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Molecular, Cellular & Developmental Biology Related ResearchPlease note: Words in italics are the official PIBS affiliations of the indicated faculty. Julian Adams, Ph.D. Population Genetics. Molecular, Cellular & Developmental Biology. Bioinformatics. Mohammed Akaaboune, Ph.D. Regulation of synaptic connections during development, maturity and aging. One major approach is to use state-of-the-art imaging methods to observe the structure of synapses in living animals. Many studies take advantage of our in vivo imaging techniques to follow the dynamics of synaptic proteins over time in the same animal. Molecular, Cellular & Developmental Biology, Neuroscience. Richard A. Altschuler, Ph.D. Neurobiology; auditory neurotransmitters and pathways and structural basis of cochlea function; plasticity in the auditory brain stem. Cell & Developmental Biology. Neuroscience. Radha Ayyagari, Ph.D Molecular genetics of retinal and macular degenerations and understanding the mechanism underlying the degeneration process. Cell and Developmental Biology. Ophthalmology and visual sciences.
James Bardwell, Ph.D. Protein folding catalysts, from genetics to
3-D structures: role of molecular chaperones and disulfide catalysts.
Biology. Biophysics. Cellular & Molecular Biology. Scott Barolo, Ph.D. Molecular genetics and biochemistry of transcriptional regulation; structure/function analysis of signaling pathway-regulated enhancers, using Drosophila as a model system. Cell & Developmental Biology. Robert A. Bender, Ph.D. Metabolic regulation in microorganisms. Molecular, Cellular & Developmental Biology. Daniel A. Bochar, Ph.D. Regulation of eukaryotic gene expression through the modulation of chromatin structure and the connection to developmental disorders and cancer. Biological Chemistry. Jimo Borjigin, Ph.D. Reseach is focused on three areas: entrainment of circadian pacemaker using melatonin as readout; molecular mechanisms of melatonin production; role of PINA (PIneal and Night-specific ATPase) in circadian rhythm and Wilson disease. Molecular & Integrative Physiology. Thomas Brock, Ph.D. Molecular and cellular aspects of cell-to-cell communication by polyunsaturated fatty acids, particularly in the contexts of immune defense and disease. Regulation of enzymes that convert fatty acids into alternative lipid mediators. Bioinformatics. Cellular & Molecular Biology. Internal Medicine Kenneth Cadigan, Ph.D. Genetics of Drosophila Devel and Signal Transduction. Molecular, Cellular & Developmental Biology. Cellular & Molecular Biology. Raymond Chan , Ph.D. Studies the packaging of chromosome in preparation for cellular division in mitosis and meiosis in the nematode C. elegans. My primary focus is on the Structural Maintenance of Chromosomes (SMC) protein family and TIM-1, a novel regulator of SMC proteins that I had previously identified. Human Genetics. http://www.umich.edu/~mmgmed/faculty/bios/Chan.htm Amy Chang, Ph.D. Genetics and cell biology of protein folding, sorting, and transport in the yeast secretory pathway; membrane biogenesis. Molecular, Cellular, and Developmental Biology.
Arul M. Chinnaiyan, M.D., Ph.D. Focus on high-throughput genomic
and proteomic technologies to analyze human disease. Lab projects include
molecular profiling of prostate cancer, profiling cancer with protein
microarrays, and molecular signatures of sepsis. Bioinformatics.
Molecular and Cellular Pathology. Steven Clark, Ph.D. Current research focuses on receptor kinase=mediated signaling pathways regulating stem cell identity and organogenesis, as well as microRNA regulation of stem cell specification. Molecular & Integrative Physiology. Molecular, Cellular & Developmental Biology. Stephen Cooper, Ph.D. Analysis of the mammalian cell cycle, analysis of the bacterial cell cycle, the logic and chemistry of cell cycle control. Microbiology & Immunology. Jonathan Demb, Ph.D. Relationship between behavior and synaptic mechanisms in the early visual system. Molecular, Cellular & Developmental Biology. Neuroscience.
Robert Denver, Ph.D.
Molecular biology of hormone action in animal development;
neuroendocrinology; evolutionary developmental biology.
