Stem Cell Biology

Please note: Words in italics are the official PIBS affiliations of the indicated faculty.

Cheng-Yu Lee, Ph.D. Currently investigating a number of evolutionarily conserved genes required for the choice of self-renewal vs. differentiation in fly, and we will apply the insight gained from studying fly neuroblasts to a clinically relevant vertebrate system such as mouse to test the roles of these fly genes in regulation of vertebrate neural stem cell self-renewal. Long-term goals: Identify many signaling pathways expressed in both insect and vertebrate neural stem cells, contribute to our understanding of neural stem cells in birth defects, regenerative medicine and cancer biology. Center For Stem Cell Biology, Life Sciences Institute, Division of Molecular Medicine And Genetics, Department Of Internal Medicine, Cellular and Developmental Biology. Lab: http://www.lsi.umich.edu/facultyresearch/labs/lee

Yasmina Laouar, Ph.D. Mechanisms of immunosuppression in the development, homeostasis, and function of innate effector cells in response to pathogens. Immunology, Microbiology & Immunology.

Ivan Maillard, M.D.-Ph.D. Our main research interests are in the following topics: Investigating the interaction of hematopoietic stem cells (HSC) with their microenvironmental niche, particularly in fetal sites of hematopoiesis; and understanding the role of Notch signaling in the regulation of T cell homeostasis and differentiation. We are using a combination of genetic, cellular and biochemical approaches to study these questions. Hematology-Oncology. Cell and Developmental Biology. http://www.med.umich.edu/immprog/faculty/maillard.htm

Sean Morrison, Ph.D. Stem cell biology using hematopoiesis and neural development as model systems. Cell & Developmental Biology. Cellular & Molecular Biology.

Jack Parent, M.D. Neural stem cells, plasticity and regeneration after brain injury; epileptogenesis. Neuroscience.

Yukiko Yamashita Mechanisms of asymmetric stem cell division, control of stem cell behavior in their natural environment (in vivo), cell polarity, spindle orientation. Cell & Developmental Biology.