DNA Repair and Genomic Stability

Please note: Words in italics are the official PIBS affiliations of the indicated faculty.

Raymond Chan , Ph.D. Studies the packaging of chromosome in preparation for cellular division in mitosis and meiosis in the nematode C. elegans.  My primary focus is on the Structural Maintenance of Chromosomes (SMC) protein family and TIM-1, a novel regulator of SMC proteins that I had previously identified. Human Genetics. http://www.umich.edu/~mmgmed/faculty/bios/Chan.htm

Yali Dou, Ph.D. Using a combination of biochemical, cellular and genetic analyses, we would like to: analyze the structure, function and regulation of MLL complex; study the cross-talks between MLL and other histone modifying activities such as histone acetyltransferase and histone ubiquitinase; elucidate the mechanism of MLL deregulation (deletion, amplification and translocation) in leukemogenesis. Molecular & Cellular Pathology.

David Ferguson, M.D., Ph.D. How DNA repair prevents cancer, provides immuno-competence, and ensures proper overall development. Molecular and Cellular Pathology

Thomas W. Glover, Ph.D. Molecular cytogenetics and the molecular biology of human disease; gene mapping; Menkes syndrome; fragile sites. Human Genetics. Cellular & Molecular Biology.

Catherine E. Keegan, MD, PhD.  Mouse models of telomere dysfunction, genomic instability, and birth defects.  Molecular genetics of caudal and urogenital development. Cellular & Molecular Biology. Pediatric Genetics.

John Kim, Ph.D. Studies how microRNAs and other emerging classes of small RNAs regulate fundamental biological processes including heterochromatin formation, neuronal cell patterning, cardiac and skeletal muscle development, germline maintenance, and oncogenic cell proliferation. Using functional genomic, genetic, biochemical, and cell biology strategies, his lab investigates the molecular mechanisms of both the small RNAs and new candidate RNAi factors identified by genome-wide screens. Human Genetics.

Jun Li, Ph.D. Genetic studies of complex human diseases, including psychiatric disorders, heart disease, and cancer, with emphases on genetic influence of gene expression, population structure, DNA copy number variation (either inherited or somatic), and application of next-generation sequencing methods to related problems. Human Genetics. Cellular & Molecular Biology. Bioinformatics.

Ming Lei, Ph.D. Structural and functional studies of the molecular mechanism of human telomere and its regulation. with an emphasis in a multi-subunit complex (telosome) which forms the protective cap of the telomere. Biological Chemistry.

Mats Ljungman, Ph.D. Cellular responses induced by DNA-damaging agents and other cellular stresses. Cellular & Molecular Biology.

Sami Malek, M.D. Hematological malignancies including CLL, Follicular Lymphoma, MDS and AML using a variety of approaches. Many questions intersect with standard immunological problems and are studied accordingly. Internal Medicine. Immunology.

John Moran, Ph.D. Molecular analysis of human and mouse retrotransposons. Characterization of a novel retrotransposition mechanism. Studies of how transposable elements influence genomic diversity. Exploitation of human and mouse retrotransposons as genetic tools. Human Genetics.

Kentaro Nabeshima, Ph.D. Mechanisms of the chromosome dynamics in meiosis with the primary focus on the establishment of the association between homologous chromosomes. Lab: http://www.med.umich.edu/cdb/sub_pages/People/nabeshima.html Cell and Developmental Biology

Patrick O'Brien, Ph.D. Biochemical, biophysical, and structural approaches to understanding mechanisms of human DNA repair. Biological Chemistry.

JoAnn Sekiguchi, Ph.D. DNA repair and how aberrant repair processes affect genomic stability, predisposition to cancer and immune system development. Human Genetics

Alice Telesnitsky, Ph.D. Retrovirus molecular genetics, reverse transcriptase structure-function studies, HIV-1 and murine leukemia virus genetic recombination and other mechanisms of genetic variation, virus-host interactions on the cellular level. Microbiology & Immunology. Cellular & Molecular Biology.
Lab: http://sitemaker.umich.edu/telesnitsky.lab

Thomas E. Wilson, MD, Ph.D. DNA double-strand break repair mechanisms and their contribution to the chromosomal instability of cancer. Molecular and Cellular Pathology. Cellular & Molecular Biology.
Lab: http://tewlab.path.med.umich.edu/