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Integrative BiologyPlease note: Words in italics are the official PIBS affiliations of the indicated faculty. Huda Akil, Ph.D. Molecular and neurobiological mechanisms of stress, opioids, endorphins, and dopamine. Psychiatry. Molecular and Chemical Neuroscience. Neuroscience. J. Wayne Aldridge, Ph.D. Neuronal activity in basal ganglia and motor cortex in movement. Neuroscience.
Philip C. Andrews, Ph.D. Bioactive
peptides--structure and function; development of new
technologies in proteome analysis and functional genomics
for identifying gene function and characterizing gene
products, including analysis of posttranslational
modifications. Biological Chemistry.
Bioinformatics.
James Bardwell, Ph.D. Protein folding catalysts, from
genetics to 3-D structures: role of molecular chaperones
and disulfide catalysts. Biology. Biophysics. Cellular & Molecular Biology. Scott Barolo, Ph.D. Molecular genetics and biochemistry of transcriptional regulation; structure/function analysis of signaling pathway-regulated enhancers, using Drosophila as a model system. Cell & Developmental Biology. Jill Becker, Ph.D. Role of estrogen and dopamine in behavior/recovery of function after brain injury. Neuroscience. Joshua Berke, Ph.D. Systems neuroscience of learning, motivation and decision-making, using electrophysiological recording in behaving rats and transgenic mice. Psychology. Neuroscience. Kent
Berridge, Ph.D. Affective neuroscience of reward
'liking' and 'wanting'; Basal ganglia roles in action
syntax and behavioral coordination. Neuroscience. Susan V. Brooks, Ph.D. Single skeletal muscle fiber mechanics; role of contraction-induced muscle injury in the changes that occur in skeletal muscle structure and function with aging and in the pathogenesis of muscular dystrophy. Molecular & Integrative Physiology. Frank Brosius, M.D. Pathways by which glucose transporter expression affects cell death and the pathogenesis of diabetic nephropathy; abnormalities of glucose transport and etabolism in the pathogenesis of vascular changes in hypertension. Molecular & Integrative Physiology. Internal Medicine. Sally A. Camper, Ph.D. Developmental genetics of the neuroendocrine system; transgenic mice; gene targeting; pituitary dwarfism. Human Genetics. Bioinformatics. Cellular & Molecular Biology. Neuroscience. Greg Cartee, Ph.D. My research is focused on understanding the mechanisms that underlie the regulation of skeletal muscle glucose transport, especially as the result of: exercise/contraction, calorie restriction (consuming approximately 60% of ad libitum intake), and/or aging. Kinesiology. Cellular & Molecular Biology. Louis G. D'Alecy, D.MD, Ph.D. Cardiovascular physiology: adaptive mechanisms in ischemia and hypoxia; therapeutic protection of brain, spinal cord, and kidney ischemia. Physiology. Surgery. Molecular & Integrative Physiology. Jonathan Demb, Ph.D. Cellular mechanisms of visual adaptation in the mammalian retina. Patch-clamp electrophysiology of retinal neurons stimulated by light, in vitro. Ophthalmology & Visual Sciences, Molecular, Cellular & Developmental Biology
Robert Denver, Ph.D.
Molecular biology of hormone action in animal development;
neuroendocrinology; evolutionary developmental biology.
