Protein Trafficking

Please note: Words in italics are the official PIBS affiliations of the indicated faculty.

Radha Ayyagari, Ph.D Molecular genetics of retinal and macular degenerations and understanding the mechanism underlying the degeneration process. Cell and Developmental Biology. Ophthalmology and visual sciences.

Frank Brosius, M.D. Pathways by which glucose transporter expression affects cell death and the pathogenesis of diabetic nephropathy; abnormalities of glucose transport and etabolism in the pathogenesis of vascular changes in hypertension. Molecular & Integrative Physiology. Internal Medicine.

Thomas Brock, Ph.D. Molecular and cellular aspects of cell-to-cell communication by polyunsaturated fatty acids, particularly in the contexts of immune defense and disease. Regulation of enzymes that convert fatty acids into alternative lipid mediators. Bioinformatics. Cellular & Molecular Biology. Internal Medicine.

Vern Carruthers, Ph.D. Pathogenesis of parasitic infections: Mechanisms of cell invasion and survival during infection. Microbiology and Immunology.

Amy Chang, Ph.D. Genetics and cell biology of protein folding, sorting, and transport in the yeast secretory pathway; membrane biogenesis. Molecular, Cellular, and Developmental Biology.

Kathleen Collins, M.D., Ph.D. Molecular Mechanisms of HIV Immune Evasion. Immunology. Cellular & Molecular Biology. Microbiology & Immunology.
http://www.med.umich.edu/cmb/faculty/directory.htm#collins

José Esteban, Ph.D. Synaptic development and synaptic plasticity. Pharmacology. Neuroscience.
http://sitemaker.umich.edu/esteban.lab

Stephen K. Fisher, Ph.D. Role of inositol phospholipids in neuronal signal transduction at cell-surface receptors. Pharmacology. Neuroscience.
http://sitemaker.umich.edu/fisher

Robert S. Fuller, Ph.D. Proteolytic processing, protein localization, and macromolecular transport in the secretory pathway; yeast cell biology; structure, mechanism, and specificity of proteases. Biological Chemistry. Cellular & Molecular Biology.
http://www.med.umich.edu/cmb/faculty/directory.htm#fuller

Sonja Gerrard, Ph.D. Replication and assembly of RNA viruses; molecular pathogenesis and evasion of host innate immune systems. Microbiology & Immunology. Cellular & Molecular Biology. Epidemiology.

David Ginsburg, MD Molecular genetics of the blood coagulation system. Human Genetics. Cellular & Molecular Biology.

Thomas W. Glover, Ph.D. Molecular cytogenetics and the molecular biology of human disease; gene mapping; Menkes syndrome; fragile sites. Human Genetics. Cellular & Molecular Biology.

Lori L. Isom, Ph.D. Cellular & Molecular Biology of voltage-gated sodium channel alpha and beta subunits. Pharmacology. Neuroscience. Cellular & Molecular Biology. Human Genetics.

Randal J. Kaufman, Ph.D. Regulation of protein synthesis and secretion; molecular biology of factor VIII and gene therapy for hemophilia A. Biological Chemistry.

Tom Kerppola, Ph.D. Regulation of gene expression by proto-oncogene transcription factors; protein interactions in living cells and organisms; and nucleoprotein complex architecture. Biological Chemistry. Biophysics.
http://sitemaker.umich.edu/kerppola.lab

Daniel J. Klionsky, Ph.D. Molecular and cellular biology of protein targeting and degradation, and organelle homeostasis in yeast. Cellular & Molecular Biology. Molecular, Cellular & Developmental Biology. Biological Chemistry.

Daniel Lawrence, Ph.D. How basic binary interactions such as protein:protein interactions regulate complex physiologic processes. Studies focus on protease inhibitors and their targets in systems such as vascular cell migration, and in models of stroke and seizure. Internal Medicine. Cellular & Molecular Biology.

