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Signal TransductionPlease note: Words in italics are the official PIBS affiliations of the indicated faculty. Huda Akil, Ph.D. Molecular and neurobiological mechanisms of stress, opioids, endorphins, and dopamine. Psychiatry. Molecular and Chemical Neuroscience. Anuska Andjelkovic-Zochowska, M.D., Ph.D. Molecular basis of inflammatory events at the blood brain barrier; the role of vascular endothelium in the pathogenesis of central nervous system inflammation; molecular mechanism of glioma associated angiogenesis. Pathology. Neuroscience. Molecular & Cellular Pathology. Helen Baghdoyan, Ph.D. Signal transduction pathways regulating arousal states such as sleep and anesthesia. Pharmacology. Neuroscience. Scott Barolo, Ph.D. Molecular genetics and biochemistry of transcriptional regulation; structure/function analysis of signaling pathway-regulated enhancers, using Drosophila as a model system. Cell & Developmental Biology. Sanford Bledsoe, Ph.D. Neuropharmacology and neurochemistry of peripheral and central auditory systems. Otolaryngology. Sensory Neurobiology. Kresge Hearing Research Institute. Neuroscience Daniel A. Bochar, Ph.D. Regulation of eukaryotic gene expression through the modulation of chromatin structure and the connection to developmental disorders and cancer. Biological Chemistry. Thomas Brock, Ph.D. Molecular and cellular aspects of cell-to-cell communication by polyunsaturated fatty acids, particularly in the contexts of immune defense and disease. Regulation of enzymes that convert fatty acids into alternative lipid mediators. Bioinformatics. Cellular & Molecular Biology. Internal Medicine Frank Brosius, M.D. Pathways by which glucose transporter expression affects cell death and the pathogenesis of diabetic nephropathy; abnormalities of glucose transport and etabolism in the pathogenesis of vascular changes in hypertension. Molecular & Integrative Physiology. Internal Medicine. Kenneth Cadigan, Ph.D. Genetics of Drosophila Devel and Signal Transduction. Molecular, Cellular & Developmental Biology. Cellular & Molecular Biology.
Christin Carter-Su, Ph.D. Signal transduction used by
cytokine receptors via JAK tyrosine kinases; regulation
of gene transcription by tyrosine kinases; cellular and
molecular actions of growth hormone and cytokines.
Molecular & Integrative Physiology. Cellular & Molecular Biology. Arul M. Chinnaiyan, M.D., Ph.D. Focus on
high-throughput genomic and proteomic technologies to
analyze human disease. Lab projects include molecular
profiling of prostate cancer, profiling cancer with
protein microarrays, and molecular signatures of sepsis.
Bioinformatics.
Molecular and
Cellular Pathology. Cheong-Hee Chang, Ph.D. Regulation of the effector function of CD4 T cells and dendritic cells. Microbiology & Immunology, Immunology, Cell & Molecular Biology. Steven Clark, Ph.D. Current research focuses on receptor kinase=mediated signaling pathways regulating stem cell identity and organogenesis, as well as microRNA regulation of stem cell specification. Molecular & Integrative Physiology. Molecular, Cellular & Developmental Biology. Jeffrey Curtis, M.D. Lung lymphocyte recruitment and apoptosis; regulation of pulmonary immunity; alveolar macrophage signal transduction pathways. Immunology. Mark Day, Ph.D. Cell-cycle regulation of epithelial programmed cell death. Cellular & Molecular Biology.
Robert Denver, Ph.D.
Molecular biology of hormone action in animal development;
neuroendocrinology; evolutionary developmental biology.
Molecular, Cellular & Developmental Biology. Neuroscience. Victor
J. DiRita, Ph.D. Molecular mechanisms in bacterial
pathogenesis; Genetic control of bacterial virulence.
Microbiology & Immunology.
