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PhysiologyPlease note: Words in italics are the official PIBS affiliations of the indicated faculty. J. Wayne Aldridge, Ph.D. Neuronal activity in basal ganglia and motor cortex in movement. Neuroscience. Robert A. Bender, Ph.D. Metabolic regulation in microorganisms. Molecular, Cellular & Developmental Biology. Joshua Berke, Ph.D. Systems neuroscience of learning, motivation and decision-making, using electrophysiological recording in behaving rats and transgenic mice. Psychology. Neuroscience. Jimo Borjigin, Ph.D. Reseach is focused on three areas: entrainment of circadian pacemaker using melatonin as readout; molecular mechanisms of melatonin production; role of PINA (PIneal and Night-specific ATPase) in circadian rhythm and Wilson disease. Molecular & Integrative Physiology Susan V. Brooks, Ph.D. Single skeletal muscle fiber mechanics; role of contraction-induced muscle injury in the changes that occur in skeletal muscle structure and function with aging and in the pathogenesis of muscular dystrophy. Molecular & Integrative Physiology. Frank Brosius, M.D. Pathways by which glucose transporter expression affects cell death and the pathogenesis of diabetic nephropathy; abnormalities of glucose transport and etabolism in the pathogenesis of vascular changes in hypertension. Molecular & Integrative Physiology. Internal Medicine. Thomas Brock, Ph.D. Molecular and cellular aspects of cell-to-cell communication by polyunsaturated fatty acids, particularly in the contexts of immune defense and disease. Regulation of enzymes that convert fatty acids into alternative lipid mediators. Bioinformatics. Cellular & Molecular Biology. Internal Medicine Greg Cartee, Ph.D. My research is focused on understanding the mechanisms that underlie the regulation of skeletal muscle glucose transport, especially as the result of: exercise/contraction, calorie restriction (consuming approximately 60% of ad libitum intake), and/or aging. Kinesiology. Cellular & Molecular Biology.
Christin Carter-Su, Ph.D. Signal transduction used by
cytokine receptors via JAK tyrosine kinases; regulation
of gene transcription by tyrosine kinases; cellular and
molecular actions of growth hormone and cytokines.
Molecular & Integrative Physiology. Cellular & Molecular Biology. Louis G. D'Alecy, D.MD, Ph.D. Cardiovascular physiology: adaptive mechanisms in ischemia and hypoxia; therapeutic protection of brain, spinal cord, and kidney ischemia. Molecular & Integrative Physiology. Surgery. Jonathan Demb, Ph.D. Cellular mechanisms of visual adaptation in the mammalian retina. Patch-clamp electrophysiology of retinal neurons stimulated by light, in vitro. Ophthalmology & Visual Sciences, Molecular, Cellular & Developmental Biology
Robert Denver, Ph.D.
Molecular biology of hormone action in animal development;
neuroendocrinology; evolutionary developmental biology.
Molecular, Cellular & Developmental Biology. Neuroscience. Steven Domino, M.D., Ph.D. Functions of cell-surface carbohydrates in reproductive and other tissues. Cellular & Molecular Biology. Cunming Duan, Ph.D. The current research focuses on the insulin-like growth factor (IGF) signaling system, including the IGF ligands, IGF binding proteins, IGF receptors, and the downstream signal transduction mechanisms. Molecular, Cellular & Developmental Biology. Cellular & Molecular Biology. R.
Keith Duncan, Ph.D. Early stages of signal processing
in the auditory periphery, particularly in the context of
hair cell physiology. Neuroscience. José
Esteban, Ph.D. Synaptic development and synaptic
plasticity. Pharmacology.
Neuroscience. Daniel
P. Ferris, Ph.D. Biomechanics and neural control of human locomotion,
neurological rehabilitation, robotic devices for human augmentation
and rehabilitation. Movement Science. Sid Gilman, MD Neurophysiological basis of motor control. Integrative and Systems Neurobiology. Neuroscience. Gary D. Hammer, MD, Ph.D. Molecular mechanisms of stress. Adrenal cortical growth and differentiation. Transcriptional regulation by adrenal-specific nuclear receptors-transcription factors. Adrenal cortical carcinogenesis. Transgenic models of adrenal development and disease. Molecular & Integrative Physiology. Cellular & Molecular Biology. Marc Hershenson, M.D. Signal transduction mechanisms underlying airway smooth muscle cell proliferation and differentiation; biochemical signaling pathways regulating pro-inflammatory molecule expression in airway epithelial cells. Molecular & Integrative Physiology Larry Holzman, MD. Our work focuses on characterizing the molecular nature of the kidney podocyte intercellular junction and its role in regulating the podocyte actin cytoskeleton. A second project investigates the biology of mixed lineage protein kinases (components of the JNK module). Cellular & Molecular Biology. Bret A. Hughes, Ph.D. Structure, function, and regulation of ion channels in the retinal pigment epithelium. Ophthalmology. Molecular & Integrative Physiology. Lori L. Isom, Ph.D. Cellular & Molecular Biology of voltage-gated sodium channel alpha and beta subunits. Pharmacology. Neuroscience. Cellular & Molecular Biology. Human Genetics. Fred J. Karsch, Ph.D. Neuroendocrine regulation of ovarian cyclicity and seasonal breeding; interactions between immune and neuroendocrine systems. Molecular & Integrative Physiology. Robert Kennedy, Ph.D. Mechanisms and regulation of neurotransmitter and hormone secretion. Chemical basis of behavior and regulation by drugs. Novel technology for in vivo and single cell studies. Pharmacology.
