sun S-C. 2006.  Regulation of T cell development by the deubiquitinating enzyme CYLD. Nature Immunology 7:411 –417.

 

Rosen ED, Macdougald OA. 2006. Adipocyte differentiation from the inside out. Nat Rev Mol Cell Biol. 7:885-96.

 

Sarapura VD, Wood WM, Woodmansee WW, Haakinson DJ, Dowding JM, Gordon DF, Ridgway EC. 2006. Pituitary tumors arising from glycoprotein hormone alpha-subunit-deficient mice contain transcription factors and receptors present in thyrotropes. Pituitary. 9:1-8.

Schreiber T, Ehlers S, Aly S, Holscher A, Hartmann S, Lipp M, Lowe JB, Holscher C. 2006. Selectin ligand-independent priming and maintenance of T cell immunity during airborne tuberculosis. J Immunol. 176:1131-1140.

 

Sclafani AM, Skidmore JM, Ramaprakash H, Trumpp A, Gage PJ, Martin DM. 2006. Nestin-Cre mediated deletion of Pitx2 in the mouse. Genesis. 44:336-44.


Shen Y, Bodary PF, Vargas FB, Homeister JW, Gordon D, Ostenso KA, Shayman JA, Eitzman DT. 2006. Alpha-galactosidase A deficiency leads to increased tissue fibrin deposition and thrombosis in mice homozygous for the factor V Leiden mutation. Stroke. 37:1106-1108.

 

Simeone DM, Zhang L, Treutelaar MK, Zhang L, Graziano K, Logsdon CD, Burant CF. 2006. Islet Hypertrophy Following Pancreatic Disruption of Smad4 Signaling. Am J Physiol Endocrinol Metab. 291:E12305-16.

St John JA, Claxton C, Robinson MW, Yamamoto F, Domino SE, Key B. 2006. Genetic manipulation of blood group carbohydrates alters development and pathfinding of primary sensory axons of the olfactory systems. Dev Biol. 298:470-84.

Wang SH. Arscott P. Wu P. Baker JR Jr. 2006. No apparent damage in the thyroid of transgenic mice expressing antiapoptotic FLIP. Thyroid. 16:1-8,

Ward RD, Davis SW, Cho M, Esposito C, Lyons RH, Cheng JF, Rubin EM, Rhodes SJ, Raetzman LT, Smith TP, Camper SA.2007. Comparative genomics reveals functional transcriptional control sequences in the Prop1 gene. Mamm Genome. 18:521-537.

Westphal NJ, Seasholtz AF. 2006. CRH-BP: the regulation and function of a phylogenetically conserved binding protein. Front Biosci.11:1878-91.

Wilkinson Iv J, Di X, Schonig K, Buss JL, Kock ND, Cline JM, Saunders TL, Bujard H, Torti SV, Torti FM. 2006. Tissue-specific expression of ferritin H regulates cellular iron homeostasis in vivo. Biochem J. 395:501-507.

Williams ME, Lehoczky JA, Innis JW. 2006. A group 13 homeodomain is neither necessary nor sufficient for posterior prevalence in the mouse limb. Dev Biol. 297:493-507.

Woodruff-Pak DS, Green JT, Levin SI, Meisler MH. 2006. Inactivation of sodium channel Scn8A (Na-sub(v)1.6) in Purkinje neurons impairs learning in Morris water maze and delay but not trace eyeblink classical conditioning. Behav Neurosci. 120:229-240.

Xiang J, Chiang PP, Hu Y, Smith DE, Keep RF. 2006. Role of PEPT2 in glycylsarcosine transport in astrocyte and glioma cultures. Neurosci Lett. 396:225-9.

Xiang J, Hu Y, Smith DE, Keep RF. 2006. PEPT2-mediated transport of 5-aminolevulinic acid and carnosine in astrocytes. Brain Res. 1122:18-23.

Yu Z, Dadgar N, Albertelli M, Gruis K, Jordan C, Robins DM, Lieberman AP. 2006. Androgen-dependent pathology demonstrates myopathic contribution to the Kennedy disease phenotype in a mouse knock-in model. J Clin Invest. 116:2663-72.

Yu Z, Dadgar N, Albertelli M, Scheller A, Albin RL, Robins DM, Lieberman AP. 2006. Abnormalities of Germ Cell Maturation and Sertoli Cell Cytoskeleton in Androgen Receptor 113 CAG Knock-In Mice Reveal Toxic Effects of the Mutant Protein.  Am J Pathol. 168:195-204.

 

Zhang HZ, Degar BA, Rogoulina S, Resor C, Booth CJ, Sinning J, Gage PJ, Forget BG. 2006. Hematopoiesis following disruption of the Pitx2 homeodomain gene. Exp Hematol. 34:167-78.

 

Zhang K, Shen X, Wu J, Sakaki K, Saunders T, Rutkowski DT, Back SH, Kaufman RJ. 2006. Endoplasmic reticulum stress activates cleavage of CREBH to induce a systemic inflammatory response. Cell. 124:587-599.

 

Zhu M, Lovell KL, Patterson JS, Saunders TL, Hughes ED, Friderici KH. 2006. {beta}-Mannosidosis mice: a model for the human lysosomal storage disease. Hum Mol Genet. 15:493-500.

 


2005

 


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Bennett CN, Longo KA, Wright WS, Suva LJ, Lane TF, Hankenson KD, MacDougald OA. 2005. Regulation of osteoblastogenesis and bone mass by Wnt10b. Proc Natl Acad Sci U S A. 102:3324-3329.

 

Brzezinski JA 4th, Brown NL, Tanikawa A, Bush RA, Sieving PA, Vitaterna MH, Takahashi JS, Glaser T. 2005. Loss of circadian photoentrainment and abnormal retinal electrophysiology in math5 mutant mice.  Invest Ophthalmol Vis Sci. 46:2540-2551.

 

Charles MA, Suh H, Hjalt TA, Drouin J, Camper SA, Gage PJ. 2005.  PITX genes are required for cell survival and Lhx3 activation. Mol Endocrinol.  19:1893-903.

 

Daniele LL, Lillo C, Lyubarsky AL, Nikonov SS, Philp N, Mears AJ, Swaroop A, Williams DS, Pugh EN Jr. 2005. Cone-like morphological, molecular, and electrophysiological features of the photoreceptors of the Nrl knockout mouse. Invest Ophthalmol Vis Sci.46:2156-67.

 

Dunnick WA, Shi J, Graves KA, Collins JT. 2005. The 3' end of the heavy chain constant region locus enhances germline transcription and switch recombination of the four gamma genes. J Exp Med. 201:1459-66.

 

Eitzman DT, Westrick RJ, Shen Y, Bodary PF, Gu S, Manning SL, Dobies SL, Ginsburg D. 2005. Homozygosity for Factor V Leiden Leads to Enhanced Thrombosis and Atherosclerosis in Mice. Circulation. 111:1822-5.

 

Evans AL, Gage PJ. 2005. Expression of the homeobox gene Pitx2 in neural crest is required for optic stalk and ocular anterior segment development. Hum Mol Genet. 15:3347-3359.

 

Flagg TP, Remedi MS, Masia R, Gomes J, McLerie M, Lopatin AN, Nichols CG. 2005.  Transgenic overexpression of SUR1 in the heart suppresses sarcolemmal K(ATP). J Mol Cell Cardiol. 39:647-56.

Gage PJ, Rhoades W, Prucka SK, Hjalt T. 2005. Fate maps of neural crest and mesoderm in the mammalian eye. Invest Ophthalmol Vis Sci. 46:4200-8.

Ginsburg D. 2005. Identifying novel genetic determinants of hemostatic balance. J Thromb Haemost. 8:1561-8.

Hammer GD, Parker KL, Schimmer BP. 2005.  Minireview: transcriptional regulation of adrenocortical development. Endocrinology.146:1018-24.

Hurd EA, Holmen JM, Hansson GC, Domino SE. 2005. Gastrointestinal Mucins of Fut2-Null Mice Lack Terminal Fucosylation without Affecting Colonization by Candida albicans. Glycobiology. 15:1002-1007.

Hutchin ME, Kariapper MS, Grachtchouk M, Wang A, Wei L, Cummings D, Liu J, Michael LE, Glick A, Dlugosz AA. 2005. Sustained Hedgehog signaling is required for basal cell carcinoma proliferation and survival: conditional skin tumorigenesis recapitulates the hair growth cycle. Genes Dev. 19:214-223.

Jain RN, Brunkan CS, Chew CS, Samuelson LC. 2005. Gene Expression Profiling of Gastrin Target Genes in Parietal Cells. Physiol Genomics. 24:124-32

Kang S, Bajnok L, Longo KA, Petersen RK, Hansen JB, Kristiansen K, MacDougald OA. 2005. Effects of Wnt signaling on brown adipocyte differentiation and metabolism mediated by PGC-1alpha. Mol Cell Biol. 25:1272-82. 

Kang W, Rathinavelu S, Samuelson LC, Merchant JL. 2005. Interferon gamma induction of gastric mucous neck cell hypertrophy. Lab Invest. 85:702-715.

