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Receptor InteractionsPlease note: Words in italics are the official PIBS affiliations of the indicated faculty. Huda Akil, Ph.D. Molecular and neurobiological mechanisms of stress, opioids, endorphins, and dopamine. Psychiatry. Molecular and Chemical Neuroscience. Neuroscience. Richard A. Altschuler, Ph.D. Neurobiology; auditory neurotransmitters and pathways and structural basis of cochlea function; plasticity in the auditory brain stem. Cell & Developmental Biology. Neuroscience. Helen Baghdoyan, Ph.D. Signal transduction pathways regulating arousal states such as sleep and anesthesia. Pharmacology. Neuroscience. Scott Barolo, Ph.D. Molecular genetics and biochemistry of transcriptional regulation; structure/function analysis of signaling pathway-regulated enhancers, using Drosophila as a model system. Cell & Developmental Biology. Sanford Bledsoe, Ph.D. Neuropharmacology and neurochemistry of peripheral and central auditory systems. Otolaryngology. Sensory Neurobiology. Kresge Hearing Research Institute. Neuroscience.
Christin Carter-Su, Ph.D. Signal transduction used by
cytokine receptors via JAK tyrosine kinases; regulation
of gene transcription by tyrosine kinases; cellular and
molecular actions of growth hormone and cytokines.
Molecular & Integrative Physiology. Cellular & Molecular Biology. Stephen W. Chensue, MD, Ph.D. Cellular and molecular mechanisms of leukocyte mobilization during granulomatous inflammation. Molecular and Cellular Pathology. Steven Clark, Ph.D. Current research focuses on receptor kinase=mediated signaling pathways regulating stem cell identity and organogenesis, as well as microRNA regulation of stem cell specification. Molecular & Integrative Physiology. Molecular, Cellular & Developmental Biology.
Robert Denver, Ph.D.
Molecular biology of hormone action in animal development;
neuroendocrinology; evolutionary developmental biology.
Molecular, Cellular & Developmental Biology. Neuroscience. Cumming Duan, Ph.D. The current research focuses on the insulin-like growth factor (IGF) signaling system, including the IGF ligands, IGF binding proteins, IGF receptors, and the downstream signal transduction mechanisms. Molecular, Cellular & Developmental Biology. Cellular & Molecular Biology. Colin S. Duckett, Ph.D. Novel roles for IAP proteins in the control of apoptosis, intracellular signaling and metabolism. IAPs as regulators of apoptosis. IAPs in cancer. E3 ubiquitination activities of IAPs. Caspase-independent signaling properties of IAPs. X-linked lymphoproliferative disorder and XIAP. Role of XIAP in copper metabolism and homeostasis. c-IAPs: Key intracellular signaling molecules with diverse roles in inflammation. IAP antagonists: Apoptotic sensitizers and signaling modulators. Immunology, Molecular and Cellular Pathology, Cellular & Molecular Biology. R.
Keith Duncan, Ph.D. Early stages of signal processing
in the auditory periphery, particularly in the context of
hair cell physiology. Neuroscience. José
Esteban, Ph.D. Synaptic development and synaptic
plasticity. Pharmacology.
Neuroscience. Eva Feldman, MD, Ph.D. Insulin-like growth factors in neuronal development and survival. Cellular & Molecular Biology. Neuroscience. Sid Gilman, MD Neurophysiological basis of motor control. Integrative and Systems Neurobiology. Neuroscience. Gary D. Hammer, MD, Ph.D. Molecular mechanisms of stress. Adrenal cortical growth and differentiation. Transcriptional regulation by adrenal-specific nuclear receptors-transcription factors. Adrenal cortical carcinogenesis. Transgenic models of adrenal development and disease. Molecular & Integrative Physiology. Cellular & Molecular Biology. Joseph Holoshitz, MD Signal transduction; MHC and DNA repair in autoimmunity. Immunology. Microbiology. Cellular & Molecular Biology. Michael Hortsch, Ph.D. Role of cell adhesion molecules in neuronal differentiation of Drosophila. Cell & Developmental Biology. Neuroscience. Patrick Hu, MD, Ph.D. We use the nematode C. elegans to study the biology of conserved signal transduction pathways that are mutated in cancer and diabetes. Cell & Developmental Biology. Jorge Iñiguez-Lluhi, Ph.D. Eukaryotic Transcriptional regulation, transcription factor interactions,Steroid hormone receptors, structure, function and genetics. Pharmacology. Randal J. Kaufman, Ph.D. Regulation of protein synthesis and secretion; molecular biology of factor VIII and gene therapy for hemophilia A. Biological Chemistry. Ron Koenig, MD, Ph.D. Gene regulation by thyroid hormone receptors and related proteins. Cellular & Molecular Biology. Catherine Krull, Ph.D. Mechanisms that control cell migration and patterning during embryonic development. Cellular and Developmental Biology. Jennifer J. Linderman, Ph.D. Digital imaging of single cells; signal transduction; mathematical modeling of receptor-mediated cell behavior. Biophysics. Chemical Engineering. Benjamin L. Margolis, MD Mechanisms of signal transduction by tyrosine kinases. Biological Chemistry. K. M. Jairam Menon, Ph.D. Signal transduction through G protein-coupled receptors; molecular aspects of hormone action. Biological Chemistry. Obstetrics & Gynecology. Daniel Michele, PhD Molecular & Integrative Physiology Molecular mechanisms of human cardiomyopathies and skeletal myopathies, with a focus on muscular dystrophy, using mouse models. Extracellular matrix receptors in central nervous system development and muscle disease. Molecular & Integrative Physiology.
Richard A. Miller, MD, Ph.D. Signal transduction in T
cells; aging and T-cell subsets; immunology of aging;
genetics of longevity. Molecular and
Cellular Pathology.
