Gene Therapy

Please note: Words in italics are the official PIBS affiliations of the indicated faculty.

James R. Baker Jr., MD Determining why autoantigens are recognized in autoimmune disease; epitope mapping thyroid autoantigens from patients with autoimmune thyroid disease. Immunology. Molecular and Cellular Pathology.

Kate F. Barald, Ph.D. Developmental neurobiology; molecular neurobiology studies of developing neuronal cells and synapses; gene expression in the neural crest; molecular studies of inner ear development. Cell & Developmental Biology. Neuroscience. Cellular & Molecular Biology.

D. Keith Bishop, Ph.D. Cellular immunology of transplant rejection and acceptance. Microbiology & Immunology. Immunology.

Sally A. Camper, Ph.D. Developmental genetics of the neuroendocrine system; transgenic mice; gene targeting; pituitary dwarfism. Human Genetics. Bioinformatics. Cellular & Molecular Biology. Neuroscience.

Kathleen Collins, M.D., Ph.D. Molecular Mechanisms of HIV Immune Evasion. Immunology. Cellular & Molecular Biology. Microbiology & Immunology.
http://www.med.umich.edu/cmb/faculty/directory.htm#collins

Eva Feldman, MD, Ph.D. Insulin-like growth factors in neuronal development and survival. Cellular & Molecular Biology. Neuroscience.

Cory Hogaboam, Ph.D. Cytokine and chemokine networks that maintain inflammatory responses in the liver and lung during chronic disease. Cytokine and chemokine networks that promote deleterious liver and lung tissue repair processes. Therapeutic interventions in idiopathic pulmonary fibrosis and asthma. Phenotypic switches in pulmonary and hepatic firboblasts during chronic inflammatory disease. Molecular and Cellular Pathology. Immunology.

Michael J. Imperiale, Ph.D. Posttranscriptional regulation of eukaryotic gene expression; interaction of virus and host cell factors in regulation of gene expression and oncogenic transformation; viral vectors. Microbiology & Immunology. Cellular & Molecular Biology.

Randal J. Kaufman, Ph.D. Regulation of protein synthesis and secretion; molecular biology of factor VIII and gene therapy for hemophilia A. Biological Chemistry.

Nicholas W. Lukacs, Ph.D. Interrelationship of cytokines, chemokines and leukocyte activation during asthmatic-type airway responses and immune responses. Molecular and Cellular Pathology.

Jonathan Maybaum, Ph.D. Gene therapy approaches to protection of host tissues during chemotherapy; role of programmed and non-programmed cell death mechanisms in cancer chemotherapy. Pharmacology. Radiation Oncology.

Joseph M. Metzger, Ph.D. Viral-based gene transfer into the heart; cellular and molecular mechanisms of contraction in skeletal and cardiac muscle; cardiac gene expression and function; gene therapy for the heart. Molecular & Integrative Physiology.

Josef Miller, MD, Ph.D. Analysis of changes that occur in auditory periphery and CNS with deafness. Sensory Neurobiology. Otorhinolaryngology. Neuroscience.

John Moran, Ph.D. Molecular analysis of human and mouse retrotransposons. Characterization of a novel retrotransposition mechanism. Studies of how transposable elements influence genomic diversity. Exploitation of human and mouse retrotransposons as genetic tools. Human Genetics.

Richard Neubig, MD, Ph.D. Molecular mechanisms of signal transduction; spectroscopic and rapid kinetic studies of receptors, G proteins and their regulators; NMR structure of receptor and G-protein peptides; mechanism of alpha-adrenergic receptors. Bioinformatics. Biophysics. Pharmacology.
Biophysics Lab

Yehoash Raphael, Ph.D. Design of biologically modified cochlear implants for combining electrical stimulation with gene therapy in the inner ear. Use of viral vectors for inner ear gene transfer aimed at repair and regeneration of cochlear and vestibular sensory epithelia. The roles of IGF-I and GDNF in protection and rescue of hearing and balance organs. Neuroscience.

Blake Roessler. Development of gene therapy for the rheumatic diseases. Internal Medicine. Immunology.

Brian D. Ross, Ph.D. Multinuclear NMR spectroscopy and imaging of intact biological systems, with an emphasis in experimental neuro-oncology, oxidative stress, and gene therapy. Biological Chemistry.

Donna S. Shewach, Ph.D. Metabolism and mechanism of action of nucleoside analog anticancer compounds. Pharmacology.

Faye Silverstein, MD Neurochemical mechanisms of perinatal brain injury. Integrative and Systems Neurobiology. Neuroscience.

Maria S. Soengas, Ph.D. Skin cancer (melanoma) initiation, progression and chemoresistance. Identification of tumor markers and drug response genes. Development of new treatments for aggressive and metastatic melanoma. Cellular & Molecular Biology. Dermatology.

Debra A. Thompson, Ph.D. Molecular studies of the function of the mammalian retina, including analysis of the mechanisms controlling signal transduction and tissue-specific gene expression in the retinal pigment epithelium. Biological Chemistry.

Margaret Westfall, Ph.D. Thin filament regulation of contractile function; cellular and molecular dissection of contractile function using viral-based gene transfer into cardiac myocytes. Molecular & Integrative Physiology. Cellular & Molecular Biology.

Max S. Wicha, MD Regulation of cell growth and death pathways in mammary cells. Cellular & Molecular Biology.