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Gene ExpressionPlease note: Words in italics are the official PIBS affiliations of the indicated faculty. Goncalo Abecasis, Ph.D Development and application of statistical methods for complex trait gene identification. Active research areas include mental disorders and aging-related diseases. Biostatistics. Bioinformatics. Huda Akil, Ph.D. Molecular and neurobiological mechanisms of stress, opioids, endorphins, and dopamine. Psychiatry. Molecular and Chemical Neuroscience. Neuroscience. Richard A. Altschuler, Ph.D. Neurobiology; auditory neurotransmitters and pathways and structural basis of cochlea function; plasticity in the auditory brain stem. Cell & Developmental Biology. Neuroscience. Kate F. Barald, Ph.D. Developmental neurobiology; molecular neurobiology studies of developing neuronal cells and synapses; gene expression in the neural crest; molecular studies of inner ear development. Cell & Developmental Biology. Neuroscience. Cellular & Molecular Biology.
James Bardwell, Ph.D. Protein folding catalysts, from genetics to
3-D structures: role of molecular chaperones and disulfide catalysts.
Biology. Biophysics. Cellular & Molecular Biology. Scott Barolo, Ph.D. Molecular genetics and biochemistry of transcriptional regulation; structure/function analysis of signaling pathway-regulated enhancers, using Drosophila as a model system. Cell & Developmental Biology. Robert A. Bender, Ph.D. Metabolic regulation in microorganisms. Molecular, Cellular & Developmental Biology. Daniel A. Bochar, Ph.D. Regulation of eukaryotic gene expression through the modulation of chromatin structure and the connection to developmental disorders and cancer. Biological Chemistry. Jimo Borjigin, Ph.D. Reseach is focused on three areas: entrainment of circadian pacemaker using melatonin as readout; molecular mechanisms of melatonin production; role of PINA (PIneal and Night-specific ATPase) in circadian rhythm and Wilson disease. Molecular & Integrative Physiology. Thomas Brock, Ph.D. Molecular and cellular aspects of cell-to-cell communication by polyunsaturated fatty acids, particularly in the contexts of immune defense and disease. Regulation of enzymes that convert fatty acids into alternative lipid mediators. Bioinformatics. Cellular & Molecular Biology. Internal Medicine Frank Brosius, M.D. Pathways by which glucose transporter expression affects cell death and the pathogenesis of diabetic nephropathy; abnormalities of glucose transport and metabolism in the pathogenesis of vascular changes in hypertension. Molecular & Integrative Physiology. Internal Medicine. Kenneth Cadigan, Ph.D. Genetics of Drosophila Devel and Signal Transduction. Molecular, Cellular & Developmental Biology. Cellular & Molecular Biology. Sally A. Camper, Ph.D. Developmental genetics of the neuroendocrine system; transgenic mice; gene targeting; pituitary dwarfism. Human Genetics. Bioinformatics. Cellular & Molecular Biology. Neuroscience. Thomas Carey, Ph.D. Genetic mechanisms in head and neck cancer progression; genetic mechanisms affecting response to therapy; and mechanisms of autoimmune hearing loss mediated by antibodies to inner ear antigens. Cellular & Molecular Biology. Pharmacology. Cheong-Hee Chang, Ph.D. Regulation of the effector function of CD4 T cells and dendritic cells. Microbiology & Immunology, Immunology, Cell & Molecular Biology.
Arul M. Chinnaiyan, M.D., Ph.D. Focus on high-throughput genomic
and proteomic technologies to analyze human disease. Lab projects include
molecular profiling of prostate cancer, profiling cancer with protein
microarrays, and molecular signatures of sepsis. Bioinformatics.
Molecular and Cellular Pathology. Steven Clark, Ph.D. Current research focuses on receptor kinase=mediated signaling pathways regulating stem cell identity and organogenesis, as well as microRNA regulation of stem cell specification. Molecular & Integrative Physiology. Molecular, Cellular & Developmental Biology. Stephen Cooper, Ph.D. Analysis of the mammalian cell cycle, analysis of the bacterial cell cycle, the logic and chemistry of cell cycle control. Microbiology & Immunology. Robert Denver, Ph.D.
