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Genetics Related ResearchPlease note: Words in italics are the official PIBS affiliations of the indicated faculty. Goncalo Abecasis, Ph.D Development and application of statistical methods for complex trait gene identification. Active research areas include mental disorders and aging-related diseases. Biostatistics. Bioinformatics. Radha Ayyagari, Ph.D Molecular genetics of retinal and macular degenerations and understanding the mechanism underlying the degeneration process. Cell and Developmental Biology. Ophthalmology and visual sciences. James Bardwell, Ph.D. Protein folding catalysts, from
genetics to 3-D structures: role of molecular chaperones
and disulfide catalysts. Biology. Biophysics. Cellular & Molecular Biology. Scott Barolo, Ph.D. Molecular genetics and biochemistry of transcriptional regulation; structure/function analysis of signaling pathway-regulated enhancers, using Drosophila as a model system. Cell & Developmental Biology. Robert A. Bender, Ph.D. Metabolic regulation in microorganisms. Molecular, Cellular & Developmental Biology. David T. Burke, Ph.D. Mammalian genetics; genetics of aging in the mouse; quantitative genetic analysis. Human Genetics.
Margit Burmeister, Ph.D. Gene mapping; genetics of
neurological, psychiatric, and behavioral disorders;
mouse models; genome organization. Human Genetics. Neuroscience. Bioinformatics Kenneth Cadigan, Ph.D. Genetics of Drosophila Devel and Signal Transduction. Molecular, Cellular & Developmental Biology. Cellular & Molecular Biology. Sally A. Camper, Ph.D. Developmental genetics of the neuroendocrine system; transgenic mice; gene targeting; pituitary dwarfism. Human Genetics. Bioinformatics. Cellular & Molecular Biology. Neuroscience. Vern Carruthers, Ph.D. Pathogenesis of parasitic infections: Mechanisms of cell invasion and survival during infection. Microbiology and Immunology. Raymond Chan , Ph.D. Studies the packaging of chromosome in preparation for cellular division in mitosis and meiosis in the nematode C. elegans. My primary focus is on the Structural Maintenance of Chromosomes (SMC) protein family and TIM-1, a novel regulator of SMC proteins that I had previously identified. Human Genetics. http://www.umich.edu/~mmgmed/faculty/bios/Chan.htm Amy Chang, Ph.D. Genetics and cell biology of protein folding, sorting, and transport in the yeast secretory pathway; membrane biogenesis. Molecular, Cellular, and Developmental Biology. Julie A. Douglas, Ph.D. Statistical genetics. Statistical genetics. Genetic mapping of complex human diseases and traits with an emphasis on the development, application, and evaluation of statistical methods. Human Genetics. Bioinformatics. Cumming Duan, Ph.D. The current research focuses on the insulin-like growth factor (IGF) signaling system, including the IGF ligands, IGF binding proteins, IGF receptors, and the downstream signal transduction mechanisms. Molecular, Cellular & Developmental Biology. Cellular & Molecular Biology. Wesley Dunnick, Ph.D. Immunoglobulin genes; DNA rearrangement. Mircrobiology and Immunology. Immunology.
Doug Engel, Ph.D. Molecular genetics of mammalian
organ specification and differentiation. Cell & Developmental Biology. Cellular & Molecular Biology.
David R. Engelke, Ph.D. Regulation of eukaryotic gene
expression at the levels of transcription and RNA
processing; catalytic and therapeutic RNA. Cellular & Molecular Biology. Biological
Chemistry.
Eric R. Fearon, MD, Ph.D. Molecular genetics of
cancer; tumor suppressor gene function. Cellular & Molecular Biology. Human Genetics.
Molecular and
Cellular Pathology. John Fink, MD Genetic analysis of inherited neurologic and psychiatric disorders. Molecular and Chemical Neuroscience. Neuroscience.
Robert S. Fuller, Ph.D. Proteolytic processing,
protein localization, and macromolecular transport in the
secretory pathway; yeast cell biology; structure,
mechanism, and specificity of proteases. Biological Chemistry. Cellular & Molecular Biology. Philip Gage,
Ph.D. Genetic analysis of mammalian eye development; cell fate
decisions in neural crest and mesoderm, transgenic mice, and gene
targeted mice. Cellular & Molecular Biology, Cell & Developmental
Biology David Ginsburg, MD Molecular genetics of the blood coagulation system. Human Genetics. Cellular & Molecular Biology. Thomas M. Glaser, MD, Ph.D. Genetic analysis of mammalian eye development. Human Genetics. Thomas W. Glover, Ph.D. Molecular cytogenetics and the molecular biology of human disease; gene mapping; Menkes syndrome; fragile sites. Human Genetics. Cellular & Molecular Biology.