Cellular & Molecular Biology. Steven Domino, M.D., Ph.D. Functions of cell-surface carbohydrates in reproductive and other tissues. Cellular & Molecular Biology. Gregory Dressler, Ph.D. Genetic basis of cellular differentiation and pattern formation in a complex multicellular tissue. Cellular & Molecular Biology. Molecular and Cellular Pathology. Cumming Duan, Ph.D. The current research focuses on the insulin-like growth factor (IGF) signaling system, including the IGF ligands, IGF binding proteins, IGF receptors, and the downstream signal transduction mechanisms. Molecular, Cellular & Developmental Biology. Cellular & Molecular Biology. Colin S. Duckett, Ph.D. Novel roles for IAP proteins in the control of apoptosis, intracellular signaling and metabolism. IAPs as regulators of apoptosis. IAPs in cancer. E3 ubiquitination activities of IAPs. Caspase-independent signaling properties of IAPs. X-linked lymphoproliferative disorder and XIAP. Role of XIAP in copper metabolism and homeostasis. c-IAPs: Key intracellular signaling molecules with diverse roles in inflammation. IAP antagonists: Apoptotic sensitizers and signaling modulators. Immunology, Molecular and Cellular Pathology, Cellular & Molecular Biology. James T. Elder, M.D., Ph.D. Genetics of psoriasis; regulation of keratinocyte growth and differentiation. Cellular & Molecular Biology. José
Esteban, Ph.D. Synaptic development and synaptic
plasticity. Pharmacology.
Neuroscience.
Eric R. Fearon, MD, Ph.D. Molecular genetics of
cancer; tumor suppressor gene function. Cellular & Molecular Biology. Human Genetics.
Molecular and
Cellular Pathology. Eva Feldman, MD, Ph.D. Insulin-like growth factors in neuronal development and survival. Cellular & Molecular Biology. Neuroscience.
Carol A. Fierke, Ph.D. RNA Processing. Protein
Prenylation. Structure, Mechanism and Inhibition of
metalloenzymes and ribozymes. Protein engineering of
biosensors and biocatalysts. Biological Chemistry. Biophysics. Stephen
K. Fisher, Ph.D. Role of inositol phospholipids in
neuronal signal transduction at cell-surface receptors.
Pharmacology.
Neuroscience. Diane Fingar, Ph.D. Signal transduction by the kinase mTOR, the mammalian target of rapamycin, using molecular, biochemical, and cell biological approaches. Cell and Developmental Biology. Renny T. Franceschi, Ph.D. Control of gene expression in osteoblasts; regulation of bone formation. Biological Chemistry. Jason Gestwicki, Ph.D. Use of organic chemistry to build new tools for exploring important biological questions. We are currently focused on generating new technologies for inhibiting protein-protein interactions in neurodegenerative diseases. Life Sciences Institute. Molecular & Cellular Pathology.
Gary Glick, Ph.D. Developing new methods to study the
structure, folding, and dynamics of both DNA and RNA.
Defining binding properties of anti-DNA autoantibodies
that arise in the autoimmune disorder systemic lupus
erythematosus. Immunology.
Chemistry. Cellular & Molecular Biology. Biophysics.
Biological Chemistry. Margaret
E. Gnegy, Ph.D. Neuropharmacology; mechanism of
amphetamine action; adaptive responses after repeated
amphetamine. Pharmacology.
Neuroscience.
Daniel J. Goldman, Ph.D. Acetylcholine receptor gene
expression at the neuromuscular junction; synaptogenesis;
sensory transduction processes; neuroreceptors; molecular
mechanisms of nerve regeneration. Biological Chemistry. Human Genetics.
