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Current Research

Pulmonary Hypertension and the Hypoxic Response in Sickle Cell Disease (PUSH)

Investigators:
Andrew D. Campbell, M.D.

Purpose of the Study:
We are conducting a study to find out how often children and adolescents with sickle cell disease have high blood pressure of the lungs (pulmonary hypertension) and to find out if children with high blood pressure of the lungs have more health problems than those without this finding. We are also looking at whether there is a genetic basis for the development of pulmonary hypertension. The total duration of the study is 5 years. As part of this study, we will make comparisons with children who do not have sickle cell disease. High blood pressure of the lungs is common and is associated with early death in adult patients with sickle cell disease, but little is known about high blood pressure of the lungs in children and adolescents. We believe that there may be a genetic basis that explains why some sickle cell patients develop pulmonary hypertension and others do not.

Who is eligible to participate?

Patients 3-20 years of age with sickle cell disease or subjects 3-20 years of age without sickle cell disease (control group).

IRB Approval # HUM00005457

For more information please see our brochure. (PDF)

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Phenotypic Differences in Twins and Siblings with Sickle Cell Disease (SCD)

Investigators:
Andrew Campbell, M.D.
Onike Rodrigues, M.D., F.W.A.C.P., University of Ghana Medical School

Purpose of the Study:
This study is being done to try to find out why children with sickle cell disease suffer differently from each other. Also from this study we are trying to understand why children with sickle cell disease within the same family (brother, sister) experience differences in sickle cell disease health problems. Some children and teenagers, for example, complain of more sickle cell pain on a regular basis when compared to others. We hope that this study will help us to improve our understanding of sickle cell disease and lead to improved care.

Who is eligible to participate?
People who participate in this study will have sickle cell disease and will be between the ages of 1 and 25 years old.

IRB APPROVAL # HUM00003524

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Understanding Differences in Physicians’ Perceptions of Genetic Counseling Needs for Parents of Newborn Cystic Fibrosis and Sickle Cell Anemia Carriers

Investigators:
Kathryn L. Moseley, M.D.
Andrew Campbell, M.D.
Samya Nasr, M.D.
Jane Schuette, M.S.

Purpose of the Study:
To determine the factors that are associated with differences in referrals for genetic counseling of parents of infants who are carriers for cystic fibrosis compared with those who are carriers for sickle cell anemia.

Who is eligible to participate:
Michigan pediatricians and family medicine specialists

IRB Approval # HUM00022114

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