Keegan CE, Hutz JE, Else T, Adamska M, Shah SP, Kent AE, Howes JM, Beamer WG, Hammer GD. 2005. Urogenital and caudal dysgenesis in adrenocortical dysplasia (acd) mice is caused by a splicing mutation in a novel telomeric regulator. Hum Mol Genet. 14:113-23.

Kieusseian A, Chagraoui J, Kerdudo C, Mangeot PE, Gage PJ, Navarro N, Izac B, Uzan G, Forget BG, Dubart-Kupperschmitt A. 2005. Expression of Pitx2 in stromal cells is required for normal hematopoiesis. Blood. 107:492-500.

Kurachi K, Kurachi S. 2005. Molecular mechanisms of age-related regulation of genes. J Thromb Haemost. 3:909-914.

Lay JM, Bane G, Brunkan CS, Davis J, Lopez-Diaz L, Samuelson LC. 2005.  Enteroendocrine cell expression of a cholecystokinin gene construct in transgenic mice and cultured cells. Am J Physiol Gastrointest Liver Physiol. 288:G354-61.

Lin J, Patel SR, Cheng X, Cho EA, Levitan I, Ullenbruch M, Phan SH, Park JM, Dressler GR. 2005. Kielin/chordin-like protein, a novel enhancer of BMP signaling, attenuates renal fibrotic disease. Nat Med. 11:387-93.

Madison BB, Braunstein K, Kuizon E, Portman K, Qiao XT, Gumucio DL. 2005. Epithelial hedgehog signals pattern the intestinal crypt-villus axis. Development. 132:279-89.

McEwen E, Kedersha N, Song B, Scheuner D, Gilks N, Han A, Chen JJ, Anderson P, Kaufman RJ. 2005. Heme-regulated inhibitor kinase-mediated phosphorylation of eukaryotic translation initiation factor 2 inhibits translation, induces stress granule formation, and mediates survival upon arsenite exposure. J Biol Chem. 280:16925-33.

McInerney GM, Kedersha NL, Kaufman RJ, Anderson P, Liljestrom P. 2005. Importance of eIF2alpha phosphorylation and stress granule assembly in alphavirus translation regulation. Mol Biol Cell. 16:3753-63.

Meadows LS, Isom LL. 2005. Sodium channels as macromolecular complexes: Implications for inherited arrhythmia syndromes.  Cardiovasc Res. 67:448-58.

Meehan TP, Harmon BG, Overcast ME, Yu KK, Camper SA, Puett D, Narayan P. 2005. Gonadal defects and hormonal alterations in transgenic mice expressing a single chain human chorionic gonadotropin-lutropin receptor complex. J Mol Endocrinol. 34:489-503.

Moeller MJ, Soofi A, Sanden SK, Floege J, Kriz W, Holzman LB. 2005.  An efficient system for tissue-specific over-expression of transgenes in podocytes in vivo. Am J Physiol Renal Physiol.  289:F481-8.

Molinari M, Galli C, Vanoni O, Arnold SM, Kaufman RJ. 2005. Persistent glycoprotein misfolding activates the glucosidase II/UGT1-driven calnexin cycle to delay aggregation and loss of folding competence. Mol Cell. 20:503-12.

Motto DG, Chauhan AK, Zhu G, Homeister J, Lamb CB, Desch KC, Zhang W, Tsai HM, Wagner DD, Ginsburg D. 2005. Shigatoxin triggers thrombotic thrombocytopenic purpura in genetically susceptible ADAMTS13-deficient mice.  J Clin Invest. 115:2752-61.

Nabulsi NB, Smith DE, Kilbourn MR. 2005. [(11)C]Glycylsarcosine: synthesis and in vivo evaluation as a PET tracer of PepT2 transporter function in kidney of PepT2 null and wild-type mice. Bioorg Med Chem. 13:2993-3001.

Nikonov SS, Daniele LL, Zhu X, Craft CM, Swaroop A, Pugh EN Jr. 2005. Photoreceptors of Nrl -/- mice coexpress functional S- and M-cone opsins having distinct inactivation mechanisms. J Gen Physiol. 125:287-304.

Ocheltree SM, Shen H, Hu Y, Keep RF, Smith DE. 2005. Role and relevance of peptide transporter 2 (PEPT2) in the kidney and choroid plexus: in vivo studies with glycylsarcosine in wild-type and PEPT2 knockout mice. J Pharmacol Exp Ther. 31:240-7.

Park SY, Meeks JJ, Raverot G, Pfaff LE, Weiss J, Hammer GD, Jameson JL. 2005. Nuclear receptors Sf1 and Dax1 function cooperatively to mediate somatic cell differentiation during testis development. Development. 132:2415-23.

Piccio L, Rossi B, Colantonio L, Grenningloh R, Gho A, Ottoboni L, Homeister JW, Scarpini E, Martinello M, Laudanna C, D'Ambrosio D, Lowe JB, Constantin G. 2005. Efficient recruitment of lymphocytes in inflamed brain venules requires expression of cutaneous lymphocyte antigen and fucosyltransferase-VII. J Immunol. 174:5805-13.

Ren D, Li M, Duan C, Rui L.2005. Identification of SH2-B as a key regulator of leptin sensitivity, energy balance, and body weight in mice. Cell Metab. 2:95-104.

Rieder G, Tessier AJ, Qiao XT, Madison B, Gumucio DL, Merchant JL. 2005. Helicobacter-induced intestinal metaplasia in the stomach correlates with Elk-1 and serum response factor induction of villin. J Biol Chem. 280:4906-12.

Roessler E, Ermilov AN, Grange DK, Wang A, Grachtchouk M, Dlugosz AA, Muenke M. 2005. A previously unidentified amino-terminal domain regulates transcriptional activity of wild-type and disease-associated human GLI2. Hum Mol Genet. 14:2181-2188.

Satoh T, Kanai Y, Wu MH, Yokozeki H, Kannagi R, Lowe JB, Nishioka K. 2005. Synthesis of {alpha}(1,3) Fucosyltransferases IV- and VII-Dependent Eosinophil Selectin Ligand and Recruitment to the Skin. Am J Pathol. 167:787-96.

Scheuner D, Mierde DV, Song B, Flamez D, Creemers JW, Tsukamoto K, Ribick M, Schuit FC, Kaufman RJ. 2005. Control of mRNA translation preserves endoplasmic reticulum function in beta cells and maintains glucose homeostasis. Nat Med. 11:757-64.

Seong E, Wainer BH, Hughes ED, Saunders TL, Burmeister M, Faundez V. 2005. Genetic analysis of the neuronal and ubiquitous AP-3 adaptor complexes reveals divergent functions in brain. Mol Biol Cell. 16:128-40.

Shen H, Keep RF, Hu Y, Smith DE. 2005. PEPT2 (Slc15a2)-Mediated Unidirectional Transport of Cefadroxil from Cerebrospinal Fluid into Choroid Plexus. J Pharmacol Exp Ther. 315:1101-8.

Siegmund K, Feuerer M, Siewert C, Ghani S, Haubold U, Dankof A, Krenn V, Schon MP, Scheffold A, Lowe JB, Hamann A, Syrbe U, Huehn J. 2005. Migration matters: regulatory T-cell compartmentalization determines suppressive activity in vivo. Blood. 106:3097-104.

van den Buuse M, van Driel IR, Samuelson LC, Pijnappel M, Martin S. 2005. Reduced effects of amphetamine on prepulse inhibition of startle in gastrin-deficient mice. Neurosci Lett. 373:237-42.

Vesper AH, Raetzman LT, Camper SA. 2005. Role of PROP1 in gonadotrope differentiation and puberty. Endocrinology. 147:1654-1663.

Ward RD, Raetzman LT, Suh H, Stone BM, Nasonkin IO, Camper SA. 2005. Role of PROP1 in pituitary gland growth. Mol Endocrinol. 19:698-710.

Wharram BL, Goyal M, Wiggins JE, Sanden SK, Hussain S, Filipiak WE, Saunders TL, Dysko RC, Kohno K, Holzman LB, Wiggins RC. 2005.  Podocyte Depletion Causes Glomerulosclerosis: Diphtheria Toxin-Induced Podocyte Depletion in Rats Expressing Human Diphtheria Toxin Receptor Transgene. J Am Soc Nephrol. J Am Soc Nephrol.16:2941-52.

Xiang J, Chiang PP, Hu Y, Smith DE, Keep RF. 2005. Role of PEPT2 in glycylsarcosine transport in astrocyte and glioma cultures. Neurosci Lett. 396:225-9.

Zavros Y, Eaton KA, Kang W, Rathinavelu S, Katukuri V, Kao JY, Samuelson LC, Merchant JL. 2005. Chronic gastritis in the hypochlorhydric gastrin-deficient mouse progresses to adenocarcinoma. Oncogene. 24:2354-66.

Zhang K, Wong HN, Song B, Miller CN, Scheuner D, Kaufman RJ. 2005.  The unfolded protein response sensor IRE1alpha is required at 2 distinct steps in B cell lymphopoiesis. J Clin Invest. 115:268-81.


