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Neuroscience Related ResearchPlease note: Words in italics are the official PIBS affiliations of the indicated faculty. Mohammed Akaaboune, Ph.D. Regulation of synaptic connections during development, maturity and aging. One major approach is to use state-of-the-art imaging methods to observe the structure of synapses in living animals. Many studies take advantage of our in vivo imaging techniques to follow the dynamics of synaptic proteins over time in the same animal. Molecular, Cellular & Developmental Biology, Neuroscience. Huda Akil, Ph.D. Molecular and neurobiological mechanisms of stress, opioids, endorphins, and dopamine. Psychiatry. Molecular and Chemical Neuroscience. Neuroscience. Roger Albin, MD Structure, function, and pathology of the basal ganglia. Neuroscience. J. Wayne Aldridge, Ph.D. Neuronal activity in basal ganglia and motor cortex in movement. Neuroscience. Richard A. Altschuler, Ph.D. Neurobiology; auditory neurotransmitters and pathways and structural basis of cochlea function; plasticity in the auditory brain stem. Cell & Developmental Biology. Neuroscience. Anuska Andjelkovic-Zochowska, M.D., Ph.D. Molecular basis of inflammatory events at the blood brain barrier; the role of vascular endothelium in the pathogenesis of central nervous system inflammation; molecular mechanism of glioma associated angiogenesis. Pathology. Neuroscience. Molecular & Cellular Pathology. Jimo Borjigin, Ph.D. Reseach is focused on three areas: entrainment of circadian pacemaker using melatonin as readout; molecular mechanisms of melatonin production; role of PINA (PIneal and Night-specific ATPase) in circadian rhythm and Wilson disease. Molecular & Integrative Physiology. Helen Baghdoyan, Ph.D. Signal transduction pathways regulating arousal states such as sleep and anesthesia. Pharmacology. Neuroscience. Kate F. Barald, Ph.D. Developmental neurobiology; molecular neurobiology studies of developing neuronal cells and synapses; gene expression in the neural crest; molecular studies of inner ear development. Cell & Developmental Biology. Neuroscience. Cellular & Molecular Biology. John D. E. Barks, MD, Mechanisms of injury in the developing brain, development of neuroprotective drugs. Neuroscience. Jill Becker, Ph.D. Role of estrogen and dopamine in behavior/recovery of function after brain injury. Neuroscience. Joshua Berke, Ph.D. Systems neuroscience of learning, motivation and decision-making, using electrophysiological recording in behaving rats and transgenic mice. Psychology. Neuroscience. Kent Berridge,
Ph.D. Affective neuroscience of reward 'liking' and 'wanting'; Basal
ganglia roles in action syntax and behavioral coordination. Neuroscience. Sanford Bledsoe, Ph.D. Neuropharmacology and neurochemistry of peripheral and central auditory systems. Otolaryngology. Kresge Hearing Research Institute. Sensory Neurobiology. Robert M. Bradley, Ph.D. Neurophysiology of the taste system; mechanisms of sensory processing in the gustatory system. Molecular & Integrative Physiology.
Margit Burmeister, Ph.D. Gene mapping; genetics of neurological,
psychiatric, and behavioral disorders; mouse models; genome organization.
Human Genetics. Neuroscience. Bioinformatics Sally A. Camper, Ph.D. Developmental genetics of the neuroendocrine system; transgenic mice; gene targeting; pituitary dwarfism. Human Genetics. Bioinformatics. Cellular & Molecular Biology. Neuroscience. Jonathan Demb, Ph.D. Relationship between behavior and synaptic mechanisms in the early visual system. Molecular, Cellular & Developmental Biology. Neuroscience.
Robert Denver, Ph.D.
Molecular biology of hormone action in animal development;
neuroendocrinology; evolutionary developmental biology.
Molecular, Cellular & Developmental Biology. Neuroscience. R. Keith Duncan,
Ph.D. Early stages of signal processing in the auditory periphery,
particularly in the context of hair cell physiology. Neuroscience. Josè Esteban,
Ph.D. Synaptic development and synaptic plasticity. Pharmacology.