David Lubman, Ph.D. The use of proteomics to study cancer biomarkers and the progression of disease. Our methods include protein fractionation techniques, liquid separations, mass spectrometry and spectroscopic methods. Surgery. Bioinformatics. Molecular and Cellular Pathology.

Benjamin L. Margolis, MD Mechanisms of signal transduction by tyrosine kinases. Biological Chemistry.

Jeff Martens, Ph.D. Protein/lipid interactions in ion channel localiztion and function. Pharmacology

Richard Neubig, MD, Ph.D. Molecular mechanisms of signal transduction; spectroscopic and rapid kinetic studies of receptors, G proteins and their regulators; NMR structure of receptor and G-protein peptides; mechanism of alpha-adrenergic receptors. Bioinformatics. Biophysics. Pharmacology.
Biophysics

Laura Olsen, Ph.D. Molecular and cellular biology of peroxisomes - peroxisome biogenesis and function. Molecular, Cellular & Developmental Biology.

Akira Ono, Ph.D. Relationships between cellular membranes and enveloped viruses with particular emphasis on the roles played by lipid rafts and endosomes in HIV-1 replication. Microbiology & Immunology.

Theodora S. Ross, M.D., Ph.D. Genetics and biology of human leukemias by using mouse modeling as well as standard biochemical, molecular biological and cellular techniques. Cellular & Molecular Biology.

Alan R. Saltiel, Ph.D. Mechanism of hormone action. Protein phosphorylation. Signal transduction. Molecular & Integrative Physiology.

Maria Sandkvist, Ph.D. Protein trafficking in bacterial pathogens. Microbiology & Immunology.

Mark A. Saper, Ph.D. Structural biology of components of the type III secretion system essential for bacterial pathogenesis. Other current projects include a novel bacterial tyrosine kinase and phosphatase important for pathogenesis, and a family of aminotransferases essential for plant photorespiration. Protein crystallography is the main technique employed in the lab. Biological Chemistry. Biophysics.

Gary Smith, Ph.D. Mammalian gamete and embryo developmental biology. Molecular & Integrative Physiology.

Edward L. Stuenkel, Ph.D. Molecular and cellular regulation of neurotransmitter and neurohormone secretion; regulation of exocytosis at central synapses. Molecular & Integrative Physiology. Molecular and Chemical Neuroscience.

Bill Tsai, Ph.D. Our overall goal is to clarify the cellular entry mechanism of both cholera toxin and polyoma/SV40 virus. Insights into these mechanisms will not only lead to a better understanding of how certain toxins and viruses infect their host cell, but will also clarify important aspects of basic cellular processes. Cell & Developmental Biology.

R. Scott Turner, MD, Ph.D. Molecular mechanisms of Alzheimer’s disease using cells and neurons in culture and transgenic mouse models; (beta) amyloid precursor protein and Alzheimer's disease. Molecular and Chemical Neuroscience. Neuroscience.
http://www.umich.edu/~neurosci/faculty/raymondt.htm

Kristen Verhey, Ph.D. Motor proteins and the cytoskeleton in neurons; axonal transport of signaling complexes; protein trafficking. Cell & Developmental Biology.

Lois Weisman, Ph.D. To uncover mechanisms of organelle inheritance, and to determine how these processes are spatially and temporally regulated. We have discovered that myosin V attaches to membranes via organelle-specific receptors. In addition inheritance requires a newly discovered signaling pathway. Cell & Developmental Biology. Cellular & Molecular Biology. Life Sciences Institute.

Steve J. Weiss, MD Regulation, expression, and function of proteinases in cell movement through the extracellular matrix. Cellular & Molecular Biology.

Matthew J. Wishart, Ph.D. Mechanisms of action for protein- and lipid-phosphatases; STYX / dead-phosphatase adapters and phosphorylation-mediated signaling; molecular mechanisms of mammalian reproduction. Molecular & Integrative Physiology.

Zhaohui Xu, Ph.D. Protein-protein interaction and molecular recognition; structural biology of protein folding, protein translocation, and cellular signal transduction; x-ray crystallography. Biological Chemistry.