2004

 


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Adamska M, MacDonald BT, Sarmast ZH, Oliver ER, Meisler MH. 2004. En1 and Wnt7a interact with Dkk1 during limb development in the mouse. Dev Biol.272:134-44.

Akimoto M, Filippova E, Gage PJ, Zhu X, Craft CM, Swaroop A. 2004 Transgenic mice expressing Cre-recombinase specifically in M- or S-cone photoreceptors. Invest Ophthalmol Vis Sci.45:42-7.

Berton MT, Linehan LA, Wick KR, Dunnick WA. 2004.  NF-kappaB elements associated with the Stat6 site in the germline gamma1 immunoglobulin promoter are not necessary for the transcriptional response to CD40 ligand. Int Immunol. 16:1741-9.

Chen C, Westenbroek RE, Xu X, Edwards CA, Sorenson DR, Chen Y, McEwen DP, O'Malley HA, Bharucha V, Meadows LS, Knudsen GA, Vilaythong A, Noebels JL, Saunders TL, Scheuer T, Shrager P, Catterall WA, Isom LL. 2004. Mice lacking sodium channel beta1 subunits display defects in neuronal excitability, sodium channel expression, and nodal architecture. J Neurosci. 24:4030-4042.

Chen D, Zhao CM, Hakanson R, Samuelson LC, Rehfeld JF, Friis-Hansen L. 2004. Altered control of gastric acid secretion in gastrin-cholecystokinin double mutant mice. Gastroenterology. 2004 126:476-87.

Dang L, Pulukuri S, Mears AJ, Swaroop A, Reese BE, Sitaramayya A.. 2004. Connexin 36 in photoreceptor cells: studies on transgenic rod-less and cone-less mouse  retinas. Mol Vis. 10:323-7.

Davis TH, Chen C, Isom LL. 2004. Sodium channel beta1 subunits promote neurite outgrowth in cerebellar granule neurons. J Biol Chem. 279:51424-32.

Domino SE, Hurd EA. 2004. LacZ expression in Fut2-LacZ reporter mice reveals estrogen-regulated endocervical glandular expression during estrous cycle, hormone replacement, and pregnancy. Glycobiology. 14:169-75.

Duan C, Yang H, White MF, Rui L. 2004. Disruption of the SH2-B gene causes age-dependent insulin resistance and glucose intolerance. Mol Cell Biol. 17:7435-43.

Dunnick WA, Shi J, Graves KA, Collins JT. 2004. Germline transcription and switch recombination of a transgene containing the entire H chain constant region locus: effect of a mutation in a STAT6 binding site in the gamma 1 promoter. J Immunol.  Nov 1;173(9):5531-9.

Franic TV, Judd M, Nguyen NV, Samuelson LC, Loveland KL, Giraud AS, Gleeson PA, Van Driel IR. 2004. Growth factors associated with gastric mucosal hypertrophy in autoimmune gastritis. Am J Physiol Gastrointest Liver Physiol.  287:G910-8.

Fu Y, Zhong H, Nanamori M, Mortensen RM, Huang X, Lan K, Neubig RR. 2004. RGS-insensitive G-protein mutations to study the role of endogenous RGS proteins. Methods Enzymol. 389:229-43

Homeister JW, Daugherty A, Lowe JB. 2004. {alpha}(1,3)Fucosyltransferases FucT-IV and FucT-VII Control Susceptibility to Atherosclerosis in Apolipoprotein E-/- Mice. Arterioscler Thromb Vasc Biol. 24:1897-903.

Hurd, EA., Domino, SE. 2004 Increased susceptibility of secretor factor gene Fut2-null mice to experimental vaginal candidiasis. Infect Immun. 72:4279-81.

Hyun TS, Li L, Oravecz-Wilson KI, Bradley SV, Provot MM, Munaco AJ, Mizukami IF, Sun H, Ross TS. 2004. Hip1-related mutant mice grow and develop normally but have accelerated spinal abnormalities and dwarfism in the absence of HIP1. Mol Cell Biol. 24:4329-40.

Imaizumi K, Benito A, Kiryu-Seo S, Gonzalez V, Inohara N, Leiberman AP, Kiyama H, Nunez G. 2004. Critical role for DP5/Harakiri, a Bcl-2 homology domain 3-only Bcl-2 family member, in axotomy-induced neuronal cell death. J Neurosci. 24:3721-5.

Iwamori M, Domino SE. 2004. Tissue-specific loss of fucosylated glycolipids in mice with targeted deletion of alpha(1,2)fucosyltransferase genes.
Biochem J.380:75-81.


Jiang D, Franceschi RT, Boules H, Xiao G. 2004. Parathyroid hormone induction of the osteocalcin gene. Requirement for an osteoblast-specific element 1 sequence in the promoter and involvement of multiple-signaling pathways. J Biol Chem. 279:5329-37.

Kaur S, Norkina O, Ziemer D, Samuelson LC, De Lisle RC. 2004. Acidic duodenal pH alters gene expression in the cystic fibrosis mouse pancreas. Am J Physiol Gastrointest Liver Physiol. 287:G480-90.

Kubisch C, Dimagno MJ, Tietz AB, Welsh MJ, Ernst SA, Brandt-Nedelev B, Diebold J, Wagner AC, Goke B, Williams JA, Schafer C. 2004. Overexpression of heat shock protein Hsp27 protects against cerulein-induced pancreatitis. Gastroenterology.  127:275-86.

Lehoczky JA, Williams ME, Innis JW. 2004. Conserved expression domains for genes upstream and within the HoxA and HoxD clusters suggests a long-range enhancer existed before cluster duplication. Evol Dev. 6:423-30.

Levin SI, Meisler MH. 2004. Floxed allele for conditional inactivation of the voltage-gated sodium channel Scn8a (Na(v)1.6). Genesis. 2004 39:234-9.

Li J, McLerie M, Lopatin AN. 2004. Transgenic Up-Regulation of IK1 in The Mouse Heart Leads to Multiple Abnormalities of Cardiac Excitability. Am J Physiol Heart Circ Physiol. 287:H2790-80.

Longo KA, Wright WS, Kang S, Gerin I, Chiang SH, Lucas PC, Opp MR, MacDougald OA. Wnt10b inhibits development of white and brown adipose tissues. J Biol Chem.  2004 Aug 20;279(34):35503-9.

MacDonald BT, Adamska M, Meisler MH. 2004. Hypomorphic expression of Dkk1 in the doubleridge mouse: dose dependence and compensatory interactions with Lrp6. Development. 131:2543-52.

Martin DM, Skidmore JM, Philips ST, Vieira C, Gage PJ, Condie BG, Raphael Y, Martinez S, Camper SA. 2004. PITX2 is required for normal development of neurons in the mouse subthalamic nucleus and midbrain. Dev Biol. 267:93-108.

Martins RP, Ostermeier GC, Krawetz SA. 2004. Nuclear matrix interactions at the human protamine domain: a working model of potentiation. J Biol Chem. 279:51862-8.

Moeller MJ, Soofi A, Hartmann I, Le Hir M, Wiggins R, Kriz W, Holzman LB. 2004. Podocytes populate cellular crescents in a murine model of inflammatory  glomerulonephritis. J Am Soc Nephrol.15:61-7.

Nasonkin IO, Ward RD, Raetzman LT, Seasholtz AF, Saunders TL, Gillespie PJ, Camper SA. Pituitary hypoplasia and respiratory distress syndrome in Prop1 knockout mice. Hum Mol Genet. 2004 Nov 15;13(22):2727-35.

Ocheltree SM, Shen H, Hu Y, Xiang J, Keep RF, Smith DE. 2004. Mechanisms of cefadroxil uptake in the choroid plexus: studies in wild-type and PEPT2 knockout mice. J Pharmacol Exp Ther.308:462-7.

Ocheltree SM, Shen H, Hu Y, Xiang J, Keep RF, Smith DE. 2004. Role of PEPT2 in the choroid plexus uptake of glycylsarcosine and 5-aminolevulinic acid: studies in wild-type and null mice. Pharm Res. 21:1680-5.

Oliver ER, Saunders TL, Tarle SA, Glaser T. 2004. Ribosomal protein L24 defect in Belly spot and tail (Bst), a mouse Minute. Development. 131:3907-20.

Oravecz-Wilson KI, Kiel MJ, Li L, Rao DS, Saint-Dic D, Kumar PD, Provot MM, Hankenson KD, Reddy VN, Lieberman AP, Morrison SJ, Ross TS. 2004. Huntingtin Interacting Protein 1 mutations lead to abnormal hematopoiesis, spinal defects and cataracts. Hum Mol Genet. 13:851-67.

Patel SR, Dressler GR. 2004. Expression of Pax2 in the intermediate mesoderm is regulated by YY1. Dev Biol. 267:505-16.

Parker AC, Mundada LV, Schmaier AH, Fay WP. 2004. Factor V Leiden inhibits fibrinolysis in vivo. Circulation. 110:3594-8.

Pittler SJ, Zhang Y, Chen S, Mears AJ, Zack DJ, Ren Z, Swain PK, Yao S, Swaroop A, White JB. 2004. Functional analysis of the rod photoreceptor cGMP phosphodiesterase alpha-subunit gene promoter: Nrl and Crx are required for full transcriptional activity. J Biol Chem. 179:19800-7.

