Hormone Action

Please note: Words in italics are the official PIBS affiliations of the indicated faculty.

Huda Akil, Ph.D. Molecular and neurobiological mechanisms of stress, opioids, endorphins, and dopamine. Psychiatry. Molecular and Chemical Neuroscience. Neuroscience.

Jill Becker, Ph.D. Role of estrogen and dopamine in behavior/recovery of function after brain injury. Neuroscience.

Thomas Brock, Ph.D. Molecular and cellular aspects of cell-to-cell communication by polyunsaturated fatty acids, particularly in the contexts of immune defense and disease. Regulation of enzymes that convert fatty acids into alternative lipid mediators. Bioinformatics. Cellular & Molecular Biology. Internal Medicine

Sally A. Camper, Ph.D. Developmental genetics of the neuroendocrine system; transgenic mice; gene targeting; pituitary dwarfism. Human Genetics. Bioinformatics. Cellular & Molecular Biology. Neuroscience.

Greg Cartee, Ph.D. My research is focused on understanding the mechanisms that underlie the regulation of skeletal muscle glucose transport, especially as the result of:  exercise/contraction, calorie restriction (consuming approximately 60% of ad libitum intake), and/or aging. Kinesiology. Cellular & Molecular Biology.

Christin Carter-Su, Ph.D. Signal transduction used by cytokine receptors via JAK tyrosine kinases; regulation of gene transcription by tyrosine kinases; cellular and molecular actions of growth hormone and cytokines. Molecular & Integrative Physiology. Cellular & Molecular Biology.
http://www.med.umich.edu/cmb/faculty/directory.htm#cartersu

Mark Day, Ph.D. Cell-cycle regulation of epithelial programmed cell death. Cellular & Molecular Biology.

Robert Denver, Ph.D. Molecular biology of hormone action in animal development; neuroendocrinology; evolutionary developmental biology. Molecular, Cellular & Developmental Biology. Neuroscience.
Lab website

Steven Domino, M.D., Ph.D. Functions of cell-surface carbohydrates in reproductive and other tissues. Cellular & Molecular Biology.

Cumming Duan, Ph.D.  The current research focuses on the insulin-like growth factor (IGF) signaling system, including the IGF ligands, IGF binding proteins, IGF receptors, and the downstream signal transduction mechanisms. Molecular, Cellular & Developmental Biology. Cellular & Molecular Biology.

Eva Feldman, MD, Ph.D. Insulin-like growth factors in neuronal development and survival. Cellular & Molecular Biology. Neuroscience.

Gary D. Hammer, MD, Ph.D. Molecular mechanisms of stress. Adrenal cortical growth and differentiation. Transcriptional regulation by adrenal-specific nuclear receptors-transcription factors. Adrenal cortical carcinogenesis. Transgenic models of adrenal development and disease. Molecular & Integrative Physiology. Cellular & Molecular Biology.

Jorge Iñiguez-Lluhi, Ph.D. Eukaryotic Transcriptional regulation, transcription factor interactions,Steroid hormone receptors, structure, function and genetics. Pharmacology.

Robert Kennedy, Ph.D. Mechanisms and regulation of neurotransmitter and hormone secretion. Chemical basis of behavior and regulation by drugs. Novel technology for in vivo and single cell studies. Pharmacology.

Ron Koenig, MD, Ph.D. Gene regulation by thyroid hormone receptors and related proteins. Cellular & Molecular Biology.

Roland Kwok, Ph.D. Hormonal regulation of cAMP-activated gene expression. Biological Chemistry. Obstetrics & Gynecology.

Theresa M. Lee, Ph.D. Study the photic and non-photic signals that entrain circadian and seasonal rhythms and the role of gonadal hormones in the development and adult manifestation of those rhythms. Neuroscience.

Ormond A. MacDougald, Ph.D. Adipocyte gene expression and metabolism; transcriptional and posttranslational regulation of the transcription factor, C/EBP (alpha). Molecular & Integrative Physiology.

Stephen Maren, Ph.D. Neurobiological basis of emotional learning and memory. Neuroscience.

K. M. Jairam Menon, Ph.D. Signal transduction through G protein-coupled receptors; molecular aspects of hormone action. Biological Chemistry. Obstetrics & Gynecology.

Ram Menon, M.D Growth hormone action, regulation of gene transcription, role of growth factors in germ cell function.  Molecular & Integrative Physiology.

Juanita L. Merchant, MD, Ph.D. Molecular mechanisms of gastric epithelial cell growth; growth factor regulation of normal and neoplastic growth; transcriptional control of gastrointestinal peptides; posttranslational modifications of transcription factors; transgenic models for stomach development; Helicobacter pylori and peptic ulcer; gastric cancer development. Cellular & Molecular Biology. Molecular & Integrative Physiology.

