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Nuclear Medicine: Grants

Federal and Foundation Grants Led by Nuclear Medicine Faculty

NIH NINDS P01 NS15655
Principal Investigator: KA Frey                 
08/01/2001 - 07/31/2007

“PET Study of Biochemistry and Metabolism of the CNS”
This program project investigates neurochemical changes in patients with neurodegenerative and movement disorders with the use of positron emission tomography.  The program includes studies of Parkinson's disease, multiple system atrophy and Tourette syndrome.

NM Faculty Roles:  KA Frey – Principal Investigator, Director of SubProject 2, Director of Admin Core; MR Kilbourn – Director of SubProject 1, Director of Radiochemistry Core; RA Koeppe – Director of Tomography and Data Processing Core


NIH NCRR M01 RR00042                 
Principal Investigator: RP Kelch               
03/01/2006 - 02/28/2011

“The University of Michigan General Clinical Research Center”
This center grant provides infrastructural support for clinical research.  The Biomedical Imaging Core supports consultation, data collection and data analysis for a range of cross-sectional imaging modalities including:  PET, SPECT, structural MR and fMRI.

NM Faculty Roles:  KA Frey – Director of Biomedical Imaging Core; MR Kilbourn – Co-Investigator; RA Koeppe – Co-Investigator


NIH NIA P50 AG08671                     
Principal Investigator: S Gilman               
06/01/2005 - 05/31/2010

“Michigan Alzheimer’s Disease Research Center”
This program grant studies animal model and human aspects of Alzheimer disease and related neurodegenerative dementing syndromes.  Project 2 investigates the relationships between PET FDG metabolism, amyloid deposition and dopaminergic denervation of the striatum and the pattern and progression of cognitive decline in early dementia and mild cognitive deficit subjects.  Project 3 investigates the relationship of PET measures of amyloid deposition and striatal dopamine denervation in patients with a variety of dementia subtypes, including AD, DLB and FTD.

NM Faculty Roles:  KA Frey – Director of Project 2, Co-Investigator of Project 3; RA Koeppe – Co-Investigator of Projects 2 and 3


Charles S Dana Foundation          
Principal Investigator:  KA Frey                
09/24/2004 - 09/23/2007

“In Vivo Amyloid Measurements in MCI: 3-Site Study”
This project will establish the feasibility of multi-site amyloid imaging in early AD with PET of the radiotracer [11C]PIB.  Sites include University Pittsburgh, Washington University (St. Louis) and The University of Michigan.

NM Faculty Roles:  KA Frey – PI for UM Site; S Shao – Co-Investigator


Veteran’s Admin Merit                  
Principal Investigator:  NI Bohnen                       
04/01/2004 – 03/31/2007

“Neurobiological and Postural Control Mechanisms underlying Risk of Falling
This project is designed to evaluate neurobiological and postural control mechanisms underlying imbalance and risk of falling in elderly veterans.  The overarching goal of this project is to examine the degree to which age-associated striatal dopaminergic denervation, as measured by in vivo striatal dopamine transporter PET.

NM Faculty Roles:  NI Bohnen -  Principal Investigator


NIH NINDS P50 NS019608                
Principal Investigator: M Zigmond                      
07/01/2003 – 06/30/2008

“Neuroprotection and Early Detection in PD”
The overarching goal of this project is to develop a multitiered approach to the diagnosis of preclinical or prodromal PD.  To accomplish this task we will focus on first degree relatives of patients with PD using postural motor system analysis and clinicometric PD test battery screening to select subjects with prodromal motor symptoms.  Dopaminergic brain PET imaging will then be used as the gold standard for the diagnosis of very early PD.  We will validate the different components of the PD test battery and postural motor system analysis as biomarkers of nigrostriatal dopaminergic denervation in patients with a clinical diagnosis of PD.

NM Faculty Roles:  NI Bohnen – SubProject Director


Michael J Fox Foundation             
Principal Investigator:  NI Bohnen                       
09/01/2005 - 08/31/2008           

“Executive, ADL, and Cholinergic Functions in PD”
The major goals of this project are to examine the degree to which cerebral cholinergic deficits, as measured by in vivo AChE binding using PET neuroimaging, are associated with executive cognitive deficits and ADL functions in patients with PD with and without mild dementia.

NM Faculty Roles:  NI Bohnen – Principal Investigator


Veteran’s Admin Merit                  
Principal Investigator:  NI Bohnen                       
07/01/2005 - 06/30/2010

“Striatal and Extra-Striatal Mechanisms of Falling in Parkinson’s Disease”
This project is designed to evaluate oculomotor, cognitive executive and visuospatial mechanisms of risk of falling in patients with Parkinson’s disease and how this related to monoaminergic and cholinergic brain activity, visuospatial, cognitive neurobiological and postural control mechanisms underlying imbalance and risk of falling in elderly veterans.  The study will consist of baseline assessment of oculomotor, cognitive and brain MRI and PET examination followed by a 6-month diary study for prospective assessment of the risk of falls.