Daniel J. Goldman, Ph.D. Acetylcholine receptor gene
expression at the neuromuscular junction; synaptogenesis;
sensory transduction processes; neuroreceptors; molecular
mechanisms of nerve regeneration. Biological Chemistry. Human Genetics.
Neuroscience. Pharmacology. Gary D. Hammer, MD, Ph.D. Molecular mechanisms of stress. Adrenal cortical growth and differentiation. Transcriptional regulation by adrenal-specific nuclear receptors-transcription factors. Adrenal cortical carcinogenesis. Transgenic models of adrenal development and disease. Molecular & Integrative Physiology. Cellular & Molecular Biology. Michael Hortsch, Ph.D. Role of cell adhesion molecules in neuronal differentiation of Drosophila. Cell & Developmental Biology. Neuroscience. Patrick Hu, MD, Ph.D. We use the nematode C. elegans to study the biology of conserved signal transduction pathways that are mutated in cancer and diabetes. Cell & Developmental Biology. Michael J. Imperiale, Ph.D. Posttranscriptional regulation of eukaryotic gene expression; interaction of virus and host cell factors in regulation of gene expression and oncogenic transformation; viral vectors. Microbiology & Immunology. Cellular & Molecular Biology. Jorge Iñiguez-Lluhi, Ph.D. Eukaryotic Transcriptional regulation, transcription factor interactions,Steroid hormone receptors, structure, function and genetics. Pharmacology. Jeffrey W. Innis, MD, Ph.D. Molecular genetics of mammalian limb development; HOX gene function. Human Genetics. Bioinformatics. Lori L. Isom, Ph.D. Cellular & Molecular Biology of voltage-gated sodium channel alpha and beta subunits. Pharmacology. Neuroscience. Cellular & Molecular Biology. Human Genetics. Ursula Jakob, Ph.D. Oxidative stress and aging - Analysis of redox regulated proteins using biochemical, cell biological and proteomic tools. Molecular, Cellular & Developmental Biology. Cellular & Molecular Biology. Catherine E. Keegan, MD, PhD. Mouse models of telomere dysfunction, genomic instability, and birth defects. Molecular genetics of caudal and urogenital development. Cellular & Molecular Biology. Pediatric Genetics. John Kim, Ph.D. Studies how microRNAs and other emerging classes of small RNAs regulate fundamental biological processes including heterochromatin formation, neuronal cell patterning, cardiac and skeletal muscle development, germline maintenance, and oncogenic cell proliferation. Using functional genomic, genetic, biochemical, and cell biology strategies, his lab investigates the molecular mechanisms of both the small RNAs and new candidate RNAi factors identified by genome-wide screens. Human Genetics.
Daniel J. Klionsky, Ph.D. Molecular and cellular
biology of protein targeting and degradation, and
organelle homeostasis in yeast. Cellular & Molecular Biology. Molecular, Cellular & Developmental Biology. Biological
Chemistry. David Kohrman, Ph.D. Molecular genetics of inner ear structure and function, including analysis of the molecular basis of hearing loss and vestibular dysfunction in mice and humans. Human Genetics. Cheng-Yu Lee, Ph.D. Currently investigating a number of evolutionarily conserved genes required for the choice of self-renewal vs. differentiation in fly, and we will apply the insight gained from studying fly neuroblasts to a clinically relevant vertebrate system such as mouse to test the roles of these fly genes in regulation of vertebrate neural stem cell self-renewal. Long-term goals: Identify many signaling pathways expressed in both insect and vertebrate neural stem cells, contribute to our understanding of neural stem cells in birth defects, regenerative medicine and cancer biology. Center For Stem Cell Biology, Life Sciences Institute, Division of Molecular Medicine And Genetics, Department Of Internal Medicine, Cellular and Developmental Biology. Lab: http://www.lsi.umich.edu/facultyresearch/labs/lee Andrew Lieberman, MD, Ph.D. Trinucleotide repeat disorders. Neuroscience. Molecular and Cellular Pathology. Jun Li, Ph.D. Genetic studies of complex human diseases, including psychiatric disorders, heart disease, and cancer, with emphases on genetic influence of gene expression, population structure, DNA copy number variation (either inherited or somatic), and application of next-generation sequencing methods to related problems. Human Genetics. Cellular & Molecular Biology. Bioinformatics. Jeffrey Long, Ph.D. Analysis of human polymorphism, including human population genetics, the inheritance of complex diseases, and statistical genetics. One focus is on how levels of polymorphism and patterns of linkage disequilibrium are influenced by the interplay among diverse factors such as historical migrations, population size, gene flow, selective environment, mutation and recombination. Human Genetics. Jill A. Macoska, Ph.D. Genetic and cellular changes associated with early neoplastic transformation. Bioinformatics. Cellular & Molecular Biology. Urology. Janine Maddock, Ph.D. Spatial organization of protein complexes in bacteria. Ribosome assembly. Molecular, Cellular & Developmental Biology. Microbiology & Immunology.
