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OrganogenesisPlease note: Words in italics are the official PIBS affiliations of the indicated faculty. Kate F. Barald, Ph.D. Developmental neurobiology; molecular neurobiology studies of developing neuronal cells and synapses; gene expression in the neural crest; molecular studies of inner ear development. Cell & Developmental Biology. Neuroscience. Cellular & Molecular Biology. Scott Barolo, Ph.D. Molecular genetics and biochemistry of transcriptional regulation; structure/function analysis of signaling pathway-regulated enhancers, using Drosophila as a model system. Cell & Developmental Biology.
Margit Burmeister, Ph.D. Gene mapping; genetics of
neurological, psychiatric, and behavioral disorders;
mouse models; genome organization. Human Genetics. Neuroscience. Bioinformatics Kenneth Cadigan, Ph.D. Genetics of Drosophila Devel and Signal Transduction. Molecular, Cellular & Developmental Biology. Cellular & Molecular Biology. Sally A. Camper, Ph.D. Developmental genetics of the neuroendocrine system; transgenic mice; gene targeting; pituitary dwarfism. Human Genetics. Bioinformatics. Cellular & Molecular Biology. Neuroscience. Steven Clark, Ph.D. Current research focuses on receptor kinase=mediated signaling pathways regulating stem cell identity and organogenesis, as well as microRNA regulation of stem cell specification. Molecular & Integrative Physiology. Molecular, Cellular & Developmental Biology.
Robert Denver, Ph.D.
Molecular biology of hormone action in animal development;
neuroendocrinology; evolutionary developmental biology.
Molecular, Cellular & Developmental Biology. Neuroscience. Andrzej Dlugosz, M.D. Hedgehog signaling; molecular regulation of skin development and tumorigenesis. Cellular & Molecular Biology. Gregory Dressler, Ph.D. Genetic basis of cellular differentiation and pattern formation in a complex multicellular tissue. Cellular & Molecular Biology. Molecular and Cellular Pathology. Cumming Duan, Ph.D. The current research focuses on the insulin-like growth factor (IGF) signaling system, including the IGF ligands, IGF binding proteins, IGF receptors, and the downstream signal transduction mechanisms. Molecular, Cellular & Developmental Biology. Cellular & Molecular Biology. James T. Elder, M.D., Ph.D. Genetics of psoriasis; regulation of keratinocyte growth and differentiation. Cellular & Molecular Biology.
Doug Engel, Ph.D. Molecular genetics of mammalian
organ specification and differentiation. Cell & Developmental Biology. Cellular & Molecular Biology. James L.M. Ferrara, M.D. Immunobiology of bone marrow transplantation. Cytokine modulation of inflammation. Immunology. Renny T. Franceschi, Ph.D. Control of gene expression in osteoblasts; regulation of bone formation. Biological Chemistry. Ari Gafni, Ph.D. Spectroscopic studies of protein structure; aging phenomena at the molecular level; protein folding mechanisms in vitro and in vivo; protein misfolding in aging and disease; mechanisms of amyloid generation and deposition in diabetes and Alzheimer's disease. Biological Chemistry. Biophysics. Philip Gage,
Ph.D. Genetic analysis of mammalian eye development; cell fate
decisions in neural crest and mesoderm, transgenic mice, and gene
targeted mice. Cellular & Molecular Biology, Cell & Developmental
Biology David Ginsburg, MD Molecular genetics of the blood coagulation system. Human Genetics. Cellular & Molecular Biology. Thomas M. Glaser, MD, Ph.D. Genetic analysis of mammalian eye development. Human Genetics.
Daniel J. Goldman, Ph.D. Acetylcholine receptor gene
expression at the neuromuscular junction; synaptogenesis;
sensory transduction processes; neuroreceptors; molecular
mechanisms of nerve regeneration. Biological Chemistry. Human Genetics.
Neuroscience. Pharmacology.
