Cellular & Molecular Immunology

Please note: Words in italics are the official PIBS affiliations of the indicated faculty.

Mohammed Akaaboune, Ph.D. Regulation of synaptic connections during development, maturity and aging. One major approach is to use state-of-the-art imaging methods to observe the structure of synapses in living animals. Many studies take advantage of our in vivo imaging techniques to follow the dynamics of synaptic proteins over time in the same animal. Molecular, Cellular & Developmental Biology, Neuroscience.

James R. Baker Jr., MD Determining why autoantigens are recognized in autoimmune disease; epitope mapping thyroid autoantigens from patients with autoimmune thyroid disease. Immunology. Molecular and Cellular Pathology.

D. Keith Bishop, Ph.D. Cellular immunology of transplant rejection and acceptance. Microbiology & Immunology. Immunology.

Thomas Brock, Ph.D. Molecular and cellular aspects of cell-to-cell communication by polyunsaturated fatty acids, particularly in the contexts of immune defense and disease. Regulation of enzymes that convert fatty acids into alternative lipid mediators. Bioinformatics. Cellular & Molecular Biology. Internal Medicine

Cheong-Hee Chang, Ph.D. Regulation of the effector function of CD4 T cells and dendritic cells. Microbiology & Immunology, Immunology, Cell & Molecular Biology.

Kathleen Collins, M.D., Ph.D. Molecular Mechanisms of HIV Immune Evasion. Immunology. Cellular & Molecular Biology. Microbiology & Immunology.
http://www.med.umich.edu/cmb/faculty/directory.htm#collins

Jeffrey Curtis, M.D. Lung lymphocyte recruitment and apoptosis; regulation of pulmonary immunity; alveolar macrophage signal transduction pathways. Immunology.

Colin S. Duckett, Ph.D. Novel roles for IAP proteins in the control of apoptosis, intracellular signaling and metabolism. IAPs as regulators of apoptosis. IAPs in cancer. E3 ubiquitination activities of IAPs. Caspase-independent signaling properties of IAPs. X-linked lymphoproliferative disorder and XIAP. Role of XIAP in copper metabolism and homeostasis. c-IAPs: Key intracellular signaling molecules with diverse roles in inflammation. IAP antagonists: Apoptotic sensitizers and signaling modulators. Immunology, Molecular and Cellular Pathology, Cellular & Molecular Biology.

Wesley Dunnick, Ph.D. Immunoglobulin genes; DNA rearrangement. Mircrobiology and Immunology. Immunology.

Gary Glick, Ph.D. Developing new methods to study the structure, folding, and dynamics of both DNA and RNA. Defining binding properties of anti-DNA autoantibodies that arise in the autoimmune disorder systemic lupus erythematosus. Chemistry. Immunology. Cellular & Molecular Biology. Biophysics. Biochemistry.
http://www.umich.edu/~michchem/faculty/glick/

Yongqun He (Oliver), DVM, Ph.D. Using high-throughput technologies (e.g., microarrays) and bioinformatics to study microbial pathogenesis and immunology of infectious diseases. Lab Animal Medicine. Microbiology & Immunology. Bioinformatics. Lab: http://helab.bioinformatics.med.umich.edu/

Cory Hogaboam, Ph.D. Cytokine and chemokine networks that maintain inflammatory responses in the liver and lung during chronic disease. Cytokine and chemokine networks that promote deleterious liver and lung tissue repair processes. Therapeutic interventions in idiopathic pulmonary fibrosis and asthma. Phenotypic switches in pulmonary and hepatic firboblasts during chronic inflammatory disease. Molecular and Cellular Pathology. Immunology.

Joseph Holoshitz, MD Signal transduction; MHC and DNA repair in autoimmunity. Immunology. Microbiology. Cellular & Molecular Biology.

Ronald W. Holz, MD, Ph.D. Molecular mechanisms of underlying neurotransmitter and hormone secretion; development and use of novel optical techniques based upon total internal reflection microscopy to study the biochemistry of events at the plasma membrane. Pharmacology. Neuroscience. Cellular & Molecular Biology.
http://sitemaker.umich.edu/holz.lab

Mariana Kaplan, M.D. Dendritic cells in autoimmune diseases; APC apoptosis in lupus; endothelial cell apoptosis and vascular damage. Immunology

Tom Kerppola, Ph.D. Regulation of gene expression by proto-oncogene transcription factors; protein interactions in living cells and organisms; and nucleoprotein complex architecture. Biological Chemistry. Biophysics.
http://sitemaker.umich.edu/kerppola.lab

Philip King, Ph.D. Molecular understanding of mechanisms of signal integration in T cells. The role of a variety of intracellular signaling molecules including protein and lipid kinases, phosphatases, adapter proteins and transcription factors as potential signal integrators. Microbiology & Immunology. Immunology.

Steven Kunkel, Ph.D. Biology and gene regulation of chemokines and cytokines; macrophage pathobiology. Cellular & Molecular Biology. Immunology. Molecular and Cellular Pathology.

Yasmina Laouar, Ph.D. Mechanisms of immunosuppression in the development, homeostasis, and function of innate effector cells in response to pathogens. Immunology, Microbiology & Immunology.

Jennifer J. Linderman, Ph.D. Digital imaging of single cells; signal transduction; mathematical modeling of receptor-mediated cell behavior. Biophysics. Chemical Engineering.