Neuroscience. Pharmacology. Jun-Lin Guan, Ph.D. Signal transduction in cell migration. FAK signaling pathways in angiogenesis and metastasis. Role of a putative tumor suppressor FIP200 in development and cancer. Cellular & Developmental Biology. Internal Medicine. Gary D. Hammer, MD, Ph.D. Molecular mechanisms of stress. Adrenal cortical growth and differentiation. Transcriptional regulation by adrenal-specific nuclear receptors-transcription factors. Adrenal cortical carcinogenesis. Transgenic models of adrenal development and disease. Molecular & Integrative Physiology. Cellular & Molecular Biology. Marc Hershenson, M.D. Signal transduction mechanisms underlying airway smooth muscle cell proliferation and differentiation; biochemical signaling pathways regulating pro-inflammatory molecule expression in airway epithelial cells. Molecular & Integrative Physiology Joseph Holoshitz, MD Signal transduction; MHC and DNA repair in autoimmunity. Immunology. Microbiology. Cellular & Molecular Biology. Larry Holzman, MD. Our work focuses on characterizing the molecular nature of the kidney podocyte intercellular junction and its role in regulating the podocyte actin cytoskeleton. A second project investigates the biology of mixed lineage protein kinases (components of the JNK module). Cellular & Molecular Biology. Michael Hortsch, Ph.D. Role of cell adhesion molecules in neuronal differentiation of Drosophila. Cell & Developmental Biology. Neuroscience. Patrick Hu, MD, Ph.D. We use the nematode C. elegans to study the biology of conserved signal transduction pathways that are mutated in cancer and diabetes. Cell & Developmental Biology. Bret A. Hughes, Ph.D. Structure, function, and regulation of ion channels in the retinal pigment epithelium. Ophthalmology. Molecular & Integrative Physiology. Jorge Iñiguez-Lluhi, Ph.D. Eukaryotic Transcriptional regulation, transcription factor interactions,Steroid hormone receptors, structure, function and genetics. Pharmacology. Lori L. Isom, Ph.D. Cellular & Molecular Biology of voltage-gated sodium channel alpha and beta subunits. Pharmacology. Neuroscience. Cellular & Molecular Biology. Human Genetics. Mariana Kaplan, M.D. Dendritic cells in autoimmune diseases; APC apoptosis in lupus; endothelial cell apoptosis and vascular damage. Immunology. Randal J. Kaufman, Ph.D. Regulation of protein synthesis and secretion; molecular biology of factor VIII and gene therapy for hemophilia A. Biological Chemistry.
Tom Kerppola, Ph.D. Regulation of gene expression by
proto-oncogene transcription factors; protein
interactions in living cells and organisms; and
nucleoprotein complex architecture. Biological Chemistry. Biophysics. Philip King, Ph.D. Molecular understanding of mechanisms of signal integration in T cells. The role of a variety of intracellular signaling molecules including protein and lipid kinases, phosphatases, adapter proteins and transcription factors as potential signal integrators. Microbiology & Immunology. Immunology. Catherine Krull, Ph.D. Mechanisms that control cell migration and patterning during embryonic development. Cellular and Developmental Biology. Roland Kwok, Ph.D. Hormonal regulation of cAMP-activated gene expression. Biological Chemistry. Obstetrics & Gynecology. Angel W.
Lee, M.D., Ph.D. Tyrosine kinase-based signal transduction mechanisms
that regulate
cell proliferation and differentiation in myeloid progenitors, embryonic and
neural stem cells; identification of novel molecules in neurogenesis. Pharmacology.
Cellular & molecular Biology. Bioinformatics. Cheng-Yu Lee, Ph.D. Currently investigating a number of evolutionarily conserved genes required for the choice of self-renewal vs. differentiation in fly, and we will apply the insight gained from studying fly neuroblasts to a clinically relevant vertebrate system such as mouse to test the roles of these fly genes in regulation of vertebrate neural stem cell self-renewal. Long-term goals: Identify many signaling pathways expressed in both insect and vertebrate neural stem cells, contribute to our understanding of neural stem cells in birth defects, regenerative medicine and cancer biology. Center For Stem Cell Biology, Life Sciences Institute, Division of Molecular Medicine And Genetics, Department Of Internal Medicine, Cellular and Developmental Biology. Lab: http://www.lsi.umich.edu/facultyresearch/labs/lee Jennifer J. Linderman, Ph.D. Digital imaging of single cells; signal transduction; mathematical modeling of receptor-mediated cell behavior. Biophysics. Chemical Engineering. Mats Ljungman, Ph.D. Cellular responses induced by DNA-damaging agents and other cellular stresses. Cellular & Molecular Biology. Anatoli Lopatin, Ph.D. Regulation of potassium channels by polyamines. Neuroscience. Molecular & Integrative Physiology. Ralph Lydic, Ph.D. Transmembrane cell signaling; integrative aspects of respiratory and arousal state control. Cellular and molecular mechanisms that cause respiratory depression during the loss of waking consciousness. Neurochemical and signal transduction processes. Neuroscience. Ormond A. MacDougald, Ph.D. Adipocyte gene expression and metabolism; transcriptional and posttranslational regulation of the transcription factor, C/EBP (alpha). Molecular & Integrative Physiology. Jill A. Macoska, Ph.D.Genetic and cellular changes associated with early neoplastic transformation. Bioinformatics. Cellular & Molecular Biology. Urology. Sami Malek, M.D. Hematological malignancies including CLL, Follicular Lymphoma, MDS and AML using a variety of approaches. Many questions intersect with standard immunological problems and are studied accordingly. Internal Medicine. Immunology. Benjamin L. Margolis, MD Mechanisms of signal transduction by tyrosine kinases. Biological Chemistry. Jeff Martens, Ph.D. Protein/lipid interactions in ion channel localiztion and function. Pharmacology. K. M. Jairam Menon, Ph.D. Signal transduction through G protein-coupled receptors; molecular aspects of hormone action. Biological Chemistry. Obstetrics & Gynecology. Juanita L. Merchant, MD, Ph.D. Molecular mechanisms of gastric epithelial cell growth; growth factor regulation of normal and neoplastic growth; transcriptional control of gastrointestinal peptides; posttranslational modifications of transcription factors; transgenic models for stomach development; Helicobacter pylori and peptic ulcer; gastric cancer development. Cellular & Molecular Biology. Molecular & Integrative Physiology.