Bioinformatics. Cellular and Developmental Biology.
Immunology. Bethany Moore, Ph.D. Cytokine and chemokine and eicosanoid regulation of pulmonary fibrosis; bacterial infections in the lung post bone-marrow transplant. Immunology. Richard Mortensen, M.D., Ph.D. Molecular signal transduction pathways important in cardiovascular risk and disease. Pathways in hypertension and diabetes. G-proteins, PPARs, growth pathways. Molecular and IntegrativePhysiology. Internal Medicine. Martin Myers, MD, Ph.D. Mechanisms of intracellular signaling by the leptin receptor/Jak2 complex. Signals than perturbed in genetically engineered animals in order to study the function of these signals in neurons and immune cells in vivo. Molecular & Integrative Physiology Richard Neubig,
MD, Ph.D. Molecular mechanisms of signal
transduction; spectroscopic and rapid kinetic studies of
receptors, G proteins and their regulators; NMR structure
of receptor and G-protein peptides; mechanism of
alpha-adrenergic receptors. Bioinformatics. Biophysics.
Pharmacology. Laura Olsen, Ph.D. Molecular and cellular biology of peroxisomes - peroxisome biogenesis and function. Molecular, Cellular & Developmental Biology. Paresh
Patel, MD, Ph.D. Neurotransmitters Regulating Mood Disorders. Neuroscience. Malini Raghavan, Ph.D. Biochemical and molecular interactions underlying immune recognition events: interactions and biochemical mechanisms of function of the transporters associated with antigen processing; mammalian and viral Fc receptors and their interactions with immunoglobulin G. Microbiology & Immunology. Immunology. Biophysics. Cellular & Molecular Biology. Pamela A. Raymond, Ph.D. Development and regeneration in the central nervous system of zebrafish, using genetics with molecular and embryological tools to uncover the molecular basis of cell-cell interactions that regulate retinal neurogenesis (the formation of neurons) and neuronal specificity (the expression of differentiated cellular features) during development and regeneration. Mechanisms of pattern formation and formation of precise arrays of cone photoreceptors in the zebrafish retina. Cell & Developmental Biology. http://www.med.umich.edu/cdb/sub_pages/People/raymond.htm Rudy J.
Richardson, ScD, DABT Mechanisms of neurological
disorders, stroke and autoimmune diseases and their
modulation by xenobiotics, genetics and age. Biomarkers
of xenobiotic exposure or disease. Interactions of
ligands with macromolecules using kinetics, molecular
modeling and mass spectrometry. Environmental
epidemiology. Scientific basis of risk assessment and
public health policy. Neuroscience. Diane M. Robins, Ph.D. Developmental and hormonal regulation of mammalian gene expression. Human Genetics. Cellular & Molecular Biology. Theodora S. Ross, M.D., Ph.D. Genetics and biology of human leukemias by using mouse modeling as well as standard biochemical, molecular biological and cellular techniques. Cellular & Molecular Biology. Liangyou Rui, Ph.D. Molecular mechanisms of obesity and type 2 diabetes. Investigation of molecular mechanisms of insulin/leptin signaling and resistance. Molecular & Integrative Physiology. Gabrielle Rudenko, Ph.D.Determining the three-dimensional structure of proteins with important functions in the brain using x-ray crystallography, augmented with biochemical, biophysical as well as mutagenesis studies. Pharmacology. Life Sciences Institute Martin Sarter, Ph.D. Regulation and function of forebrain cholinergic systems. Neurobiology of attention. Neuronal mediation of the cognitive dysfunctions in neurodegenerative and neurospychiatric disorders. Psychology. Neuroscience. Alan R. Saltiel, Ph.D. Mechanism of hormone action. Protein phosphorylation. Signal transduction. Molecular & Integrative Physiology. Jessica Schwartz, Ph.D. Cellular and molecular mechanisms of growth factor action; regulation of gene expression. Molecular & Integrative Physiology. Cellular & Molecular Biology. Roger Sunahara, Ph.D. Structure/function of the G-protein-coupled signaling cascade; molecular mechanisms of hormone receptor-mediated activation of G proteins; molecular mechanisms of activation and regulation of adenylyl cyclase. Pharmacology. John Tesmer, Ph.D. Structural studies of heterotrimeric G protein signaling using X-ray crystallography and other biophysical techniques. Life Sciences Institute, Pharmacology. John Traynor, Ph.D. Pharmacology of Opioid Drugs. Pharmacology. Anne Vojtek, Ph.D. Regulation of cell growth and differentiation by signal transduction pathways. Biological Chemistry. Stanley Watson, MD, Ph.D. Regulatory neurobiology of opioid and related peptides; Molecular and neurobiological mechanisms of stress. Cellular & Molecular Biology. Neuroscience. Michael J. Welsh, Ph.D. Cellular stress response and stress-induced proteins; molecular mechanisms of toxicant action; regulation and function of hsp27 and related small stress proteins in muscle and cancer; cell biology; cell cytoskeleton and cytoskeletal proteins. Cell & Developmental Biology. Cellular & Molecular Biology. Eric S. White, M.D. Our lab focuses on fibroblast biology, extracellular matrix influences on cellular biology, and immunology of granulomatous lung diseases. Internal Medicine-Pulmonary & Critical Care Medicine. Immunology. Christiane Wobus, Ph.D. Entry of enteric murine norovirus into macrophages and dendritic cells in vitro and in vivo. Microbiology and Immunology. James
H. Woods, Ph.D. Behavioral pharmacology; mechanisms
of drug tolerance, dependence, and reinforcement.
Pharmacology.
Neuroscience. |