Molecular, Cellular & Developmental Biology. Neuroscience. Steven Domino, M.D., Ph.D. Functions of cell-surface carbohydrates in reproductive and other tissues. Cellular & Molecular Biology. Cumming Duan, Ph.D. The current research focuses on the insulin-like growth factor (IGF) signaling system, including the IGF ligands, IGF binding proteins, IGF receptors, and the downstream signal transduction mechanisms. Molecular, Cellular & Developmental Biology. Cellular & Molecular Biology. John A. Faulkner, Ph.D. Muscle mechanics and mechanisms involved in injury, degeneration, and regeneration of skeletal muscle fibers. Molecular & Integrative Physiology. Daniel
P. Ferris, Ph.D. Biomechanics and neural control of human locomotion,
neurological rehabilitation, robotic devices for human augmentation
and rehabilitation. Movement Science. David Ginsburg, MD Molecular genetics of the blood coagulation system. Human Genetics. Cellular & Molecular Biology. Thomas M. Glaser, MD, Ph.D. Genetic analysis of mammalian eye development. Human Genetics. Gary D. Hammer, MD, Ph.D. Molecular mechanisms of stress. Adrenal cortical growth and differentiation. Transcriptional regulation by adrenal-specific nuclear receptors-transcription factors. Adrenal cortical carcinogenesis. Transgenic models of adrenal development and disease. Molecular & Integrative Physiology. Cellular & Molecular Biology. Yongqun He (Oliver), DVM, Ph.D. Using high-throughput technologies (e.g., microarrays) and bioinformatics to study microbial pathogenesis and immunology of infectious diseases. Lab Animal Medicine. Microbiology & Immunology. Bioinformatics. Lab: http://helab.bioinformatics.med.umich.edu/ Larry Holzman, MD. Our work focuses on characterizing the molecular nature of the kidney podocyte intercellular junction and its role in regulating the podocyte actin cytoskeleton. A second project investigates the biology of mixed lineage protein kinases (components of the JNK module). Cellular & Molecular Biology. Fred J. Karsch, Ph.D. Neuroendocrine regulation of ovarian cyclicity and seasonal breeding; interactions between immune and neuroendocrine systems. Molecular & Integrative Physiology. W. Michael King, Ph.D. Motor learning and signal processing in the vestibulo-ocular reflex (VOR), binocular coordination and eye movement control, single cell recording. Neuroscience. Denise E. Kirschner, Ph.D. Computational pathogenesis and host-pathogen interactions. Microbiology & Immunology. Bioinformatics. Immunology. Human Genetics. Theresa M. Lee, Ph.D. Study the photic and non-photic signals that entrain circadian and seasonal rhythms and the role of gonadal hormones in the development and adult manifestation of those rhythms. Neuroscience. Ralph
Lydic, Ph.D. Transmembrane cell signaling;
integrative aspects of respiratory and arousal state
control. Cellular and molecular mechanisms that cause
respiratory depression during the loss of waking
consciousness. Neurochemical and signal transduction
processes. Neuroscience. Juanita L. Merchant, MD, Ph.D. Molecular mechanisms of gastric epithelial cell growth; growth factor regulation of normal and neoplastic growth; transcriptional control of gastrointestinal peptides; posttranslational modifications of transcription factors; transgenic models for stomach development; Helicobacter pylori and peptic ulcer; gastric cancer development. Cellular & Molecular Biology. Molecular & Integrative Physiology. Joseph M. Metzger, Ph.D. Viral-based gene transfer into the heart; cellular and molecular mechanisms of contraction in skeletal and cardiac muscle; cardiac gene expression and function; gene therapy for the heart. Molecular & Integrative Physiology.
Daniel Michele, PhD Molecular & Integrative Physiology Molecular mechanisms of human cardiomyopathies
and skeletal myopathies, with a focus on muscular
dystrophy, using mouse models. Extracellular matrix
receptors in central nervous system development and
muscle John Middlebrooks, Ph.D. Psychophysical and cortical physiological studies of directional hearing. Physiological stimulus of cochlear prosthesis. Neuroscience.
Richard A. Miller, MD, Ph.D. Signal transduction in T
cells; aging and T-cell subsets; immunology of aging;
genetics of longevity. Molecular and
Cellular Pathology.
Cellular & Molecular Biology. Immunology. Thomas Morrow, Ph.D. Neurobehavioral mechanisms of pain and somatic sensation. Molecular & Integrative Physiology. Sensory Neurobiology. Richard Mortensen, M.D., Ph.D. Molecular signal transduction pathways important in cardiovascular risk and disease. Pathways in hypertension and diabetes. G-proteins, PPARs, growth pathways. Molecular & Integrative Physiology. Internal Medicine. Martin Myers, MD, Ph.D. Mechanisms of intracellular signaling by the leptin receptor/Jak2 complex. Signals than perturbed in genetically engineered animals in order to study the function of these signals in neurons and immune cells in vivo. Molecular & Integrative Physiology Richard Neubig,
MD, Ph.D. Molecular mechanisms of signal
transduction; spectroscopic and rapid kinetic studies of
receptors, G proteins and their regulators; NMR structure
of receptor and G-protein peptides; mechanism of
alpha-adrenergic receptors. Bioinformatics. Biophysics.