NM Faculty Roles:  NI Bohnen – Principal Investigator


NIH NCI P01 CA87634                     
Principal Investigator:  CR Meyer                       
08/01/2002 - 07/31/2007

“Automatic 3D registration for Enhanced Cancer Management”
This program project is a pre-clinical test of the role of 3D registration techniques to assist detection and interpretation of lesion changes between interval exams, define organs automatically for radiation therapy treatment planning, apply diagnostic pre-surgical planning fMRI studies in patients with lesion-induced hyperkinesis via 3D slice-based motion correction, apply registered CT side information to improve PET sensitivity and specificity for small lung neoplasms.

NM Faculty Roles: JA Fessler – SubProject Director;  KA Frey – Co-Investigator; Robert A. Koeppe – Co-Investigator; JR Corbett – Co-Investigator


Dept Energy DE FG02 02ER63479  
Principal Investigator:  MR Kilbourn        
09/01/2002 - 07/31/2007     

“In Vivo Radionuclide Imaging of Mesenchymal Stem Cells”
Use of microPET and SPECT to track stem cell biodistribution and retention in tissues.

NM Faculty Roles:  MR Kilbourn – Principal Investigator


NIH NIDA P01 DA00254 32             
Principal Investigator:  J Woods              
07/01/2001 - 06/31/2007     

“Narcotic Drug and Opioid Peptide Basic Research Project”
Synthesis of labeled opioid receptor ligands for PET imaging.

NM Faculty Roles:  MR Kilbourn – Sub-Project Director; J-K Zubieta – Sub-Project Director


NIH NIBIB R21 EB002171                 
Principal Investigator:  MR Kilbourn        
07/01/2004 - 06/30/2007     

“Imaging Vesicular Monamine Transporters in the Brain” (Subcontract from U Pennsylvania)
Design, synthesis and in vivo evaluation of new fluorine-18 labeled radiotracers for the vesicular monoamine transporter (VMAT2). Perform pharmacokinetic studies in primates using microPET.

NM Faculty Roles:  MR Kilbourn – Subcontract Principal Investigator


NIH NCI P30 CA046592                   
Principal Investigator:  M Wicha             
06/01/2006 - 05/31/2011     

“University of Michigan Comprehensive Cancer Center Support Grant”
The major goal of this core is to provide human and animal imaging (MRI/S) capabilities to member of the University of Michigan Comprehensive Cancer Center.

NM Faculty Roles:  MR Kilbourn – Core Director


NIH NIMH R21 MH66506                 
Principal Investigator:  RA Koeppe         
09/01/2002 - 08/31/2007

“Implementation of [18F]FEOBV for VAChT Imaging Using PET”
Synthesis optimization and biological evaluation of fluorine-18 labeled benzovesamicol preparatory for use in humans.

NM Faculty Roles:  RA Koeppe – Principal Investigator; MR Kilbourn – Co-Investigator


NIH NIA U01 AG024904                  
Principal Investigator:  RA Koeppe         
09/01/2005 - 08/31/2009

“Alzheimer's Disease Neuroimaging Initiative”
The major goals of this project are to collect longitudinal biomarker data on normal elderly subjects and patients with MCI and AD.  Our center will be responsible for quality control and analysis of PET data.

NM Faculty Roles:  RA Koeppe – Director of PET Data Processing Core


NIH NIMH RO1 AT001415                
Principal Investigator: J-K Zubieta                       
09/01/2003 - 05/31/2007

“Neurochemical Mediation of Placebo Responses in Humans”
Examine the brain’s release of endogenous opioids in response pain with and without placebo administration.

NM Faculty Roles:  J-K Zubieta – Principal Investigator; RA Koeppe – Co-Investigator


NIH NIDA RO1 DA016423               
Principal Investigator:  J-K Zubieta          
09/01/2004 - 06/30/2008

“Neurochemical Endophenotype Responses to Pain-Stress”
To investigate pain perception and opiate neurotransmitter activity measured with PET.

NM Faculty Roles:  J-K Zubieta – Principal Investigator; RA Koeppe – Co-Investigator


NIH NIMH R21 MH069612               
Principal Investigator:  J-K Zubieta                      
07/01/2004 - 06/30/2007

“Mu-Opioid Mediated Stress Regulation of BPD”
To investigate pain perception and opiate neurotransmitter regulation in patients with borderline personality disorder.