Molecular biology of hormone action in animal development;
neuroendocrinology; evolutionary developmental biology.
Molecular, Cellular & Developmental Biology. Neuroscience. Victor J. DiRita,
Ph.D. Molecular mechanisms in bacterial pathogenesis; Genetic control
of bacterial virulence. Microbiology & Immunology. Cellular
& Molecular Biology. Steven Domino, M.D., Ph.D. Functions of cell-surface carbohydrates in reproductive and other tissues. Cellular & Molecular Biology. Yali Dou, Ph.D. Using a combination of biochemical, cellular and genetic analyses, we would like to: analyze the structure, function and regulation of MLL complex; study the cross-talks between MLL and other histone modifying activities such as histone acetyltransferase and histone ubiquitinase; elucidate the mechanism of MLL deregulation (deletion, amplification and translocation) in leukemogenesis. Molecular & Cellular Pathology. Cumming Duan, Ph.D. The current research focuses on the insulin-like growth factor (IGF) signaling system, including the IGF ligands, IGF binding proteins, IGF receptors, and the downstream signal transduction mechanisms. Molecular, Cellular & Developmental Biology. Cellular & Molecular Biology. Colin S. Duckett, Ph.D. Novel roles for IAP proteins in the control of apoptosis, intracellular signaling and metabolism. IAPs as regulators of apoptosis. IAPs in cancer. E3 ubiquitination activities of IAPs. Caspase-independent signaling properties of IAPs. X-linked lymphoproliferative disorder and XIAP. Role of XIAP in copper metabolism and homeostasis. c-IAPs: Key intracellular signaling molecules with diverse roles in inflammation. IAP antagonists: Apoptotic sensitizers and signaling modulators. Immunology, Molecular and Cellular Pathology, Cellular & Molecular Biology. Wesley Dunnick, Ph.D. Immunoglobulin genes; DNA rearrangement. Mircrobiology and Immunology. Immunology. Doug Engel,
Ph.D. Molecular genetics of mammalian organ specification and differentiation.
Cell & Developmental Biology. Cellular & Molecular Biology.
David R. Engelke, Ph.D. Regulation of eukaryotic gene expression
at the levels of transcription and RNA processing; catalytic and therapeutic
RNA. Cellular & Molecular Biology. Biological Chemistry.
Eric R. Fearon, MD, Ph.D. Molecular genetics of cancer; tumor suppressor
gene function. Cellular & Molecular Biology. Human Genetics.
Molecular and Cellular Pathology. Renny T. Franceschi, Ph.D. Control of gene expression in osteoblasts; regulation of bone formation. Biological Chemistry. Philip Gage,
Ph.D. Genetic analysis of mammalian eye development; cell fate
decisions in neural crest and mesoderm, transgenic mice, and gene
targeted mice. Cellular & Molecular Biology, Cell & Developmental
Biology Debashis Ghosh, Ph.D. Statistical and computational methods for analysis of high-throughput genomic and proteomic expression data, statistical modelling of transcription regulatory systems, protein modelling and cancer biology modelling. Bioinformatics. Thomas M. Glaser, MD, Ph.D. Genetic analysis of mammalian eye development. Human Genetics.
Daniel J. Goldman, Ph.D. Acetylcholine receptor gene expression
at the neuromuscular junction; synaptogenesis; sensory transduction
processes; neuroreceptors; molecular mechanisms of nerve regeneration.
