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Developmental BiologyPlease note: Words in italics are the official PIBS affiliations of the indicated faculty. Kate F. Barald, Ph.D. Developmental neurobiology; molecular neurobiology studies of developing neuronal cells and synapses; gene expression in the neural crest; molecular studies of inner ear development. Cell & Developmental Biology. Neuroscience. Cellular & Molecular Biology. Scott Barolo, Ph.D. Molecular genetics and biochemistry of transcriptional regulation; structure/function analysis of signaling pathway-regulated enhancers, using Drosophila as a model system. Cell & Developmental Biology. Jill Becker, Ph.D. Role of estrogen and dopamine in behavior/recovery of function after brain injury. Neuroscience. Kenneth Cadigan, Ph.D. Genetics of Drosophila Devel and Signal Transduction. Molecular, Cellular & Developmental Biology. Cellular & Molecular Biology. Sally A. Camper, Ph.D. Developmental genetics of the neuroendocrine system; transgenic mice; gene targeting; pituitary dwarfism. Human Genetics. Bioinformatics. Cellular & Molecular Biology. Neuroscience. Cheong-Hee Chang, Ph.D. Regulation of the effector function of CD4 T cells and dendritic cells. Microbiology & Immunology, Immunology, Cell & Molecular Biology. Steven Clark, Ph.D. Current research focuses on receptor kinase=mediated signaling pathways regulating stem cell identity and organogenesis, as well as microRNA regulation of stem cell specification. Molecular & Integrative Physiology. Molecular, Cellular & Developmental Biology.
Robert Denver, Ph.D.
Molecular biology of hormone action in animal development;
neuroendocrinology; evolutionary developmental biology.
Molecular, Cellular & Developmental Biology. Neuroscience. Andrzej Dlugosz, M.D. Hedgehog signaling; molecular regulation of skin development and tumorigenesis. Cellular & Molecular Biology. Gregory Dressler, Ph.D. Genetic basis of cellular differentiation and pattern formation in a complex multicellular tissue. Cellular & Molecular Biology. Molecular and Cellular Pathology. Cumming Duan, Ph.D. The current research focuses on the insulin-like growth factor (IGF) signaling system, including the IGF ligands, IGF binding proteins, IGF receptors, and the downstream signal transduction mechanisms. Molecular, Cellular & Developmental Biology. Cellular & Molecular Biology.
Doug Engel, Ph.D. Molecular genetics of mammalian
organ specification and differentiation. Cell & Developmental Biology. Cellular & Molecular Biology.
Eric R. Fearon, MD, Ph.D. Molecular genetics of
cancer; tumor suppressor gene function. Cellular & Molecular Biology. Human Genetics.
Molecular and
Cellular Pathology. Diane Fingar, Ph.D. Signal transduction
by the kinase mTOR, the mammalian target of rapamycin, using molecular,
biochemical, and cell biological approaches. Cell and Developmental
Biology. Philip
Gage, Ph.D. Genetic analysis of mammalian eye
development; cell fate decisions in neural crest and
mesoderm, transgenic mice, and gene targeted mice.
Cellular & Molecular Biology, Cell & Developmental Biology Thomas M. Glaser, MD, Ph.D. Genetic analysis of mammalian eye development. Human Genetics.
Daniel J. Goldman, Ph.D. Acetylcholine receptor gene
expression at the neuromuscular junction; synaptogenesis;
sensory transduction processes; neuroreceptors; molecular
mechanisms of nerve regeneration. Biological Chemistry. Human Genetics.
Neuroscience. Pharmacology. Deborah L. Gumucio, Ph.D. Cell-Cell interactions controlling intestinal organogenesis. Isolation and characterization of gastric progenitor cells. Cell & Developmental Biology. Cellular & Molecular Biology. Jun-Lin Guan, Ph.D. Signal transduction in cell migration. FAK signaling pathways in angiogenesis and metastasis. Role of a putative tumor suppressor FIP200 in development and cancer. Cellular & Developmental Biology. Internal Medicine. Gary D. Hammer, MD, Ph.D. Molecular mechanisms of stress. Adrenal cortical growth and differentiation. Transcriptional regulation by adrenal-specific nuclear receptors-transcription factors. Adrenal cortical carcinogenesis. Transgenic models of adrenal development and disease. Molecular & Integrative Physiology. Cellular & Molecular Biology. Peter
F. Hitchcock, Ph.D. Developmental neurobiology;
retinal neurobiology; vision research; neuronal
regeneration in retina and ocular morphogenesis.