Tom Kerppola, Ph.D. Regulation of gene expression by
proto-oncogene transcription factors; protein
interactions in living cells and organisms; and
nucleoprotein complex architecture. Biological Chemistry.
Biophysics. Lisa M. Larkin, Ph.D., Fabrication of engineered musculoskeletal tissues to restore the function of complex tissues such as muscle, tendon, nerve, ligament and bone following traumatic injury or to be used as a models for studying developmental biology and tissue specific pharmacology. Molecular & Integrative Physiology. http://www-personal.umich.edu/~llarkin Theresa M. Lee, Ph.D. Study the photic and non-photic signals that entrain circadian and seasonal rhythms and the role of gonadal hormones in the development and adult manifestation of those rhythms. Neuroscience. Jiandie Lin, Ph.D. - Genome-wide mapping and functional analysis of transcriptional networks in the control metabolism in cells and in vivo. Metabolic basis of diseases including obesity, type 2 diabetes, neurodegeneration and cancer. Cell & Developmental Biology. Life Sciences Institute. Anatoli Lopatin, Ph.D. Regulation of potassium channels by polyamines. Neuroscience. Molecular & Integrative Physiology. Benedict R. Lucchesi, MD, Ph.D. Cardiovascular pharmacology. Biological Chemistry. Ralph Lydic, Ph.D. Transmembrane cell signaling; integrative aspects of respiratory and arousal state control. Cellular and molecular mechanisms that cause respiratory depression during the loss of waking consciousness. Neurochemical and signal transduction processes. Neuroscience. Ormond A. MacDougald, Ph.D. Adipocyte gene expression and metabolism; transcriptional and posttranslational regulation of the transcription factor, C/EBP (alpha). Molecular & Integrative Physiology. Juanita L. Merchant, MD, Ph.D. Molecular mechanisms of gastric epithelial cell growth; growth factor regulation of normal and neoplastic growth; transcriptional control of gastrointestinal peptides; posttranslational modifications of transcription factors; transgenic models for stomach development; Helicobacter pylori and peptic ulcer; gastric cancer development. Cellular & Molecular Biology. Molecular & Integrative Physiology. Joseph M. Metzger, Ph.D. Viral-based gene transfer into the heart; cellular and molecular mechanisms of contraction in skeletal and cardiac muscle; cardiac gene expression and function; gene therapy for the heart. Molecular & Integrative Physiology.
Daniel Michele, PhD Molecular & Integrative Physiology Molecular mechanisms of human cardiomyopathies
and skeletal myopathies, with a focus on muscular
dystrophy, using mouse models. Extracellular matrix
receptors in central nervous system development and
muscle John Middlebrooks, Ph.D. Psychophysical and cortical physiological studies of directional hearing. Physiological stimulus of cochlear prosthesis. Neuroscience. Josef Miller, MD, Ph.D. Analysis of changes that occur in auditory periphery and CNS with deafness. Sensory Neurobiology. Otorhinolaryngology. Thomas Morrow, Ph.D. Neurobehavioral mechanisms of pain and somatic sensation. Molecular & Integrative Physiology. Sensory Neurobiology. Richard Mortensen, M.D., Ph.D. Molecular signal transduction pathways important in cardiovascular risk and disease. Pathways in hypertension and diabetes. G-proteins, PPARs, growth pathways. Molecular & Integrative Physiology. Internal Medicine. Martin Myers, MD, Ph.D. Mechanisms of intracellular signaling by the leptin receptor/Jak2 complex. Signals than perturbed in genetically engineered animals in order to study the function of these signals in neurons and immune cells in vivo. Molecular & Integrative Physiology Richard Neubig,
MD, Ph.D. Molecular mechanisms of signal
transduction; spectroscopic and rapid kinetic studies of
receptors, G proteins and their regulators; NMR structure
of receptor and G-protein peptides; mechanism of
alpha-adrenergic receptors. Bioinformatics. Biophysics.
