Molecular Membrane Biology

Please note: Words in italics are the official PIBS affiliations of the indicated faculty.

Philip C. Andrews, Ph.D. Bioactive peptides--structure and function; development of new technologies in proteome analysis and functional genomics for identifying gene function and characterizing gene products, including analysis of posttranslational modifications. Biological Chemistry.
http://www.proteome.med.umich.edu

James Bardwell, Ph.D. Protein folding catalysts, from genetics to 3-D structures: role of molecular chaperones and disulfide catalysts. Biology. Biophysics. Cellular & Molecular Biology.
http://www.med.umich.edu/cmb/faculty/directory.htm#bardwell

Frank Brosius, M.D. Pathways by which glucose transporter expression affects cell death and the pathogenesis of diabetic nephropathy; abnormalities of glucose transport and etabolism in the pathogenesis of vascular changes in hypertension. Molecular & Integrative Physiology. Internal Medicine.

Amy Chang, Ph.D. Genetics and cell biology of protein folding, sorting, and transport in the yeast secretory pathway; membrane biogenesis. Molecular, Cellular, and Developmental Biology.

Victor J. DiRita, Ph.D. Molecular mechanisms in bacterial pathogenesis; Genetic control of bacterial virulence. Microbiology & Immunology. Cellular & Molecular Biology.
http://www.med.umich.edu/cmb/faculty/directory.htm#dirita

R. Keith Duncan, Ph.D. Early stages of signal processing in the auditory periphery, particularly in the context of hair cell physiology. Neuroscience.
http://www.khri.med.umich.edu/research/duncan_lab/index.php

A. Oveta Fuller, Ph.D. Virus-cell interactions during HSV entry and pathogenesis; herpesvirus tropism determinants; viral vectors. Microbiology & Immunology. Cellular & Molecular Biology.

Michael Hortsch, Ph.D. Role of cell adhesion molecules in neuronal differentiation of Drosophila. Cell & Developmental Biology. Developmental Neuroscience.

Bret A. Hughes, Ph.D. Structure, function, and regulation of ion channels in the retinal pigment epithelium. Ophthalmology. Molecular & Integrative Physiology.

Richard Hume, Ph.D. Growth cone guidance mechanisms and neurotransmitter receptors. Neuroscience. Molecular, Cellular & Developmental Biology.

Lori L. Isom, Ph.D. Cellular & Molecular Biology of voltage-gated channel alpha and beta subunits. Pharmacology. Neuroscience. Cell and Molecular Biology

Daniel J. Klionsky, Ph.D. Molecular and cellular biology of protein targeting and degradation, and organelle homeostasis in yeast. Cellular & Molecular Biology. Molecular, Cellular & Developmental Biology. Biological Chemistry.
Lab: http://www.biology.lsa.umich.edu/research/labs/klionsky/klionskylab.html

Janine Maddock, Ph.D. Spatial organization of protein complexes in bacteria. Ribosome assembly. Molecular, Cellular & Developmental Biology. Microbiology & Immunology. Bioinformatics.
Lab: http://www.biology.lsa.umich.edu/research/labs/maddock/

Jeff Martens, Ph.D. Protein/lipid interactions in ion channel localiztion and function. Pharmacology

Daniel Michele, PhD Molecular & Integrative Physiology Molecular mechanisms of human cardiomyopathies and skeletal myopathies, with a focus on muscular dystrophy, using mouse models. Extracellular matrix receptors in central nervous system development and muscle disease. Molecular & Integrative Physiology

Richard Neubig, MD, Ph.D. Molecular mechanisms of signal transduction; spectroscopic and rapid kinetic studies of receptors, G proteins and their regulators; NMR structure of receptor and G-protein peptides; mechanism of alpha-adrenergic receptors. Bioinformatics. Biophysics. Pharmacology.
Biophysics Lab

Laura Olsen, Ph.D. Molecular and cellular biology of peroxisomes - peroxisome biogenesis and function. Molecular, Cellular & Developmental Biology.

Akira Ono, Ph.D. Relationships between cellular membranes and enveloped viruses with particular emphasis on the roles played by lipid rafts and endosomes in HIV-1 replication. Microbiology & Immunology.