Molecular, Cellular & Developmental Biology. Neuroscience. Andrzej Dlugosz, M.D. Hedgehog signaling; molecular regulation of skin development and tumorigenesis. Cellular & Molecular Biology. Yali Dou, Ph.D. Using a combination of biochemical, cellular and genetic analyses, we would like to: analyze the structure, function and regulation of MLL complex; study the cross-talks between MLL and other histone modifying activities such as histone acetyltransferase and histone ubiquitinase; elucidate the mechanism of MLL deregulation (deletion, amplification and translocation) in leukemogenesis. Molecular & Cellular Pathology. Cumming Duan, Ph.D. The current research focuses on the insulin-like growth factor (IGF) signaling system, including the IGF ligands, IGF binding proteins, IGF receptors, and the downstream signal transduction mechanisms. Molecular, Cellular & Developmental Biology. Cellular & Molecular Biology. Colin S. Duckett, Ph.D. Novel roles for IAP proteins in the control of apoptosis, intracellular signaling and metabolism. IAPs as regulators of apoptosis. IAPs in cancer. E3 ubiquitination activities of IAPs. Caspase-independent signaling properties of IAPs. X-linked lymphoproliferative disorder and XIAP. Role of XIAP in copper metabolism and homeostasis. c-IAPs: Key intracellular signaling molecules with diverse roles in inflammation. IAP antagonists: Apoptotic sensitizers and signaling modulators. Immunology, Molecular and Cellular Pathology, Cellular & Molecular Biology. R. Keith Duncan,
Ph.D. Early stages of signal processing in the auditory periphery,
particularly in the context of hair cell physiology. Neuroscience. Daniel Eitzman, M.D. Our lab studies genetic determinants of thrombosis and atherosclerosis using murine models. Cellular & Molecular Biology. James T. Elder, M.D., Ph.D. Genetics of psoriasis; regulation of keratinocyte growth and differentiation. Cellular & Molecular Biology.
David R. Engelke, Ph.D. Regulation of eukaryotic gene expression
at the levels of transcription and RNA processing; catalytic and therapeutic
RNA. Cellular & Molecular Biology. Biological Chemistry.
José Esteban,
Ph.D. Synaptic development and synaptic plasticity. Pharmacology.
Neuroscience. David Ferguson, M.D., Ph.D. How DNA repair prevents cancer, provides immuno-competence, and ensures proper overall development. Molecular and Cellular Pathology.
Robert S. Fuller, Ph.D. Proteolytic processing, protein localization,
and macromolecular transport in the secretory pathway; yeast cell biology;
structure, mechanism, and specificity of proteases. Biological Chemistry.
Cellular & Molecular Biology. Thomas M. Glaser, MD, Ph.D. Genetic analysis of mammalian eye development. Human Genetics.
Daniel J. Goldman, Ph.D. Acetylcholine receptor gene expression
at the neuromuscular junction; synaptogenesis; sensory transduction
processes; neuroreceptors; molecular mechanisms of nerve regeneration.
Biological Chemistry. Human Genetics. Neuroscience. Pharmacology. Yongqun He (Oliver), DVM, Ph.D. Using high-throughput technologies (e.g., microarrays) and bioinformatics to study microbial pathogenesis and immunology of infectious diseases. Lab Animal Medicine. Microbiology & Immunology. Bioinformatics. Lab: http://helab.bioinformatics.med.umich.edu/ Jay Hess, M.D., Ph.D. Mechanisms of transformation by the mixed lineage leukemia protein and its downstream targets, the clustered (Hox) genes. Molecular and Cellular Pathology. Cellular & Molecular Biology. Larry Holzman, MD. Our work focuses on characterizing the molecular nature of the kidney podocyte intercellular junction and its role in regulating the podocyte actin cytoskeleton. A second project investigates the biology of mixed lineage protein kinases (components of the JNK module). Cellular & Molecular Biology. Richard Hume, Ph.D. Growth cone guidance mechanisms and neurotransmitter receptors. Neuroscience. Molecular, Cellular & Developmental Biology. Jorge Iñiguez-Lluhi, Ph.D. Eukaryotic Transcriptional regulation, transcription factor interactions,Steroid hormone receptors, structure, function and genetics. Pharmacology. Ursula Jakob, Ph.D. Structure and function of new heat shock proteins and analysis of their involvement in heat and oxidative stress protection of the cell. Molecular, Cellular & Developmental Biology. Cellular & Molecular Biology. Mariana Kaplan, M.D. Interactions of autoreactive lupus T cells with different autologous APCs (in particular dendritic cells). Immunology.
Tom Kerppola, Ph.D. Regulation of gene expression by proto-oncogene
transcription factors; protein interactions in living cells and organisms;
and nucleoprotein complex architecture. Biological Chemistry. Biophysics. John Kim, Ph.D. Studies how microRNAs and other emerging classes of small RNAs regulate fundamental biological processes including heterochromatin formation, neuronal cell patterning, cardiac and skeletal muscle development, germline maintenance, and oncogenic cell proliferation. Using functional genomic, genetic, biochemical, and cell biology strategies, his lab investigates the molecular mechanisms of both the small RNAs and new candidate RNAi factors identified by genome-wide screens. Human Genetics. Daniel J. Klionsky, Ph.D. Molecular and cellular biology of protein targeting and degradation, and organelle homeostasis in yeast. Cellular & Molecular Biology. Molecular, Cellular & Developmental Biology. Biological Chemistry. Ron Koenig, MD, Ph.D. Gene regulation by thyroid hormone receptors and related proteins. Cellular & Molecular Biology. John Kuwada, Ph.D.