Richard A. Miller, MD, Ph.D. Signal transduction in T
cells; aging and T-cell subsets; immunology of aging;
genetics of longevity. Pathology. Cellular & Molecular Biology. Immunology. Bethany Moore, Ph.D. Cytokine and chemokine and eicosanoid regulation of pulmonary fibrosis; bacterial infections in the lung post bone-marrow transplant. Immunology. Richard Mortensen, M.D., Ph.D. Molecular signal transduction pathways important in cardiovascular risk and disease. Pathways in hypertension and diabetes. G-proteins, PPARs, growth pathways. Molecular & Integrative Physiology. Internal Medicine. Martin Myers, MD, Ph.D. Mechanisms of intracellular signaling by the leptin receptor/Jak2 complex. Signals than perturbed in genetically engineered animals in order to study the function of these signals in neurons and immune cells in vivo. Molecular & Integrative Physiology. Richard Neubig,
MD, Ph.D. Molecular mechanisms of signal
transduction; spectroscopic and rapid kinetic studies of
receptors, G proteins and their regulators; NMR structure
of receptor and G-protein peptides; mechanism of
alpha-adrenergic receptors. Bioinformatics. Biophysics.
Pharmacology. Ruthann Nichols, Ph.D. Structure-activity relationship of neuropeptides and neuropeptide receptors with emphasis on the RFamide peptide family and their role in regulating heart rate and muscle contraction; role of FMRF-amide neuropeptides in Drosophila and mammalian nervous systems. Biological Chemistry. Neuroscience. Human Genetics. Alexander J. Ninfa, Ph.D. Reconstitution of signal transduction systems from purified components, structure/function analysis of signal transduction enzymes, protein crystallography. Characterization of protein kinases, phosphatases, and nucleotidy/transferases involved in signal transduction. Organization of the gene cascade controlling nitrogen assimilation in bacteria. Development of synthetic systems that perform useful functions. Biological Chemistry. Microbiology & Immunology. Bennett Novitch, Ph.D. Regulation of progenitor and stem cell proliferation and differentiation in the developing vertebrate central nervous system. Cell & Developmental Biology. Neuroscience. Gabriel Nuñez, MD Molecular regulation of programmed cell death (apoptosis); identification and characterization of apoptosis regulatory genes. Cellular & Molecular Biology. Molecular and Cellular Pathology. Microbiology & Immunology. Paresh
Patel, MD, Ph.D. Neurotransmitters Regulating Mood Disorders. Neuroscience. Ayyalusamy Ramamoorthy, Ph.D. Structure, dynamics and function of membrane-associated proteins. Biophysics. Pamela A.
Raymond, Ph.D. Development and regeneration in the
central nervous system of zebrafish, using genetics with
molecular and embryological tools to uncover the
molecular basis of cell-cell interactions that regulate
retinal neurogenesis (the formation of neurons) and
neuronal specificity (the expression of differentiated
cellular features) during development and regeneration.
Mechanisms of pattern formation and formation of precise
arrays of cone photoreceptors in the zebrafish
retina.Cell & Developmental Biology. Rudy J.
