Welcome to the Schnell Lab

The Schnell Lab is located in the Brehm Center for Diabetes Research  at the University of Michigan Medical School. We combine chemical kinetics, molecular modeling, biochemical measurements and computational modeling to build a comprehensive understanding of proteostasis and protein folding diseases.


Although our primary research interest is in protein folding diseases, we also investigate other complex physiological systems comprising many interacting components, where modeling and theory may aid in the identification of the key mechanisms underlying the behavior of the system as a whole.


Dr. Santiago Schnell, the principal investigator of the laboratory, is a Professor in the Department of Molecular & Integrative Physiology and Department of Computational Medicine & Bioinformatics at the University of Michigan Medical School.  He is also a William K. Brehm Investigator at the Brehm Center for Diabetes Research.


The work of our laboratory is sponsored by National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of General Medical Sciences, the James S. McDonnell Foundation and the University of Michigan Protein Folding Diseases Initiative. We also receive support from Brehm Center for Diabetes Research, Deparment of Molecular & Integrative Physiology, Endowment for Basic Sciences' Computational Biology Initiative, University of Michigan Office of the Provost, and University of Michigan Medical School.

News and Media

Dr. Santiago Schnell was elected President of the Society for Mathematical Biology.  He will take over the presidency office at the Annual Meeting of the Society to be held in Atlanta, Georgia, USA on June 30-July 3, 2015.


The Society for Mathematical Biology was founded in 1972 to promote the development and dissemination of research at the interface between the mathematical and biological sciences. It does so through its meetings, awards, and publications.

Dr. Santiago Schnell was recognized as one of the 175 Faces of Chemistry by the Royal Society of Chemistry.  175 Faces of Chemistry highlights and celebrates the diversity of the individuals, both past and present, who have helped to shape chemistry and science as a whole.  Visit Prof. Santiago Schnell's profile in the 175 Faces of Chemistry.

The Schnell Lab  developed a computer simulation algorithm to model biochemical reactions under conditions more realistic to those found in the cell. This University of Michigan research appears as a cover story in the March 21, 2014 issue of Physical Chemistry Chemical Physics.  The Schnell lab simulation approach will have considerable impact in understanding the role of new drug treatments for diseases. For more information, visit the University of Michigan Health System Headlines.

For more news, please visit our News and Media webpage.

The Schnell Lab, University of Michigan Medical School

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