Molecular and genetic analysis of cell proliferation regulation in the
CNS, axon guidance and the formation and function of neural circuits,
and the behaviors controlled by these neural circuits in zebrafish.
Molecular, Cellular & Developmental Biology. Neuroscience. Cellular
& Molecular Biology. Daniel Lawrence, Ph.D How basic binary interactions such as protein:protein interactions regulate complex physiologic processes. Studies focus on protease inhibitors and their targets in systems such as vascular cell migration, and in models of stroke and seizure. Internal Medicine. Cellular & Molecular Biology. Cheng-Yu Lee, Ph.D. Currently investigating a number of evolutionarily conserved genes required for the choice of self-renewal vs. differentiation in fly, and we will apply the insight gained from studying fly neuroblasts to a clinically relevant vertebrate system such as mouse to test the roles of these fly genes in regulation of vertebrate neural stem cell self-renewal. Long-term goals: Identify many signaling pathways expressed in both insect and vertebrate neural stem cells, contribute to our understanding of neural stem cells in birth defects, regenerative medicine and cancer biology. Center For Stem Cell Biology, Life Sciences Institute, Division of Molecular Medicine And Genetics, Department Of Internal Medicine, Cellular and Developmental Biology. Lab: http://www.lsi.umich.edu/facultyresearch/labs/lee Jianming Li, Ph.D. Plant Molecular Physiology. Molecular, Cellular & Developmental Biology. Ormond A. MacDougald, Ph.D. Adipocyte gene expression and metabolism; transcriptional and posttranslational regulation of the transcription factor, C/EBP (alpha). Molecular & Integrative Physiology. Janine Maddock, Ph.D. Spatial organization of protein complexes in bacteria. Ribosome assembly. Molecular, Cellular & Developmental Biology. Microbiology & Immunology.
Bioinformatics. Ivan Maillard, M.D.-Ph.D. Our main research interests are in the following topics: Investigating the interaction of hematopoietic stem cells (HSC) with their microenvironmental niche, particularly in fetal sites of hematopoiesis; and understanding the role of Notch signaling in the regulation of T cell homeostasis and differentiation. We are using a combination of genetic, cellular and biochemical approaches to study these questions. Hematology-Oncology. Cell and Developmental Biology. http://www.med.umich.edu/immprog/faculty/maillard.htm Sami Malek, M.D. Hematological malignancies including CLL, Follicular Lymphoma, MDS and AML using a variety of approaches. Many questions intersect with standard immunological problems and are studied accordingly. Internal Medicine. Immunology. Martin Myers, MD, Ph.D. Mechanisms of intracellular signaling by the leptin receptor/Jak2 complex. Signals than perturbed in genetically engineered animals in order to study the function of these signals in neurons and immune cells in vivo. Molecular & Integrative Physiology. Kentaro Nabeshima, Ph.D. Mechanisms of the chromosome dynamics in meiosis with the primary focus on the establishment of the association between homologous chromosomes. Lab: http://www.med.umich.edu/cdb/sub_pages/People/nabeshima.html Cell and Developmental Biology Bennett Novitch, Ph.D. Regulation of progenitor and stem cell proliferation and differentiation in the developing vertebrate central nervous system. Cell & Developmental Biology. Neuroscience. Laura Olsen, Ph.D. Molecular and cellular biology of peroxisomes - peroxisome biogenesis and function. Molecular, Cellular & Developmental Biology. Akira Ono, Ph.D. Relationships between cellular membranes and enveloped viruses with particular emphasis on the roles played by lipid rafts and endosomes in HIV-1 replication. Microbiology & Immunology. Paresh Patel, MD,
Ph.D. Neurotransmitters Regulating Mood Disorders. Neuroscience. Elizabeth M. Petty, MD Molecular genetics of solid tumor development; translation of molecular genetic discoveries to clinical applications; medical ethics. Cellular & Molecular Biology. Human Genetics. Diane M. Robins, Ph.D. Developmental and hormonal regulation of mammalian gene expression. Human Genetics. Cellular & Molecular Biology. Theodora S. Ross, M.D., Ph.D. Genetics and biology of human leukemias by using mouse modeling as well as standard biochemical, molecular biological and cellular techniques. Cellular & Molecular Biology. John Schiefelbein,
Ph.D. Molecular genetics of cell morphogenesis; plant molecular
biology. Molecular, Cellular & Developmental Biology. Cellular