Bioinformatics. Donna Martin, M.D., Ph.D. Genetic control of neuronal differentiation. Neuroscience. Human Genetics. Miriam H. Meisler, Ph.D. Human and mouse disease gene isolation and mutation detection; disease gene isolation neurogenetics; comparative genomics; genetics of sodium and calcium channels expressed in the nervous system. Neuroscience. Human Genetics. Cellular & Molecular Biology. Molecular & Integrative Physiology. Joseph M. Metzger, Ph.D. Viral-based gene transfer into the heart; cellular and molecular mechanisms of contraction in skeletal and cardiac muscle; cardiac gene expression and function; gene therapy for the heart. Molecular & Integrative Physiology.
Daniel Michele, PhD Molecular & Integrative Physiology Molecular mechanisms of human cardiomyopathies
and skeletal myopathies, with a focus on muscular
dystrophy, using mouse models. Extracellular matrix
receptors in central nervous system development and
muscle
Richard A. Miller, MD, Ph.D. Signal transduction in T
cells; aging and T-cell subsets; immunology of aging;
genetics of longevity. Molecular and
Cellular Pathology.
Cellular & Molecular Biology. Immunology. John Moran, Ph.D. Molecular analysis of human and mouse retrotransposons. Characterization of a novel retrotransposition mechanism. Studies of how transposable elements influence genomic diversity. Exploitation of human and mouse retrotransposons as genetic tools. Human Genetics. Sean Morrison, Ph.D. Stem cell biology using hematopoiesis and neural development as model systems. Cell & Developmental Biology. Cellular & Molecular Biology. Richard Mortensen, M.D., Ph.D. Molecular signal transduction pathways important in cardiovascular risk and disease. Pathways in hypertension and diabetes. G-proteins, PPARs, growth pathways. Molecular & Integrative Physiology. Internal Medicine. Kentaro Nabeshima, Ph.D. Mechanisms of the chromosome dynamics in meiosis with the primary focus on the establishment of the association between homologous chromosomes. Cell and Developmental Biology. Lab: http://www.med.umich.edu/cdb/sub_pages/People/nabeshima.html Ruthann Nichols, Ph.D. Structure-activity relationship of neuropeptides and neuropeptide receptors with emphasis on the RFamide peptide family and their role in regulating heart rate and muscle contraction; role of FMRF-amide neuropeptides in Drosophila and mammalian nervous systems. Biological Chemistry. Neuroscience. Human Genetics. Alexander J. Ninfa, Ph.D. Reconstitution of signal transduction systems from purified components, structure/function analysis of signal transduction enzymes, protein crystallography. Characterization of protein kinases, phosphatases, and nucleotidy/transferases involved in signal transduction. Organization of the gene cascade controlling nitrogen assimilation in bacteria. Development of synthetic systems that perform useful functions. Biological Chemistry. Microbiology & Immunology. Bennett Novitch, Ph.D. Regulation of progenitor and stem cell proliferation and differentiation in the developing vertebrate central nervous system. Cell & Developmental Biology. Neuroscience. Gabriel Nuñez, MD Molecular regulation of programmed cell death (apoptosis); identification and characterization of apoptosis regulatory genes. Cellular & Molecular Biology. Molecular and Cellular Pathology. Microbiology & Immunology. Gilbert Omenn, MD. Ph.D. Proteomics and bioinformatics for development of cancer biomarkers. Human Genetics. Bioinformatics. Internal Medicine. Elizabeth M. Petty, MD Molecular genetics of solid tumor development; translation of molecular genetic discoveries to clinical applications; medical ethics. Cellular & Molecular Biology. Human Genetics. Steve Qin, Ph.D. Statistical genetics, disease mapping, computational biology, comparative genomics, functional genomics. Biostatistics. Bioinformatics. Diane M. Robins, Ph.D. Developmental and hormonal regulation of mammalian gene expression. Human Genetics. Cellular & Molecular Biology. Noah Rosenberg, Ph.D. Mathematical models in genetics and evolution, human population genetics, statistical methods for inference of human genetic history, role of human genetic variation in disease-gene mapping, human statistical genetics, genetic variation in pathogens, gene trees and species trees, phylogenetics. Bioinformatics. Human Genetics. Linda C. Samuelson, Ph.D. Regulation of gastrointestinal function by peptide hormones; mouse developmental genetics; gene targeting in embryonic stem cells; molecular physiology of cholecystokinin and gastrin. Molecular & Integrative Physiology. Cellular & Molecular Biology. John
Schiefelbein, Ph.D. Molecular genetics of cell
morphogenesis; plant molecular biology. Molecular, Cellular & Developmental Biology.