Deborah L. Gumucio, Ph.D. Cell-Cell interactions controlling intestinal organogenesis. Isolation and Gary D. Hammer, MD, Ph.D. Molecular mechanisms of stress. Adrenal cortical growth and differentiation. Transcriptional regulation by adrenal-specific nuclear receptors-transcription factors. Adrenal cortical carcinogenesis. Transgenic models of adrenal development and disease. Molecular & Integrative Physiology. Cellular & Molecular Biology. Peter
F. Hitchcock, Ph.D. Developmental neurobiology;
retinal neurobiology; vision research; neuronal
regeneration in retina and ocular morphogenesis.
Cell & Developmental Biology.
Neuroscience. Michael Hortsch, Ph.D. Role of cell adhesion molecules in neuronal differentiation of Drosophila. Cell & Developmental Biology. Neuroscience. Jeffrey W. Innis, MD, Ph.D. Molecular genetics of mammalian limb development; HOX gene function. Human Genetics. Bioinformatics. Lori L. Isom, Ph.D. Cellular & Molecular Biology of voltage-gated sodium channel alpha and beta subunits. Pharmacology. Neuroscience. Cellular & Molecular Biology. Human Genetics. Catherine E. Keegan, MD, PhD. Mouse models of telomere dysfunction, genomic instability, and birth defects. Molecular genetics of caudal and urogenital development. Cellular & Molecular Biology. Pediatric Genetics.
Tom Kerppola, Ph.D. Regulation of gene expression by
proto-oncogene transcription factors; protein
interactions in living cells and organisms; and
nucleoprotein complex architecture. Biological Chemistry. Biophysics. Daniel J. Klionsky, Ph.D. Molecular and cellular biology of protein targeting and degradation, and organelle homeostasis in yeast. Cellular & Molecular Biology. Molecular, Cellular & Developmental Biology. Biological Chemistry. Ron Koenig, MD, Ph.D. Gene regulation by thyroid hormone receptors and related proteins. Cellular & Molecular Biology. David Kohrman, Ph.D. Molecular genetics of inner ear structure and function, including analysis of the molecular basis of hearing loss and vestibular dysfunction in mice and humans. Human Genetics. Catherine Krull, Ph.D. Mechanisms that control cell migration and patterning during embryonic development. Cellular and Developmental Biology
John Kuwada, Ph.D. Molecular and genetic analysis of
cell proliferation regulation in the CNS, axon guidance
and the formation and function of neural circuits, and
the behaviors controlled by these neural circuits in
zebrafish. Molecular, Cellular & Developmental Biology. Neuroscience. Cellular & Molecular Biology. Roland Kwok, Ph.D. Hormonal regulation of cAMP-activated gene expression. Biological Chemistry. Obstetrics & Gynecology. Cheng-Yu Lee, Ph.D. Currently investigating a number of evolutionarily conserved genes required for the choice of self-renewal vs. differentiation in fly, and we will apply the insight gained from studying fly neuroblasts to a clinically relevant vertebrate system such as mouse to test the roles of these fly genes in regulation of vertebrate neural stem cell self-renewal. Long-term goals: Identify many signaling pathways expressed in both insect and vertebrate neural stem cells, contribute to our understanding of neural stem cells in birth defects, regenerative medicine and cancer biology. Center For Stem Cell Biology, Life Sciences Institute, Division of Molecular Medicine And Genetics, Department Of Internal Medicine, Cellular and Developmental Biology. Lab: http://www.lsi.umich.edu/facultyresearch/labs/lee Ormond A. MacDougald, Ph.D. Adipocyte gene expression and metabolism; transcriptional and posttranslational regulation of the transcription factor, C/EBP (alpha). Molecular & Integrative Physiology. Benjamin L. Margolis, MD Mechanisms of signal transduction by tyrosine kinases. Biological Chemistry. David M. Markovitz, MD Regulation of retroviral gene expression. Cellular & Molecular Biology. Immunology. Donna Martin, M.D., Ph.D. Genetic control of neuronal differentiation. Neuroscience, Human Genetics. Miriam H. Meisler, Ph.D. Human and mouse disease gene isolation and mutation detection; disease gene isolation neurogenetics; comparative genomics; genetics of sodium and calcium channels expressed in the nervous system. Neuroscience. Human Genetics. Cellular & Molecular Biology. Molecular & Integrative Physiology. Joseph M. Metzger, Ph.D. Viral-based gene transfer into the heart; cellular and molecular mechanisms of contraction in skeletal and cardiac muscle; cardiac gene expression and function; gene therapy for the heart. Molecular & Integrative Physiology. Charlotte Mistretta, Ph.D. Early development of peripheral and central taste systems. Dentistry. Nursing. Sensory Neurobiology. Neuroscience. Bennett Novitch, Ph.D. Regulation of progenitor and stem cell proliferation and differentiation in the developing vertebrate central nervous system. Cell & Developmental Biology. Neuroscience. K. Sue O'Shea, Ph.D. Developmental neurobiology; extracellular matrix; epithelial polarity. Cell & Developmental Biology. Jack Parent, M.D. Neural stem cells, plasticity and regeneration after brain injury; epileptogenesis. Neuroscience. Elizabeth M. Petty, MD Molecular genetics of solid tumor development; translation of molecular genetic discoveries to clinical applications; medical ethics. Cellular & Molecular Biology. Human Genetics. Pamela A.