Richardson, ScD, DABT Mechanisms of neurological
disorders, stroke and autoimmune diseases and their
modulation by xenobiotics, genetics and age. Biomarkers
of xenobiotic exposure or disease. Interactions of
ligands with macromolecules using kinetics, molecular
modeling and mass spectrometry. Environmental
epidemiology. Scientific basis of risk assessment and
public health policy. Neuroscience. Diane M. Robins, Ph.D. Developmental and hormonal regulation of mammalian gene expression. Human Genetics. Cellular & Molecular Biology. Theodora S. Ross, M.D., Ph.D. Genetics and biology of human leukemias by using mouse modeling as well as standard biochemical, molecular biological and cellular techniques. Cellular & Molecular Biology. Liangyou Rui, Ph.D. Molecular mechanisms of obesity and type 2 diabetes. Investigation of molecular mechanisms of insulin/leptin signaling and resistance. Molecular & Integrative Physiology. Alan R. Saltiel, Ph.D. Mechanism of hormone action. Protein phosphorylation. Signal transduction. Molecular & Integrative Physiology. Linda C. Samuelson, Ph.D. Regulation of gastrointestinal function by peptide hormones; mouse developmental genetics; gene targeting in embryonic stem cells; molecular physiology of cholecystokinin and gastrin. Molecular & Integrative Physiology. Cellular & Molecular Biology. Mark A. Saper, Ph.D. Structural biology of components of the type III secretion system essential for bacterial pathogenesis. Other current projects include a novel bacterial tyrosine kinase and phosphatase important for pathogenesis, and a family of aminotransferases essential for plant photorespiration. Protein crystallography is the main technique employed in the lab. Biological Chemistry. Biophysics.
Jochen H. Schacht, Ph.D. Neurochemistry; biochemical
mechanisms of hearing processes and drug-induced hearing
loss. Biological Chemistry.
Neuroscience. Jessica Schwartz, Ph.D. Cellular and molecular mechanisms of growth factor action; regulation of gene expression. Molecular & Integrative Physiology. Cellular & Molecular Biology. James A. Shayman, MD. Mechanisms of cellular signaling by sphingolipid development of inhibitors for treating sphingolipid storage disorders. Pharmacology. Internal Medicine. Robert U. Simpson, Ph.D. Receptors: calcium-regulating hormones and drugs. Pharmacology. Gary Smith, Ph.D. Mammalian gamete and embryo developmental biology. Molecular & Integrative Physiology. William L. Smith, Ph.D. Chemical processes underlying the biosynthesis and functions of prostaglandins. Current research is focused on understanding (a) the enzymology of prostaglandin endoperoxide H synthases (PGHSs) and (b) the regulation of PGHS gene expression. PGHSs are also known as “cyclooxygenases”. Biological Chemistry. Edward L. Stuenkel, Ph.D. Molecular and cellular regulation of neurotransmitter and neurohormone secretion; regulation of exocytosis at central synapses. Molecular & Integrative Physiology. Molecular and Chemical Neuroscience. Yi Sun, Ph.D. 1) Mechanism of p53 tumor suppressor and SCF E3 ubiquitin ligase (for protein ubiquitination and degradation) in apoptosis induction and suppression, respectively; 2) Identification and validation of cancer targets in the p53 and E3 ubiquitin ligase signaling pathways for anti-cancer drug discovery. Cellular & Molecular Biology. Radiation Oncology. Roger Sunahara, Ph.D. Structure/function of the G-protein-coupled signaling cascade; molecular mechanisms of hormone receptor-mediated activation of G proteins; molecular mechanisms of activation and regulation of adenylyl cyclase. Pharmacology. Joel Swanson, Ph.D. Endocytosis in macrophages. Cellular & Molecular Biology. Microbiology & Immunology. Immunology. Biophysics. Anand Swaroop,
Ph.D. Molecular genetics of inherited eye diseases;
animal models for retinal degeneration; regulation of
development and tissue-specific gene expression;
expression mapping of human genome. Human Genetics. Cellular & Molecular Biology.