Richard Mortensen, M.D., Ph.D. Molecular signal transduction pathways important in cardiovascular risk and disease. Pathways in hypertension and diabetes. G-proteins, PPARs, growth pathways.  Molecular & Integrative Physiology. Internal Medicine.

Martin Myers, MD, Ph.D. Mechanisms of intracellular signaling by the leptin receptor/Jak2 complex. Signals than perturbed in genetically engineered animals in order to study the function of these signals in neurons and immune cells in vivo. Molecular & Integrative Physiology.

Richard Neubig, MD, Ph.D. Molecular mechanisms of signal transduction; spectroscopic and rapid kinetic studies of receptors, G proteins and their regulators; NMR structure of receptor and G-protein peptides; mechanism of alpha-adrenergic receptors. Bioinformatics. Biophysics. Pharmacology.
Biophysics Lab

Paresh Patel, MD, Ph.D. Neurotransmitters regulating mood disorders. Neuroscience.

Diane M. Robins, Ph.D. Developmental and hormonal regulation of mammalian gene expression. Human Genetics. Cellular & Molecular Biology.

Liangyou Rui, Ph.D. Molecular mechanisms of obesity and type 2 diabetes. Investigation of molecular mechanisms of insulin/leptin signaling and resistance. Molecular & Integrative Physiology.

Alan R. Saltiel, Ph.D. Mechanism of hormone action. Protein phosphorylation. Signal transduction. Molecular & Integrative Physiology.

Linda C. Samuelson, Ph.D. Regulation of gastrointestinal function by peptide hormones; mouse developmental genetics; gene targeting in embryonic stem cells; molecular physiology of cholecystokinin and gastrin. Molecular & Integrative Physiology. Cellular & Molecular Biology.

Jessica Schwartz, Ph.D. Cellular and molecular mechanisms of growth factor action; regulation of gene expression. Molecular & Integrative Physiology. Cellular & Molecular Biology.

Audrey F. Seasholtz, Ph.D. Regulation of expression of the corticotropin-releasing hormone gene in mammalian stress. Biological Chemistry. Neuroscience. Cellular & Molecular Biology.

Robert U. Simpson, Ph.D. Receptors: calcium-regulating hormones and drugs. Pharmacology.

William L. Smith, Ph.D. Chemical processes underlying the biosynthesis and functions of prostaglandins. Current research is focused on understanding (a) the enzymology of prostaglandin endoperoxide H synthases (PGHSs) and (b) the regulation of PGHS gene expression. PGHSs are also known as “cyclooxygenases”. Biological Chemistry.

Roger Sunahara, Ph.D. Structure/function of the G-protein-coupled signaling cascade; molecular mechanisms of hormone receptor-mediated activation of G proteins; molecular mechanisms of activation and regulation of adenylyl cyclase. Pharmacology.

Joel Swanson, Ph.D. Endocytosis in macrophages. Cellular & Molecular Biology. Microbiology & Immunology. Immunology. Biophysics.

Robert Thompson, Ph.D. Mechanisms of antidepressant action and nutritional regulation of reproductive functions (regulation of gene expression; molecular biology, neuroendocrinology and anatomy). Neuroscience.Psychiatry.

Michael D. Uhler, Ph.D. Regulation and specificity of serine-threonine protein kinase structures; regulation of calcium channels and neurotransmitter secretion; function and regulation of neuronal activity; Cyclic nucleotides and phosphorylation in neuronal plasticity. Cellular & Molecular Biology. Biological Chemistry.Molecular and Chemical Neuroscience.

Delia Vazquez, MD Development of the classical endocrine system which responds to stress, the hypothalamic pituitary adrenal (HPA) axis. Regulation of the serotonin system during development. Neuroscience.

Michael J. Welsh, Ph.D. Cellular stress response and stress-induced proteins; molecular mechanisms of toxicant action; regulation and function of hsp27 and related small stress proteins in muscle and cancer; cell biology; cell cytoskeleton and cytoskeletal proteins. Cell & Developmental Biology. Cellular & Molecular Biology.

John A. Williams, MD, Ph.D. Membrane receptor regulation of cell function; cellular mechanisms of pancreatic secretion; regulation of intracellular Ca2+. Molecular & Integrative Physiology. Cellular & Molecular Biology.

James H. Woods, Ph.D. Behavioral pharmacology; mechanisms of drug tolerance, dependence, and reinforcement. Pharmacology. Neuroscience.
http://sitemaker.umich.edu/woods