Cell & Developmental Biology.
Neuroscience. Michael Hortsch, Ph.D. Role of cell adhesion molecules in neuronal differentiation of Drosophila. Cell & Developmental Biology. Neuroscience. Patrick Hu, MD, Ph.D. We use the nematode C. elegans to study the biology of conserved signal transduction pathways that are mutated in cancer and diabetes. Cell & Developmental Biology. Richard Hume, Ph.D. Growth cone guidance mechanisms and neurotransmitter receptors. Neuroscience. Molecular, Cellular & Developmental Biology. Jeffrey W. Innis, MD, Ph.D. Molecular genetics of mammalian limb development; HOX gene function. Human Genetics. Bioinformatics. Lori L. Isom, Ph.D. Cellular & Molecular Biology of voltage-gated sodium channel alpha and beta subunits. Pharmacology. Neuroscience. Cellular & Molecular Biology. Human Genetics. Catherine E. Keegan, MD, PhD. Mouse models of telomere dysfunction, genomic instability, and birth defects. Molecular genetics of caudal and urogenital development. Cellular & Molecular Biology. Pediatric Genetics.
Tom Kerppola, Ph.D. Regulation of gene expression by
proto-oncogene transcription factors; protein
interactions in living cells and organisms; and
nucleoprotein complex architecture. Biological Chemistry. Biophysics. Ron Koenig, MD, Ph.D. Gene regulation by thyroid hormone receptors and related proteins. Cellular & Molecular Biology. Catherine Krull, Ph.D. Mechanisms that control cell migration and patterning during embryonic development. Cellular and Developmental Biology
John Kuwada, Ph.D. Molecular and genetic analysis of
cell proliferation regulation in the CNS, axon guidance
and the formation and function of neural circuits, and
the behaviors controlled by these neural circuits in
zebrafish. Molecular, Cellular & Developmental Biology. Neuroscience. Cellular & Molecular Biology. Cheng-Yu Lee, Ph.D. Currently investigating a number of evolutionarily conserved genes required for the choice of self-renewal vs. differentiation in fly, and we will apply the insight gained from studying fly neuroblasts to a clinically relevant vertebrate system such as mouse to test the roles of these fly genes in regulation of vertebrate neural stem cell self-renewal. Long-term goals: Identify many signaling pathways expressed in both insect and vertebrate neural stem cells, contribute to our understanding of neural stem cells in birth defects, regenerative medicine and cancer biology. Center For Stem Cell Biology, Life Sciences Institute, Division of Molecular Medicine And Genetics, Department Of Internal Medicine, Cellular and Developmental Biology. Lab: http://www.lsi.umich.edu/facultyresearch/labs/lee Margaret I. Lomax, Ph.D. Molecular biology of mitochondrial cytochrome c oxidase and recombinant DNA. Cell & Developmental Biology. Ormond A. MacDougald, Ph.D. Adipocyte gene expression and metabolism; transcriptional and posttranslational regulation of the transcription factor, C/EBP (alpha). Molecular & Integrative Physiology. Ivan Maillard, M.D.-Ph.D. Our main research interests are in the following topics: Investigating the interaction of hematopoietic stem cells (HSC) with their microenvironmental niche, particularly in fetal sites of hematopoiesis; and understanding the role of Notch signaling in the regulation of T cell homeostasis and differentiation. We are using a combination of genetic, cellular and biochemical approaches to study these questions. Hematology-Oncology. Cell and Developmental Biology. http://www.med.umich.edu/immprog/faculty/maillard.htm David M. Markovitz, MD Regulation of retroviral gene expression. Cellular & Molecular Biology. Immunology. Donna Martin, M.D., Ph.D. Genetic control of neuronal differentiation. Neuroscience, Human Genetics. Miriam H. Meisler, Ph.D. Human and mouse disease gene isolation and mutation detection; disease gene isolation neurogenetics; comparative genomics; genetics of sodium and calcium channels expressed in the nervous system. Neuroscience. Human Genetics. Cellular & Molecular Biology. Molecular & Integrative Physiology. Charlotte Mistretta, Ph.D. Early development of peripheral and central taste systems. Dentistry. Nursing. Sensory Neurobiology. Neuroscience. Sean Morrison, Ph.D. Stem cell biology using hematopoiesis and neural development as model systems. Cell & Developmental Biology. Cellular & Molecular Biology.
Bennett Novitch, Ph.D. Regulation of progenitor and
stem cell proliferation and differentiation in the
developing vertebrate central nervous system.