Biological Chemistry. Human Genetics. Neuroscience. Pharmacology. Deborah L. Gumucio, Ph.D. Regulation of globin genes in transgenic mice. Potential to impact the treatment of Sickle Cell anemia and beta thalassemia. Molecular factors that control development of the intestine. Factors that regulate this program may be the same factors that are involved in the development of intestinal metaplasias in stomach and esophagus. Metaplasias are precursors to cancer. Cell & Developmental Biology. Cellular & Molecular Biology. Gary D. Hammer, MD, Ph.D. Molecular mechanisms of stress. Adrenal cortical growth and differentiation. Transcriptional regulation by adrenal-specific nuclear receptors-transcription factors. Adrenal cortical carcinogenesis. Transgenic models of adrenal development and disease. Molecular & Integrative Physiology. Cellular & Molecular Biology. Yongqun He (Oliver), DVM, Ph.D. Using high-throughput technologies (e.g., microarrays) and bioinformatics to study microbial pathogenesis and immunology of infectious diseases. Lab Animal Medicine. Microbiology & Immunology. Bioinformatics. Lab: http://helab.bioinformatics.med.umich.edu/ Jay Hess, M.D., Ph.D. Mechanisms of transformation by the mixed lineage leukemia protein and its downstream targets, the clustered (Hox) genes. Molecular and Cellular Pathology. Cellular & Molecular Biology. Peter F. Hitchcock,
Ph.D. Developmental neurobiology; retinal neurobiology; vision research;
neuronal regeneration in retina and ocular morphogenesis. Cell &
Developmental Biology. Neuroscience. Paul F. Hollenberg, Ph.D. Chemical carcinogenesis: metabolic activation and detoxication of carcinogens, mechanisms of carcinogen-activating enzymes, cytochrome P-450 and biological oxidations and peroxidations. Pharmacology. Bret A. Hughes, Ph.D. Structure, function, and regulation of ion channels in the retinal pigment epithelium. Ophthalmology. Molecular & Integrative Physiology. Michael J. Imperiale, Ph.D. Posttranscriptional regulation of eukaryotic gene expression; interaction of virus and host cell factors in regulation of gene expression and oncogenic transformation; viral vectors. Microbiology & Immunology. Cellular & Molecular Biology. Jorge Iñiguez-Lluhi, Ph.D. Eukaryotic Transcriptional regulation, transcription factor interactions,Steroid hormone receptors, structure, function and genetics. Pharmacology. Jeffrey W. Innis, MD, Ph.D. Molecular genetics of mammalian limb development; HOX gene function. Human Genetics. Bioinformatics. Lori L. Isom, Ph.D. Cellular & Molecular Biology of voltage-gated sodium channel alpha and beta subunits. Pharmacology. Neuroscience. Cellular & Molecular Biology. Human Genetics. Mariana Kaplan, M.D. Dendritic cells in autoimmune diseases; APC apoptosis in lupus; endothelial cell apoptosis and vascular damage. Immunology Randal J. Kaufman, Ph.D. Regulation of protein synthesis and secretion; molecular biology of factor VIII and gene therapy for hemophilia A. Biological Chemistry.
Tom Kerppola, Ph.D. Regulation of gene expression by proto-oncogene
transcription factors; protein interactions in living cells and organisms;
and nucleoprotein complex architecture. Biological Chemistry. Biophysics. John Kim, Ph.D. Studies how microRNAs and other emerging classes of small RNAs regulate fundamental biological processes including heterochromatin formation, neuronal cell patterning, cardiac and skeletal muscle development, germline maintenance, and oncogenic cell proliferation. Using functional genomic, genetic, biochemical, and cell biology strategies, his lab investigates the molecular mechanisms of both the small RNAs and new candidate RNAi factors identified by genome-wide screens. Human Genetics. Philip King, Ph.D. Molecular understanding of mechanisms of signal integration in T cells. The role of a variety of intracellular signaling molecules including protein and lipid kinases, phosphatases, adapter proteins and transcription factors as potential signal integrators. Microbiology & Immunology. Immunology. Catherine Krull, Ph.D. Mechanisms that control cell migration and patterning during embryonic development. Cellular and Developmental Biology Roland Kwok, Ph.D. Hormonal regulation of cAMP-activated gene expression. Biological Chemistry. Obstetrics and Gynecology. Jun Li, Ph.D. Genetic studies of complex human diseases, including psychiatric disorders, heart disease, and cancer, with emphases on genetic influence of gene expression, population structure, DNA copy number variation (either inherited or somatic), and application of next-generation sequencing methods to related problems. Human Genetics. Cellular & Molecular Biology. Bioinformatics. Angel W. Lee, M.D., Ph.D.
