Immunology Related Research

Please note: Words in italics are the official PIBS affiliations of the indicated faculty.

Anuska Andjelkovic-Zochowska, M.D., Ph.D.  Molecular basis of inflammatory events at the blood brain barrier; the role of vascular endothelium in the pathogenesis of central nervous system inflammation; molecular mechanism of glioma associated angiogenesis. Pathology. Neuroscience. Molecular & Cellular Pathology.  

James R. Baker Jr., MD Determining why autoantigens are recognized in autoimmune disease; epitope mapping thyroid autoantigens from patients with autoimmune thyroid disease. Immunology. Molecular and Cellular Pathology.

D. Keith Bishop, Ph.D. Cellular immunology of transplant rejection and acceptance. Microbiology & Immunology. Immunology.

Thomas Brock, Ph.D. Molecular and cellular aspects of cell-to-cell communication by polyunsaturated fatty acids, particularly in the contexts of immune defense and disease. Regulation of enzymes that convert fatty acids into alternative lipid mediators. Bioinformatics. Cellular & Molecular Biology. Internal Medicine

Thomas Carey, Ph.D. Genetic mechanisms in head and neck cancer progression; genetic mechanisms affecting response to therapy; and mechanisms of autoimmune hearing loss mediated by antibodies to inner ear antigens. Cellular & Molecular Biology. Pharmacology.

Fred Chang Tumor immunology and immunotherapy. Immunology.

Cheong-Hee Chang, Ph.D. Regulation of the effector function of CD4 T cells and dendritic cells. Microbiology & Immunology, Immunology, Cell & Molecular Biology.

Stephen W. Chensue, MD, Ph.D. Cellular and molecular mechanisms of leukocyte mobilization during granulomatous inflammation. Molecular and Cellular Pathology.

Kathleen Collins, M.D., Ph.D. Molecular Mechanisms of HIV Immune Evasion. Immunology. Cellular & Molecular Biology. Microbiology & Immunology.
http://www.med.umich.edu/cmb/faculty/directory.htm#collins

Jeffrey Curtis, M.D. Lung lymphocyte recruitment and apoptosis; regulation of pulmonary immunity; alveolar macrophage signal transduction pathways. Immunology.

Wesley Dunnick, Ph.D. Immunoglobulin genes; DNA rearrangement. Mircrobiology and Immunology. Immunology.

Colin S. Duckett, Ph.D. Novel roles for IAP proteins in the control of apoptosis, intracellular signaling and metabolism. IAPs as regulators of apoptosis. IAPs in cancer. E3 ubiquitination activities of IAPs. Caspase-independent signaling properties of IAPs. X-linked lymphoproliferative disorder and XIAP. Role of XIAP in copper metabolism and homeostasis. c-IAPs: Key intracellular signaling molecules with diverse roles in inflammation. IAP antagonists: Apoptotic sensitizers and signaling modulators. Immunology, Molecular and Cellular Pathology, Cellular & Molecular Biology.

James L.M. Ferrara, M.D. Immunobiology of bone marrow transplantation. Cytokine modulation of inflammation. Immunology.

David A. Fox, MD Human T-cell activation; immunopathogenesis of T-lymphocyte-mediated diseases, particularly rheumatoid arthritis. Cellular & Molecular Biology. Immunology.

Gary Glick, Ph.D. Developing new methods to study the structure, folding, and dynamics of both DNA and RNA. Defining binding properties of anti-DNA autoantibodies that arise in the autoimmune disorder systemic lupus erythematosus. Immunology. Chemistry. Cellular and Molecular Biology. Biophysics. Biological chemistry.
http://www.umich.edu/~michchem/faculty/glick/

Margaret Gyetko, MD Regulation of macrophage functions. Genetic regulation of protease/antiprotease systems in the lung. The role of urokinase in the modulation of pulmonary inflammation. Protease/cytokine interactions. The role of the urokinase receptor in cell movement and recruitment. Immunology.

Yongqun He (Oliver), DVM, Ph.D. Using high-throughput technologies (e.g., microarrays) and bioinformatics to study microbial pathogenesis and immunology of infectious diseases. Lab Animal Medicine. Microbiology & Immunology. Bioinformatics. Lab: http://helab.bioinformatics.med.umich.edu/

Cory Hogaboam, Ph.D. Cytokine and chemokine networks that maintain inflammatory responses in the liver and lung during chronic disease. Cytokine and chemokine networks that promote deleterious liver and lung tissue repair processes. Therapeutic interventions in idiopathic pulmonary fibrosis and asthma. Phenotypic switches in pulmonary and hepatic firboblasts during chronic inflammatory disease. Molecular and Cellular Pathology. Immunology.