Malini Raghavan, Ph.D. Biochemical and molecular interactions underlying immune recognition events: interactions and biochemical mechanisms of function of the transporters associated with antigen processing; mammalian and viral Fc receptors and their interactions with immunoglobulin G. Biophysics. Microbiology & Immunology. Immunology.

Ayyalusamy Ramamoorthy, Ph.D. Structure, dynamics and function of membrane-associated proteins. Chemistry. Biophysics.

Rudy J. Richardson, ScD, DABT Mechanisms of neurological disorders, stroke and autoimmune diseases and their modulation by xenobiotics, genetics and age. Biomarkers of xenobiotic exposure or disease. Interactions of ligands with macromolecules using kinetics, molecular modeling and mass spectrometry. Environmental epidemiology. Scientific basis of risk assessment and public health policy. Environmental Health Sciences. Toxicology. Neuroscience.
http://www.umich.edu/~neurosci/faculty/rjrich.htm

Alan R. Saltiel, Ph.D. Mechanism of hormone action. Protein phosphorylation. Signal transduction. Molecular & Integrative Physiology.

Maria Sandkvist, Ph.D. Protein trafficking in bacterial pathogens. Microbiology & Immunology.

Richard H. Sands, Ph.D. Spin-label studies on keratinocyte membranes and structure and function of redox proteins using various physical-chemical techniques including EPR, ENDOR, and Mossbauer. Biophysics. Physics.

Gary Smith, Ph.D. Mammalian gamete and embryo developmental biology. Physiology. OB/GYN. Reproductive Sciences. Molecular & Integrative Physiology.

William L. Smith, Ph.D. Chemical processes underlying the biosynthesis and functions of prostaglandins. Current research is focused on understanding (a) the enzymology of prostaglandin endoperoxide H synthases (PGHSs) and (b) the regulation of PGHS gene expression. PGHSs are also known as "cyclooxygenases". Biological Chemistry.

Edward L. Stuenkel, Ph.D. Molecular and cellular regulation of neurotransmitter and neurohormone secretion; regulation of exocytosis at central synapses. Molecular & Integrative Physiology. Molecular and Chemical Neuroscience.

Joel Swanson, Ph.D. Endocytosis in macrophages. Cellular & Molecular Biology. Microbiology & Immunology. Immunology.
http://www.med.umich.edu/cmb/faculty/swanson.htm

Debra A. Thompson, Ph.D. Molecular studies of the function of the mammalian retina, including analysis of the mechanisms controlling signal transduction and tissue-specific gene expression in the retinal pigment epithelium. Biological Chemistry.

Tetsufumi Ueda, Ph.D. Protein phosphorylation in the nervous system and neuropharmacology; Biochemistry and function of synaptic vesicles. Neuroscience. Pharmacology.
http://sitemaker.umich.edu/ueda

Nils Walter, Ph.D. Systems of small RNA catalysts, such as the hammerhead and hepatitis delta virus ribozymes, to large RNA-protein complexes, such as the spliceosome. Fluorescence based techniques to acquire unique kinetic data that allow to dissect the reaction pathways of ribozymes. Chemistry. Biophysics.

Lois Weisman, Ph.D. To uncover mechanisms of organelle inheritance, and to determine how these processes are spatially and temporally regulated. We have discovered that myosin V attaches to membranes via organelle-specific receptors. In addition inheritance requires a newly discovered signaling pathway. Cell & Developmental Biology. Cellular & Molecular Biology. Life Sciences Institute.

Zhaohui Xu, Ph.D. Protein-protein interaction and molecular recognition; structural biology of protein folding, protein translocation, and cellular signal transduction; x-ray crystallography. Biological Chemistry.

Charles F. Yocum, Ph.D. Mechanisms of photosynthetic energy transduction. Biophysics. Biological Sciences and Chemistry.

Robert Zand, Ph.D. Spectroscopic and chemical assessment of structure, binding behavior, and properties of neuropeptide Y (NPY) chimeras and the NPY1 and NPY2 receptors; posttranslational modification, evolution, and biological properties of myelin basic protein from lower vertebrates; mechanism of calcification in bioprosthetic heart valve leaflets; synthesis of biopolymers and their nonlinear electrooptical and electronic conduction properties. Biophysics. Biological Chemistry. Macromolecular Science and Engineering.