Molecular Imaging Division
Alnawaz Rehemtulla, PhD:
Professor and Director of the Molecular Imaging Division
In response to specific stimuli, cells, through a coordinated action of many proteins forming a so-called signal transduction cascade or network, will generate a specific response. Achieving an understanding of these signaling networks in tissue culture models let alone in living individuals is a major challenge. The complexity and dynamic behavior of individual signaling cascades is such that the simple knowledge of the players (proteins) and their interacting partners is not enough to provide an accurate quantitative description of the system. Molecular Imaging provides for a unique opportunity to quantify these signaling cascades in a non-invasive and dynamic manner. The development of genetically encoded proteins, which enable real-time, high-resolution and semi-quantitative visualization of molecular concentrations and protein-protein interactions. More interestingly, the ability to image specific enzymatic activities (kinase, phosphatase, proteases, glycanase etc.) within a signaling cascade dynamically and quantitatively will serve as key experimental tools that will ultimately allow an intuitive understanding of the signal–response relation. The Rehemtulla laboratory has used the ability image signaling cascades in mouse models to provide novel insights into the biology of cancer. Additionally, cell based have been used to delineate novel signaling events that promote the transformed phenotype.
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- Inhibition of furin/proprotein convertase-catalyzed surface and intracellular processing by small molecules. Komiyama T, Coppola JM, Larsen MJ, van Dort ME, Ross BD, Day R, Rehemtulla A, Fuller RS. J Biol Chem. 2009 Jun 5;284(23):15729-38.
- Noninvasive imaging of apoptosis and its application in cancer therapeutics. Coppola JM, Ross BD, Rehemtulla A., Clin Cancer Res. 2008 Apr 15;14(8):2492-501.
- Evaluation of D-methionine as a novel oral radiation protector for prevention of mucositis. Vuyyuri SB, Hamstra DA, Khanna D, Hamilton CA, Markwart SM, Campbell KC, Sunkara P, Ross BD, Rehemtulla A. Clin Cancer Res. 2008 Apr 1;14(7):2161-70.
- Molecular imaging of Akt kinase activity. Zhang L, Lee KC, Bhojani MS, Khan AP, Shilman A, Holland EC, Ross BD, Rehemtulla A. Nat Med. 2007 Sep;13(9):1114-9.
- Noninvasive molecular imaging sheds light on the synergy between 5-fluorouracil and TRAIL/Apo2L for cancer therapy. Lee KC, Hamstra DA, Bhojani MS, Khan AP, Ross BD, Rehemtulla A. Clin Cancer Res. 2007 Mar 15;13(6):1839-46.
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