Inflammation

Please note: Words in italics are the official PIBS affiliations of the indicated faculty.

Anuska Andjelkovic-Zochowska, M.D., Ph.D.  Molecular basis of inflammatory events at the blood brain barrier; the role of vascular endothelium in the pathogenesis of central nervous system inflammation; molecular mechanism of glioma associated angiogenesis. Pathology. Neuroscience. Molecular & Cellular Pathology.  

D. Keith Bishop, Ph.D. Cellular immunology of transplant rejection and acceptance. Microbiology & Immunology. Immunology.

Thomas Brock, Ph.D. Molecular and cellular aspects of cell-to-cell communication by polyunsaturated fatty acids, particularly in the contexts of immune defense and disease. Regulation of enzymes that convert fatty acids into alternative lipid mediators. Bioinformatics. Cellular & Molecular Biology. Internal Medicine

Cheong-Hee Chang, Ph.D. Regulation of the effector function of CD4 T cells and dendritic cells. Microbiology & Immunology, Immunology, Cell & Molecular Biology.

Stephen W. Chensue, MD, Ph.D. Cellular and molecular mechanisms of leukocyte mobilization during granulomatous inflammation. Molecular and Cellular Pathology.

Arul M. Chinnaiyan, M.D., Ph.D. Focus on high-throughput genomic and proteomic technologies to analyze human disease. Lab projects include molecular profiling of prostate cancer, profiling cancer with protein microarrays, and molecular signatures of sepsis. Bioinformatics. Molecular and Cellular Pathology.
Lab: http://www.pathology.med.umich.edu/dynamo/chinnaiyan/bioSketch.jsp?uid=arul

James L.M. Ferrara, M.D. Immunobiology of bone marrow transplantation. Cytokine modulation of inflammation. Immunology.

Gary Glick, Ph.D. Developing new methods to study the structure, folding, and dynamics of both DNA and RNA. Defining binding properties of anti-DNA autoantibodies that arise in the autoimmune disorder systemic lupus erythematosus. Chemistry. Immunology. Cellular & Molecular Biology. Biophysics. Biological Chemistry.
http://www.umich.edu/~michchem/faculty/glick/

Deborah L. Gumucio, Ph.D. Molecular etiology of an autoinflammatory disease, familial Mediterranean
fever. Cell & Developmental Biology. Cellular & Molecular Biology.

Margaret Gyetko, MD Regulation of macrophage functions. Genetic regulation of protease/antiprotease systems in the lung. The role of urokinase in the modulation of pulmonary inflammation. Protease/cytokine interactions. The role of the urokinase receptor in cell movement and recruitment. Immunology.

Yongqun He (Oliver), DVM, Ph.D. Using high-throughput technologies (e.g., microarrays) and bioinformatics to study microbial pathogenesis and immunology of infectious diseases. Lab Animal Medicine. Microbiology & Immunology. Bioinformatics. Lab: http://helab.bioinformatics.med.umich.edu/

Marc Hershenson, M.D. Signal transduction mechanisms underlying airway smooth muscle cell proliferation and differentiation; biochemical signaling pathways regulating pro-inflammatory molecule expression in airway epithelial cells. Molecular & Integrative Physiology.

Cory Hogaboam, Ph.D. Cytokine and chemokine networks that maintain inflammatory responses in the liver and lung during chronic disease. Cytokine and chemokine networks that promote deleterious liver and lung tissue repair processes. Therapeutic interventions in idiopathic pulmonary fibrosis and asthma. Phenotypic switches in pulmonary and hepatic firboblasts during chronic inflammatory disease. Molecular and Cellular Pathology. Immunology.

Mariana Kaplan, M.D. Dendritic cells in autoimmune diseases; APC apoptosis in lupus; endothelial cell apoptosis and vascular damage. Immunology.

Fred J. Karsch, Ph.D. Neuroendocrine regulation of ovarian cyclicity and seasonal breeding; interactions between immune and neuroendocrine systems. Molecular & Integrative Physiology.

Steven Kunkel, Ph.D. Biology and gene regulation of chemokines and cytokines; macrophage pathobiology. Cellular & Molecular Biology. Immunology. Molecular and Cellular Pathology.

Yasmina Laouar, Ph.D. Mechanisms of immunosuppression in the development, homeostasis, and function of innate effector cells in response to pathogens. Immunology, Microbiology & Immunology.

Benedict R. Lucchesi, MD, Ph.D. Cardiovascular pharmacology. Biological Chemistry.

