Microbial Pathogenesis

Please note: Words in italics are the official PIBS affiliations of the indicated faculty.

Philip C. Andrews, Ph.D. Bioactive peptides--structure and function; development of new technologies in proteome analysis and functional genomics for identifying gene function and characterizing gene products, including analysis of posttranslational modifications. Biological Chemistry. Bioinformatics.
http://www.proteome.med.umich.edu

James R. Baker Jr., MD Determining why autoantigens are recognized in autoimmune disease; epitope mapping thyroid autoantigens from patients with autoimmune thyroid disease. Immunology. Molecular and Cellular Pathology.

Cheong-Hee Chang, Ph.D. Regulation of the effector function of CD4 T cells and dendritic cells. Microbiology & Immunology, Immunology, Cell & Molecular Biology.

Kathleen Collins, M.D., Ph.D. Molecular Mechanisms of HIV Immune Evasion. Immunology. Cellular & Molecular Biology. Microbiology & Immunology.
http://www.med.umich.edu/cmb/faculty/directory.htm#collins

Vern Carruthers, Ph.D. Pathogenesis of parasitic infections: Mechanisms of cell invasion and survival during infection. Microbiology and Immunology.

Victor J. DiRita, Ph.D. Molecular mechanisms in bacterial pathogenesis; Genetic control of bacterial virulence. Microbiology & Immunology. Cellular & Molecular Biology.
http://www.med.umich.edu/cmb/faculty/directory.htm#dirita

Steven Domino, M.D., Ph.D. Functions of cell-surface carbohydrates in reproductive and other tissues. Cellular & Molecular Biology.

David R. Engelke, Ph.D. Regulation of eukaryotic gene expression at the levels of transcription and RNA processing; catalytic and therapeutic RNA. Cellular & Molecular Biology. Biological Chemistry.
http://www.med.umich.edu/cmb/faculty/directory.htm#engelke

Robert S. Fuller, Ph.D. Proteolytic processing, protein localization, and macromolecular transport in the secretory pathway; yeast cell biology; structure, mechanism, and specificity of proteases. Biological Chemistry. Cellular & Molecular Biology.
http://www.med.umich.edu/cmb/faculty/directory.htm#fuller

Sonja Gerrard, Ph.D. Replication and assembly of RNA viruses; molecular pathogenesis and evasion of host innate immune systems. Microbiology & Immunology. Cellular & Molecular Biology. Epidemiology.

Philip C. Hanna, Ph.D. Anthrax: Molecular Pathogenesis and Host Responses; Use of Bacterial Toxins to Probe Macrophage-mediated Inflammation. Microbiology & Immunology.

Yongqun He (Oliver), DVM, Ph.D. Using high-throughput technologies (e.g., microarrays) and bioinformatics to study microbial pathogenesis and immunology of infectious diseases. Lab Animal Medicine. Microbiology & Immunology. Bioinformatics. Lab: http://helab.bioinformatics.med.umich.edu/

Cory Hogaboam, Ph.D. Cytokine and chemokine networks that maintain inflammatory responses in the liver and lung during chronic disease. Cytokine and chemokine networks that promote deleterious liver and lung tissue repair processes. Therapeutic interventions in idiopathic pulmonary fibrosis and asthma. Phenotypic switches in pulmonary and hepatic firboblasts during chronic inflammatory disease. Molecular and Cellular Pathology. Immunology.

Gary Huffnagle, Ph.D. Pulmonary immunology (innate and acquired), fungal and bacterial pathogenesis, modulation of host defenses by microbial virulence factors. Internal Medicine (Pulmonary). Immunology. Microbiology & Immunology.

Michael J. Imperiale, Ph.D. Posttranscriptional regulation of eukaryotic gene expression; interaction of virus and host cell factors in regulation of gene expression and oncogenic transformation; viral vectors. Microbiology & Immunology. Cellular & Molecular Biology.

Denise E. Kirschner, Ph.D. Computational pathogenesis and host-pathogen interactions. Microbiology & Immunology. Bioinformatics. Immunology. Human Genetics.

Yasmina Laouar, Ph.D. Mechanisms of immunosuppression in the development, homeostasis, and function of innate effector cells in response to pathogens. Immunology, Microbiology & Immunology.

David Lubman, Ph.D. The use of proteomics to study cancer biomarkers and the progression of disease. Our methods include protein fractionation techniques, liquid separations, mass spectrometry and spectroscopic methods. Surgery. Bioinformatics. Molecular and Cellular Pathology.

