Molecular computer model defective insulin molecules forming several threaded fibrils

Knitting Proteins

Molecular computer model defective insulin molecules forming several threaded fibrils

Knitting Proteins

Abstract

Proteins are made of a long sequence of building blocks called amino acids. Proteins fold into a complicated three-dimensional shape using spontaneous origami rules designed by nature. How a protein folds into a specific shape determines how it will act. If protein folding origami fails, proteins remain misfolded and cannot function. Many misfolded proteins can trigger diseases known as protein folding diseases. As a matter of fact, a growing number of aging and degenerative diseases are associated with inappropriate deposition of misfolded proteins into aggregates or fibrils in our cells and tissues. Aggregates or fibrils can assemble through a molecular knitting process, in which misfolded protein molecules bind together in a disorganized structure (aggregates) or regularly organized chain (firbil). The time it takes to complete the molecular knitting process is important to design treatments to inhibit aggregation or fibrillation in protein folding diseases

Publication
IN: THE ART OF THEORETICAL BIOLOGY, pp 54-55