Neuroscience. Eva Feldman, MD, Ph.D. Insulin-like growth factors in neuronal development and survival. Cellular & Molecular Biology. Neuroscience. Daniel
P. Ferris, Ph.D. Biomechanics and neural control of human locomotion,
neurological rehabilitation, robotic devices for human augmentation
and rehabilitation. Movement Science. David Fink, M.D. Investigation into the pathophysiology of, and novel treatments for, conditions affecting sensory neurons including peripheral polyneuropathy and chronic pain, using gene transfer with Herpes simplex virus-based vectors. Neurology John Fink, MD Genetic analysis of inherited neurologic and psychiatric disorders. Molecular and Chemical Neuroscience. Neuroscience. Stephen K. Fisher,
Ph.D. Role of inositol phospholipids in neuronal signal transduction
at cell-surface receptors. Pharmacology. Neuroscience. Sid Gilman, MD Neurophysiological basis of motor control. Integrative and Systems Neurobiology. Neuroscience. Thomas M. Glaser, MD, Ph.D. Genetic analysis of mammalian eye development. Human Genetics. Margaret E. Gnegy,
Ph.D. Neuropharmacology; mechanism of amphetamine action; adaptive
responses after repeated amphetamine. Pharmacology. Neuroscience.
Daniel J. Goldman, Ph.D. Acetylcholine receptor gene expression
at the neuromuscular junction; synaptogenesis; sensory transduction
processes; neuroreceptors; molecular mechanisms of nerve regeneration.
Biological Chemistry. Human Genetics. Neuroscience. Pharmacology. Peter F. Hitchcock,
Ph.D. Developmental neurobiology; retinal neurobiology; vision research;
neuronal regeneration in retina and ocular morphogenesis. Cell &
Developmental Biology. Neuroscience. Ronald W. Holz, MD,
Ph.D. Molecular mechanisms of underlying neurotransmitter and hormone secretion; development and use of novel optical techniques based upon total internal reflection microscopy to study the biochemistry of events at the plasma membrane. Pharmacology.
Neuroscience. Cellular & Molecular Biology. Michael Hortsch, Ph.D. Role of cell adhesion molecules in neuronal differentiation of Drosophila. Cell & Developmental Biology. Neuroscience. Richard Hume, Ph.D. Growth cone guidance mechanisms and neurotransmitter receptors. Neuroscience. Molecular, Cellular & Developmental Biology. Lori L. Isom, Ph.D. Cellular & Molecular Biology of voltage-gated sodium channel alpha and beta subunits. Pharmacology. Neuroscience. Cellular & Molecular Biology. Human Genetics. John Jonides, Ph.D. Working memory, reasoning, and the biological basis of cognition. Psychology. Neuroscience. Fred J. Karsch, Ph.D. Neuroendocrine regulation of ovarian cyclicity and seasonal breeding; interactions between immune and neuroendocrine systems. Molecular & Integrative Physiology. Robert Kennedy, Ph.D. Mechanisms and regulation of neurotransmitter and hormone secretion. Chemical basis of behavior and regulation by drugs. Novel technology for in vivo and single cell studies. Pharmacology. John Kim, Ph.D. Studies how microRNAs and other emerging classes of small RNAs regulate fundamental biological processes including heterochromatin formation, neuronal cell patterning, cardiac and skeletal muscle development, germline maintenance, and oncogenic cell proliferation. Using functional genomic, genetic, biochemical, and cell biology strategies, his lab investigates the molecular mechanisms of both the small RNAs and new candidate RNAi factors identified by genome-wide screens. Human Genetics. W. Michael King, Ph.D. Motor learning and signal processing in the vestibulo-ocular reflex (VOR), binocular coordination and eye movement control, single cell recording. Neuroscience. Catherine Krull, Ph.D. Mechanisms that control cell migration and patterning during embryonic development. Cellular and Developmental Biology. John Kuwada, Ph.D.
Molecular and genetic analysis of cell proliferation regulation in the
CNS, axon guidance and the formation and function of neural circuits,
and the behaviors controlled by these neural circuits in zebrafish.
