Drug Metabolism

Please note: Words in italics are the official PIBS affiliations of the indicated faculty.

David P. Ballou, Ph.D. Mechanisms of biological redox reactions and reactions with oxygen, especially metalloproteins and flavoproteins; physical and chemical studies, including rapid reaction techniques and instrumentation development. Biological Chemistry. Biophysics.

Dean E. Brenner, MD Pharmacodynamics of anticancer drugs in animal models and humans. Pharmacology.

Jason Gestwicki, Ph.D. Use of organic chemistry to build new tools for exploring important biological questions. We are currently focused on generating new technologies for inhibiting protein-protein interactions in neurodegenerative diseases. Life Sciences Institute. Molecular & Cellular Pathology.

Paul F. Hollenberg, Ph.D. Chemical carcinogenesis: metabolic activation and detoxication of carcinogens, mechanisms of carcinogen-activating enzymes, cytochrome P-450 and biological oxidations and peroxidations. Pharmacology.

Yoichi Osawa, Ph.D. Formation of reactive intermediates such as nitric oxide, oxygen metabolites, and drug metabolites and their subsequent interactions with important cellular targets as potential mechanisms by which drugs, environmental pollutants, and certain pathological conditions lead to toxicity or disease. Pharmacology.

James Rae, Ph.D. Regulation of breast cancer growth. Predicting drug response using pharmacogenetics and genomics. Drug metabolism and the cytochrome P450s. Biomarker discovery and clinical correlative studies. Preclinical drug discovery and testing. Internal Medicine. Pharmacology.

Donna S. Shewach, Ph.D. Metabolism and mechanism of action of nucleoside analog anticancer compounds. Pharmacology.

Maria S. Soengas, Ph.D. Skin cancer (melanoma) initiation, progression and chemoresistance. Identification of tumor markers and drug response genes. Development of new treatments for aggressive and metastatic melanoma. Cellular & Molecular Biology. Dermatology.

Robert Thompson, Ph.D. Mechanisms of antidepressant action and nutritional regulation of reproductive functions (regulation of gene expression; molecular biology, neuroendocrinology and anatomy). Neuroscience. Psychiatry.