Welcome to the Schnell Lab

The Schnell Lab is located in the Brehm Center for Diabetes Research  at the University of Michigan Medical School. We combine chemical kinetics, mathematical, computational and statistical methods to develop standard-based approaches to measure the rates of biochemical reactions and distinguish their molecular mechanisms under physiological conditions. The lab primarily  focuses on studying enzyme catalyzed reactions and aberrant protein aggregation reactions leading to pathological conditions. We also develop quantitative approaches to measure other phenomena in the biomedical sciences.


Our goal is to develop standard-based methods in biology and medicine to obtain high-quality measurements with rigor, reproducibility, and robustness. This research in measurement innovation science - biometrology and chemometrics - will facilitate the translation of basic science and clinical research to inspire breakthroughs in the biomedical sciences.


In addition of our work in  biometrology  and chemometrics, the Schnell lab works on collaborative projects investigating complex biomedical systems comprising many interacting components, where modeling and theory may aid in the identification of the key mechanisms underlying the behavior of the system as a whole.


Dr. Santiago Schnell, the principal investigator of the laboratory, is the interim chair of the Department of Molecular & Integrative Physiology, the John A. Jacquez Collegiate Professor of Physiology, and a Professor in the Department of Molecular & Integrative Physiology, and Department of Computational Medicine & Bioinformatics at the University of Michigan Medical School.  He is also a William K. Brehm Investigator at the Brehm Center for Diabetes Research.


The work of our laboratory is sponsored by National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of General Medical Sciences, Eunice Kennedy Shriver National Institute of Child Health and Human Development and the University of Michigan Protein Folding Diseases Initiative. We also receive support from Brehm Center for Diabetes Research, Department of Molecular & Integrative Physiology, Endowment for Basic Sciences' Computational Biology Initiative, University of Michigan Office of the Provost, and University of Michigan Medical School.

News and Media

A team of Michigan Medicine researchers working with scientists from the Technion – Israel Institute of Technology has developed a simple model that explains how the ER is able to efficiently launch this protein cleanup response. For more information, visit MHealth Lab.

Dr. Wylie Stroberg, a Michigan IRACDA Fellow, pursuing his postdoctoral fellowship in the Schnell Lab, is one of ten recipients of the 2018 University of Michigan Outstanding Postdoctoral Fellow Award. The recipients have demonstrated a breadth of excellence in all areas of research, teaching, mentoring, service, and leadership. For more information, visit this page.

Dr. Santiago Schnell was  elected Foreign Corresponding Fellow of the Latin American Academy of Sciences on May 2018.


Fellows of the Latin American Academy of Sciences are some of the best scientists in the world, and represent the best Hispanic American scientists. They are selectively inducted into the Academy for their outstanding contributions to research and innovation. The Fellows are key to the Academy’s fundamental purpose of using science for the benefit of Latin America and the Caribbean. For more information, visit this page.

For more news, please visit our News and Media webpage.

The Schnell Lab, University of Michigan Medical School

All Rights Reserved