Molecular, Cellular & Developmental Biology. Neuroscience. Cellular
& Molecular Biology. Daniel Lawrence, Ph.D How basic binary interactions such as protein:protein interactions regulate complex physiologic processes. Studies focus on protease inhibitors and their targets in systems such as vascular cell migration, and in models of stroke and seizure. Internal Medicine. Cellular & Molecular Biology. Jiandie Lin, Ph.D. - Genome-wide mapping and functional analysis of transcriptional networks in the control metabolism in cells and in vivo. Metabolic basis of diseases including obesity, type 2 diabetes, neurodegeneration and cancer. Cell & Developmental Biology. Life Sciences Institute. Angel W. Lee, M.D., Ph.D.
Tyrosine kinase-based signal transduction mechanisms that regulate Cheng-Yu Lee, Ph.D. Currently investigating a number of evolutionarily conserved genes required for the choice of self-renewal vs. differentiation in fly, and we will apply the insight gained from studying fly neuroblasts to a clinically relevant vertebrate system such as mouse to test the roles of these fly genes in regulation of vertebrate neural stem cell self-renewal. Long-term goals: Identify many signaling pathways expressed in both insect and vertebrate neural stem cells, contribute to our understanding of neural stem cells in birth defects, regenerative medicine and cancer biology. Center For Stem Cell Biology, Life Sciences Institute, Division of Molecular Medicine And Genetics, Department Of Internal Medicine, Cellular and Developmental Biology. Lab: http://www.lsi.umich.edu/facultyresearch/labs/lee Theresa M. Lee, Ph.D. Study the photic and non-photic signals that entrain circadian and seasonal rhythms and the role of gonadal hormones in the development and adult manifestation of those rhythms. Neuroscience. Israel Liberzon, MD Functional neuroanatomy of emotions and neuroendocrinology of stress response in traumatized individuals and in animal models. Neuroscience. Andrew Lieberman, MD, Ph.D. Trinucleotide repeat disorders. Neuroscience. Molecular and Cellular Pathology. Karley Y. Little, M.D. Biochemistry and pharmacology of monoamine synaptic transporters, particularly in relationship to altered mood and reward. Neuropharmacology. Neurochemical anatomy. Anatoli Lopatin, Ph.D. Regulation of potassium channels by polyamines. Neuroscience. Molecular & Integrative Physiology. Ralph Lydic, Ph.D. Transmembrane cell signaling; integrative aspects of respiratory and arousal state control. Cellular and molecular mechanisms that cause respiratory depression during the loss of waking consciousness. Neurochemical and signal transduction processes. Neuroscience. Donna Martin, M.D., Ph.D. Genetic control of neuronal differentiation. Neuroscience, Human Genetics. Stephen Maren, Ph.D. Neurobiological basis of emotional learning and memory. Neuroscience. Miriam H. Meisler, Ph.D. Human and mouse disease gene isolation and mutation detection; disease gene isolation neurogenetics; comparative genomics; genetics of sodium and calcium channels expressed in the nervous system. Neuroscience. Human Genetics. Cellular & Molecular Biology. Molecular & Integrative Physiology.
Daniel
Michele, PhD Molecular & Integrative Physiology Molecular mechanisms
of human cardiomyopathies and skeletal myopathies, with a focus on muscular
dystrophy, using mouse models. Extracellular matrix receptors in central
nervous system development and muscle John Middlebrooks, Ph.D. Psychophysical and cortical physiological studies of directional hearing. Physiological stimulus of cochlear prosthesis. Neuroscience. Daniel Mikol, M.D, Ph.D. Myelination. Neuroscience. Josef Miller, MD, Ph.D. Analysis of changes that occur in auditory periphery and CNS with deafness. Sensory Neurobiology. Otorhinolaryngology. Neuroscience. Charlotte Mistretta, Ph.D. Early development of peripheral and central taste systems. Dentistry. Nursing. Sensory Neurobiology. Neuroscience. Sean Morrison, Ph.D. Stem cell biology using hematopoiesis and neural development as model systems. Cell & Developmental Biology. Cellular & Molecular Biology. Thomas Morrow, Ph.D. Neurobehavioral mechanisms of pain and somatic sensation. Sensory Neurobiology. Neuroscience. Molecular & Integrative Physiology. Geoffry Murphy Ph.D. Use transgenic mice to study the cellular and molecular mechanisms of hippocampal dependent learning and memory. Neuroscience. Martin Myers, MD, Ph.D. Mechanisms of intracellular signaling by the leptin receptor/Jak2 complex. Signals than perturbed in genetically engineered animals in order to study the function of these signals in neurons and immune cells in vivo. Molecular & Integrative Physiology. Bennett Novitch, Ph.D. Regulation of progenitor and stem cell proliferation and differentiation in the developing vertebrate central nervous system. Cell & Developmental Biology. Neuroscience. Richard Neubig, MD, Ph.D.