Tyrosine kinase-based signal transduction mechanisms that regulate Cheng-Yu Lee, Ph.D. Currently investigating a number of evolutionarily conserved genes required for the choice of self-renewal vs. differentiation in fly, and we will apply the insight gained from studying fly neuroblasts to a clinically relevant vertebrate system such as mouse to test the roles of these fly genes in regulation of vertebrate neural stem cell self-renewal. Long-term goals: Identify many signaling pathways expressed in both insect and vertebrate neural stem cells, contribute to our understanding of neural stem cells in birth defects, regenerative medicine and cancer biology. Center For Stem Cell Biology, Life Sciences Institute, Division of Molecular Medicine And Genetics, Department Of Internal Medicine, Cellular and Developmental Biology. Lab: http://www.lsi.umich.edu/facultyresearch/labs/lee Jiandie Lin, Ph.D. - Genome-wide mapping and functional analysis of transcriptional networks in the control metabolism in cells and in vivo. Metabolic basis of diseases including obesity, type 2 diabetes, neurodegeneration and cancer. Cell & Developmental Biology. Life Sciences Institute. Warren E. Lockette, MD Vascular reactivity in hypertension; cardiovascular aspects of space flight; molecular genetics of hypertension. Molecular & Integrative Physiology. Margaret I. Lomax, Ph.D. Molecular biology of mitochondrial cytochrome c oxidase and recombinant DNA. Cell & Developmental Biology. Ormond A. MacDougald, Ph.D. Adipocyte gene expression and metabolism; transcriptional and posttranslational regulation of the transcription factor, C/EBP (alpha). Molecular & Integrative Physiology. Jill A. Macoska, Ph.D. Genetic and cellular changes associated with early neoplastic transformation. Bioinformatics. Cellular & Molecular Biology. Urology. Janine Maddock, Ph.D. Spatial organization of protein complexes in bacteria. Ribosome assembly. Molecular, Cellular & Developmental Biology. Microbiology & Immunology.
Bioinformatics. David M. Markovitz, MD Regulation of retroviral gene expression. Cellular & Molecular Biology. Immunology. Donna Martin, M.D., Ph.D. Genetic control of neuronal differentiation. Neuroscience, Human Genetics. Jens-Christian Meiners, Ph.D. Experimental biophysics with single DNA molecules. Mechanics of transcriptional control in prokaryotes; statistical mechanics of DNA molecules; knots and entanglements in DNA; development of laser tweezers for ultra-sensitive force measurements. Biophysics. Miriam H. Meisler, Ph.D. Human and mouse disease gene isolation and mutation detection; disease gene isolation neurogenetics; comparative genomics; genetics of sodium and calcium channels expressed in the nervous system. Neuroscience. Human Genetics. Cellular & Molecular Biology. Molecular & Integrative Physiology. Ram Menon, M.D Growth hormone action, regulation of gene transcription, role of growth factors in germ cell function. Molecular & Integrative Physiology Juanita L. Merchant, MD, Ph.D. Molecular mechanisms of gastric epithelial cell growth; growth factor regulation of normal and neoplastic growth; transcriptional control of gastrointestinal peptides; posttranslational modifications of transcription factors; transgenic models for stomach development; Helicobacter pylori and peptic ulcer; gastric cancer development. Cellular & Molecular Biology. Molecular & Integrative Physiology. Richard
A. Miller, MD, Ph.D. Signal transduction in T cells; aging and T-cell
subsets; immunology of aging; genetics of longevity. Molecular and
