Welcome to the Schnell Lab

The Schnell Lab is located in the Brehm Center for Diabetes Research  at the University of Michigan Medical School. We combine chemical kinetics, mathematical, computational and statistical methods to develop standard-based approaches to measure the rates of biochemical reactions and distinguish their molecular mechanisms under physiological conditions. The lab primarily  focuses on studying enzyme catalyzed reactions and aberrant protein aggregation reactions leading to pathological conditions. We also develop quantitative approaches to measure other phenomena in the biomedical sciences.


Our goal is to develop standard-based methods in biology and medicine to obtain high-quality measurements with rigor, reproducibility, and robustness. This research in measurement innovation science - biometrology and chemometrics - will facilitate the translation of basic science and clinical research to inspire breakthroughs in the biomedical sciences.


In addition of our work in  biometrology  and chemometrics, the Schnell lab works on collaborative projects investigating complex biomedical systems comprising many interacting components, where modeling and theory may aid in the identification of the key mechanisms underlying the behavior of the system as a whole.


Dr. Santiago Schnell, the principal investigator of the laboratory, is the interim chair of the Department of Molecular & Integrative Physiology, the John A. Jacquez Collegiate Professor of Physiology, and a Professor in the Department of Molecular & Integrative Physiology, and Department of Computational Medicine & Bioinformatics at the University of Michigan Medical School.  He is also a William K. Brehm Investigator at the Brehm Center for Diabetes Research.


The work of our laboratory is sponsored by National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of General Medical Sciences, Eunice Kennedy Shriver National Institute of Child Health and Human Development and the University of Michigan Protein Folding Diseases Initiative. We also receive support from Brehm Center for Diabetes Research, Department of Molecular & Integrative Physiology, Endowment for Basic Sciences' Computational Biology Initiative, University of Michigan Office of the Provost, and University of Michigan Medical School.

News and Media

Santiago Schnell, D.Phil., has been appointed interim chair of the Department of Molecular & Integrative Physiology in the Medical School, effective August 1. He will assume leadership of the department while a national search is conducted for a permanent chair. For more information, visit the Michigan Medicine Headlines.

American's still first in science - but China rose fast as funding stalled in U.S. and other countries. A University of Michigan team examines global cooperation and output in original biomedical research publications and funding. The new findings, published in JCI Insights, come at a critical time for the debate over the future of U.S. federal research funding. For more information, visit the Michigan Medicine Headlines.

Santiago Schnell was been elected as Fellow of the American Association for the Advancement of Science (AAAS) in October 2016. Dr. Schnell is one of four new 2016 AAAS Fellows in Mathematics.


Election as a Fellow of AAAS honors members whose efforts on behalf of the advancement of science or its applications in service to society have distinguished them among their peers and colleagues. For more information visit the University Record Headlines.

For more news, please visit our News and Media webpage.

The Schnell Lab, University of Michigan Medical School

All Rights Reserved