Molecular mechanisms of signal transduction; spectroscopic and rapid
kinetic studies of receptors, G proteins and their regulators; NMR structure
of receptor and G-protein peptides; mechanism of alpha-adrenergic receptors.
Bioinformatics. Biophysics. Pharmacology. Ruthann Nichols, Ph.D. Structure-activity relationship of neuropeptides and neuropeptide receptors with emphasis on the RFamide peptide family and their role in regulating heart rate and muscle contraction; role of FMRF-amide neuropeptides in Drosophila and mammalian nervous systems. Biological Chemistry. Neuroscience. Human Genetics. Mark Opp, Ph.D. Stressor-induced alterations in arousal state. Elucidating mechanisms by which stressors alter arousal state may shed some light on the fundamental question of what sleep does for the brain. We focus on two types of stressors, those that are psychological in nature (ie, no tissue injury, trauma, or physical insult), and infection. Neuroscience. Jack Parent, M.D. Neural stem cells, plasticity and regeneration after brain injury; epileptogenesis. Neuroscience. Paresh Patel, MD,
Ph.D. Neurotransmitters Regulating Mood Disorders. Neuroscience. Bryan Pfingst, Ph.D. Perception and processing of auditory information. Neuroscience. Gina Poe, Ph.D. Basic sleep processes, development, learning and memory, and optimization of cognitive performance. Molecular & Integrative Physiology. Neuroscience. Thad Polk, Ph.D. Cognitive neuroscience; functional neuroimaging; computational modeling; environmental influences on cognitive architecture; reading; reasoning; unified theories of cognition. Neuroscience. Donald G. Puro, MD, Ph.D. Physiology of ion channels in retinal cells and pathophysiology of glial cells. Molecular & Integrative Physiology. Neuroscience. Yehoash Raphael, Ph.D. Design of biologically modified cochlear implants for combining electrical stimulation with gene therapy in the inner ear. Use of viral vectors for inner ear gene transfer aimed at repair and regeneration of cochlear and vestibular sensory epithelia. The roles of IGF-I and GDNF in protection and rescue of hearing and balance organs.Neuroscience. Pamela A. Raymond, Ph.D. Development and regeneration in the central nervous system of zebrafish, using genetics with molecular and embryological tools to uncover the molecular basis of cell-cell interactions that regulate retinal neurogenesis (the formation of neurons) and neuronal specificity (the expression of differentiated cellular features) during development and regeneration. Mechanisms of pattern formation and formation of precise arrays of cone photoreceptors in the zebrafish retina.Cell & Developmental Biology. http://www.med.umich.edu/cdb/sub_pages/People/raymond.htm Patricia Reuter-Lorenz, Ph.D. Cognitive Neuroscience of Attention. Psychology. Neuroscience. Rudy J. Richardson, ScD,
DABT Mechanisms of neurological disorders, stroke and autoimmune
diseases and their modulation by xenobiotics, genetics and age. Biomarkers
of xenobiotic exposure or disease. Interactions of ligands with macromolecules
using kinetics, molecular modeling and mass spectrometry. Environmental
epidemiology. Scientific basis of risk assessment and public health
policy. Neuroscience. Terry E. Robinson, Ph.D. Neurobiology and biopsychology of addiction, and the nature of long-term neuroadaptations engendered by drug use. Psychology. Neuroscience. Gabrielle Rudenko, Ph.D.Determining the three-dimensional structure of proteins with important functions in the brain using x-ray crystallography, augmented with biochemical, biophysical as well as mutagenesis studies. Pharmacology. Life Sciences Institute Martin Sarter, Ph.D. Regulation and function of forebrain cholinergic systems. Neurobiology of attention. Neuronal mediation of the cognitive dysfunctions in neurodegenerative and neurospychiatric disorders. Psychology. Neuroscience.