Joseph Holoshitz, MD Signal transduction; MHC and DNA repair in autoimmunity. Immunology. Microbiology & Immunology. Cellular & Molecular Biology.

Gary Huffnagle, Ph.D. Pulmonary immunology (innate and acquired), fungal and bacterial pathogenesis, modulation of host defenses by microbial virulence factors. Internal Medicine (Pulmonary). Immunology. Microbiology & Immunology.

Mariana Kaplan, M.D. Dendritic cells in autoimmune diseases; APC apoptosis in lupus; endothelial cell apoptosis and vascular damage. Immunology.

Fred J. Karsch, Ph.D. Neuroendocrine regulation of ovarian cyclicity and seasonal breeding; interactions between immune and neuroendocrine systems. Molecular & Integrative Physiology.

Evan Keller. Immunologic aging. Comparative Medicine. Immunology. Molecular and Cellular Pathology.

Tom Kerppola, Ph.D. Regulation of gene expression by proto-oncogene transcription factors; protein interactions in living cells and organisms; and nucleoprotein complex architecture. Biological Chemistry. Biophysics.
http://sitemaker.umich.edu/kerppola.lab

Philip King, Ph.D. Molecular understanding of mechanisms of signal integration in T cells. The role of a variety of intracellular signaling molecules including protein and lipid kinases, phosphatases, adapter proteins and transcription factors as potential signal integrators. Microbiology & Immunology. Immunology.

Steven Kunkel, Ph.D. Biology and gene regulation of chemokines and cytokines; macrophage pathobiology. Cellular & Molecular Biology. Immunology. Molecular and Cellular Pathology.

Yasmina Laouar, Ph.D. Mechanisms of immunosuppression in the development, homeostasis, and function of innate effector cells in response to pathogens. Immunology, Microbiology & Immunology.

Yang Liu Cellular and molecular interactions critical for the development, induction and effector function of T-cell and Natural Killer cell-mediated immunity and cancer evasion of host immunity. Immunology.

Benedict R. Lucchesi, MD, Ph.D. Cardiovascular pharmacology. Biological Chemistry.

Nick Lukacs, Ph.D. Lung inflammation; chemokines. Molecular and Cellular Pathology.

Gary Luker, Ph.D. Understanding how interactions between“invaders”, either DNA viruses or cancer cells, and the environment of a normal host affect disease pathogenesis. Emphasis on non-invasive imaging to analyze signaling pathways and disease outcome in living mice. Microbiology & Immunology. Immunology.

Ivan Maillard, M.D.-Ph.D. Our main research interests are in the following topics: Investigating the interaction of hematopoietic stem cells (HSC) with their microenvironmental niche, particularly in fetal sites of hematopoiesis; and understanding the role of Notch signaling in the regulation of T cell homeostasis and differentiation. We are using a combination of genetic, cellular and biochemical approaches to study these questions. Hematology-Oncology. Cell and Developmental Biology. http://www.med.umich.edu/immprog/faculty/maillard.htm

Sami Malek, M.D. Hematological malignancies including CLL, Follicular Lymphoma, MDS and AML using a variety of approaches. Many questions intersect with standard immunological problems and are studied accordingly. Internal Medicine. Immunology.

David M. Markovitz, MD Regulation of retroviral gene expression. Cellular & Molecular Biology. Immunology.

Richard A. Miller, MD, Ph.D. Signal transduction in T cells; aging and T-cell subsets; immunology of aging; genetics of longevity. Molecular and Cellular Pathology. Cellular & Molecular Biology. Immunology.
http://www.med.umich.edu/cmb/faculty/directory.htm#millerr

Bethany Moore, Ph.D. Cytokine and chemokine and eicosanoid regulation of pulmonary fibrosis; bacterial infections in the lung post bone-marrow transplant. Immunology.

Thomas Moore, Ph.D. Innate host responses during bacterial infection, microbial pathogenesis, T cells and bacterial infection. Immunology.

Sean Morrison, Ph.D. Stem cell biology using hematopoiesis and neural development as model systems. Cell & Developmental Biology. Cellular & Molecular Biology.