Nicholas W. Lukacs, Ph.D. Interrelationship of cytokines, chemokines and leukocyte activation during asthmatic-type airway responses and immune responses. Molecular and Cellular Pathology.

Juanita L. Merchant, MD, Ph.D. Molecular mechanisms of gastric epithelial cell growth; growth factor regulation of normal and neoplastic growth; transcriptional control of gastrointestinal peptides; posttranslational modifications of transcription factors; transgenic models for stomach development; Helicobacter pylori and peptic ulcer; gastric cancer development. Cellular & Molecular Biology. Molecular & Integrative Physiology.

Bethany Moore, Ph.D. Cytokine and chemokine and eicosanoid regulation of pulmonary fibrosis; bacterial infections in the lung post bone-marrow transplant. Immunology.

Gabriel Nuñez, M.D. Role of Innate Immunity in Host Defense, Cancer and Inflammatory Disease. Cellular & Molecular Biology. Molecular and Cellular Pathology. Microbiology & Immunology.
http://www.pathology.med.umich.edu/faculty/Nunez/index.html

Mark Opp, Ph.D. Stressor-induced alterations in arousal state. Elucidating mechanisms by which stressors alter arousal state may shed some light on the fundamental question of what sleep does for the brain. We focus on two types of stressors, those that are psychological in nature (ie, no tissue injury, trauma, or physical insult), and infection. Neuroscience.

Marc Peters-Golden, MD Cellular and molecular regulation of synthesis, as well as actions, of arachidonic acid metabolites (prostaglandins and leukotrienes) in inflammation, antimicrobial defense, and fibrosis. Immunology.

Sem H. Phan, MD, Ph.D. Mechanisms of fibrosis; myofibroblast biology; regulation of þ-smooth muscle actin gene expression; eosinophils and cytokines in pulmonary fibrosis. Molecular and Cellular Pathology. Immunology.
Lab: http://www.pathology.med.umich.edu/faculty/Phan/research.html

David J. Pinsky, Ph.D. To elucidate mechanisms driving ischemic modulation of the vascular phenotype, to understand endogenous mechanisms of ischemic vascular injury and protection at the intersection of thrombotic, fibrinolytic, and inflammatory axes. Molecular & Integrative Physiology

Faye Silverstein, MD Neurochemical mechanisms of perinatal brain injury. Integrative and Systems Neurobiology. Neuroscience.

William L. Smith, Ph.D. Chemical processes underlying the biosynthesis and functions of prostaglandins. Current research is focused on understanding (a) the enzymology of prostaglandin endoperoxide H synthases (PGHSs) and (b) the regulation of PGHS gene expression. PGHSs are also known as “cyclooxygenases”. Biological Chemistry.

Lloyd M. Stoolman, MD Lymphocyte recirculation and migration; functional characterization of the lymphocyte and endothelial receptors that mediate migration into lymphoid organs and sites of chronic inflammation; role of lymphocyte homing receptors in the hematogenous dissemination of lymphoid malignancies; role of lymphocyte-extracellular matrix interactions in lymphocyte migration. Immunology. Molecular and Cellular Pathology.

James Varani, Ph.D. Cell-substrate adhesion and cell motility in normal mammalian cells and their malignant counterparts; biosynthesis and surface expression of extracellular matrix molecules, such as fibronectin, laminin, and thrombospondin and their involvement as endogenous regulators of adhesion, motility, invasion, and metastasis. Molecular and Cellular Pathology.

Peter A. Ward, MD Mechanisms of the inflammatory response and its regulation; role of oxidants in tissue injury; mechanisms and participation of cytokines and chemokines; role of complement activation products in the inflammatory response. Molecular and Cellular Pathology.

Jeffrey S. Warren, MD Role of cellular redox status in modulating chemokine expression; pathogenesis of granulomatous vasculitis. Molecular and Cellular Pathology.

Jason Weinberg, M.D. Pathogenesis of persistent viral infections. Lung inflammatory responses to acute and persistent viral infection. Contributions of specific chemokines and cytokines to the control of viral infection. Modulation of host inflammatory responses by persistent viral infection. Reactivation of latent gammaherpesvirus infection by host inflammatory responses. Pediatrics and Communicable Diseases. Microbiology and Immunology.
Weinberg Lab Homepage

Steve J. Weiss, MD Regulation, expression, and function of proteinases in cell movement through the extracellular matrix. Cellular & Molecular Biology.

Eric S. White, M.D. Our lab focuses on fibroblast biology, extracellular matrix influences on cellular biology, and immunology of granulomatous lung diseases. Internal Medicine-Pulmonary & Critical Care Medicine. Immunology.