Raetzman LT, Ross SA, Cook S, Dunwoodie SL, Camper SA, Thomas PQ. 2004. Developmental regulation of Notch signaling genes in the embryonic pituitary: Prop1 deficiency affects Notch2 expression. Dev Biol.265:329-40.

Sun H, Ringdahl U, Homeister JW, Fay WP, Engleberg NC, Yang AY, Rozek LS, Wang X, Sjobring U, Ginsburg D. 2004. Plasminogen is a critical host pathogenicity factor for group A streptococcal infection. Science. 305:1283-6.

Seong E, Saunders TL, Stewart CL, Burmeister M.2004. To knockout in 129 or in C57BL/6: that is the question. Trends Genet. 20:59-62.

Strettoi E, Mears AJ, Swaroop A. 2004. Recruitment of the rod pathway by cones in the absence of rods. J Neurosci. 24:7576-82.

Teuscher NS, Shen H, Shu C, Xiang J, Keep RF, Smith DE. 2004. Carnosine uptake in rat choroid plexus primary cell cultures and choroid plexus whole tissue from PEPT2 null mice. J Neurochem. 91:1024.

Teuscher NS, Shen H, Shu C, Xiang J, Keep RF, Smith DE. 2004. Carnosine uptake in rat choroid plexus primary cell cultures and choroid plexus whole tissue from PEPT2 null mice. J Neurochem. 89:375-82.

Van Keuren ML, Saunders TL. 2004.Rederivation of Transgenic and Gene-Targeted Mice by Embryo Transfer. Transgenic Res. 13:363-371.

Wang Y, Boeck AT, Duysen EG, Van Keuren M, Saunders TL, Lockridge O. 2004. Resistance to organophosphorus agent toxicity in transgenic mice expressing the G117H mutant of human butyrylcholinesterase. Toxicol Appl Pharmacol. 196:356-66.

Wei Q, Lu XY, Liu L, Schafer G, Shieh KR, Burke S, Robinson TE, Watson SJ, Seasholtz AF, Akil H. 2004.Glucocorticoid receptor overexpression in forebrain: a mouse model of increased emotional lability. Proc Natl Acad Sci U S A. 101:11851-6.


2003

 


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Adamska M, MacDonald BT, Meisler MH. 2004. Doubleridge, a mouse mutant with defective compaction of the apical ectodermal ridge and normal dorsal-ventral patterning of the limb. Dev Biol. 2003 Mar 15;255(2):350-62.

Ameri A, Kurachi S, Sueishi K, Kuwahara M, Kurachi K. 2003. Myocardial fibrosis in mice with overexpression of human blood coagulation factor IX. Blood. 101(5):1871-3.

Becker DJ, Myers JT, Ruff MM, Smith PL, Gillespie BW, Ginsburg DW, Lowe JB. 2003. Strain-specific modification of lethality in fucose-deficient mice. Mamm Genome. 14:130-9.

Ben-Yosef T, Belyantseva IA, Saunders TL, Hughes ED, Kawamoto K, Van Itallie CM, Beyer LA, Halsey K, Gardner DJ, Wilcox ER, Rasmussen J, Anderson JM, Dolan DF, Forge A, Raphael Y, Camper SA, Friedman TB. 2003. Claudin 14 knockout mice, a model for autosomal recessive deafness DFNB29, are deaf due to cochlear hair cell degeneration. Hum Mol Genet. 12(16):2049-2061.

Cho EA, Prindle MJ, Dressler GR. 2003. BRCT domain-containing protein PTIP is essential for progression through mitosis. Mol Cell Biol. 23:1666-73.

Gopalakrishnan R, Thomas PE, Benson MD, Wang D, Franceschi RT. 2003. A homeodomain protein binding element in the bone sialoprotein promoter is critical for tissue-specific expression in bone. Connect Tissue Res. 44:154-60.

Grachtchouk V, Grachtchouk M, Lowe L, Johnson T, Wei L, Wang A, de Sauvage F, Dlugosz AA. 2003 The magnitude of hedgehog signaling activity defines skin tumor phenotype.EMBO J. 22:2741-51.

Heilig CW, Saunders T, Brosius FC 3rd, Moley K, Heilig K, Baggs R, Guo L, Conner D.2003. Glucose transporter-1-deficient mice exhibit impaired development and deformities that are similar to diabetic embryopathy. Proc Natl Acad Sci U S A.100:15613-8. 

Hinkle KL, Bane GC, Jazayeri A, Samuelson LC. 2003. Enhanced calcium signaling and acid secretion in parietal cells isolated from gastrin-deficient mice. Am J Physiol Gastrointest Liver Physiol. 284(1):G145-53.

Jahroudi N, Schmaier A, Srikanth S, Mahdi F, Lutka FA, Bowser R. 2003. Von Willebrand factor promoter targets the expression of amyloid beta protein precursor to brain vascular endothelial cells of transgenic mice. J Alzheimers Dis. 5:149-58.

Jones JM, Datta P, Srinivasula SM, Ji W, Gupta S, Zhang Z, Davies E, Hajnoczky G, Saunders TL, Van Keuren ML, Fernandes-Alnemri T, Meisler MH, Alnemri ES. 2003. Nature. 425:721-7.

Krebs CJ, Larkins LK, Price R, Tullis KM, Miller RD, Robins DM. 2003. Regulator of sex-limitation (Rsl) encodes a pair of KRAB zinc-finger genes that control sexually dimorphic liver gene expression. Genes Dev.17:2664-74.

Marcil A, Dumontier E, Chamberland M, Camper SA, Drouin J.2003. Pitx1 and Pitx2 are required for development of hindlimb buds. Development. 130:45-55.

McLerie M, Lopatin A.2003. Dominant-negative suppression of I(K1) in the mouse heart leads to altered cardiac excitability. J Mol Cell Cardiol. 35:367-78.

Mill P, Mo R, Fu H, Grachtchouk M, Kim PC, Dlugosz AA, Hui CC. 2003. Sonic hedgehog-dependent activation of Gli2 is essential for embryonic hair follicle development. Genes Dev. 17:282-94.

Moeller MJ, Sanden SK, Soofi A, Wiggins RC, Holzman LB. 2003. Podocyte-specific expression of cre recombinase in transgenic mice. Genesis. 2003 Jan;35(1):39-42.

Norman LP, Jiang W, Han X, Saunders TL, Bond JS. 2003. Targeted disruption of the meprin Beta gene in mice leads to underrepresentation of knockout mice and changes in renal gene expression profiles. Mol Cell Biol. Feb;23(4):1221-30.

Samuelson LC, Hinkle KL. 2003. Insights into the regulation of gastric Acid secretion through analysis of genetically engineered mice. Annu Rev Physiol. 65:383-400.

Saunders TL. 2003. Reporter molecules in genetically engineered mice. Methods Mol Biol.209:125-43.

Shen H, Smith DE, Keep RF, Xiang J, Brosius FC 3rd. 2003. Targeted disruption of the PEPT2 gene markedly reduces dipeptide uptake in choroid plexus. J Biol Chem. 278(7):4786-91.

Shigehara T, Zaragoza C, Kitiyakara C, Takahashi H, Lu H, Moeller M, Holzman LB, Kopp JB. 2003. Inducible podocyte-specific gene expression in transgenic mice. J Am Soc Nephrol. 14:1998-2003.

Sun FJ, Kaur S, Ziemer D, Banerjee S, Samuelson LC, De Lisle RC. 2003. Decreased gastric bacterial killing and up-regulation of protective genes in small intestine in gastrin-deficient mouse. Dig Dis Sci. 48:976-85.

Sun H, Yang TL, Yang A, Wang X, Ginsburg D. 2003. The murine platelet and plasma factor V pools are biosynthetically distinct and sufficient for minimal hemostasis. Blood. 102:2856-61.

Swain JE, Wang X, Saunders TL, Dunn R, Smith GD. 2003. Specific inhibition of mouse oocyte nuclear protein phosphatase-1 stimulates germinal vesicle breakdown. Mol Reprod Dev. 65:96-103.

Van Mater D, Kolligs FT, Dlugosz AA, Fearon ER. 2003. Transient activation of beta -catenin signaling in cutaneous keratinocytes is sufficient to trigger the active growth phase of the hair cycle in mice. Genes Dev. 17:1219-24.

Yang TL, Pipe SW, Yang A, Ginsburg D. 2003. Biosynthetic origin and functional significance of murine platelet factor V. Blood.102:2851-5.


2002

 


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Babu PS, Bavers DL, Beuschlein F, Shah S, Jeffs B, Jameson JL, Hammer GD. 2002. Interaction between Dax-1 and steroidogenic factor-1 in vivo: increased adrenal responsiveness to ACTH in the absence of Dax-1.  Endocrinology. Feb;143(2):665-73.

Braunstein EM, Qiao XT, Madison B, Pinson K, Dunbar L, Gumucio DL. 2002. Villin: A marker for development of the epithelial pyloric border.  Dev Dyn. 224:90-102.