Cellular Pathology. Cellular & Molecular Biology. Immunology. Bethany Moore, Ph.D. Cytokine and chemokine and eicosanoid regulation of pulmonary fibrosis; bacterial infections in the lung post bone-marrow transplant. Immunology. Richard Mortensen, M.D., Ph.D. Molecular signal transduction pathways important in cardiovascular risk and disease. Pathways in hypertension and diabetes. G-proteins, PPARs, growth pathways. Molecular & Integrative Physiology. Internal Medicine. Ruthann Nichols, Ph.D. Structure-activity relationship of neuropeptides and neuropeptide receptors with emphasis on the RFamide peptide family and their role in regulating heart rate and muscle contraction; role of FMRF-amide neuropeptides in Drosophila and mammalian nervous systems. Biological Chemistry. Neuroscience. Human Genetics. Alexander J. Ninfa, Ph.D. Reconstitution of signal transduction systems from purified components, structure/function analysis of signal transduction enzymes, protein crystallography. Characterization of protein kinases, phosphatases, and nucleotidy/transferases involved in signal transduction. Organization of the gene cascade controlling nitrogen assimilation in bacteria. Development of synthetic systems that perform useful functions. Biological Chemistry. Microbiology & Immunology. Bennett Novitch, Ph.D. Regulation of progenitor and stem cell proliferation and differentiation in the developing vertebrate central nervous system. Cell & Developmental Biology. Neuroscience. K. Sue O'Shea, Ph.D. Developmental neurobiology; extracellular matrix; epithelial polarity. Cell & Developmental Biology. Paresh Patel, MD,
Ph.D. Neurotransmitters Regulating Mood Disorders. Neuroscience. Elizabeth M. Petty, MD Molecular genetics of solid tumor development; translation of molecular genetic discoveries to clinical applications; medical ethics. Cellular & Molecular Biology. Human Genetics. Sem H.
Phan, MD, Ph.D. Mechanisms of fibrosis; myofibroblast biology; regulation
of þ-smooth muscle actin gene expression; eosinophils and cytokines
in pulmonary fibrosis. Pathology. Immunology. Steve Qin, Ph.D. Statistical genetics, disease mapping, computational biology, comparative genomics, functional genomics. Biostatistics. Bioinformatics. Stephen W. Ragsdale, Ph.D. We are studying the microbial metabolism of one-carbon compounds (CO, CO 2 , methane) and xenobiotics (e.g., PCBs); oxygen sensing in the human carotid body; and the roles of metal ions in biology, including the mechanisms of nickel, B 12 , heme, and iron-sulfur enzymes. We use transient and steady-state kinetics, spectroscopy, and molecular biology to uncover mechanistic information. Biological Chemistry. Chemical Biology. Pamela A. Raymond,
Ph.D.
Development and regeneration in the central nervous system of zebrafish,
using genetics with molecular and embryological tools to uncover the
molecular basis of cell-cell interactions that regulate retinal neurogenesis
(the formation of neurons) and neuronal specificity (the expression
of differentiated cellular features) during development and regeneration.
Mechanisms of pattern formation and formation of precise arrays of cone
photoreceptors in the zebrafish retina.Cell & Developmental
Biology. Diane M. Robins, Ph.D. Developmental and hormonal regulation of mammalian gene expression. Human Genetics. Cellular & Molecular Biology. Theodora S. Ross, M.D., Ph.D. Genetics and biology of human leukemias by using mouse modeling as well as standard biochemical, molecular biological and cellular techniques. Cellular & Molecular Biology. Liangyou Rui, Ph.D. Molecular mechanisms of obesity and type 2 diabetes. Investigation of molecular mechanisms of insulin/leptin signaling and resistance. Molecular & Integrative Physiology. Gabrielle Rudenko, Ph.D.Determining the three-dimensional structure of proteins with important functions in the brain using x-ray crystallography, augmented with biochemical, biophysical as well as mutagenesis studies. Pharmacology. Life Sciences Institute Linda C. Samuelson, Ph.D. Regulation of gastrointestinal function by peptide hormones; mouse developmental genetics; gene targeting in embryonic stem cells; molecular physiology of cholecystokinin and gastrin. Molecular & Integrative Physiology. Cellular & Molecular Biology. Jessica Schwartz, Ph.D. Cellular and molecular mechanisms of growth factor action; regulation of gene expression. Molecular & Integrative Physiology. Cellular & Molecular Biology. Audrey