Schematic of possible regulation of the reproductive neuroendocrine system in adults. Source: SM Moenter (2018) Endocrinology 159, 199-205.

Mathematical Modeling of Biomedical Systems

Schematic of possible regulation of the reproductive neuroendocrine system in adults. Source: SM Moenter (2018) Endocrinology 159, 199-205.

Mathematical Modeling of Biomedical Systems

The Schnell lab works on collaborative projects investigating complex biomedical systems comprising many interacting components, where modeling and theory may aid in the identification of the key mechanisms underlying the behavior of the system as a whole. In these projects, we combine biophysical principles with mathematical, computational and statistical methods to develop models that provide novel insights about the mechanisms of biological processes, and refine current views of these processes.

Most of our projects involved collaborations with both theoretical and experimental researchers working at the University of Michigan, the USA and around the world. We are working on an extensive list of topics, such as the physiological feedback effects of estradiol on the underlying episodic gonadotropin-releasing hormone (GnRH) secretion, discovering the signalling crosstalk controlling the development and parterning of the small intestine, investigating the developmental mechanism controlling germ cell fate determination during mouse oogenesis, studying the molecular mechanism of RNA interference, identifying the developmental signals triggering neuroblastoma disease progression, and others.

You can learn more about current research through our Publications.

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Santiago Schnell
John A. Jacquez Collegiate Professor of Physiology

My research focuses on developing standard-methods to obtain high quality measurements in the biomedical sciences and mathematical models of biomedical systems.