Patrick Nelson, Ph.D. Applied mathematics specializing in mathematical biology. Develop and use models to study the dynamics of HIV and HBV infections. Mathematics. Microbiology & Immunology.

Gabriel Nuñez, M.D. Role of Innate Immunity in Host Defense, Cancer and Inflammatory Disease. Cellular & Molecular Biology. Molecular and Cellular Pathology. Microbiology & Immunology.
http://www.pathology.med.umich.edu/faculty/Nunez/index.html

Akira Ono, Ph.D. Relationships between cellular membranes and enveloped viruses with particular emphasis on the roles played by lipid rafts and endosomes in HIV-1 replication. Microbiology & Immunology.

Mark Opp, Ph.D. Stressor-induced alterations in arousal state. Elucidating mechanisms by which stressors alter arousal state may shed some light on the fundamental question of what sleep does for the brain. We focus on two types of stressors, those that are psychological in nature (ie, no tissue injury, trauma, or physical insult), and infection. Neuroscience.

Marc Peters-Golden, MD Cellular and molecular regulation of synthesis, as well as actions, of arachidonic acid metabolites (prostaglandins and leukotrienes) in inflammation, antimicrobial defense, and fibrosis. Immunology.

Sem H. Phan, MD, Ph.D. Mechanisms of fibrosis; myofibroblast biology; regulation of þ-smooth muscle actin gene expression; eosinophils and cytokines in pulmonary fibrosis. Molecular and Cellular Pathology. Immunology.
Lab: http://www.pathology.med.umich.edu/faculty/Phan/research.html

Malini Raghavan, Ph.D. Biochemical and molecular interactions underlying immune recognition events: interactions and biochemical mechanisms of function of the transporters associated with antigen processing; mammalian and viral Fc receptors and their interactions with immunoglobulin G. Microbiology & Immunology. Immunology. Biophysics. Cellular & Molecular Biology.

Bruce Richardson, MD, Ph.D. Mechanisms of autoimmune lupus. Immunology.

Blake Roessler. Development of gene therapy for the rheumatic diseases. Internal Medicine.

JoAnn Sekiguchi, Ph.D. Mechanisms of DNA repair and how aberrant repair processes affect genomic stability, predisposition to cancer and immune system development. Human Genetics.

Katherine Spindler, Ph.D. Molecular genetics of mouse adenovirus (MAV-1) pathogenesis; host immune response to MAV-1; genetics of host susceptibility to viral infection. Microbiology & Immunology. Cellular & Molecular Biology. Human Genetics.

Theodore J. Standiford. Lung inflammation. Immunology. Internal Medicine.

Lloyd M. Stoolman, MD Lymphocyte recirculation and migration; functional characterization of the lymphocyte and endothelial receptors that mediate migration into lymphoid organs and sites of chronic inflammation; role of lymphocyte homing receptors in the hematogenous dissemination of lymphoid malignancies; role of lymphocyte-extracellular matrix interactions in lymphocyte migration. Immunology. Molecular and Cellular Pathology.

Grace Su, M.D. Liver and innate immunity. Immunology.

Joel Swanson, Ph.D. Endocytosis in macrophages. Cellular & Molecular Biology. Microbiology & Immunology. Immunology. Biophysics.

Peter Ward, MD Regulation and role of adhesion-promoting molecules and cytokines in the inflammatory response. Immunology. Molecular and Cellular Pathology.

Jeffrey S. Warren, MD Role of cellular redox status in modulating chemokine expression; pathogenesis of granulomatous vasculitis. Molecular and Cellular Pathology.

Eric S. White, M.D. Our lab focuses on fibroblast biology, extracellular matrix influences on cellular biology, and immunology of granulomatous lung diseases. Internal Medicine-Pulmonary & Critical Care Medicine. Immunology.

Pan Zheng Mechanism in immune tolerance to tumor antigens in cancer models. Explore different ways to rescue the high avidity tumor antigen reactive T cells from negative selection and to modulate the function of regulatory T cells. Study protein phosphatase as tumor suppressor in Wnt signaling. Immunology, Molecular and Cellular Pathology.

Weiping Zou, M.D., Ph.D. Research interests: B7 family members and dendritic cells in tumors, regulatory T cells in tumors, immune cell trafficking in tumors, novel animal models for cancer, mechanistic interaction between tumor, host immune cells and stems cells, and the translational aspects of novel immune-based interventions in patients with cancer. Molecular and Cellular Pathology, Immunology.