A two-step kinetic model of insulin aggregation with a competitive inhibitor

Abstract

We present a novel model of the inhibition of insulin aggregation using a two-step autocatalytic reaction mechanism with an explicitly competitive inhibition pathway. The kinetic rate constants are estimated using nonlinear regression to analyze previously obtained experimental data for inhibition by synthetic hybrid peptides. This framework provides a method for uniquely characterizing the inhibitory capacity of compounds on protein aggregation.

Publication
IN: BIOMAT 2013: INTERNATIONAL SYMPOSIUM ON MATHEMATICAL AND COMPUTATIONAL BIOLOGY, 107-120

**Cite this chapter as:** Whidden M, HO A, Schnell S (2014) A two-step kinetic model of insulin aggregation with a competitive inhibitor. In: Mondaini RP (eds) BIOMAT 2013: International Symposium on Mathematical and Computational Biology. World Scientific, Singapore, pp. 107-120.