Raymond, Ph.D. Development and regeneration in the
central nervous system of zebrafish, using genetics with
molecular and embryological tools to uncover the
molecular basis of cell-cell interactions that regulate
retinal neurogenesis (the formation of neurons) and
neuronal specificity (the expression of differentiated
cellular features) during development and regeneration.
Mechanisms of pattern formation and formation of precise
arrays of cone photoreceptors in the zebrafish
retina.Cell & Developmental Biology. Diane M. Robins, Ph.D. Developmental and hormonal regulation of mammalian gene expression. Human Genetics. Cellular & Molecular Biology. Linda C. Samuelson, Ph.D. Regulation of gastrointestinal function by peptide hormones; mouse developmental genetics; gene targeting in embryonic stem cells; molecular physiology of cholecystokinin and gastrin. Molecular & Integrative Physiology. Cellular & Molecular Biology. Jessica Schwartz, Ph.D. Cellular and molecular mechanisms of growth factor action; regulation of gene expression. Molecular & Integrative Physiology. Cellular & Molecular Biology. Robert U. Simpson, Ph.D. Receptors: calcium-regulating hormones and drugs. Pharmacology. Maria S. Soengas, Ph.D. Skin cancer (melanoma) initiation, progression and chemoresistance. Identification of tumor markers and drug response genes. Development of new treatments for aggressive and metastatic melanoma. Cellular & Molecular Biology. Dermatology. Anand Swaroop,
Ph.D. Molecular genetics of inherited eye diseases;
animal models for retinal degeneration; regulation of
development and tissue-specific gene expression;
expression mapping of human genome. Human Genetics. Cellular & Molecular Biology.
Neuroscience. Kathryn Tosney, Ph.D. Identification of interactions and second messengers that mediate guidance of neurons. Molecular, Cellular & Developmental Biology. Neuroscience. Steve J. Weiss, MD Regulation, expression, and function of proteinases in cell movement through the extracellular matrix. Cellular & Molecular Biology. Deneen M Wellik , Ph.D. How Hox genes function to pattern the mammalian body plan. Focused on kidney and limb development as well as axial skeletal patterning using mouse developmental genetics as our primary model organism. Molecular Medicine & Genetics. Internal Medicine. Cell & Developmental Biology. Michael J. Welsh, Ph.D. Cellular stress response and stress-induced proteins; molecular mechanisms of toxicant action; regulation and function of hsp27 and related small stress proteins in muscle and cancer; cell biology; cell cytoskeleton and cytoskeletal proteins. Cell & Developmental Biology. Cellular & Molecular Biology. Matthew J. Wishart, Ph.D. Mechanisms of action for protein- and lipid-phosphatases; STYX / dead-phosphatase adapters and phosphorylation-mediated signaling; molecular mechanisms of mammalian reproduction. Molecular & Integrative Physiology Yuan Zhu, Ph.D. Molecular genetics of disease, the role of tumor suppressor genes in neural development and tumorigenesis in the nervous system. Cell & Developmental Biology |