Chen C, Bharucha V, Chen Y, Westenbroek RE, Brown A, Malhotra JD, Jones D, Avery C, Gillespie PJ 3rd, Kazen-Gillespie KA, Kazarinova-Noyes K, Shrager P, Saunders TL, Macdonald RL, Ransom BR, Scheuer T, Catterall WA, Isom LL. 2002. Reduced sodium channel density, altered voltage dependence of inactivation, and increased susceptibility to seizures in mice lacking sodium channel beta 2-subunits. Proc Natl Acad Sci U S A.99: 17072-17027.

Eitzman DT, Westrick RJ, Bi X, Manning SL, Wilkinson JE, Broze GJ, Ginsburg D. 2002. Lethal perinatal thrombosis in mice resulting from the interaction of tissue factor pathway inhibitor deficiency and factor V Leiden. Circulation. May 7;105(18):2139-42.

Erdmann I, Scheidegger EP, Koch FK, Heinzerling L, Odermatt B, Burg G, Lowe JB, Kundig TM. 2002. Fucosyltransferase VII-deficient mice with defective E-, P-, and L-selectin ligands show impaired CD4+ and CD8+ T cell migration into the skin, but normal extravasation into visceral organs. J Immunol. 168: 2139-2146.

Innis JW, Margulies EH, Kardia S. 2002. Integrative biology and the developing limb bud. Evol Dev. 4: 378-389.

Ishida S, Lee J, Thiele DJ, Herskowitz I. 2002. Uptake of the anticancer drug cisplatin mediated by the copper transporter Ctr1 in yeast and mammals. Proc Natl Acad Sci U S A. 99:14298-302.

Lee K, Tirasophon W, Shen X, Michalak M, Prywes R, Okada T, Yoshida H, Mori K, Kaufman RJ. 2002. IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response. Genes Dev. 16:452-66.

Lee J, Petris MJ, Thiele DJ. 2002. Characterization of mouse embryonic cells deficient in the Ctr1 high affinity copper transporter: Identification of a Ctr1-independent copper system. J Biol Chem. 277:40253-9.

Madison BB, Dunbar L, Qiao XT, Braunstein KA, Braunstein EM, Gumucio DL. 2002. Cis elements of the villin gene control expression in restricted domains of the vertical (crypt) and horizontal (duodenum, cecum) axes of the intestine. J Biol Chem. J Biol Chem. 277:33275-83.

Martin DM, Skidmore JM, Fox SE, Gage PJ, Camper SA.2002. Pitx2 distinguishes subtypes of terminally differentiated neurons in the developing mouse neuroepithelium. Dev Biol. 252:84-99.

Michele DE, Gomez CA, Hong KE, Westfall MV, Metzger JM. 2002. Cardiac dysfunction in hypertrophic cardiomyopathy mutant tropomyosin mice is transgene-dependent, hypertrophy-independent, and improved by beta-blockade. Circ Res. 91:255-262.

Moeller MJ, Sanden SK, Soofi A, Wiggins RC, Holzman LB. 2002. Two Gene Fragments that Direct Podocyte-Specific Expression in Transgenic Mice. J Am Soc Nephrol. 13:1561-1567.

Pendl GG, Robert C, Steinert M, Thanos R, Eytner R, Borges E, Wild MK, Lowe JB, Fuhlbrigge RC, Kupper TS, Vestweber D, Grabbe S. Immature mouse dendritic cells enter inflamed tissue, a process that requires E- and P-selectin, but not P-selectin glycoprotein ligand 1. Blood. 2002 Feb 1;99(3):946-56.

Peng L, Bhatia N, Parker AC, Zhu Y, Fay WP. 2002. Endogenous vitronectin and plasminogen activator inhibitor-1 promote neointima formation in murine carotid arteries. Arterioscler Thromb Vasc Biol. 22(6):934-9.

Raetzman LT, Ward R, Camper SA. 2002. Lhx4 and Prop1 are required for cell survival and expansion of the pituitary primordia. Development. 129: 4229-4239.

Sheng H, Goich S, Wang A, Grachtchouk M, Lowe L, Mo R, Lin K, de Sauvage FJ, Sasaki H, Hui CC, Dlugosz AA. 2002. Dissecting the oncogenic potential of Gli2: deletion of an NH(2)-terminal fragment alters skin tumor phenotype. Cancer Res. 62: 5308-16.

Smith PL, Myers JT, Rogers CE, Zhou L, Petryniak B, Becker DJ, Homeister JW, Lowe JB.2002. Conditional control of selectin ligand expression and global fucosylation events in mice with a targeted mutation at the FX locus. J Cell Biol. 158:801-815.

Suh H. Gage PJ. Drouin J. Camper SA. 2002. Pitx2 is required at multiple stages of pituitary organogenesis: pituitary primordium formation and cell specification. Development - Supplement. 129:329-37.

Wishart MJ, Dixon JE. 2002. The archetype STYX/dead-phosphatase complexes with a spermatid mRNA-binding protein and is essential for normal sperm production. Proc Natl Acad Sci U S A. 99:2112-2117.

Yu T, Thomas DM, Zhu W, Goodman M, Gumucio DL. 2002. Regulation of fetal versus embryonic gamma globin genes: appropriate developmental stage expression patterns in the presence of HS2 of the locus control region. Blood. 99:1082-1084.

Zavros Y, Rieder G, Ferguson A, Samuelson LC, Merchant JL. 2002. Hypergastrinemia in response to gastric inflammation suppresses somatostatin. Am J Physiol Gastrointest Liver Physiol. 282:G175-83.

Zavros Y, Rieder G, Ferguson A, Samuelson LC, Merchant JL. 2002. Genetic or chemical hypochlorhydria is associated with inflammation that modulates parietal and G-cell populations in mice. Gastroenterology. 122:119-33.

Zhang K, Kurachi S, Kurachi K.2 002. Genetic mechanisms of age regulation of protein C and blood coagulation.  J Biol Chem. 277:4532-4540.


2001

 


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Brinkmeier ML, Stahl JH, Gordon DF, Ross BD, Sarapura VD, Dowding JM, Kendall SK, Lloyd RV, Ridgway EC, Camper SA. 2001. Thyroid hormone-responsive pituitary hyperplasia independent of somatostatin receptor 2.Mol Endocrinol. 15:2129-2136.
 
Brown NL, Patel S, Brzezinski J, Glaser T. 2001. Math5 is required for retinal ganglion cell and optic nerve formation.  Development. 128:2497-508.

Cushman LJ, Watkins-Chow DE, Brinkmeier ML, Raetzman LT, Radak AL, Lloyd RV, Camper SA. 2001. Persistent Prop1 expression delays gonadotrope differentiation and enhances pituitary tumor susceptibility. Hum Mol Genet. 10:1141-53.

Domino SE, Zhang L, Gillespie PJ, Saunders TL, Lowe, JB. 2001. Deficiency of reproductive tract alpha(1,2)fucosylated glycans and normal fertility in mice with targeted deletions of the FUT1 or FUT2 alpha(1,2)fucosyltransferase locus. Molec. Cell. Biol. 21:8336-8345.

Franic TV, Judd LM, Robinson D, Barrett SP, Scarff KL, Gleeson PA, Samuelson LC, Van Driel IR. 2001. Regulation of gastric epithelial cell development revealed in H(+)/K(+)-ATPase beta-subunit- and gastrin-deficient mice. Am J Physiol Gastrointest Liver Physiol. 281:G1502-11.

Homeister JW, Thall AD, Petryniak B, Maly P, Rogers CE, Smith PL, Kelly RJ, Gersten KM, Askari SW, Cheng G, Smithson G, Marks RM, Misra AK, Hindsgaul O, von Andrian UH, Lowe JB. 2001. The alpha(1,3)fucosyltransferases FucT-IV and FucT-VII exert collaborative control over selectin-dependent leukocyte recruitment and lymphocyte homing. Immunity. 15:115-26.

Kearney JA. Plummer NW. Smith MR. Kapur J. Cummins TR. Waxman SG. Goldin AL. Meisler MH. 2001. A gain-of-function mutation in the sodium channel gene Scn2a results in seizures and behavioral abnormalities. Neuroscience. 102:307-17.

Lee J, Prohaska JR, Thiele DJ. 2001. Essential role for mammalian copper transporter Ctr1 in copper homeostasis and embryonic development. Proc Natl Acad Sci U S A. 98:6842-7.

Mears AJ, Kondo M, Swain PK, Takada Y, Bush RA, Saunders TL, Sieving PA, Swaroop A. 2001. Nrl is required for rod photoreceptor development. Nat Genet. 29:447-52.

Rao DS, Chang JC, Kumar PD, Mizukami I, Smithson GM, Bradley SV, Parlow AF, Ross TS.  Huntingtin Interacting Protein 1 Is a Clathrin Coat Binding Protein Required for Differentiation of late Spermatogenic  Progenitors.  Mol Cell Biol. 2001 Nov;21(22):7796-806.