Gary Luker, Ph.D. Understanding how interactions between“invaders”, either DNA viruses or cancer cells, and the environment of a normal host affect disease pathogenesis. Emphasis on non-invasive imaging to analyze signaling pathways and disease outcome in living mice. Microbiology & Immunology. Immunology.

Janine Maddock, Ph.D. Spatial organization of protein complexes in bacteria. Ribosome assembly. Molecular, Cellular & Developmental Biology. Microbiology & Immunology. Bioinformatics.
Lab: http://www.biology.lsa.umich.edu/research/labs/maddock/

David M. Markovitz, MD Regulation of retroviral gene expression. Cellular & Molecular Biology. Immunology.

Juanita L. Merchant, MD, Ph.D. Molecular mechanisms of gastric epithelial cell growth; growth factor regulation of normal and neoplastic growth; transcriptional control of gastrointestinal peptides; posttranslational modifications of transcription factors; transgenic models for stomach development; Helicobacter pylori and peptic ulcer; gastric cancer development. Cellular & Molecular Biology. Molecular & Integrative Physiology.

Harry Mobley, Ph.D. Molecular mechanisms of bacterial pathogenesis. Reseaerching virulence mechanisms of uropathogenic Escherichia coli and Proteus mirabilis that cause urinary tract infection and Helicobacter pylori that causes gastritis and peptic ulcer disease. Cellular & Molecular Biology. Microbiology & Immunology.

Thomas Moore, Ph.D. Innate host responses during bacterial infection, microbial pathogenesis, T cells and bacterial infection. Immunology.

Gabriel Nuñez, M.D. Role of Innate Immunity in Host Defense, Cancer and Inflammatory Disease. Cellular & Molecular Biology. Molecular and Cellular Pathology. Microbiology & Immunology.
http://www.pathology.med.umich.edu/faculty/Nunez/index.html

Akira Ono, Ph.D. Relationships between cellular membranes and enveloped viruses with particular emphasis on the roles played by lipid rafts and endosomes in HIV-1 replication. Microbiology & Immunology.

Marc Peters-Golden, MD Cellular and molecular regulation of synthesis, as well as actions, of arachidonic acid metabolites (prostaglandins and leukotrienes) in inflammation, antimicrobial defense, and fibrosis. Immunology.

Malini Raghavan, Ph.D. Biochemical and molecular interactions underlying immune recognition events: interactions and biochemical mechanisms of function of the transporters associated with antigen processing; mammalian and viral Fc receptors and their interactions with immunoglobulin G. Microbiology & Immunology. Immunology. Biophysics. Cellular & Molecular Biology.

Maria Sandkvist, Ph.D. Protein trafficking in bacterial pathogens. Microbiology & Immunology.

Mark A. Saper, Ph.D. Structural biology of components of the type III secretion system essential for bacterial pathogenesis. Other current projects include a novel bacterial tyrosine kinase and phosphatase important for pathogenesis, and a family of aminotransferases essential for plant photorespiration. Protein crystallography is the main technique employed in the lab. Biological Chemistry. Biophysics.

Katherine Spindler, Ph.D. Molecular genetics of mouse adenovirus (MAV-1) pathogenesis; host immune response to MAV-1; genetics of host susceptibility to viral infection. Microbiology & Immunology. Cellular & Molecular Biology. Human Genetics.

Joel Swanson, Ph.D. Endocytosis in macrophages. Cellular & Molecular Biology. Microbiology & Immunology. Immunology. Biophysics.

Michele S. Swanson, Ph.D. Legionella pneumophila growth in macrophages. Microbiology & Immunology.
http://myprofile.cos.com/mswanson98

Alice Telesnitsky, Ph.D. Retrovirus molecular genetics, reverse transcriptase structure-function studies, HIV-1 and murine leukemia virus genetic recombination and other mechanisms of genetic variation, virus-host interactions on the cellular level. Microbiology & Immunology. Cellular & Molecular Biology.
Lab: http://sitemaker.umich.edu/telesnitsky.lab

Jason Weinberg, M.D. Pathogenesis of persistent viral infections. Lung inflammatory responses to acute and persistent viral infection. Contributions of specific chemokines and cytokines to the control of viral infection. Modulation of host inflammatory responses by persistent viral infection. Reactivation of latent gammaherpesvirus infection by host inflammatory responses. Pediatrics and Communicable Diseases. Microbiology and Immunology.
Weinberg Lab Homepage

Christiane Wobus, Ph.D. Entry of enteric murine norovirus into macrophages and dendritic cells in vitro and in vivo. Microbiology and Immunology.