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VirologyPlease note: Words in italics are the official PIBS affiliations of the indicated faculty.
Kathleen R. Cho, MD Molecular pathogenesis of the
common gynecological tumors (carcinomas of the ovary,
enometrium and uterine cervix). Current lab projects
include molecular profiling of ovarian and cervical
carcinomas and analysis of Wnt signaling pathway defects
in ovarian endometrioid adenocarcinomas. Molecular and
Cellular Pathology. Kathleen
Collins, M.D., Ph.D. Molecular Mechanisms of HIV
Immune Evasion. Immunology. Cellular & Molecular Biology. Microbiology & Immunology. Michael J. Imperiale, Ph.D. Posttranscriptional regulation of eukaryotic gene expression; interaction of virus and host cell factors in regulation of gene expression and oncogenic transformation; viral vectors. Microbiology & Immunology. Cellular & Molecular Biology. Sonja Gerrard, Ph.D. Replication and assembly of RNA viruses; molecular pathogenesis and evasion of host innate immune systems. Microbiology & Immunology. Cellular & Molecular Biology. Epidemiology. Yasmina Laouar, Ph.D. Mechanisms of immunosuppression in the development, homeostasis, and function of innate effector cells in response to pathogens. Immunology, Microbiology & Immunology. Nicholas W. Lukacs, Ph.D. Interrelationship of cytokines, chemokines and leukocyte activation during asthmatic-type airway responses and immune responses. Molecular and Cellular Pathology. Gary Luker, Ph.D. Understanding how interactions between“invaders”, either DNA viruses or cancer cells, and the environment of a normal host affect disease pathogenesis. Emphasis on non-invasive imaging to analyze signaling pathways and disease outcome in living mice. Microbiology & Immunology. Immunology. David M. Markovitz, MD Regulation of retroviral gene expression. Cellular & Molecular Biology. Immunology. John Moran, Ph.D. Molecular analysis of human and mouse retrotransposons. Characterization of a novel retrotransposition mechanism. Studies of how transposable elements influence genomic diversity. Exploitation of human and mouse retrotransposons as genetic tools. Human Genetics. Patrick Nelson, Ph.D. Applied mathematics specializing in mathematical biology. Develop and use models to study the dynamics of HIV and HBV infections. Mathematics. Microbiology & Immunology. David Mindell, Ph.D. Molecular evolution and phylogenetics of vertebrate genomes and of viruses. Bioinformatics. Ecology & Evolutionary Biology. University of Michigan Museum of Zoology. Akira Ono, Ph.D. Relationships between cellular membranes and enveloped viruses with particular emphasis on the roles played by lipid rafts and endosomes in HIV-1 replication. Microbiology & Immunology. Malini Raghavan, Ph.D. Biochemical and molecular interactions underlying immune recognition events: interactions and biochemical mechanisms of function of the transporters associated with antigen processing; mammalian and viral Fc receptors and their interactions with immunoglobulin G. Microbiology & Immunology. Immunology. Biophysics. Cellular & Molecular Biology. Janet Smith, Ph.D. Structure-function studies of proteins using X-ray crystallography with an emphasis on complex enzymes and the replication proteins of flaviviruses and alphaviruses. Biological Chemistry. Katherine Spindler, Ph.D. Molecular genetics of mouse adenovirus (MAV-1) pathogenesis; host immune response to MAV-1; genetics of host susceptibility to viral infection. Microbiology & Immunology. Cellular & Molecular Biology. Human Genetics. Alice
Telesnitsky, Ph.D. Retrovirus molecular genetics,
reverse transcriptase structure-function studies, HIV-1
and murine leukemia virus genetic recombination and other
mechanisms of genetic variation, virus-host interactions
on the cellular level. Microbiology & Immunology. Cellular & Molecular Biology. Bill Tsai, Ph.D. Our overall goal is to clarify the cellular entry mechanism of both cholera toxin and polyoma/SV40 virus. Insights into these mechanisms will not only lead to a better understanding of how certain toxins and viruses infect their host cell, but will also clarify important aspects of basic cellular processes. Cell & Developmental Biology. Jason Weinberg, M.D. Pathogenesis of persistent viral infections. Lung inflammatory responses to acute and persistent viral infection. Contributions of specific chemokines and cytokines to the control of viral infection. Modulation of host inflammatory responses by persistent viral infection. Reactivation of latent gammaherpesvirus infection by host inflammatory responses. Pediatrics and Communicable Diseases. Microbiology and Immunology. Christiane Wobus, Ph.D. Entry of enteric murine norovirus into macrophages and dendritic cells in vitro and in vivo. Microbiology and Immunology.
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