Scheuner D, Song B, McEwen E, Liu C, Laybutt R, Gillespie P, Saunders T, Bonner-Weir S, Kaufman RJ. 2001. Translational control is required for the unfolded protein response and in vivo glucose homeostasis. Mol Cell. 7:1165-76.

Seasholtz AF, Burrows HL, Karolyi IJ, Camper SA.2001. Mouse models of altered CRH-binding protein expression. 22:743-51.

Smithson G, Rogers CE, Smith PL, Scheidegger EP, Petryniak B, Myers JT, Kim DS, Homeister JW, Lowe JB.2001.  Fuc-TVII is required for T helper 1 and T cytotoxic 1 lymphocyte selectin ligand expression and recruitment in inflammation,  and together with Fuc-TIV regulates naive T cell trafficking to lymph nodes.  J Exp Med. ;194:601-14.

Sun D, Samuelson LC, Yang T, Huang Y, Paliege A, Saunders T, Briggs J, Schnermann J. 2001. Mediation of tubuloglomerular feedback by adenosine: evidence from mice lacking adenosine 1 receptors. Proc Natl Acad Sci U S A. 98:9983-8.

Zhao L. Bakke M. Krimkevich Y. Cushman LJ. Parlow AF. Camper SA. Parker KL. 2001. Steroidogenic factor 1 (SF1) is essential for pituitary gonadotrope function. Development. 128(2):147-54.

Zhao L, Bakke M, Krimkevich Y, Cushman LJ, Parlow AF, Camper SA, Parker KL.  Hypomorphic phenotype in mice with pituitary-specific knockout of steroidogenic factor 1. Genesis. 2001 Jun;30(2):65-9.


2000

 


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Adams K. Ackerly H. Cunningham K. Dunnick W. 2000. A DNase I hypersensitive site near the murine gamma1 switch region contributes to insertion site independence of transgenes and modulates the amount of transcripts induced by CD40 ligation. International Immunology. 12(12):1705-13.

Ahmad A. Brinson M. Hodges BL. Chamberlain JS. Amalfitano A. 2000. Mdx mice inducibly expressing dystrophin provide insights into the potential of gene therapy for duchenne muscular dystrophy. Human Molecular Genetics. 9(17):2507-15.

Crawford GE. Faulkner JA. Crosbie RH. Campbell KP. Froehner SC. Chamberlain JS. 2000. Assembly of the dystrophin-associated protein complex does not require the dystrophin COOH-terminal domain. Journal of Cell Biology. 150(6):1399-410.

Cui J. Eitzman DT. Westrick RJ. Christie PD. Xu ZJ. Yang AY. Purkayastha AA. Yang TL. Metz AL. Gallagher KP. Tyson JA. Rosenberg RD. Ginsburg D. 2000. Spontaneous thrombosis in mice carrying the factor V Leiden mutation. Blood. 96(13):4222-6.

Cushman LJ. Burrows HL. Seasholtz AF. Lewandoski M. Muzyczka N. Camper SA. 2000. Cre-mediated recombination in the pituitary gland. Genesis: the Journal of Genetics & Development. 28(3-4):167-74.

Disatnik MH. Chamberlain JS. Rando TA.  2000. Dystrophin mutations predict cellular susceptibility to oxidative stress. Muscle & Nerve. 23(5):784-92.

Eitzman DT, Westrick RJ, Nabel EG, Ginsburg D. 2000. Plasminogen activator inhibitor-1 and vitronectin promote vascular thrombosis in mice. Blood. 95:577-580.

Escayg A., De Waard, M., Lee, D.D., Bichet, D., Wolf, P., Mayer, T., Johnston, J., Baloh, R., Sander, T. and Meisler, M.H., 2000. Coding and noncoding variation of the human calcium channel 4 subunit gene CACNB4 in patients with idiopathic generalized epilepsy and episodic ataxia. Am. J. Hum. Genet. 66:1531–1539.

Grachtchouk M, Mo R, Yu S, Zhang X, Sasaki H, Hui Cc, Dlugosz AA. 2000. Basal cell carcinomas in mice overexpressing Gli2 in skin. Nature Genetics 24:216-217.

Kurachi K, Kurachi S. 2000. Genetic mechanisms of age regulation of blood coagulation: factor IX model.Arterioscler Thromb Vasc Biol. 20:902-906.

Kurachi K, Zhang K, Ameri A, Huo J, Atoda H, Kurachi S.2000. Genetic and molecular mechanisms of age regulation (homeostasis) of blood coagulation. IUBMB Life. 49:189-96.

Lynch GS, Rafael JA, Chamberlain JS, Faulkner JA. 2000. Contraction-induced injury to single permeabilized muscle fibers from mdx, transgenic mdx, and control mice.  Am J Physiol Cell Physiol. Oct;279(4):C1290-4.

Moeller MJ, Kovari IA, Holzman LB. 2000. Evaluation of a new tool for exploring podocyte biology: mouse Nphs1 5' flanking region drives LacZ expression in podocytes. J Am Soc Nephrol. Dec;11(12):2306-14.

Post LC, Margulies EH, Kuo A, Innis JW . 2000. Severe limb defects in Hypodactyly mice result from the expression of a novel, mutant HOXA13 protein. Dev Biol 217:290-300.

Tanaka M, Yamasaki N, Izumo S. 2000. Phenotypic characterization of the murine Nkx2.6 homeobox gene by gene targeting. Mol Cell Biol. 20:2874-9.

Wells AD. Li XC. Li Y. Walsh MC. Zheng XX. Wu Z. Nunez G. Tang A. 1999. Sayegh M. Hancock WW. Strom TB. Turka LA. Requirement for T-cell apoptosis in the induction of peripheral transplantation tolerance. Nature Medicine. 5(11):1303-7.

Weninger W, Ulfman LH, Cheng G, Souchkova N, Quackenbush EJ, Lowe JB, von Andrian UH.2000.  Specialized contributions by alpha(1,3)-fucosyltransferase-IV and FucT-VII during leukocyte rolling in dermal microvessels.  Immunity. 12:665-676.

Wharram BL. Goyal M. Gillespie PJ. Wiggins JE. Kershaw DB. Holzman LB. Dysko RC. Saunders TL. Samuelson LC. Wiggins RC. 2000. Altered podocyte structure in GLEPP1 (Ptpro)-deficient mice associated with hypertension and low glomerular filtration rate. Journal of Clinical Investigation. 106:1281-90.

Yang TL, Cui J, Taylor JM, Yang A, Gruber SB, Ginsburg D. 2000. Rescue of fatal neonatal hemorrhage in factor V deficient mice by low level transgene expression. Thromb Haemost. 83:70-77.


1999

 


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Kurachi S, Deyashiki Y, Takeshita J, Kurachi K. 1999. Genetic mechanisms of age regulation of human blood coagulation factor IX.Science. 285:739-743.

Beurskens FJ, Kuenen JD, Hofhuis F, Fluit AC, Robins DM, Van Dijk H. 1999. Sex-limited protein: in vitro and in vivo functions. Clin Exp Immunol 1999 Jun;116(3):395-400.

Collins JT, Dunnick WA. 1999. Cutting edge: IFN-gamma regulated germline transcripts are expressed from gamma2a transgenes independently of the heavy chain 3' enhancers. J Immunol. 163:5758-5762.

Dougherty KM, Pearson JM, Yang AY, Westrick RJ, Baker MS, Ginsburg D. 1999. The plasminogen activator inhibitor-2 gene is not required for normal murine development or survival. Proc Natl Acad Sci U S A 1999 96:686-91.

Fay WP, Parker AC, Ansari MN, Zheng X, Ginsburg D. 1999. Vitronectin inhibits the thrombotic response to arterial injury in mice. Blood 93:1825-30.

Gage PJ, Suh H, Camper SA . 1999. Dosage requirement of pitx2 for development of multiple organs. Development 126:4643-4651.

Hinkle KL, Samuelson LC. 1999. III. Lessons learned from gastrin gene deletion in mice. Am J Physiol 277:G500-G505.

Karolyi IJ, Burrows HL, Ramesh TM, Nakajima M, Lesh JS, Seong E, Camper SA, Seasholtz AF. 1999. Altered anxiety and weight gain in corticotropin-releasing hormone-binding protein-deficient mice.Proc Natl Acad Sci U S A 1999 Sep 28;96(20):11595-11600.

Lacourse KA, Swanberg LJ, Gillespie PJ, Rehfeld JF, Saunders TL, Samuelson LC. 1999. Pancreatic function in CCK-deficient mice: adaptation to dietary protein does not require CCK. Am J Physiol 276:G1302-309.

Lay JM, Gillespie PJ, Samuelson LC. 1999. Murine prenatal expression of cholecystokinin in neural crest, enteric neurons, and enteroendocrine cells. Developmental Dynamics. 216:290-200.

Lumeng CN, Hauser M, Brown V, Chamberlain JS. 1999. Expression of the 71 kDa dystrophin isoform (Dp71) evaluated by gene targeting. Brain Res 830:174-178.

Mohlke KL, Purkayastha AA, Westrick RJ, Smith PL, Petryniak B, Lowe JB, Ginsburg D. 1999. Mvwf, a dominant modifier of murine von Willebrand factor, results from altered lineage-specific expression of a glycosyltransferase. Cell 96:111-120.

