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Molecular Basis of AgingPlease note: Words in italics are the official PIBS affiliations of the indicated faculty. Goncalo Abecasis, Ph.D Development and application of statistical methods for complex trait gene identification. Active research areas include mental disorders and aging-related diseases. Biostatistics. Bioinformatics. Richard C. Adelman, Ph.D. Public information at the interface of science and society. Biological Chemistry. Susan V. Brooks, Ph.D. Single skeletal muscle fiber mechanics; role of contraction-induced muscle injury in the changes that occur in skeletal muscle structure and function with aging and in the pathogenesis of muscular dystrophy. Molecular & Integrative Physiology. David T. Burke, Ph.D. Mammalian genetics; genetics of aging in the mouse; quantitative genetic analysis. Human Genetics. Thomas Brock, Ph.D. Molecular and cellular aspects of cell-to-cell communication by polyunsaturated fatty acids, particularly in the contexts of immune defense and disease. Regulation of enzymes that convert fatty acids into alternative lipid mediators. Bioinformatics. Cellular & Molecular Biology. Internal Medicine Greg Cartee, Ph.D. My research is focused on understanding the mechanisms that underlie the regulation of skeletal muscle glucose transport, especially as the result of: exercise/contraction, calorie restriction (consuming approximately 60% of ad libitum intake), and/or aging. Kinesiology. Cellular & Molecular Biology. Cumming Duan, Ph.D. The current research focuses on the insulin-like growth factor (IGF) signaling system, including the IGF ligands, IGF binding proteins, IGF receptors, and the downstream signal transduction mechanisms. Molecular, Cellular & Developmental Biology. Cellular & Molecular Biology. John A. Faulkner, Ph.D. Muscle mechanics and mechanisms involved in injury, degeneration, and regeneration of skeletal muscle fibers. Molecular & Integrative Physiology. Ari Gafni, Ph.D. Spectroscopic studies of protein structure; aging phenomena at the molecular level; protein folding mechanisms in vitro and in vivo; protein misfolding in aging and disease; mechanisms of amyloid generation and deposition in diabetes and Alzheimer's disease. Biological Chemistry. Biophysics. Jason Gestwicki, Ph.D. Use of organic chemistry to build new tools for exploring important biological questions. We are currently focused on generating new technologies for inhibiting protein-protein interactions in neurodegenerative diseases. Life Sciences Institute. Molecular & Cellular Pathology. Thomas W. Glover, Ph.D. Molecular cytogenetics and the molecular biology of human disease; gene mapping; Menkes syndrome; fragile sites. Human Genetics. Cellular & Molecular Biology. Ao-Lin (Allen) Hsu, Ph.D. The Hsu laboratory studies genetics and cell biology of aging using C. elegans as a model organism. Current projects have been focused on unraveling the role of Heat-shock Factor (HSF) in specifying longevity, stress resistance, and the onset of age-related neurodegenerative diseases. Another research focus of his group is to identify genes that are responsible for the longevity response to dietary restriction. Finally, his group is also working on developing new therapeutic agents that can delay the rate of aging using the C. elegans model. Internal Medicine, Molecular & Integrative Physiology, Geriatric Center. Patrick Hu, MD, Ph.D. We use the nematode C. elegans to study the biology of conserved signal transduction pathways that are mutated in cancer and diabetes. Cell & Developmental Biology. Evan Keller. Immunologic aging. Immunology. Comparative Medicine. Molecular and Cellular Pathology. Andrew Lieberman, MD, Ph.D. Trinucleotide repeat disorders. Neuroscience. Molecular and Cellular Pathology. Jiandie Lin, Ph.D. - Genome-wide mapping and functional analysis of transcriptional networks in the control metabolism in cells and in vivo. Metabolic basis of diseases including obesity, type 2 diabetes, neurodegeneration and cancer. Cell & Developmental Biology. Life Sciences Institute. Ormond A. MacDougald, Ph.D. Adipocyte gene expression and metabolism; transcriptional and posttranslational regulation of the transcription factor, C/EBP (alpha). Molecular & Integrative Physiology. Jill A. Macoska, Ph.D. Genetic and cellular changes associated with early neoplastic transformation. Bioinformatics. Cellular & Molecular Biology. Urology. Joseph M. Metzger, Ph.D. Viral-based gene transfer into the heart; cellular and molecular mechanisms of contraction in skeletal and cardiac muscle; cardiac gene expression and function; gene therapy for the heart. Molecular & Integrative Physiology.
Richard A. Miller, MD, Ph.D. Signal transduction in T
cells; aging and T-cell subsets; immunology of aging;
genetics of longevity. Molecular and
Cellular Pathology.
Cellular & Molecular Biology. Immunology. Geoffry Murphy Ph.D. Use transgenic mice to study the cellular and molecular mechanisms of hippocampal dependent learning and memory. Neuroscience. Ayyalusamy Ramamoorthy, Ph.D. Structure, dynamics and function of membrane-associated proteins. Biophysics. Rudy J.
Richardson, ScD, DABT Mechanisms of neurological
disorders, stroke and autoimmune diseases and their
modulation by xenobiotics, genetics and age. Biomarkers
of xenobiotic exposure or disease. Interactions of
ligands with macromolecules using kinetics, molecular
modeling and mass spectrometry. Environmental
epidemiology. Scientific basis of risk assessment and
public health policy. Neuroscience. Diane M. Robins, Ph.D. Developmental and hormonal regulation of mammalian gene expression. Human Genetics. Cellular & Molecular Biology. Liangyou Rui, Ph.D. Molecular mechanisms of obesity and type 2 diabetes. Investigation of molecular mechanisms of insulin/leptin signaling and resistance. Molecular & Integrative Physiology. Martin Sarter, Ph.D. Regulation and function of forebrain cholinergic systems. Neurobiology of attention. Neuronal mediation of the cognitive dysfunctions in neurodegenerative and neurospychiatric disorders. Psychology. Neuroscience. Anand Swaroop,
Ph.D. Molecular genetics of inherited eye diseases;
animal models for retinal degeneration; regulation of
development and tissue-specific gene expression;
expression mapping of human genome. Human Genetics. Cellular & Molecular Biology.
Neuroscience. R.
Scott Turner, MD, Ph.D. Molecular mechanisms of
Alzheimer’s disease using cells and neurons in
culture and transgenic mouse models; (beta) amyloid
precursor protein and Alzheimer's disease. Molecular and
Chemical Neuroscience. Neuroscience. James Varani, Ph.D. Cell-substrate adhesion and cell motility in normal mammalian cells and their malignant counterparts; biosynthesis and surface expression of extracellular matrix molecules, such as fibronectin, laminin, and thrombospondin and their involvement as endogenous regulators of adhesion, motility, invasion, and metastasis. Molecular and Cellular Pathology. Matthew J. Wishart, Ph.D. Mechanisms of action for protein- and lipid-phosphatases; STYX / dead-phosphatase adapters and phosphorylation-mediated signaling; molecular mechanisms of mammalian reproduction. Molecular & Integrative Physiology. Yukiko Yamashita Mechanisms of asymmetric stem cell division, control of stem cell behavior in their natural environment (in vivo), cell polarity, spindle orientation. Cell & Developmental Biology.
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