Pharmacology. Ruthann Nichols, Ph.D. Structure-activity relationship of neuropeptides and neuropeptide receptors with emphasis on the RFamide peptide family and their role in regulating heart rate and muscle contraction; role of FMRF-amide neuropeptides in Drosophila and mammalian nervous systems. Biological Chemistry. Neuroscience. Human Genetics. Gilbert Omenn, MD. Ph.D. Proteomics and bioinformatics for development of cancer biomarkers. Human Genetics. Bioinformatics. Internal Medicine. Mark Opp, Ph.D. Stressor-induced alterations in arousal state. Elucidating mechanisms by which stressors alter arousal state may shed some light on the fundamental question of what sleep does for the brain. We focus on two types of stressors, those that are psychological in nature (ie, no tissue injury, trauma, or physical insult), and infection. Neuroscience. David J. Pinsky, Ph.D. To elucidate mechanisms driving ischemic modulation of the vascular phenotype, to understand endogenous mechanisms of ischemic vascular injury and protection at the intersection of thrombotic, fibrinolytic, and inflammatory axes. Molecular & Integrative Physiology Gina Poe, Ph.D. Basic sleep processes, development, learning and memory, and optimization of cognitive performance. Molecular & Integrative Physiology. Neuroscience. Yehoash Raphael, Ph.D. Design of biologically modified cochlear implants for combining electrical stimulation with gene therapy in the inner ear. Use of viral vectors for inner ear gene transfer aimed at repair and regeneration of cochlear and vestibular sensory epithelia. The roles of IGF-I and GDNF in protection and rescue of hearing and balance organs. Neuroscience. Diane M. Robins, Ph.D. Developmental and hormonal regulation of mammalian gene expression. Human Genetics. Cellular & Molecular Biology. Gus Rosania, Ph.D. We study the transport of small molecules at the cellular and subcellular levels, and develop chemical, biological, and mathematical/computational tools to understand the transport of nutrients and drugs. Bioinformatics. Liangyou Rui, Ph.D. Molecular mechanisms of obesity and type 2 diabetes. Investigation of molecular mechanisms of insulin/leptin signaling and resistance. Molecular & Integrative Physiology. Alan R. Saltiel, Ph.D. Mechanism of hormone action. Protein phosphorylation. Signal transduction. Molecular & Integrative Physiology. Linda C. Samuelson, Ph.D. Regulation of gastrointestinal function by peptide hormones; mouse developmental genetics; gene targeting in embryonic stem cells; molecular physiology of cholecystokinin and gastrin. Molecular & Integrative Physiology. Cellular & Molecular Biology. Jessica Schwartz, Ph.D. Cellular and molecular mechanisms of growth factor action; regulation of gene expression. Molecular & Integrative Physiology. Cellular & Molecular Biology. Audrey F. Seasholtz, Ph.D. Regulation of expression of the corticotropin-releasing hormone gene in mammalian stress. Biological Chemistry. Neuroscience. Cellular & Molecular Biology. Stanley Watson, MD, Ph.D. Regulatory neurobiology of opioid and related peptides; Molecular and neurobiological mechanisms of stress. Cellular & Molecular Biology. Neuroscience. Michael J. Welsh, Ph.D. Cellular stress response and stress-induced proteins; molecular mechanisms of toxicant action; regulation and function of hsp27 and related small stress proteins in muscle and cancer; cell biology; cell cytoskeleton and cytoskeletal proteins. Cell & Developmental Biology. Cellular & Molecular Biology. Margaret Westfall, Ph.D. Thin filament regulation of contractile function; cellular and molecular dissection of contractile function using viral-based gene transfer into cardiac myocytes. Molecular & Integrative Physiology. Cellular & Molecular Biology. John A. Williams, MD, Ph.D. Membrane receptor regulation of cell function; cellular mechanisms of pancreatic secretion; regulation of intracellular Ca2+. Molecular & Integrative Physiology. Cellular & Molecular Biology. Matthew J. Wishart, Ph.D. Mechanisms of action for protein- and lipid-phosphatases; STYX / dead-phosphatase adapters and phosphorylation-mediated signaling; molecular mechanisms of mammalian reproduction. Molecular & Integrative Physiology. Patricia Wittkopp, Ph.D. Genetic and developmental bases of evolutionary change. Molecular mechanisms that regulate gene expression and genetic changes that alter regulation are of particular interest. Molecular, Cellular, & Developmental Biology. Ecology & Evolutionary Biology. James
H. Woods, Ph.D. Behavioral pharmacology; mechanisms
of drug tolerance, dependence, and reinforcement.
Pharmacology.
Neuroscience. X.Z. Shawn Xu, Ph.D. Neurobiology of behavior and drug addiction in the genetic model organism C. elegans. Regulation of neuronal activity and fertilization by calcium signaling. Molecular & Integrative Physiology. Jianzhi Zhang, Ph.D. Molecular and genomic evolution, with both experimental and computational approaches. Bioinformatics. |