Cellular & Molecular Biology. JoAnn Sekiguchi, Ph.D. Mechanisms of DNA repair and how aberrant repair processes affect genomic stability, predisposition to cancer and immune system development. Human Genetics. Katherine Spindler, Ph.D. Molecular genetics of mouse adenovirus (MAV-1) pathogenesis; host immune response to MAV-1; genetics of host susceptibility to viral infection. Microbiology & Immunology. Cellular & Molecular Biology. Human Genetics. David States, MD, Ph.D. Current projects focus on the application of quantitative analytic methods and machine learning technology to problems of molecular biology and genome analysis. Computational techniques include simulation, classification, database construction and analysis, and parallel computation. Integration of statistical and heuristic techniques with algorithm development is viewed as critical to solving problems of biological interest. Bioinformatics. Human Genetics.
Michele S. Swanson, Ph.D. Legionella pneumophila growth in
macrophages. Microbiology & Immunology Anand Swaroop,
Ph.D. Molecular genetics of inherited eye diseases;
animal models for retinal degeneration; regulation of
development and tissue-specific gene expression;
expression mapping of human genome. Human Genetics. Cellular & Molecular Biology.
Neuroscience. Alice
Telesnitsky, Ph.D. Retrovirus molecular genetics,
reverse transcriptase structure-function studies, HIV-1
and murine leukemia virus genetic recombination and other
mechanisms of genetic variation, virus-host interactions
on the cellular level. Microbiology & Immunology. Cellular & Molecular Biology. Anne Vojtek, Ph.D. Regulation of cell growth and differentiation by signal transduction pathways. Biological Chemistry. Lois Weisman, Ph.D. To uncover mechanisms of organelle inheritance, and to determine how these processes are spatially and temporally regulated. We have discovered that myosin V attaches to membranes via organelle-specific receptors. In addition inheritance requires a newly discovered signaling pathway. Cell & Developmental Biology. Cellular & Molecular Biology. Life Sciences Institute. Deneen M. Wellik, Ph. D. The developmental and genetic role of the Hox genes during embryogenesis with a primary focus on kidney development and patterning of the axial skeleton. Internal Medicine-Molecular Medicine and Genetics, Cell and Developmental Biology.
Thomas E. Wilson, MD, Ph.D. DNA double-strand break
repair mechanisms and their contribution to the
chromosomal instability of cancer. Molecular and
Cellular Pathology. Cellular & Molecular Biology. Patricia Wittkopp, Ph.D. Genetic and developmental bases of evolutionary change. Molecular mechanisms that regulate gene expression and genetic changes that alter regulation are of particular interest. Molecular, Cellular, & Developmental Biology. Ecology & Evolutionary Biology. X.Z. Shawn Xu, Ph.D. Neurobiology of behavior and drug addiction in the genetic model organism C. elegans. Regulation of neuronal activity and fertilization by calcium signaling. Molecular & Integrative Physiology. Yukiko Yamashita Mechanisms of asymmetric stem cell division, control of stem cell behavior in their natural environment (in vivo), cell polarity, spindle orientation. Cell & Developmental Biology. Jianzhi Zhang, Ph.D. Molecular and genomic evolution, with both experimental and computational approaches. Bioinformatics.
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