F. Seasholtz, Ph.D. Regulation of expression of the corticotropin-releasing hormone gene in mammalian stress. Biological Chemistry. Neuroscience. Cellular & Molecular Biology. Robert U. Simpson, Ph.D. Receptors: calcium-regulating hormones and drugs. Pharmacology. William L. Smith, Ph.D. Chemical processes underlying the biosynthesis and functions of prostaglandins. Current research is focused on understanding (a) the enzymology of prostaglandin endoperoxide H synthases (PGHSs) and (b) the regulation of PGHS gene expression. PGHSs are also known as "cyclooxygenases". Biological Chemistry. Maria S. Soengas, Ph.D. Skin cancer (melanoma) initiation, progression and chemoresistance. Identification of tumor markers and drug response genes. Development of new treatments for aggressive and metastatic melanoma. Cellular & Molecular Biology. Dermatology. Yi Sun, Ph.D. 1) Mechanism of p53 tumor suppressor and SCF E3 ubiquitin ligase (for protein ubiquitination and degradation) in apoptosis induction and suppression, respectively; 2) Identification and validation of cancer targets in the p53 and E3 ubiquitin ligase signaling pathways for anti-cancer drug discovery. Cellular & Molecular Biology. Radiation Oncology. Anand Swaroop, Ph.D. Molecular
genetics of inherited eye diseases; animal models for retinal degeneration;
regulation of development and tissue-specific gene expression; expression
mapping of human genome. Human Genetics. Cellular & Molecular
Biology. Neuroscience. Debra A. Thompson, Ph.D. Molecular studies of the function of the mammalian retina, including analysis of the mechanisms controlling signal transduction and tissue-specific gene expression in the retinal pigment epithelium. Biological Chemistry. Robert Thompson, Ph.D. Mechanisms of antidepressant action and nutritional regulation of reproductive functions (regulation of gene expression; molecular biology, neuroendocrinology and anatomy). Neuroscience. Psychiatry. Raymond C. Trievel, Ph.D. Structural and functional studies of enzymes that catalyze post-translational modifications of proteins, especially those involved in transcriptional regulation and chromatin remodeling. Biological Chemistry.
David Turner, Ph.D. Molecular mechanisms that regulate cell-fate
decisions during the development of the vertebrate nervous system. Biological
Chemistry. Neuroscience. Michael D. Uhler, Ph.D. Regulation and specificity of serine-threonine protein kinase structures; regulation of calcium channels and neurotransmitter secretion; function and regulation of neuronal activity; Cyclic nucleotides and phosphorylation in neuronal plasticity. Cellular & Molecular Biology. Biological Chemistry. Molecular and Chemical Neuroscience. Hisashi
Umemori, M.D. Molecular mechanisms of specific neural network
and synapse formation in the mammalian nervous system. Biological
Chemistry, Neuroscience, Molecular & Behavioral Neuroscience
Institute. Delia Vazquez, MD Development of the classical endocrine system which responds to stress, the hypothalamic pituitary adrenal (HPA) axis. Regulation of the serotonin system during development. Neuroscience. Stanley Watson, MD, Ph.D. Regulatory neurobiology of opioid and related peptides; Molecular and neurobiological mechanisms of stress. Cellular & Molecular Biology. Neuroscience. Michael J. Welsh, Ph.D. Cellular stress response and stress-induced proteins; molecular mechanisms of toxicant action; regulation and function of hsp27 and related small stress proteins in muscle and cancer; cell biology; cell cytoskeleton and cytoskeletal proteins. Cell & Developmental Biology. Cellular & Molecular Biology. Patricia Wittkopp, Ph.D. Genetic and developmental bases of evolutionary change. Molecular mechanisms that regulate gene expression and genetic changes that alter regulation are of particular interest. Molecular, Cellular, & Developmental Biology. Ecology & Evolutionary Biology. Jianzhi Zhang, Ph.D. Molecular and genomic evolution, with both experimental and computational approaches. Bioinformatics. |