Stahl JH, Kendall SK, Brinkmeier ML, Greco TL, Watkins-Chow DE, Campos-Barros A, Lloyd RV, Camper SA.1999. Thyroid hormone is essential for pituitary somatotropes and lactotropes. Endocrinology 140:1884-1892.

Tanaka M, Wechsler SB, Lee IW, Yamasaki N, Lawitts JA, Izumo S. 1999. Complex modular cis-acting elements regulate expression of the cardiac specifying homeobox gene Csx/Nkx2.5.Development 1999 Apr;126(7):1439-1450.

Tanaka M, Chen Z, Bartunkova S, Yamasaki N, Izumo S. 1999. The cardiac homeobox gene Csx/Nkx2.5 lies genetically upstream of multiple genes essential for heart development. Development 1999 Mar;126(6):1269-80.

Türkay A , Saunders TL, Kurachi K.1999. Intrauterine gene transfer: gestational stage-specific gene delivery in mice.Gene Therapy. 6:1685-1694.

Xiao JH, Feng X, Di W, Peng ZH, Li LA, Chambon P, Voorhees JJ. 1999. Identification of heparin-binding EGF-like growth factor as a target in intercellular regulation of epidermal basal cell growth by suprabasal retinoic acid receptors. EMBO J 18:1539-48.

Wells AD, Li XC, Li Y, Walsh MC, Zheng XX, Wu Z, Nunez G, Tang A, Sayegh M, Hancock WW, Strom TB, Turka LA. 1999. Requirement for T-cell apoptosis in the induction of peripheral transplantation tolerance. Nat Med. 5:1303-7.

Zhu W, TomHon C, Mason M, Campbell T, Shelden E, Richards N, Goodman M, Gumucio DL.1999. Analysis of linked human epsilon and gamma transgenes: effect of locus control region hypersensitive sites 2 and 3 or a distal YY1 mutation on stage-specific expression patterns. Blood 93:3540-3549.


1998

 


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Brinkmeier ML, Gordon DF, Dowding JM, Saunders TL, Kendall SK, Sarapura VD, Wood WM, Ridgway EC, Camper SA.Cell-specific expression of the mouse glycoprotein hormone alpha-subunit gene requires multiple interacting DNA elements in transgenic mice and cultured cells. Mol Endocrinol. 12:622-33.

Burrows HL, Nakajima M, Lesh JS, Goosens KA, Samuelson LC, Inui A, Camper SA, Seasholtz AF. 1998 Excess corticotropin releasing hormone-binding protein in the hypothalamic-pituitary-adrenal axis in transgenic mice. J. Clin. Invest. 101:1439-447.

Cunningham K, Ackerly H, Alt F, Dunnick W. 1998. Potential regulatory elements for germline transcription in or near murine Sgamma1.Int Immunol. 10:527-536.

Cunningham K, Ackerly H, Claflin L, Collins J, Wu P, Ford C, Lansford R, Alt F, Dunnick WA. 1998. Germline transcription and recombination of a murine VDJmudeltagamma1 transgene. Int Immunol. 10:1027-1037.

Friis-Hansen, L, Sundler, F, Li, Y, Gillespie, PJ, Saunders, TL, Greenson, JK, Owyang, C, Rehfeld, JF, Samuelson, LC. 1998. Impaired Gastric Acid Secretion in Gastrin-Deficient Mice. Am. J. Physiol. 274:G561-G568.

Kulig E, Camper SA, Kuecker S, Jin L, Lloyd RV. 1998. Remodeling of Hyperplastic Pituitaries in Hypothyroid us-Subunit Knockout Mice After Thyroxine and 1713-Estradiol Treatment: Role of Apoptosis. Endocr Pathol. 9:261-274.

Lay JM, Friis-Hansen L, Gillespie PJ, Samuelson LC. 1998. Rapid confirmation of gene targeting in embryonic stem cells using two long-range PCR techniques.Transgenic Res.7:135-140.

Petschner, F, Zimmermann, C, Strasser, A, Grillot, D, Nunez, G, Pircher, H. 1998. Constitutive expression of Bcl-x(L) or Bcl-2 prevents peptide antigen-induced T cell deletion but does not influence T cell homeostasis after a viral infection. Eur. J. Immunol. 28:560-569.

Pinson, KI, Dunbar, L, Samuelson, L, Gumucio, DL. 1998. Targeted disruption of the mouse villin gene does not impair the morphogenesis of microvilli. Dev. Dyn. 211:109-121.

Probst FJ, Fridell RA, Raphael y, Saunders TL, Wang A, Liang Y, Morell RJ, Touchman JW, Lyons RH, Noben-Trauth K, Friedman TB, Camper SA. 1998. Correction of Deafness in shaker-2 Mice by an Unconventional Myosin in a BAC Transgene.Science. 280:1444-1447.

WangA, Liang Y, Fridell RA, Probst FJ, Wilcox ER, Touchman JW, MortonCC, Morell RJ, Noben-Trauth K, Camper SA, Friedman TB. 1998. Association of Unconventional Myosin MYO15 Mutations with Human Nonsyndromic Deafness DFNB3. Science. 280:1447 - 1451.

Solvason, N, Wu, WW, Kabra, N, Lund-Johansen, F, Roncarolo, MG, Behrens, TW, Grillot, DAM, Nunez, G, Lees, E, Howard, M. 1998. Transgene expression of bcl-x(L) permits anti-immunoglobulin (Ig)-induced proliferation in xid B cells J. Exp. Med. 187: 1081-1091.

Wu P, Claflin L. 1998. Promoter-associated displacement of hypermutations.Int Immunol. 10:1131-1138.

Yu RN, Ito M, Saunders TL, Camper SA, Jameson JL. 1998. Role of Ahch in gonadal development and gametogenesis. Nat Genet 20:353-7.


1997

 


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Chamberlain, JS. 1997. Dystrophin levels required for genetic correction of Duchenne muscular dystrophy. Bas. Appl. Myol. 7:251-255.

Chamberlain, JS, Corrado, K, Rafael ,JA, Cox, GA, Hauser, M, Lumeng, C. 1997. Interactions between dystrophin and the sarcolemma membrane. Soc Gen Physiol Ser 52:19-29.

Elenich, LA, Ford, CS, Collins, JT, Dunnick, WA. 1997. gamma1 Heavy Chain Transgenes are Responsive to IFN-gamma Repression and CD40 Ligation. J. Immunol. 158:4564-4573.

Feng, X, Peng, ZH, Di, W, Li, XY, Rochette-Egly, C, Chambon, P, Voorhees, JJ, Xiao JH. 1997. Suprabasal expression of a dominant-negative RXR alpha mutant in transgenic mouse epidermis impairs regulation of gene transcription and basal keratinocyte proliferation by RAR-selective retinoids. Genes Dev. 11:59-71.

Lowe JB.1997. Selectin ligands, leukocyte trafficking, and fucosyltransferase genes. Kidney Int. 51:1418-1426.

Lynch, GS, Rafael, JA, Hinkle, RT, Cole, NM, Chamberlain, JS, Faulkner, JA. 1997. Contractile properties of diaphragm muscle segments from old mdx and old transgenic mdx mice. Am. J. Phys-Cell Phys. 41:C2063-C2068.

Nelson, SA, Robins, DM. 1997. Regulatory capacity of an androgen-specific enhancer of the mouse Slp gene in transgenic mice. Mol. Cell. Endo. 133:89-97.

Ohnishi, H, Samuelson, LC, Yule, DI, Ernst, SA, Williams, JA. 1997. Overexpression of Rab3D enhances regulated amylase secretion from pancreatic acini of transgenic mice J Clin. Inv. 100:3044-3052.

Straub, V, Rafael, JA, Chamberlain, JS, Campbell, KP. 1997. Animal models for muscular dystrophy show different patterns of sarcolemmal disruption. J. Cell. Biol. 139:375-385.

TomHon, C, Zhu, W, Millinoff, D, Hayasaka, K, Slightom, JL, Goodman, M, Gumucio, DL.1997. Evolution of a fetal expression pattern via cis changes near the gamma globin gene. J. Biol. Chem. 272:14062-14066.


1996

 


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Burrows, HL, Birkmeier, TS, Seasholtz, AF, Camper, SA. 1996. Targeted Ablation of Cells in the Pituitary Primordia of Transgenic Mice. Mol. Endo. 10:1467-1477.

Corrado, K, Rafael, JA, Mills, PL, Cole, NM, Faulkner, JA, Wang, K, Chamberlain, JS. 1996. Transgenic mdx Mice Expressing Dystrophin with a Deletion in the Actin-Binding Domain Display a "Mild Becker" Phenotype. J. Cell Biology. 134:873-884.

Cui, J, O'Shea KS, Purkayastha A, Saunders TL, Ginsburg, D. 1996. Fatal Haemorrhage and Incomplete Block to Embryogenesis in Mice Lacking Coagulation Factor V. Nature. 382:66-68.