Jochen H. Schacht, Ph.D. Neurochemistry; biochemical mechanisms
of hearing processes and drug-induced hearing loss. Biological Chemistry.
Neuroscience. Audrey F. Seasholtz, Ph.D. Regulation of expression of the corticotropin-releasing hormone gene in mammalian stress. Biological Chemistry. Neuroscience. Cellular & Molecular Biology. Susan Shore, Ph.D. Auditory physiology. Study of the cochlear nucleus and its interactions with descending auditory information and somatosensory information. Neuroscience. Faye Silverstein, MD Neurochemical mechanisms of perinatal brain injury. Integrative and Systems Neurobiology. Neuroscience. Charles Smith, Ph.D. Regulation of neurochemical transmission at synapses. Pharmacology. Edward L. Stuenkel, Ph.D. Molecular and cellular regulation of neurotransmitter and neurohormone secretion; regulation of exocytosis at central synapses. Molecular & Integrative Physiology. Molecular and Chemical Neuroscience. Michael A. Sutton, Ph.D. My lab studies mechanisms that control synapse development and plasticity. Molecular and Behavioral Neuroscience Institute. Molecular and Integrative Physiology. Anand Swaroop, Ph.D. Molecular
genetics of inherited eye diseases; animal models for retinal egeneration;
regulation of development and tissue-specific gene expression; expression
mapping of human genome. Human Genetics. Cellular & Molecular
Biology. Neuroscience. Stephan Taylor, M.D. Emotion and cognitive control in healthy and psychiatric (schizophrenia, OCD) populations. Neuroscience. Psychology. Robert Thompson, Ph.D. Mechanisms of antidepressant action and nutritional regulation of reproductive functions (regulation of gene expression; molecular biology, neuroendocrinology and anatomy). Neuroscience. Psychiatry. John Traynor, Ph.D. Pharmacology of Opioid Drugs. Pharmacology.
David Turner, Ph.D. Molecular mechanisms that regulate cell-fate
decisions during the development of the vertebrate nervous system. Biological
Chemistry. Neuroscience. Tetsufumi Ueda, Ph.D.
Protein phosphorylation in the nervous system and neuropharmacology;
Biochemistry and function of synaptic vesicles. Neuroscience. Pharmacology. Michael Uhler, Ph.D. Cyclic nucleotides in the signal transduction mechanisms that mediate neuronal plasticity. Biological Chemistry. Hisashi
Umemori, M.D. Molecular mechanisms of specific neural network
and synapse formation in the mammalian nervous system. Biological
Chemistry, Neuroscience Delia Vazquez, MD Development of the classical endocrine system which responds to stress, the hypothalamic pituitary adrenal (HPA) axis. Regulation of the serotonin system during development. Neuroscience. Kristen Verhey, Ph.D. Motor proteins and the cytoskeleton in neurons; axonal transport of signaling complexes; protein trafficking. Cell & Developmental Biology. Stanley Watson, MD, Ph.D. Regulatory neurobiology of opioid and related peptides; Molecular and neurobiological mechanisms of stress. Cellular & Molecular Biology. Neuroscience. Michael Wang, Ph.D. Molecular basis of neuronal injury and protection. Neuroscience. James H. Woods,
Ph.D. Behavioral pharmacology; mechanisms of drug tolerance, dependence,
and reinforcement. Pharmacology. Neuroscience. X.Z. Shawn Xu, Ph.D. Neurobiology of behavior and drug addiction in the genetic model organism C. elegans. Regulation of neuronal activity and fertilization by calcium signaling. Molecular & Integrative Physiology. Elizabeth Young, MD Role of steroid hormones in control of hypothalamic-pituary adrenal axis. Neuroscience. Yuan Zhu, Ph.D. Molecular genetics of disease, the role of tumor suppressor genes in neural development and tumorigenesis in the nervous system. Cell & Developmental Biology. Jon-Kar Zubieta, MD, Ph.D. Functional Brain Imaging in Mood Disorders and Substance Abuse. Psychiatry. Neuroscience. |