Pharmacology. Ruthann Nichols, Ph.D. Structure-activity relationship of neuropeptides and neuropeptide receptors with emphasis on the RFamide peptide family and their role in regulating heart rate and muscle contraction; role of FMRF-amide neuropeptides in Drosophila and mammalian nervous systems. Biological Chemistry. Neuroscience. Human Genetics. Vasantha Padmanabhan, Ph.D. Prenatal programming of adult reproductive disorders by native steroids and environmental disruptors; Neuroendocrine control of ovarian cyclicity with emphasis on neuroendcorine and paracrine regulation of follicle-stimulating hormone and ovarian folliculogenesis. Molecular & Integrative Physiology Bryan Pfingst, Ph.D. Perception and processing of auditory information. Neuroscience. David J. Pinsky, Ph.D. To elucidate mechanisms driving ischemic modulation of the vascular phenotype, to understand endogenous mechanisms of ischemic vascular injury and protection at the intersection of thrombotic, fibrinolytic, and inflammatory axes. Molecular & Integrative Physiology Gina Poe, Ph.D. Basic sleep processes, development, learning and memory, and optimization of cognitive performance. Molecular & Integrative Physiology. Neuroscience. Donald G. Puro, MD, Ph.D. Physiology of ion channels in retinal cells and pathophysiology of glial cells. Molecular & Integrative Physiology. Neuroscience. Rudy J.
Richardson, ScD, DABT Mechanisms of neurological
disorders, stroke and autoimmune diseases and their
modulation by xenobiotics, genetics and age. Biomarkers
of xenobiotic exposure or disease. Interactions of
ligands with macromolecules using kinetics, molecular
modeling and mass spectrometry. Environmental
epidemiology. Scientific basis of risk assessment and
public health policy. Neuroscience. Diane M. Robins, Ph.D. Developmental and hormonal regulation of mammalian gene expression. Human Genetics. Cellular & Molecular Biology. Liangyou Rui, Ph.D. Molecular mechanisms of obesity and type 2 diabetes. Investigation of molecular mechanisms of insulin/leptin signaling and resistance. Molecular & Integrative Physiology. Alan R. Saltiel, Ph.D. Mechanism of hormone action. Protein phosphorylation. Signal transduction. Molecular & Integrative Physiology. Linda C. Samuelson, Ph.D. Regulation of gastrointestinal function by peptide hormones; mouse developmental genetics; gene targeting in embryonic stem cells; molecular physiology of cholecystokinin and gastrin. Molecular & Integrative Physiology. Cellular & Molecular Biology. Jessica Schwartz, Ph.D. Cellular and molecular mechanisms of growth factor action; regulation of gene expression. Molecular & Integrative Physiology. Cellular & Molecular Biology. Gary Smith, Ph.D. Mammalian gamete and embryo developmental biology. Molecular & Integrative Physiology. Edward L. Stuenkel, Ph.D. Molecular and cellular regulation of neurotransmitter and neurohormone secretion; regulation of exocytosis at central synapses. Molecular & Integrative Physiology. Molecular and Chemical Neuroscience. Lois Weisman, Ph.D. To uncover mechanisms of organelle inheritance, and to determine how these processes are spatially and temporally regulated. We have discovered that myosin V attaches to membranes via organelle-specific receptors. In addition inheritance requires a newly discovered signaling pathway. Cell & Developmental Biology. Cellular & Molecular Biology. Life Sciences Institute. Michael J. Welsh, Ph.D. Cellular stress response and stress-induced proteins; molecular mechanisms of toxicant action; regulation and function of hsp27 and related small stress proteins in muscle and cancer; cell biology; cell cytoskeleton and cytoskeletal proteins. Cell & Developmental Biology. Cellular & Molecular Biology. Margaret Westfall, Ph.D. Thin filament regulation of contractile function; cellular and molecular dissection of contractile function using viral-based gene transfer into cardiac myocytes. Molecular & Integrative Physiology. Cellular & Molecular Biology. John A. Williams, MD, Ph.D. Membrane receptor regulation of cell function; cellular mechanisms of pancreatic secretion; regulation of intracellular Ca2+. Molecular & Integrative Physiology. Cellular & Molecular Biology. Matthew J. Wishart, Ph.D. Mechanisms of action for protein- and lipid-phosphatases; STYX / dead-phosphatase adapters and phosphorylation-mediated signaling; molecular mechanisms of mammalian reproduction. Molecular & Integrative Physiology X.Z. Shawn Xu, Ph.D. Neurobiology of behavior and drug addiction in the genetic model organism C. elegans. Regulation of neuronal activity and fertilization by calcium signaling. Molecular & Integrative Physiology. |
