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Pharmacology Related ResearchPlease note: Words in italics are the official PIBS affiliations of the indicated faculty. Helen Baghdoyan, Ph.D. Signal transduction pathways regulating arousal states such as sleep and anesthesia. Pharmacology. Neuroscience. David P. Ballou, Ph.D. Mechanisms of biological redox reactions and reactions with oxygen, especially metalloproteins and flavoproteins; physical and chemical studies, including rapid reaction techniques and instrumentation development. Biological Chemistry. Biophysics. Jill Becker, Ph.D. Role of estrogen and dopamine in behavior/recovery of function after brain injury. Neuroscience. Sanford Bledsoe, Ph.D. Neuropharmacology and neurochemistry of peripheral and central auditory systems. Otolaryngology. Sensory Neurobiology. Kresge Hearing Research Institute. Neuroscience. Dean E. Brenner Clinical pharmacology focused upon cancer prevention in humans. The scientific goal of the laboratory is to validate interventions aimed at delay or reversal of carcinogenesis (progression of cancer). Tools used are gas chromatography, liquid chromatography, and Mass spectroscopy to identify low concentration analytes of drug or nutritional interventions in humans or biomarkers of cancer. Internal Medicine, Pharmacology. Thomas Carey, Ph.D. Genetic mechanisms in head and neck cancer progression; genetic mechanisms affecting response to therapy; and mechanisms of autoimmune hearing loss mediated by antibodies to inner ear antigens. Cellular & Molecular Biology. Pharmacology. Louis G. D'Alecy, D.MD, Ph.D. Cardiovascular physiology: adaptive mechanisms in ischemia and hypoxia; therapeutic protection of brain, spinal cord, and kidney ischemia. Molecular & Integrative Physiology. Surgery. José
Esteban, Ph.D. Synaptic development and synaptic
plasticity. Pharmacology.
Neuroscience.
Carol A. Fierke, Ph.D. RNA Processing. Protein
Prenylation. Structure, Mechanism and Inhibition of
metalloenzymes and ribozymes. Protein engineering of
biosensors and biocatalysts. Biological Chemistry. Biophysics. Stephen
K. Fisher, Ph.D. Role of inositol phospholipids in
neuronal signal transduction at cell-surface receptors.
Pharmacology.
Neuroscience. Jason Gestwicki, Ph.D. Use of organic chemistry to build new tools for exploring important biological questions. We are currently focused on generating new technologies for inhibiting protein-protein interactions in neurodegenerative diseases. Life Sciences Institute. Molecular & Cellular Pathology. Margaret E. Gnegy,
Ph.D. Neuropharmacology; mechanism of amphetamine action; adaptive
responses after repeated amphetamine. Pharmacology. Neuroscience. Daniel
J. Goldman, Ph.D. Acetylcholine receptor gene
expression at the neuromuscular junction; synaptogenesis;
sensory transduction processes; neuroreceptors; molecular
mechanisms of nerve regeneration. Biological Chemistry. Human Genetics.
Neuroscience. Pharmacology. Cory Hogaboam, Ph.D. Cytokine and chemokine networks that maintain inflammatory responses in the liver and lung during chronic disease. Cytokine and chemokine networks that promote deleterious liver and lung tissue repair processes. Therapeutic interventions in idiopathic pulmonary fibrosis and asthma. Phenotypic switches in pulmonary and hepatic firboblasts during chronic inflammatory disease. Molecular and Cellular Pathology. Immunology. Paul F. Hollenberg, Ph.D. Chemical carcinogenesis: metabolic activation and detoxication of carcinogens, mechanisms of carcinogen-activating enzymes, cytochrome P-450 and biological oxidations and peroxidations. Pharmacology. Jorge Iñiguez-Lluhi, Ph.D. Eukaryotic Transcriptional regulation, transcription factor interactions,Steroid hormone receptors, structure, function and genetics. Pharmacology. Lori L. Isom, Ph.D. Cellular & Molecular Biology of voltage-gated sodium channel alpha and beta subunits. Pharmacology. Neuroscience. Cellular & Molecular Biology. Human Genetics. Robert Kennedy, Ph.D. Mechanisms and regulation of neurotransmitter and hormone secretion. Chemical basis of behavior and regulation by drugs. Novel technology for in vivo and single cell studies. Pharmacology. Angel W.