& Molecular Biology. Audrey F. Seasholtz, Ph.D. Regulation of expression of the corticotropin-releasing hormone gene in mammalian stress. Biological Chemistry. Neuroscience. Cellular & Molecular Biology. JoAnn Sekiguchi, Ph.D. Mechanisms of DNA repair and how aberrant repair processes affect genomic stability, predisposition to cancer and immune system development. Human Genetics. Maria S. Soengas, Ph.D. Skin cancer (melanoma) initiation, progression and chemoresistance. Identification of tumor markers and drug response genes. Development of new treatments for aggressive and metastatic melanoma. Cellular & Molecular Biology. Dermatology. Yi Sun, Ph.D. 1) Mechanism of p53 tumor suppressor and SCF E3 ubiquitin ligase (for protein ubiquitination and degradation) in apoptosis induction and suppression, respectively; 2) Identification and validation of cancer targets in the p53 and E3 ubiquitin ligase signaling pathways for anti-cancer drug discovery. Cellular & Molecular Biology. Radiation Oncology. Michael A. Sutton, Ph.D. My lab studies mechanisms that control synapse development and plasticity. Molecular and Behavioral Neuroscience Institute. Molecular and Integrative Physiology. Anand Swaroop, Ph.D. Molecular
genetics of inherited eye diseases; animal models for retinal degeneration;
regulation of development and tissue-specific gene expression; expression
mapping of human genome. Human Genetics. Cellular & Molecular
Biology. Neuroscience. Alice Telesnitsky,
Ph.D. Retrovirus molecular genetics, reverse transcriptase structure-function
studies, HIV-1 and murine leukemia virus genetic recombination and other
mechanisms of genetic variation, virus-host interactions on the cellular
level. Microbiology & Immunology. Cellular & Molecular Biology. Hisashi
Umemori, M.D. Molecular mechanisms of specific neural network
and synapse formation in the mammalian nervous system. Biological
Chemistry, Neuroscience Kristen Verhey, Ph.D. Motor proteins and the cytoskeleton in neurons; axonal transport of signaling complexes; protein trafficking. Cell & Developmental Biology. Nils G. Walter, Ph.D.
Folding and function of non-coding RNA; structural and single molecule RNA enzymology; ribosome and spliceosome function by single molecule microscopy; single molecule systems biology. Biophysics. Cellular & Molecular Biology. Yanzhuang Wang, Ph.D. Molecular organization and biogenesis of the Golgi apparatus during the cell cycle. Molecular, Cellular & Developmental Biology Lois Weisman, Ph.D. To uncover mechanisms of organelle inheritance, and to determine how these processes are spatially and temporally regulated. We have discovered that myosin V attaches to membranes via organelle-specific receptors. In addition inheritance requires a newly discovered signaling pathway. Cell & Developmental Biology. Cellular & Molecular Biology. Life Sciences Institute. Steve J. Weiss, MD Regulation, expression, and function of proteinases in cell movement through the extracellular matrix. Cellular & Molecular Biology. Deneen M Wellik , Ph.D. How Hox genes function to pattern the mammalian body plan. Focused on kidney and limb development as well as axial skeletal patterning using mouse developmental genetics as our primary model organism. Molecular Medicine & Genetics. Internal Medicine. Cell & Developmental Biology. Eric S. White, M.D. Our lab focuses on fibroblast biology, extracellular matrix influences on cellular biology, and immunology of granulomatous lung diseases. Internal Medicine-Pulmonary & Critical Care Medicine. Immunology. Thomas
E. Wilson, MD, Ph.D. DNA double-strand break repair mechanisms and
their contribution to the chromosomal instability of cancer. Molecular
and Cellular Pathology. Cellular & Molecular Biology. Matthew J. Wishart, Ph.D. Mechanisms of action for protein- and lipid-phosphatases; STYX / dead-phosphatase adapters and phosphorylation-mediated signaling; molecular mechanisms of mammalian reproduction. Molecular & Integrative Physiology. Patricia Wittkopp, Ph.D. Genetic and developmental bases of evolutionary change. Molecular mechanisms that regulate gene expression and genetic changes that alter regulation are of particular interest. Molecular, Cellular, & Developmental Biology. Ecology & Evolutionary Biology. Charles F. Yocum, Ph.D. Mechanisms of photosynthetic energy transduction. Molecular, Cellular & Developmental Biology. Biophysics. Yuan Zhu, Ph.D. Molecular genetics of disease, the role of tumor suppressor genes in neural development and tumorigenesis in the nervous system. Cell & Developmental Biology. |
