Radiation and Cancer Biology
Ted Lawrence, MD, PhD:
Isadore Lampe Professor and Department Chair
The Lawrence laboratory can be found at Rm 4310 of the Medical Science I Building of the UM Medical School. We are part of the Cancer Biology division of the Radiation Oncology Department. Our lab operates in conjunction with the laboratories of Meredith Morgan, Mukesh Nyati, and Dipankar Ray. We also have a long-term collaboration with the laboratory of Jonathan Maybaum in the Pharmacology Department and interaction with the Feng and Speers laboratories in the Radiation Oncology Department. We do primarily translational research in the general area of radiosensitizers and radioprotectors. Within that framework are projects involving inhibitors of cell cycle checkpoints as radiosensitizers (Morgan lab), mechanistic studies involving gemcitabine, investigations of tyrosine kinase inhibitors as radiosensitizers in vivo and in vitro as well as the role of EGFR signaling in the response to therapy (Nyati lab). The Ray lab is seeking to understand the molecular alterations during radiation-induced lung toxicity and identifying new therapeutic targets for thoracic cancers.
Our laboratory also manages the Experimental Irradiation Core of the UM Cancer Center. Mary Davis or David Karnak or are the contact persons for information about the core.
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