Nicholas W. Lukacs, Ph.D. Interrelationship of cytokines, chemokines and leukocyte activation during asthmatic-type airway responses and immune responses. Molecular and Cellular Pathology.

Ralph Lydic, Ph.D. Transmembrane cell signaling; integrative aspects of respiratory and arousal state control. Cellular and molecular mechanisms that cause respiratory depression during the loss of waking consciousness. Neurochemical and signal transduction processes. Neuroscience.

Jill A. Macoska, Ph.D. Genetic and cellular changes associated with early neoplastic transformation. Bioinformatics. Cellular & Molecular Biology. Urology.

Ivan Maillard, M.D.-Ph.D. Our main research interests are in the following topics: Investigating the interaction of hematopoietic stem cells (HSC) with their microenvironmental niche, particularly in fetal sites of hematopoiesis; and understanding the role of Notch signaling in the regulation of T cell homeostasis and differentiation. We are using a combination of genetic, cellular and biochemical approaches to study these questions. Hematology-Oncology. Cell and Developmental Biology. http://www.med.umich.edu/immprog/faculty/maillard.htm

Sami Malek, M.D. Hematological malignancies including CLL, Follicular Lymphoma, MDS and AML using a variety of approaches. Many questions intersect with standard immunological problems and are studied accordingly. Internal Medicine. Immunology.

David M. Markovitz, MD Regulation of retroviral gene expression. Cellular & Molecular Biology. Immunology.

Richard A. Miller, MD, Ph.D. Signal transduction in T cells; aging and T-cell subsets; immunology of aging; genetics of longevity. Molecular and Cellular Pathology. Cellular & Molecular Biology. Immunology.
http://www.med.umich.edu/cmb/faculty/directory.htm#millerr

Bethany Moore, Ph.D. Cytokine and chemokine and eicosanoid regulation of pulmonary fibrosis; bacterial infections in the lung post bone-marrow transplant. Immunology.

Patrick Nelson, Ph.D. Applied mathematics specializing in mathematical biology. Develop and use models to study the dynamics of HIV and HBV infections. Mathematics. Microbiology & Immunology.

Gabriel Nuñez, M.D. Role of Innate Immunity in Host Defense, Cancer and Inflammatory Disease. Cellular & Molecular Biology. Molecular and Cellular Pathology. Microbiology & Immunology.
http://www.pathology.med.umich.edu/faculty/Nunez/index.html

Akira Ono, Ph.D. Relationships between cellular membranes and enveloped viruses with particular emphasis on the roles played by lipid rafts and endosomes in HIV-1 replication. Microbiology & Immunology.

Marc Peters-Golden, MD Cellular and molecular regulation of synthesis, as well as actions, of arachidonic acid metabolites (prostaglandins and leukotrienes) in inflammation, antimicrobial defense, and fibrosis. Immunology.

Malini Raghavan, Ph.D. Biochemical and molecular interactions underlying immune recognition events: interactions and biochemical mechanisms of function of the transporters associated with antigen processing; mammalian and viral Fc receptors and their interactions with immunoglobulin G. Microbiology & Immunology. Immunology. Biophysics. Cellular & Molecular Biology.

Bruce Richardson, MD, Ph.D. Mechanisms of autoimmune lupus. Immunology.

Rudy J. Richardson, ScD, DABT Mechanisms of neurological disorders, stroke and autoimmune diseases and their modulation by xenobiotics, genetics and age. Biomarkers of xenobiotic exposure or disease. Interactions of ligands with macromolecules using kinetics, molecular modeling and mass spectrometry. Environmental epidemiology. Scientific basis of risk assessment and public health policy. Neuroscience.
http://www.umich.edu/~neurosci/faculty/rjrich.htm

JoAnn Sekiguchi, Ph.D. Mechanisms of DNA repair and how aberrant repair processes affect genomic stability, predisposition to cancer and immune system development. Human Genetics

Lloyd M. Stoolman, MD Lymphocyte recirculation and migration; functional characterization of the lymphocyte and endothelial receptors that mediate migration into lymphoid organs and sites of chronic inflammation; role of lymphocyte homing receptors in the hematogenous dissemination of lymphoid malignancies; role of lymphocyte-extracellular matrix interactions in lymphocyte migration. Immunology. Molecular and Cellular Pathology.

Michele S. Swanson, Ph.D. Legionella pneumophila growth in macrophages. Microbiology & Immunology

Eric S. White, M.D. Our lab focuses on fibroblast biology, extracellular matrix influences on cellular biology, and immunology of granulomatous lung diseases. Internal Medicine-Pulmonary & Critical Care Medicine. Immunology.

Weiping Zou, M.D., Ph.D. Research interests: B7 family members and dendritic cells in tumors, regulatory T cells in tumors, immune cell trafficking in tumors, novel animal models for cancer, mechanistic interaction between tumor, host immune cells and stems cells, and the translational aspects of novel immune-based interventions in patients with cancer. Molecular and Cellular Pathology, Immunology.

Peter A. Ward, MD Mechanisms of the inflammatory response and its regulation; role of oxidants in tissue injury; mechanisms and participation of cytokines and chemokines; role of complement activation products in the inflammatory response. Molecular and Cellular Pathology.