Lee, M.D., Ph.D. Tyrosine kinase-based signal transduction mechanisms
that regulate Karley Y. Little, M.D. Biochemistry and pharmacology of monoamine synaptic transporters, particularly in relationship to altered mood and reward. Neuropharmacology. Neurochemical anatomy. Neuroscience. Benedict R. Lucchesi, MD, Ph.D. Cardiovascular pharmacology. Biological Chemistry. Jeff Martens, Ph.D. Protein/lipid interactions in ion channel localiztion and function. Pharmacology. Richard Mortensen, M.D., Ph.D. Molecular signal transduction pathways important in cardiovascular risk and disease. Pathways in hypertension and diabetes. G-proteins, PPARs, growth pathways. Molecular & Integrative Physiology. Internal Medicine. Richard Neubig,
MD, Ph.D. Molecular mechanisms of signal
transduction; spectroscopic and rapid kinetic studies of
receptors, G proteins and their regulators; NMR structure
of receptor and G-protein peptides; mechanism of
alpha-adrenergic receptors. Bioinformatics. Biophysics.
Pharmacology. Yoichi Osawa, Ph.D. Formation of reactive intermediates such as nitric oxide, oxygen metabolites, and drug metabolites and their subsequent interactions with important cellular targets as potential mechanisms by which drugs, environmental pollutants, and certain pathological conditions lead to toxicity or disease. Pharmacology. Bruce Palfey, Ph.D. Mechanistic enzymology with a focus on flavoproteins involved in pyrimidine biosynthesis, tRNA maturation, inhibitor design, and structure/function relationships. Biological Chemistry. James Rae, Ph.D. Regulation of breast cancer growth. Predicting drug response using pharmacogenetics and genomics. Drug metabolism and the cytochrome P450s. Biomarker discovery and clinical correlative studies. Preclinical drug discovery and testing. Internal Medicine. Pharmacology. Rudy J.
Richardson, ScD, DABT Mechanisms of neurological
disorders, stroke and autoimmune diseases and their
modulation by xenobiotics, genetics and age. Biomarkers
of xenobiotic exposure or disease. Interactions of
ligands with macromolecules using kinetics, molecular
modeling and mass spectrometry. Environmental
epidemiology. Scientific basis of risk assessment and
public health policy. Neuroscience. Terry E. Robinson, Ph.D. Neurobiology and biopsychology of addiction, and the nature of long-term neuroadaptations engendered by drug use. Psychology. Neuroscience. Gus Rosania, Ph.D. We study the transport of small molecules at the cellular and subcellular levels, and develop chemical, biological, and mathematical/computational tools to understand the transport of nutrients and drugs. Bioinformatics. Alan R. Saltiel, Ph.D. Mechanism of hormone action. Protein phosphorylation. Signal transduction. Molecular & Integrative Physiology.
Jochen H. Schacht, Ph.D. Neurochemistry; biochemical
mechanisms of hearing processes and drug-induced hearing
loss. Biological Chemistry.
Neuroscience. Donna S. Shewach, Ph.D. Metabolism and mechanism of action of nucleoside analog anticancer compounds. Pharmacology. Robert U. Simpson, Ph.D. Receptors: calcium-regulating hormones and drugs. Pharmacology. Maria S. Soengas, Ph.D. Skin cancer (melanoma) initiation, progression and chemoresistance. Identification of tumor markers and drug response genes. Development of new treatments for aggressive and metastatic melanoma. Cellular & Molecular Biology. Dermatology. Yi Sun, Ph.D. 1) Mechanism of p53 tumor suppressor and SCF E3 ubiquitin ligase (for protein ubiquitination and degradation) in apoptosis induction and suppression, respectively; 2) Identification and validation of cancer targets in the p53 and E3 ubiquitin ligase signaling pathways for anti-cancer drug discovery. Cellular & Molecular Biology. Radiation Oncology. Roger Sunahara, Ph.D. Structure/function of the G-protein-coupled signaling cascade; molecular mechanisms of hormone receptor-mediated activation of G proteins; molecular mechanisms of activation nd regulation of adenylyl cyclase. Pharmacology. John Tesmer, Ph.D. Structural studies of heterotrimeric G protein signaling using X-ray crystallography and other biophysical techniques. Life Sciences Institute, Pharmacology. John Traynor, Ph.D. Pharmacology of Opioid Drugs. Pharmacology. Tetsufumi
Ueda, Ph.D. Protein phosphorylation in the nervous
system and neuropharmacology; Biochemistry and function
of synaptic vesicles. Neuroscience.
Pharmacology. James
H. Woods, Ph.D. Behavioral pharmacology; mechanisms
of drug tolerance, dependence, and reinforcement.
Pharmacology.
Neuroscience. X.Z. Shawn Xu, Ph.D. Neurobiology of behavior and drug addiction in the genetic model organism C. elegans. Regulation of neuronal activity and fertilization by calcium signaling. Molecular & Integrative Physiology. |