Cell & Developmental Biology.
Neuroscience. Vasantha Padmanabhan, Ph.D. Prenatal programming of adult reproductive disorders by native steroids and environmental disruptors; Neuroendocrine control of ovarian cyclicity with emphasis on neuroendcorine and paracrine regulation of follicle-stimulating hormone and ovarian folliculogenesis. Molecular & Integrative Physiology Jack Parent, M.D. Neural stem cells, plasticity and regeneration after brain injury; epileptogenesis. Neuroscience. Gina Poe, Ph.D. Basic sleep processes, development, learning and memory, and optimization of cognitive performance. Molecular & Integrative Physiology. Neuroscience. Yehoash Raphael, Ph.D. Design of biologically modified cochlear implants for combining electrical stimulation with gene therapy in the inner ear. Use of viral vectors for inner ear gene transfer aimed at repair and regeneration of cochlear and vestibular sensory epithelia. The roles of IGF-I and GDNF in protection and rescue of hearing and balance organs. Neuroscience. Pamela A. Raymond, Ph.D. Development and regeneration in the central nervous system of zebrafish, using genetics with molecular and embryological tools to uncover the molecular basis of cell-cell interactions that regulate retinal neurogenesis (the formation of neurons) and neuronal specificity (the expression of differentiated cellular features) during development and regeneration. Mechanisms of pattern formation and formation of precise arrays of cone photoreceptors in the zebrafish retina.Cell & Developmental Biology. http://www.med.umich.edu/cdb/sub_pages/People/raymond.htm Diane M. Robins, Ph.D. Developmental and hormonal regulation of mammalian gene expression. Human Genetics. Cellular & Molecular Biology. Linda C. Samuelson, Ph.D. Regulation of gastrointestinal function by peptide hormones; mouse developmental genetics; gene targeting in embryonic stem cells; molecular physiology of cholecystokinin and gastrin. Molecular & Integrative Physiology. Cellular & Molecular Biology. John
Schiefelbein, Ph.D. Molecular genetics of cell
morphogenesis; plant molecular biology. Molecular, Cellular & Developmental Biology.
Cellular & Molecular Biology. Robert U. Simpson, Ph.D. Receptors: calcium-regulating hormones and drugs. Pharmacology. Gary Smith, Ph.D. Mammalian gamete and embryo developmental biology. Molecular & Integrative Physiology. Anand Swaroop,
Ph.D. Molecular genetics of inherited eye diseases;
animal models for retinal degeneration; regulation of
development and tissue-specific gene expression;
expression mapping of human genome. Human Genetics. Cellular & Molecular Biology.
Neuroscience. David Turner, Ph.D. Molecular mechanisms that regulate cell-fate decisions during the development of the vertebrate nervous system. Biological Chemistry. Neuroscience. Hisashi
Umemori, M.D. Molecular mechanisms of specific neural network
and synapse formation in the mammalian nervous system. Biological
Chemistry, Neuroscience Delia Vazquez, MD Development of the classical endocrine system which responds to stress, the hypothalamic pituitary adrenal (HPA) axis. Regulation of the serotonin system during development. Neuroscience. Deneen M Wellik , Ph.D. How Hox genes function to pattern the mammalian body plan. Focused on kidney and limb development as well as axial skeletal patterning using mouse developmental genetics as our primary model organism. Molecular Medicine & Genetics. Internal Medicine. Cell & Developmental Biology. Michael J. Welsh, Ph.D. Cellular stress response and stress-induced proteins; molecular mechanisms of toxicant action; regulation and function of hsp27 and related small stress proteins in muscle and cancer; cell biology; cell cytoskeleton and cytoskeletal proteins. Cell & Developmental Biology. Cellular & Molecular Biology. Matthew J. Wishart, Ph.D. Mechanisms of action for protein- and lipid-phosphatases; STYX / dead-phosphatase adapters and phosphorylation-mediated signaling; molecular mechanisms of mammalian reproduction. Molecular & Integrative Physiology Patricia Wittkopp, Ph.D. Genetic and developmental bases of evolutionary change. Molecular mechanisms that regulate gene expression and genetic changes that alter regulation are of particular interest. Molecular, Cellular, & Developmental Biology. Ecology & Evolutionary Biology. Yukiko Yamashita Mechanisms of asymmetric stem cell division, control of stem cell behavior in their natural environment (in vivo), cell polarity, spindle orientation. Cell & Developmental Biology.
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