Eitzman, DT, Krauss, JC, Shen, T, Cui, J, Ginsburg, D. 1996. Lack of plasminogen activator inhibitor-1 effect in a transgenic mouse model of metastatic melanoma. Blood. 87:4718-4722.

Eitzman, DT, McCoy, RD, Zheng, X, Fay, WP, Shen, T, Ginsburg, D, Simon, RH. 1996. Bleomycin-Induced Pulmonary Fibrosis in Transgenic Mice that Either Lack or Overexpress the Murine Plasminogen Activator Inhibitor-1 Gene. J. Clin. Invest. 97:232-237.

Elenich, LA, Ford, CS, Dunnick, WA. 1996. The gamma 1 Heavy Chain Gene Includes all of the cis-Acting Elements Necessary for Expression of Properly Regulated Germ-Line Transcripts. J. Immunol. 157:176-182.

Grillot, DA, Merino, R, Pena, JC, Fanslow, WC, Finkelman, FD, Thompson, CB, Nunez, G. 1996. bcl-x exhibits regulated expression during B cell development and activation and modulates lymphocyte survival in transgenic mice. J. Exp. Med. 183:381-391.

Maly P, Thall AD, Petryniak B, Rogers CE, Smith PL, Marks RM, Kelly RJ, Gersten KM, Cheng G, Saunders TL, Camper SA, Camphausen RT, Sullivan RX, Isogai Y, Hindsgaul O, von Andrian UH, Lowe JB. 1996. The alpha(1,3)Fucosyltransferase Fuc-TVII Controls Leukocyte Trafficking through an Essential Role in L-, E-, and P-selectin Ligand Biosynthesis. Cell 86:643-653.

Rafael, JA, Cox, GA, Corrado, K, Jung, D, Campbell, KP, Chamberlain, JS. 1996. Forced expression of dystrophin deletion constructs reveals structure-function correlations. J .Cell Biol. 134:93-102.

Samuelson, LC. 1996. Transgenic approaches to salivary gland research. Ann. Rev. Phys. 58: 209-229.

Thall, AD, Murphy, HS, Lowe, JB. 1996. alpha 1,3-Galactosyltransferase-deficient mice produce naturally occurring cytotoxic anti-Gal antibodies.Transplant. Proc. 28:556-557.

Tucker RM, Burke DT. 1996. Transgenic mice for the establishment of histidinol-resistant embryonic fibroblast feeder layers.FASEB J. 10:1641-1645.


1995

 


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Camper, SA, Saunders, TL, Kendall, SK, Keri, RA, Seasholtz, AF, Gordon, DF, Birkmeier, TS, Keegan, CE, Karolyi, IJ, Roller, ML, Burrows, HL, Samuelson, LC. 1995. Implementing transgenic and embryonic stem cell technology to study gene expression, cell-cell interactions and gene function. Biol. Reprod. 52:246-2457.

Chen C, Nagy Z, Radic MZ, Hardy RR, Huszar D, Camper SA, Weigert M. 1995 . The site and stage of anti-DNA B-cell deletion. Nature. 373:252-255.

Dunnick W Elenich L Cunningham K Chrisp C Claflin L. 1995. Tumorigenesis in mice with an SV40 T antigen transgene driven by the immunoglobulin gamma 1 heavy chain germline promoter. Curr. Top. Microbiol. Immunol. 194:163-169.

Grillot, DA, Merino, R, Nunez, G. 1995. Bcl-XL Displays Restricted Distribution During T Cell Development and Inhibits Multiple Forms of Apoptosis but not Clonal Deletion in Transgenic Mice. J. Exp. Med. 182:1973-1983.

Kendall, SK, Samuelson, LC, Saunders, TL, Wood, RI, Camper, SA. 1995. Targeted Disruption of the Pituitary Glycoprotein Hormone alpha-subunit Produces Hypogonadal and Hypothyroid Mice. Genes Dev. 9:2007-2019.

Phelps SF, Hauser MA, Cole NM, Rafael JA, Hinkle RT, Faulkner JA, Chamberlain JS. 1995. Expression of full-length and truncated dystrophin mini-genes in transgenic mdx mice. Human Mol. Genet. 4:1251-1258.

Radic, MZ, Ibrahim, SM, Rauch, J, Camper, SA, Weigert, M. 1995. Constitutive secretion of transgene-encoded IgG2b autoantibodies leads to symptoms of autoimmune disease. J. Immunol. 155:3213-3222.

Thall, AD, Maly, P, Lowe, JB. 1995. Oocyte Gal-alpha1,3Gal Epitopes Implicated in Sperm Adhesion to the Zona Pellucida Glycoprotein ZP3 are not Required for Fertilization in the Mouse. J. Biol. Chem. 270:21437-21440.

Zheng, XX, Saunders, TL, Samuelson, LC, Camper, SA, Ginsburg, D. 1995. Vitronectin is not Essential for Mammalian Development. Proc. Natl. Acad. Sci. U.S.A. 92:12326-12430.


1994

 


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Chen C, Radic MZ, Erikson J, Camper SA, Litwin S, Hardy RR, Weigert M, 1994 . Deletion and editing of B cells that express antibodies to DNA. J. Immunol. 152:1970-1982.

Chen EH, Mitchell BS. 1994. Hereditary overexpression of adenosine deaminase in erythrocytes: studies in erythroid cell lines and transgenic mice. Blood. 84:2346-2353.

Denetclaw WF, Jr Hopf FW, Cox GA, Chamberlain JS, Steinhardt RA. 1994. Myotubes from transgenic mdx mice expressing full-length dystrophin show normal calcium regulation. Mol. Biol. Cell. 5:1159-1167.

Cox GA, Sunada Y, Campbell KP, Chamberlain JS.1994. Dp71 can restore the dystrophin-associated glycoprotein complex in muscle but fails to prevent dystrophy. Nat. Genet. 8:333-339.

Keegan, CE, Karolyi, IJ, Knapp, LT, Bourbonais, FJ, Camper, SA, Seasholtz, AF. 1994. Expression of corticotropin-releasing hormone transgenes in neurons of adult and developing mice. Mol. Cell. Neurosci. 5:505-514.

Keri RA, Wolfe MW, Saunders TL, Anderson I Kendall SK Wagner T, Yeung J, Gorski J, Nett TM, Camper SA, Nilson, JH. 1994. The proximal promoter of the bovine luteinizing hormone beta-subunit gene confers gonadotrope-specific expression and regulation by gonadotropin-releasing hormone, testosterone, and 17 beta-estradiol in transgenic mice. Mol. Endocrinol. 8:1807-1816.

Kendall SK, Gordon DF, Birkmeier TS, Petrey D, Sarapura VD, O'Shea KS, Wood WM, Lloyd RV, Ridgway EC, Camper SA. 1994. Enhancer-mediated high level expression of mouse pituitary glycoprotein hormone alpha-subunit transgene in thyrotropes, gonadotropes, and developing pituitary gland. Mol. Endocrinol. 8:1420-1433.

Rafael JA, Sunada Y, Cole NM, Campbell KP, Faulkner JA, Chamberlain JS. 1994. Prevention of dystrophic pathology in mdx mice by a truncated dystrophin isoform. Hum. Mol. Genet. 3:1725-1733.

 

 

1993


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Cox GA, Cole NM, Matsumura K, Phelps SF, Hauschka, SD Campbell KP, Faulkner JA, Chamberlain JS. 1993. Overexpression of dystrophin in transgenic mdx mice eliminates dystrophic symptoms without toxicity. Nature 364:725-729.

Gay, D, Saunders, T, Camper, S, Weigert, M. 1993. Receptor editing: an approach by autoreactive B cells to escape tolerance. J. Exp. Med. 177:999-1008.

Shlomchik, MJ, Zharhary, D, Saunders, T, Camper, SA, Weigert, MG. 1993 . A rheumatoid factor transgenic mouse model of autoantibody regulation. Int. Immunol. 5:1329-1341.

1992

Dunnick, W, Elenich, L, Berry, J, Albrecht, D, Stavnezer, J, Claflin, JL. 1992. Regulation of switch recombination to the murine gamma 1 gene. Curr. Top. Microbiol. Immunol. 182:143-147.

 

Ting CN, Rosenberg MP, Snow CM, Samuelson LC, Meisler MH. 1992. Endogenous retroviral sequences are required for tissue-specific expression of a human salivary amylase gene. Genes Dev. 6:1457-1465.

1991

Carmack CE, Camper SA, Mackle JJ, Gerhard WU, Weigert MG. 1991. Influence of a V kappa 8 L chain transgene on endogenous rearrangements and the immune response to the HA(Sb) determinant on influenza virus. J. Immunol. 147:2024-2033.

 

Erikson J Radic MZ Camper SA Hardy RR Carmack C Weigert M. 1991 .Expression of anti-DNA immunoglobulin transgenes in non-autoimmune mice. Nature. 349:331-334.

Kendall SK, Saunders TL, Jin L, Lloyd RV, Glode LM, Nett TM, Keri RA, Nilson JH, Camper SA. 1991. Targeted ablation of pituitary gonadotropes in transgenic mice. Mol. Endocrinol. 5:2025-2036.


 


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