NM Faculty Roles:  J-K Zubieta – Principal Investigator; RA Koeppe – Co-Investigator


NIH NIDA R01 DA022520               
Principal Investigator:  J-K Zubieta                      
09/30/2006 - 08/31/2011

“Neurochemistry of Opiate Abuse Risk in Chronic Pain”
This project is to examine individual variations in the function of opioid and dopaminergic neurotransmitter systems in patients diagnosed with non-malignant chronic pain and their relationship with elements of risk for opiate abuse.

NM Faculty Roles:  J-K Zubieta – Principal Investigator; RA Koeppe – Co-Investigator


NIH NCI P50 CA069568                   
Principal Investigator:  M Piert                 
06/01/2005-05/31/2008       

“Multi-Modality Molecular Imaging of Prostate Cancer”
This program project is a phase I clinical trial assessing of the role of molecular imaging in the identification of tumor proliferation and hypoxia to subsequently direct intensity modulated radiotherapy and targeted biopsies. Imaging includes [11C]choline and [18F]FAZA PET/CT, endorectal coil MRI, dynamic contrast-enhanced MRI, MI spectroscopy and histological/immunohistochemical verification of imaging findings including 3D-comparison of data sets using dedicated image fusion software.

NM Faculty Roles:  M Piert – Project Director


NIH NHLBI R01 HL079540                 
Prinicpal Investigator:  D Raffel               
12/01/2004 - 11/30/2007

“Heart Imaging Agents: A Structural-Mechanistic Study“   
To develop C-11 and F-18-labeled tracers for mapping regional sympathetic nerve density in mammalian heart by Positron Emission Tomography (PET). The long-range goal is to develop tracers to quantitatively assess cardiac nerve damage in heart diseases such as diabetic neuropathy, congestive heart failure and myocardial infarction.

NM Faculty Roles:  D Raffel – Principal Investigator



Federal and Foundation Grants with Important Contributions from Nuclear Medicine Faculty

J Diabetes Res Fnd #4 2004 806    
Principal Investigator:  E Feldman                       
01/01/2005 - 12/31/2007

“Oxidative Injury and Diabetic Complications”
The aim of this study is evaluate the efficacy of antioxidant therapy to reverse established microvascular complications, especially cardiac autonomic neuropathy in patients with type 1 diabetes.

NM Faculty Roles:  D Raffel –- Co-Investigator


NIH NCI RO1 CA102435                 
Principal Investigator:  L Pierce               
02/01/2004 01/31/2008

“IMRT in the Treatment of Node-Positive Breast Cancer”
The long-term objective of the proposed research plan is to study comprehensive RT delivered using IMRT versus the best 3D standard treatment technique (Partially Wide Tangential Fields). Quantitative nuclear medicine imaging indicators of potential cardiac and lung toxicity will be compared to assess the improvements that may be achieved with the new approach. 

NM Faculty Roles:  KA Frey – Co-Investigator; JR Corbett – Co-Investigator


NIH NIDA RO1 DA018974               
Principal Investigator: E Domino              
09/15/2006 - 08/31/2009

“Effects of Nicotine on Human Cerebral Transmitters”
To determine the effects of 1) smoking denicotinized and average nicotine research cigarettes and tobacco smoking equivalent doses of intravenous nicotine (2) and (3) on regional cerebral release of dopamine and endogenous mu-opioids in adult male and female tobacco smokers.

NM Faculty Roles:  RA Koeppe – Co-Investigator


Dept Army W81XWH 06 1 0107      
Principal Investigator:  S Goldstein          
11/01/2005 - 11/30/2009

The influence of physical forces on progenitor cell migration, proliferation and differentiation in fracture repair, in vivo imaging of radiolabeled stem cells in bone repair. Perform SPECT and PET studies of radiolabeled stem cell distributions.

NM Faculty Roles:  MR Kilbourn – Co-Investigator


NIH NHLBI U01 HL077150                
Principal Investigatro:  J Weg                  
08/01/2005 - 05/31/2010     

“Prospective Investigation of Pulmonary Embolism Dx III”
Goals are to survey for evidence of pulmonary and peripheral vascular thrombus via contrast-enhanced MRA.

NM Faculty Roles:  KA Frey – Co-Investigator


NIH NCI P01 CA059827                   
Principal Investigator: B Fraass                
04/01/2006 - 06/30/2011

“Optimization of High Dose Conformal Therapy”
The overall objective of this program project is to continue the study and improvement of high dose conformal radiation therapy treatments for cancer.

NM Faculty Roles:  KA Frey – Co-Investigator