Neuroscience. John Tesmer, Ph.D. Structural studies of heterotrimeric G protein signaling using X-ray crystallography and other biophysical techniques. Life Sciences Institute, Pharmacology. Debra A. Thompson, Ph.D. Molecular studies of the function of the mammalian retina, including analysis of the mechanisms controlling signal transduction and tissue-specific gene expression in the retinal pigment epithelium. Biological Chemistry. John Traynor, Ph.D. Pharmacology of Opioid Drugs. Pharmacology. Raymond C. Trievel, Ph.D. Structural and functional studies of enzymes that catalyze post-translational modifications of proteins, especially those involved in transcriptional regulation and chromatin remodeling. Biological Chemistry. Tetsufumi
Ueda, Ph.D. Protein phosphorylation in the nervous
system and neuropharmacology; Biochemistry and function
of synaptic vesicles. Neuroscience.
Pharmacology. Michael D. Uhler, Ph.D. Regulation and specificity of serine-threonine protein kinase structures; regulation of calcium channels and neurotransmitter secretion; function and regulation of neuronal activity; Cyclic nucleotides and phosphorylation in neuronal plasticity. Cellular & Molecular Biology. Biological Chemistry. Molecular and Chemical Neuroscience. Hisashi
Umemori, M.D. Molecular mechanisms of specific neural network
and synapse formation in the mammalian nervous system. Biological
Chemistry, Neuroscience James Varani, Ph.D. Cell-substrate adhesion and cell motility in normal mammalian cells and their malignant counterparts; biosynthesis and surface expression of extracellular matrix molecules, such as fibronectin, laminin, and thrombospondin and their involvement as endogenous regulators of adhesion, motility, invasion, and metastasis. Molecular and Cellular Pathology. Kristen Verhey, Ph.D. Motor proteins and the cytoskeleton in neurons; axonal transport of signaling complexes; protein trafficking. Cell & Developmental Biology. Claudius Vincenz, Ph.D. Apoptosis; Molecular events involved in this evolutionary conserved process. Cloning and characterization of caspases and A20 homologues. Molecular and Cellular Pathology. Anne Vojtek, Ph.D. Regulation of cell growth and differentiation by signal transduction pathways. Biological Chemistry. Stanley Watson, MD, Ph.D. Regulatory neurobiology of opioid and related peptides; Molecular and neurobiological mechanisms of stress. Cellular & Molecular Biology. Neuroscience. Lois Weisman, Ph.D. To uncover mechanisms of organelle inheritance, and to determine how these processes are spatially and temporally regulated. We have discovered that myosin V attaches to membranes via organelle-specific receptors. In addition inheritance requires a newly discovered signaling pathway. Cell & Developmental Biology. Cellular & Molecular Biology. Life Sciences Institute. Michael J. Welsh, Ph.D. Cellular stress response and stress-induced proteins; molecular mechanisms of toxicant action; regulation and function of hsp27 and related small stress proteins in muscle and cancer; cell biology; cell cytoskeleton and cytoskeletal proteins. Cell & Developmental Biology. Cellular & Molecular Biology. Margaret Westfall, Ph.D. Thin filament regulation of contractile function; cellular and molecular dissection of contractile function using viral-based gene transfer into cardiac myocytes. Molecular & Integrative Physiology. Cellular & Molecular Biology. Eric S. White, M.D. Our lab focuses on fibroblast biology, extracellular matrix influences on cellular biology, and immunology of granulomatous lung diseases. Internal Medicine-Pulmonary & Critical Care Medicine. Immunology. John A. Williams, MD, Ph.D. Membrane receptor regulation of cell function; cellular mechanisms of pancreatic secretion; regulation of intracellular Ca2+. Molecular & Integrative Physiology. Cellular & Molecular Biology. Matthew J. Wishart, Ph.D. Mechanisms of action for protein- and lipid-phosphatases; STYX / dead-phosphatase adapters and phosphorylation-mediated signaling; molecular mechanisms of mammalian reproduction. Molecular & Integrative Physiology X.Z. Shawn Xu, Ph.D. Neurobiology of behavior and drug addiction in the genetic model organism C. elegans. Regulation of neuronal activity and fertilization by calcium signaling. Molecular & Integrative Physiology. Zhaohui Xu, Ph.D. Protein-protein interaction and molecular recognition; structural biology of protein folding, protein translocation, and cellular signal transduction; x-ray crystallography. Biological Chemistry. Matt Young, Ph.D. Regulatory mechanisms of the Cyclin Dependent Kinases and other protein kinases. Structural studies and computational modeling of molecular dynamics in signaling proteins. Biological Chemistry. Bioinformatics. |
